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압전변압기를 이용한 LCD Backlight용 구동회로의 개발
강태구,안형근,한득영 건국대학교 산업기술연구원 1998 건국기술연구논문지 Vol.23 No.-
This paper describes a driving circuit with a multi-layered piezoelectric transformer(MPT) for the LCD backlight of a portable computer. In order to develop the circuit, we measured at first the L, C, R of the MPT concerned. And, using the measured parameters of L,C,R, we designed and implemented circuits such as a voltage-frequency converter, comparator for tracking resonance frequencies varying when the backlight is turned on, power circuit with two MOSFETs, and triggering circuit with flip/flops. We showed the possibility of tracking the resonance frequency of the MPT under the various load conditions.
Park, Jin Seok,Yi, Tac-Ghee,Park, Jong-Min,Han, Young Min,Kim, Jun-Hyung,Shin, Dong-Hee,Tak, Seon Ji,Lee, Kyuheon,Lee, Youn Sook,Jeon, Myung-Shin,Hahm, Ki-Baik,Song, Sun U,Park, Seok Hee the Society for Free Radical Research Japan 2015 Journal of clinical biochemistry and nutrition Vol.57 No.3
<P>Mouse bone marrow-derived clonal mesenchymal stem cells (mcMSCs), which were originated from a single cell by a subfractionation culturing method, are recognized as new paradigm for stem cell therapy featured with its homogenous cell population. Next to proven therapeutic effects against pancreatitis, in the current study we demonstrated that mcMSCs showed significant therapeutic effects in dextran sulfate sodium (DSS)-induced experimental colitis model supported with anti-inflammatory and restorative activities. mcMSCs significantly reduced the disease activity index (DAI) score, including weight loss, stool consistency, and intestinal bleeding and significantly increased survival rates. The pathological scores were also significantly improved with mcMSC. We have demonstrated that especial mucosal regeneration activity accompanied with significantly lowered level of apoptosis as beneficiary actions of mcMSCs in UC models. The levels of inflammatory cytokines including TNF-α, IFN-γ, IL-1β, IL-6, and IL-17 were all significantly concurrent with significantly repressed NF-κB activation compared to the control group and significantly decreased infiltrations of responsible macrophage and neutrophil. Conclusively, our findings provide the rationale that mcMSCs are applicable as a potential source of cell-based therapy in inflammatory bowel diseases, especially contributing either to prevent relapse or to accelerate healing as solution to unmet medical needs in IBD therapy.</P>
( Jaesuk Yun ),( Sun Mi Gu ),( Tac-hyung Lee ),( Yun Jeong Song ),( Seonhwa Seong ),( Young-hoon Kim ),( Hye Jin Cha ),( Kyoung Moon Han ),( Jisoon Shin ),( Hokyung Oh ),( Kikyung Jung ),( Chiyoung Ah 한국응용약물학회 2017 Biomolecules & Therapeutics(구 응용약물학회지) Vol.25 No.3
Synthetic cannabinoids are one of most abused new psychoactive substances. The recreational use of abused drug has aroused serious concerns about the consequences of these drugs on infection. However, the effects of synthetic cannabinoid on resistance to tetanus toxin are not fully understood yet. In the present study, we aimed to determine if the administration of synthetic cannabinoids increase the susceptibility to tetanus toxin-induced motor behavioral deficit and functional changes in cerebellar neurons in mice. Furthermore, we measured T lymphocytes marker levels, such as CD8 and CD4 which against tetanus toxin. JWH-210 administration decreased expression levels of T cell activators including cluster of differentiation (CD) 3ε, CD3γ, CD74p31, and CD74p41. In addition, we demonstrated that JWH-210 induced motor impairment and decrement of vesicle-associated membrane proteins 2 levels in the cerebellum of mice treated with tetanus toxin. Furthermore, cerebellar glutamatergic neuronal homeostasis was hampered by JWH-210 administration, as evidenced by increased glutamate concentration levels in the cerebellum. These results suggest that JWH-210 may increase the vulnerability to tetanus toxin via the regulation of immune function.
Yun, Jaesuk,Gu, Sun Mi,Lee, Tac-hyung,Song, Yun Jeong,Seong, Seonhwa,Kim, Young-Hoon,Cha, Hye Jin,Han, Kyoung Moon,Shin, Jisoon,Oh, Hokyung,Jung, Kikyung,Ahn, Chiyoung,Park, Hye-Kyung,Kim, Hyung Soo The Korean Society of Applied Pharmacology 2017 Biomolecules & Therapeutics(구 응용약물학회지) Vol.25 No.3
Synthetic cannabinoids are one of most abused new psychoactive substances. The recreational use of abused drug has aroused serious concerns about the consequences of these drugs on infection. However, the effects of synthetic cannabinoid on resistance to tetanus toxin are not fully understood yet. In the present study, we aimed to determine if the administration of synthetic cannabinoids increase the susceptibility to tetanus toxin-induced motor behavioral deficit and functional changes in cerebellar neurons in mice. Furthermore, we measured T lymphocytes marker levels, such as CD8 and CD4 which against tetanus toxin. JWH-210 administration decreased expression levels of T cell activators including cluster of differentiation (CD) $3{\varepsilon}$, $CD3{\gamma}$, CD74p31, and CD74p41. In addition, we demonstrated that JWH-210 induced motor impairment and decrement of vesicle-associated membrane proteins 2 levels in the cerebellum of mice treated with tetanus toxin. Furthermore, cerebellar glutamatergic neuronal homeostasis was hampered by JWH-210 administration, as evidenced by increased glutamate concentration levels in the cerebellum. These results suggest that JWH-210 may increase the vulnerability to tetanus toxin via the regulation of immune function.
Synthetic cannabinoid, JWH-030, induces QT prolongation through hERG channel inhibition
Yun, Jaesuk,Yoon, Kyung Sik,Lee, Tac-Hyung,Lee, Hyunjin,Gu, Sun Mi,Song, Yun Jeong,Cha, Hye Jin,Han, Kyoung Moon,Seo, Hyewon,Shin, Jisoon,Park, Hye-Kyung,Kim, Hyung Soo,Kim, Young-Hoon Oxford University Press 2016 Toxicology research Vol.5 No.6
<P>The problem of new psychoactive substance (NPS) abuse, which includes synthetic cannabinoids, is emerging globally, and the cardiotoxicity of these synthetic cannabinoids has not yet been evaluated extensively. In the present study, we investigated the effects of synthetic cannabinoids on the cytotoxicity, human Ether-à-go-go-related gene (hERG) channel, action potential duration (APD), and QT interval. The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay showed that JWH-030 was more cytotoxic than JWH-210, JWH-250, and RCS4 in H9c2 cells at 0.1 μM. In addition, the cytotoxicity was associated with its pro-apoptotic effects as evidenced by the increase in caspase-3 levels. We demonstrated that a cannabinoid receptor type 2 (CB2) antagonist, AM630, inhibited JWH-030-induced cytotoxicity, whereas a CB1 antagonist, rimonabant, did not. Furthermore, fluorescence polarization assay showed JWH-030 to block the hERG channel (half-maximal inhibitory concentration, IC50 was 88.36 μM). JWH-030 significantly reduced the APD at 90% repolarization (APD90) in rabbit Purkinje fibers and decreased the left ventricular end diastolic pressure (LVEDP) in Langendorff-perfused Sprague-Dawley (SD) rat hearts at 30 μM. In addition, the electrocardiogram (ECG) measurement revealed that the intravenous injection of JWH-030 (0.5 mg kg<SUP>−1</SUP>) prolonged the QT interval in SD rats. These results suggest that JWH-030 is cytotoxic and its cytotoxicity is mediated by its action on the CB2 receptor; it prolongs the QT interval by regulating ion current channels and APD.</P>
한아군,강신출,김관형,탁한호,Han, Ya-Jun,Kang, Chin-Chul,Kim, Gwan-Hyung,Tac, Han-Ho 한국정보통신학회 2017 한국정보통신학회논문지 Vol.21 No.10
본 논문에서는 시간에 따라 방향 속도와 위치가 변하는 무인자동차의 궤적 추적 제어시스템에 대해 논한다. 무인자동차는 운전자의 도움이 없어도 스스로 주위환경을 인식하여 지정된 도로를 주행할 수 있는 자동차로 올바른 주행을 위해 고려해야 할 변수가 다양하다. 무인자동차의 궤적 추적 시스템에서 인식한 정보는 이산적인 값을 가지므로 센스 간의 간격으로 인하여 비연속성 및 비선형성을 가지고 있다. 이로 인하여 목표 궤적을 정확하게 추적하는 것 어렵다. 본 논문은 차량의 운동학 모델링을 통하여 선형오차, 제약 조건, 제어 목표함수의 세 가지 조건을 갖는 무인자동차 궤적 추적시스템을 제안한다. 제안된 궤적 추적시스템을 기반으로 동적 시뮬레이션 소프트웨어-카심(Dynamic Simulation Software-CarSim)의 결합시뮬레이션을 통해 시스템의 성능을 평가하였고, 그 결과로 더욱 정밀하게 목표 궤적을 추적할 수 있음을 확인하였다. This paper discusses the trajectory tracking system of unmanned ground vehicles based on predictive control. Because the unmanned ground vehicles can not satisfactorily complete the path tracking task, highly efficient and stable trajectory control system is necessary for unmanned ground vehicle to be realized intelligent and practical. According to the characteristics of unmanned vehicle, this paper built the kinematics tracking models firstly. Then studied algorithm solution with the tools of the optimal stability analysis method and proposed a tracking control method based on the model predictive control. The controller used a kinematics-based prediction model to calculate the predictive error. This controller helps the unmanned vehicle drive along the target trajectory quickly and accurately. The designed control strategy has the true robustness, simplicity as well as generality for kinematics model of the unmanned vehicle. Furthermore, the computer Simulink/Carsim results verified the validity of the proposed control method.