Anisotropic Magnetization and Charge Density Wave in a Na0.78CoO2 Single Crystal

이종수,J. B. Peng,S. M. Lee,C. T. Lin 한국물리학회 2008 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.52 No.2

Single crystals of γ-Na0.78CoO2 were grown using the floating zone method. The static magnetic susceptibility M/H(T) of Na0.78CoO2 showed significant anisotropic behavior for different crystal orientations of H ∥ (ab) and H ∥ (c). While (M/H)ab(T) for a magnetic field H= 1 T in an ab-plane followed the Curie-Weiss law at high temperatures (T ≥ 100 K), (M/H)c(T) for H ∥ c-axis deviated from Curie-Weiss behavior, which may be understood by using phonon localization from strong electron-phonon coupling. The impurity spin-1/2 effect, dressed by spin fluctuation, was significant at low temperatures (T ≤ 30 K) for both field orientations of H ∥ (ab) and H ∥ (c). The electrical resistivity ρ(T) of Na0.78CoO2 showed a clear metallic character down to 16 K, with a weak increase in the resistivity ρ(T) at low temperatures T ≤ 16 K). The gap-like behavior of ρ(T) was insensitive to applied magnetic fields up to 7 T, which indicates a non-degenerate charge gap. The electrical conductivity σ(T) followed the density wave behavior with a small energy gap (0.64 meV) at low temperatures. We discussed the electrical resistivity ρ(T)$ and the anisotropic M/H(T) behavior of Na0.78CoO2 in terms of the charge density wave and a strong electron-phonon interaction. Single crystals of γ-Na0.78CoO2 were grown using the floating zone method. The static magnetic susceptibility M/H(T) of Na0.78CoO2 showed significant anisotropic behavior for different crystal orientations of H ∥ (ab) and H ∥ (c). While (M/H)ab(T) for a magnetic field H= 1 T in an ab-plane followed the Curie-Weiss law at high temperatures (T ≥ 100 K), (M/H)c(T) for H ∥ c-axis deviated from Curie-Weiss behavior, which may be understood by using phonon localization from strong electron-phonon coupling. The impurity spin-1/2 effect, dressed by spin fluctuation, was significant at low temperatures (T ≤ 30 K) for both field orientations of H ∥ (ab) and H ∥ (c). The electrical resistivity ρ(T) of Na0.78CoO2 showed a clear metallic character down to 16 K, with a weak increase in the resistivity ρ(T) at low temperatures T ≤ 16 K). The gap-like behavior of ρ(T) was insensitive to applied magnetic fields up to 7 T, which indicates a non-degenerate charge gap. The electrical conductivity σ(T) followed the density wave behavior with a small energy gap (0.64 meV) at low temperatures. We discussed the electrical resistivity ρ(T)$ and the anisotropic M/H(T) behavior of Na0.78CoO2 in terms of the charge density wave and a strong electron-phonon interaction.

임신 및 각종 갑상선질환에서 갑상선 기능 판정에 관한 연구 : 혈청유리 T4의 진단적 의의에 관한 고찰 The diagnostic value of free thyroxine by RIA

이종철,유명희,윤휘중,신영태,정순일,조보연,이문호,이명철 대한핵의학회 1981 핵의학 분자영상 Vol.15 No.1

To evaluate the diagnostic accuracy of the measurement of free thyroxine(FT4) by radioimmunoassay, we measured free T4 and T4, T3, T3RU, TSH and TBG serum levels by radioimmunoassay in 18 healthy persons and 52 patients with various thyroid diseases and 11 normal pregnant women. The results are as follows. 1) In 19 cases of overt hyperthyroidism, T3, free T4 and FTI, T4/TBG ratio reflect hyperfunction in all cases. T4 is increased in 94%(18/19) and TBG and TSH are decreased in 79%(15/19). 2) In 8 patients with overt hypothyroidism, TSH is increased in all cases and free T4 and FTI is decreased in all cases. T4 is decreased in 87.5%(7/8), T3 is decreased in 75%(6/8) and T4/TBG ratio is decreased in 62.5%(5/8). 3) In 5 patients who are clinically in euthyroid state after treatment of hyperthyroidism, T4 free T4, FTI and TSH are in the normal range in all cases and T3 is normal in 60%(3/5) and slightly increased in 40%(2/5). 4) In 10 patients who showed clinically borderline hypothyroidism after treatment of hyperthyroidism, TSH is increased in all cases and free T4 and FTI are decreased in all cases, but T4 and T3, T4/TBG ratio are in the normal limit in all cases. So after treatment of hyperthyroidism, TSH, free T4 or FTI are recommended as optimal function test. 5) In normal pregnancy, free T4, FTI and T4/TBG ratio reflect normal function, but the other parameters unreliable due to the influence of increased TBG. Also TBG and TSH level in pregnancy is increased significantly compared with normal healthy control group. 6) The coefficients of correlation between T4 and FTI were 0.862(p〈0.001) and 0.685(p〈0.001) between free T4 and T4/TBG ratio. In most patients, diagnostic value of free T4 was comparable and even superior to FTI, so free T4 measurement can be used routinely with thyrotropin assay in the diagnosis of hypothyrodism or with T3 for the diagnosis of hyperthyroidism.

Anomalous flux jump and supercooling phenomenon around the order-disorder transition in MgB₂ single crystals

Chotoku, M.,Nojima, T.,Ochiai, A.,Aoki, H.,Lee, H.G.,Lee, S.I. North-Holland 2009 Physica. C, Superconductivity Vol.469 No.15

We have performed the detailed measurements of temperature dependence of magnetization M(T) on MgB<SUB>2</SUB> single crystals in a wide range of field H using torque magnetometry. In a field region, where the peak effect in M(H) is observed, we find that M(T) of the warming branch increases monotonously with T and exhibits a small step-like increase at T<SUB>1</SUB><SUP>*</SUP>, which is related to the order-disorder transition, while M(T) of the cooling branch, showing the larger values than that in warming branch below T<SUB>1</SUB><SUP>*</SUP>, drops suddenly toward the warming branch at T<SUB>2</SUB><SUP>*</SUP>. We ascribe this anomalous behavior of M(T) of the cooling branch to a supercooling phenomenon of disordered phase, which transforms to the ordered state at T<SUB>2</SUB><SUP>*</SUP>.

Metabolic characterization of (1-(5-fluoropentyl)-1H-indol-3-yl)(4-methyl-1-naphthalenyl)-methanone (MAM-2201) using human liver microsomes and cDNA-overexpressed cytochrome P450 enzymes

Kong, T. Y.,Kim, J. H.,Choi, W. G.,Lee, J. Y.,Kim, H. S.,Kim, J. Y.,In, M. K.,Lee, H. S. Springer Science + Business Media 2017 Analytical and bioanalytical chemistry Vol.409 No.6

<P>MAM-2201 is a synthetic cannabinoid that is increasingly found in recreational drug abusers and cases of severe intoxication. Thus, characterization of the metabolic pathways of MAM-2201 is necessary to predict individual pharmacokinetics and toxicity differences, and to avoid toxic drug-drug interactions. Collectively, 19 phase 1 metabolites of MAM-2201 were identified using liquid chromatography-Orbitrap mass spectrometry following human liver microsomal incubations in the presence of NADPH: 7 hydroxy-MAM-2201 (M1-M7), 4 dihydroxy-MAM-2201 (M8-M11), dihydrodiol-MAM-2201 (M12), N-(5-hydroxypentyl)-MAM-2201 (M13), hydroxy-M13 (M14), N-dealkyl-MAM-2201 (M15), 2 hydroxy-M15 (M16, M17), MAM-2201 N-pentanoic acid (M18), and hydroxy-M18 (M19). On the basis of intrinsic clearance values in human liver microsomes, hydroxy-MAM-2201 (M1), N-(5-hydroxypentyl)-MAM-2201 (M13), and hydroxy-M13 (M14) were the major metabolites. Based on an enzyme kinetics study using human cDNA-expressed cytochrome P450 (CYP) enzymes and an immunoinhibition study using selective CYP antibodies in human liver microsomes, CYP1A2, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, and CYP3A4 enzymes were responsible for MAM-2201 metabolism. The CYP3A4 enzyme played a prominent role in MAM-2201 metabolism, and CYP1A2, CYP2B6, CYP2C8, and CYP2C9 enzymes played major roles in the formation of some metabolites. MAM-2201 is extensively metabolized by multiple CYP enzymes, indicating that MAM-2201 and its metabolites should be used as markers of MAM-2201 abuse and toxicity.</P>

Nasal-type NK/T-cell lymphomas are more frequently T rather than NK lineage based on T-cell receptor gene, RNA, and protein studies: lineage does not predict clinical behavior

Hong, M.,Lee, T.,Young Kang, S.,Kim, S. J.,Kim, W.,Ko, Y. H. Nature Publishing Group 2016 Modern pathology Vol.29 No.5

<P>Extranodal natural killer (NK)/T-cell lymphoma (ENKTL), nasal type, comprises NK or cytotoxic T cells. We evaluated the clinical impact of cell type and the usefulness of T-cell receptor (TCR) gene transcripts in distinguishing cell lineage. One hundred and eight cases of ENKTL were analyzed for TCR gene rearrangements using the BIOMED-2 protocol and for TCR gene expression using immunohistochemistry for TCR-beta F1 and TCR-c gamma M1, and RNA in situ hybridization for TCR gene transcripts. Prognostic factors were analyzed. Among the 108 cases, 44 were monoclonal for a TCR rearrangement (40%) while 64 (60%) were undefinable. The monoclonal cases expressed TCR-beta F1 in 14 out of 40 cases (35%) and TCR-c gamma M1 in 1 out of 44 cases (2%). The 64 undetermined cases expressed TCR-beta F1 in 15 cases (23%) and TCR-c gamma M1 in 1 (2%). Thirteen of 40 TCR-beta constant gene transcript-positive cases (33%) expressed TCR-beta F1 and one of nine TCR-gamma constant gene transcript-positive cases (11%) expressed TCR-c gamma M1. TCR gene transcripts were not useful in the distinction of cell lineages. TCR gene transcripts were positive in ENKTLs as well as in normal B cells and aggressive NK-cell leukemia. Based on gene rearrangements and immunohistochemistry for TCR, there were 60 T-cell type cases (56%), 32 NK-cell type cases (30%), and 16 cases with an undetermined cell type (14%). TCR protein was expressed in 30/60 T-ENKTLs (50%) in a variable fraction of tumor cells. There were no significant differences in clinical findings or overall patient survival between T-or NK-cell types of ENKTL, although those with a T-cell type tended to show a better prognosis for those with localized nasal lymphomas. Univariate and multivariate analysis showed that a non-nasal ENKTL, age 460 years, high level of lactate dehydrogenase, bone marrow involvement, and the absence of radiotherapy were independent prognostic factors.</P>

Sorghum × Sudangrass hybrid 의 입모저장에 관한 연구 ; 1 . 입모저장기간이 생육특성 및 기호성 변화에 미치는 영향

이상무 ( S M Lee ),문상호 ( S H Moon ),백인철 ( I C Baek ),전병태 ( B T Jeon ) 한국축산학회 1994 한국축산학회지 Vol.36 No.1

Growth characteristics and palatability by different harvesting dates were measured in order to determine its availability and effective storage period when sorghum × sudangrass hybrid were stored as foggage. Experiment was carried out with six treatments as follows; T1, T2 and T3 were foggaged at 120, 160 and 200㎝ in plant length and T4, T5 and T6 were foggaged at boot, milk and dough stage on 7 october after regrowth respectively. Rice straw was offered to examine the relative palatability a, control. 1. Growth characteristics such as plant length, leaf length, leaf width, leaf number and stem hardness were decreased with prolongation of foggage period at all treatments. Especially, decrease and falling ratio were a heigher at T5 and T6 than the other treatments. 2. Greeness grade of leaf showed fast decoloration at TI and T2 treatments, but stem showed fast decoloration at TS and T6 treatments. Leaf and stem decolorized in mid-October and mid-november in all treatments. 3. Leaf ratio was deceased with prolongation of foggage period, but stem showed gradually increase. Grain ratio was stable increase at T6 treatments, but not at T5 treatment, 4. Dry matter contents of leaf and grain were stable increased at all treatment but stem was multifarious according to weather conditions. 5. Changes of palatability were high at T1, T2 and T3 treatments untill mid-October, but T4 treatment and rice straw showed high in early December. 6. According to the results obtained in this study, it was suggested that when sorghum x sudangrass hybrid is used as foggage, foggaging period would be suitable until mid-november and growth stage for foggaging would be recommendable from T2 to boot stage for maximum availability.

한우 사골, 꼬리, 우족 및 잡뼈 추출물의 이화학적 특성

이진규(J. K. Lee),정지택(J. T. Jeong),최정석(J. S. Choi1),정명옥(M. O. Jung),최양일(Y. I. Choi) 충북대학교 동물생명과학연구소 2017 동물생명과학연구 Vol.9 No.-

This study was conducted to investigate the physico-chemical characteristics of various bone extracts in Hanwoo cattle. The experimental materials are as follows; T1(Shank bone extract), T2(Tail extract), T3(Beef feet extract), and T4(The other bones extract). In the proximate composition, the T1 and T2 showed higher moisture and fat contents than those of T3 and T4(p<0.05), and the T3 had the highest protein content among the bone extracts(p<0.05). The quality properties including salinity, sugar content, turbidity and yellowness(b*) values were significantly higher in the T3 than the other bone extracts(p<0.05). However, the pH value of T3 was significantly lower than the other bone extracts. In the mineral contents, calcium contents of bone extracts were 36.33-48.57mg/kg, and the content of phosphorus was the lowest in T1(4.62mg/kg) and T2(19.88mg/kg) was the highest(p<0.05). Contents of sodium and potassium were the highest in T3(215.83mg/kg) and T2(54.59mg/kg), while the content of magnesium was the lowest in T3(12.28mg/kg). In conclusion, these results could be suggested to be the basis information for processed meat extract products industry in korea using Hanwoo bone extract.

정상 임신에서 임신주기에 따른 갑상선기능의 변화

김원배,정재훈,윤보현,이석인,김민선,오태근,조보연,이홍규,고창순 대한내분비학회 1994 Endocrinology and metabolism Vol.9 No.3

It is well known that normal pregnancy is accompanied by a rise in serum concentrations of thyroxine-binding globulin(TBG) and human chorionic gonadotropin (hCG). Alterations of biochemical parameters of thyroid function are recognized during gestation and sensitive tests to evaluate the alterations easily are required. Therefore, a cross-sectional study was undertaken in 140 healthy pregnant women to evaluate the efficacy of free T_4 measured by 2-step RIA compared to other thyroid function tests and to confirm the changes of thyroid function according to the stages of normal pregnancy. The sensitivities of free T_4 index, free T_4(by 2-step RIA), T_3 and TSH were realtively high(99.3%, 93.6%, 92.9%, 83.6%, respectively) compared to those of T_4 and T_3 bead upgake(49.3%, 21.4%) during all stages of pregnancy. There were positive correlations between free T_4 index and free T_4 or total T_4(r=0.68, r=0.72; p$lt;0.001). The values of free T_4 index sharply decreased from 3.22+-0.10(meam +-SEM) during 6th-12th week to an plateau after 16th-20th week of gestation(p$lt;0.01). The serum concentrations free T_4 and T_3 bead uptake also significantly decreased from 1.65+-0.05 ng/dl, 24.7+- 0.7% during 6th-12th week to an plateau after 16th-20th week of gestation, respectively(p$lt;0.001), No differences were found in the changes of serum concentrations of T_3, T_4 and TSH according to the stages of pregnancy. In conclusion, it is adequate to measure some tests including free T_4 index and free T_4 to evaluate thyroid function during pregnancy. The thyroid physiology and changes of thyroid function according to the stages of pregnancy should be considered in the interpretation of thyroid function status during pregnancy(J Kor Soc Endocrinol 9: 183-189, 1994).

Relationship between microstructure and mechanical properties of fibrous HAp-(t-ZrO₂)/Al₂O₃-(m-ZrO₂) composites

Lee, B.T.,Lee, C.W.,Youn, M.H.,Song, H.Y. Elsevier Sequoia 2007 Materials science & engineering. properties, micro Vol.458 No.1

The microstructure and mechanical properties of core/shell, fibrous HAp-(t-ZrO<SUB>2</SUB>)/Al<SUB>2</SUB>O<SUB>3</SUB>-(m-ZrO<SUB>2</SUB>) composites, which were fabricated by the multi-pass extrusion process, were investigated depending on the sintering temperature. In the composite sintered at 1200<SUP>o</SUP>C, many pores were observed in both HAp-(t-ZrO<SUB>2</SUB>) core and Al<SUB>2</SUB>O<SUB>3</SUB>-(m-ZrO<SUB>2</SUB>) shell regions. However, at 1500<SUP>o</SUP>C, the shell regions showed dense and anisotropic grain growth and the core region were transformed to α-TCP and β-TCP phase. Also, as a minor reaction phase, the CaAl<SUB>12</SUB>O<SUB>19</SUB> peaks detected. The values of relative density, hardness, bending strength and fracture toughness increased as the sintering temperature increased, and their maximum values were at 1500<SUP>o</SUP>C about 890Hv, 280MPa and 4.1MPam<SUP>1/2</SUP>, respectively. The fracture morphology was appeared with homogeneously rough surface, and indentation cracks showed short length due to the crack deflection and microcracking toughening mechanisms.

Association of tumor necrosis factor- gene polymorphisms with advanced stage endometriosis

Lee, G. H.,Choi, Y. M.,Kim, S. H.,Hong, M. A.,Oh, S. T.,Lim, Y. T.,Moon, S. Y. Oxford University Press 2008 Human reproduction Vol.23 No.4

<P>BACKGROUND: This study was performed to investigate whether specific haplotypes and several single nucleotide polymorphisms in the promoter region of the tumor necrosis factor (TNF)-alpha gene are associated with the risk of advanced stage endometriosis in a Korean population. METHODS: This study comprised women with (n = 246) or without (n = 248) endometriosis. The TNF:g.[-1031T > C], TNF:g.[-863C > A] and TNF:g.[-857C > T] polymorphism in the TNF-alpha gene were assessed by PCR-restriction fragment length polymorphism analysis, which utilized digestion by BbsI, HypCH4IV and HypCH4IV restriction enzymes, respectively. In silico haplotypes were deduced by using the Haploview version 3.32. RESULTS: The genotype distribution of TNF:g.[-1031T > C] was significantly different between total endometriosis patients and the controls (T/T of 56.9 versus 60.1%, T/C of 35.4 versus 37.5% and C/C of 7.7 versus 2.4%, respectively, P = 0.027). This difference at the TNF:g.[-1031T > C] tends to increase in Stage IV endometriosis (P = 0.01). However, there was no difference in the TNF:g.[-863C > A] and TNF:g.[-857C > T] site between the two groups. Even when the endometriosis cases were subdivided into American Society for Reproductive Medicine Stages III and IV, genotype differences were not found. The CC homozygote at TNF:g.-863 was more frequently found in the controls than Non-CC group (P = 0.04; odds ratio = 0.67; 95% confidence interval = 0.45-0.98). All haplotypes and diplotypes, deduced by in silico analysis, showed no association with subgroups or controls. CONCLUSIONS: Our results suggest that the genotype frequencies at the TNF:g.[-1031T > C] and the TNF:g.[-863C > A] sites may be associated with advanced stage endometriosis in the Korean population.</P>