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Adhim, Z,Matsuoka, T,Bito, T,Shigemura, K,Lee, K-M,Kawabata, M,Fujisawa, M,Nibu, K,Shirakawa, T Nature Publishing Group 2011 The British journal of cancer Vol.105 No.3
<P><B>Background:</B></P><P>Although the anti-tumour effect of cyclooxygenase-2 (Cox-2) inhibitors in invasive bladder cancer has been confirmed, its mechanisms of action are unclear. Recently, the concept of an epithelial-to-mesenchymal transition (EMT) promoting carcinoma progression has been suggested, and a key feature of the EMT is the downregulation of E-cadherin. In this study, we investigated the effect of Cox-2 inhibitors on reversal EMT and tumour growth inhibition in bladder cancer cells.</P><P><B>Methods:</B></P><P>We used three Cox-2 inhibitors, etodolac, celecoxib and NS-398 and three human bladder cancer cell lines, T24, 5637 and KK47, in this study. T24 xenograft tumour mouse model was used in the <I>in vivo</I> study.</P><P><B>Results:</B></P><P>Within the clinical drug concentrations, only etodolac showed the <I>in vitro</I> growth inhibition in T24 not in the other cell lines. Etodolac reduced <I>SNAIL</I> mRNA and vimentin cell surface expression, and induced <I>E-cadherin</I> mRNA and E-cadherin cell surface expression, in T24. Etodolac also most strongly inhibited the cell migration of T24 <I>in vitro</I> and showed the highest tumour growth inhibition in T24 tumour <I>in vivo</I>.</P><P><B>Conclusion:</B></P><P>Etodolac at clinical doses exhibited induced <I>in vitro</I> and <I>in vivo</I> anti-tumour effects and reversal effect of EMT in T24. These results suggest that etodolac is a good candidate for an anti-tumour or chemopreventive reagent for high-grade bladder cancer.</P>
NUMERICAL ANALYSIS OF INTERACTION BETWEEN SUPERSONIC JET AND PERPENDICULAR PLATE
T. Yasunobu,T. Matsuoka,H. Kashimura,T. Setoguchi 한국전산유체공학회 2005 한국전산유체공학회지 Vol.10 No.1
The numerical investigation of the interaction between the underexpanded supersonic jet and the perpendicular plate is carried out using the TVD numerical method. The wave structure in the flowfield and the pressure and temperature distributions on the plate surface are obtained by the numerical analysis. Especially, the influence of self-induced flow oscillation caused by the impinging jet and the characteristic of impinging jet are shown. From the result of the numerical analysis, it is concluded that the pressure and the temperature fluctuations on the plate surface strongly depends on the pressure ratio in the flowfield and the position of plate.
NUMERICAL ANALYSIS OF INTERACTION BETWEEN SUPERSONIC JET AND PERPENDICULAR PLATE
Yasunobu T,Matsuoka T,Kashimura H,Setoguchi T Korea Society of Computational Fluids Engineering 2005 한국전산유체공학회지 Vol.10 No.1
The numerical investigation of the interaction between the underexpanded supersonic jet and the perpendicular plate is carried out using the TVD numerical method. The wave structure in the flowfield and the pressure and temperature distributions on the plate surface are obtained by the numerical analysis. Especially, the influence of self-induced flow oscillation caused by the impinging jet and the characteristic of impinging jet are shown. From the result of the numerical analysis, it is concluded that the pressure and the temperature fluctuations on the plate surface strongly depends on the pressure ratio in the flowfield and the position of plate.
Studies on electron Bernstein wave heating in CHS and LHD at NIFS
Y. Yoshimura,H. Igami,S. Ferrando-Margalet,K. Nagasaki,S. Kubo,T. Shimozuma,M. Isobe,C. Suzuki,A. Shimizu,T. Akiyama,C. Takahashi,K. Nagaoka,S. Nishimura,T. Minami,K. Matsuoka,S. Okamura,T. Mutoh 한국진공학회 2007 한국진공학회 학술발표회초록집 Vol.16 No.2
Characteristics of second harmonic ECCD on CHS
yasuo Yoshimura,H. Matsushita,H. Igami,K. Nagasaki,K. Matsuoka,K. Ohkubo,K. Nagaoka,M. Isobe,S. Kobayashi,S. Okamura,S. Kubo,S. Nishimura,T. Minami,T. Akiyama,T. Notake,T. Shimozuma,A. Shimizu,C. Suzu 한국물리학회 2006 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.49 No.III
Second harmonic electron cyclotron current drive (ECCD) has been investigated on CHS (Compact Helical System) by using a 2-D steerable EC-beam injection system. The direction of the plasma current, which is the sum of bootstrap current and EC-driven current, is clearly reversed by a reversal of the EC-beam injection direction. The direction of driven current is consistent with expectation in the case of low-field side injection of EC wave. So far, a driven current up to 6 kA has been obtained when bootstrap current is less than 2 kA. It is confirmed that right-hand polarization and low density are effective for ECCD.