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Adhim, Z,Matsuoka, T,Bito, T,Shigemura, K,Lee, K-M,Kawabata, M,Fujisawa, M,Nibu, K,Shirakawa, T Nature Publishing Group 2011 The British journal of cancer Vol.105 No.3
<P><B>Background:</B></P><P>Although the anti-tumour effect of cyclooxygenase-2 (Cox-2) inhibitors in invasive bladder cancer has been confirmed, its mechanisms of action are unclear. Recently, the concept of an epithelial-to-mesenchymal transition (EMT) promoting carcinoma progression has been suggested, and a key feature of the EMT is the downregulation of E-cadherin. In this study, we investigated the effect of Cox-2 inhibitors on reversal EMT and tumour growth inhibition in bladder cancer cells.</P><P><B>Methods:</B></P><P>We used three Cox-2 inhibitors, etodolac, celecoxib and NS-398 and three human bladder cancer cell lines, T24, 5637 and KK47, in this study. T24 xenograft tumour mouse model was used in the <I>in vivo</I> study.</P><P><B>Results:</B></P><P>Within the clinical drug concentrations, only etodolac showed the <I>in vitro</I> growth inhibition in T24 not in the other cell lines. Etodolac reduced <I>SNAIL</I> mRNA and vimentin cell surface expression, and induced <I>E-cadherin</I> mRNA and E-cadherin cell surface expression, in T24. Etodolac also most strongly inhibited the cell migration of T24 <I>in vitro</I> and showed the highest tumour growth inhibition in T24 tumour <I>in vivo</I>.</P><P><B>Conclusion:</B></P><P>Etodolac at clinical doses exhibited induced <I>in vitro</I> and <I>in vivo</I> anti-tumour effects and reversal effect of EMT in T24. These results suggest that etodolac is a good candidate for an anti-tumour or chemopreventive reagent for high-grade bladder cancer.</P>
Matsui, T.,Kawabata, T.,Harumoto, T.,Yano, H. Asian Australasian Association of Animal Productio 1992 Animal Bioscience Vol.5 No.2
Three female sheep were daily administered a pyrophosphate analogue, disodium 1-hydroxyethylidene-1, 1-bisphosphonate (HEBP) at the level of 4 mg/kg body weight. HEBP largely suppressed bone resorption, which was indicated by the reduction in plasma free hydroxyproline concentration and in calcium mobilization rate during the intravenous infusion of disodium ethylenediaminetetraacetate (EDTA). Contrary to the suppression of bone resorption, plasma total-calcium, magnesium and phosphorus concentrations were not changed by HEBP administration. These results suggest that bone mineral crystals play a meaningless role on calcium, magnesium and phosphorus homeostasis in ruminants if they are fed adequate amounts of these minerals. Plasma magnesium and phosphorus concentrations were not significantly changed after feeding. However, plasma total-calcium was decreased after feeding in both periods and the reduction seemed to be remarkable in the HEBP-treated period. Infusion of EDTA more remarkably reduced plasma ionized calcium concentration in the HEBP-treated that in the untreated period and the recovery of ionized calcium was retarded by HEBP administration. These results suggest that calcium release from bone is necessary for maintenance of plasma calcium when animals rapidly lose calcium.
Kwon, Y. G.,Ishiguro, M.,Shinnaka, Y.,Nakaoka, T.,Kuroda, D.,Hanayama, H.,Takahashi, J.,Baar, S.,Saito, T.,Kawabata, M.,Uemura, M.,Morokuma, T.,Murata, K. L.,Takagi, S.,Morihana, K.,Nagayama, T.,Sekig Springer-Verlag 2018 Astronomy and astrophysics Vol.620 No.-
<P><I>Context.</I> Spectropolarimetry is a powerful technique for investigating the physical properties of gas and solid materials in cometary comae without mutual contamination, but only a few spectropolarimetric studies have been conducted to extract each component.</P><P><I>Aims.</I> We attempt to derive the continuum (i.e., scattered light from dust coma) polarization degree of comet 2P/Encke, free of the influence of molecular emissions. The target is unique in that its orbit is dynamically decoupled from Jupiter, like the main-belt asteroids, but it ejects gas and dust like ordinary comets.</P><P><I>Methods.</I> We observed the comet using the Hiroshima Optical and Near-Infrared Camera attached to the Cassegrain focus of the 150 cm Kanata telescope on UT 2017 February 21 when the comet was at the solar phase angle of <I>α</I> = 75°.7.</P><P><I>Results.</I> We find that the continuum polarization degree with respect to the scattering plane is <I>P</I>cont, r = 33.8 ± 2.7% at the effective wavelength of 0.82 <I>μ</I>m, which is significantly higher than those of cometary dust in a high-<I>P</I>max group at similar phase angles. Assuming that an ensemble polarimetric response of the dust of 2P/Encke as a function of phase angle is morphologically similar with those of other comets, its maximum polarization degree is estimated to <I>P</I>max ≳ 40% at <I>α</I>max ≈ 100°. In addition, we obtain the polarization degrees of the C2 swan bands (0.51-0.56 <I>μ</I>m), the NH2<I>α</I> bands (0.62-0.69 <I>μ</I>m), and the CN-red system (0.78-0.94 <I>μ</I>m) in a range of 3-19%, which depend on the molecular species and rotational quantum numbers of each branch. The polarization vector is aligned nearly perpendicularly to the scattering plane with an average of 0°.4 over a wavelength range of 0.50-0.97 <I>μ</I>m.</P><P><I>Conclusions.</I> From the observational evidence, we conjecture that the high polarization degree of 2P/Encke might be attributable to a dominance of large dust particles around the nucleus, which have remained after frequent perihelion passages near the Sun.</P>
김아람,N. H. Lee,I. S. Hahn,J. S. Yoo,M. H. Han,S. Kubono,H. Yamaguchi,S. Hayakawa,Y. Wakabayashi,D. Binh,H. Hashimoto,T. Kawabata,D. Kahl,Y. Kurihara,Y. K. Kwon,T. Teranishi,S. Kato,T. Komatsubara,B. Gu 한국물리학회 2010 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.57 No.1
For the study of astrophysically important states in 18Ne, the 14O(α, α)14O cross section was measured in inverse kinematics using a radioactive 14O beam. This reaction was investigated for properties of resonant states of 18Ne for determining the 14O(α, p)17F reaction rate, which is one of the most important reactions for understanding the breakout mechanism from the Hot CNO cycle to the rp-process. Alpha-induced elastic scattering on 14O was performed using the lowenergy radioactive ion (RI) beam separator at the Center for Nuclear Study (CNS) in the RIKEN Accelerator Research Facility. The energy range Ex = 7.2 ∽ 13.1 MeV of 18Ne was scanned with the thick target method. Recoiled alpha particles were measured with Si dE-E telescopes. Spins and widths of three resonances at Ex = 8.6, 9.22, and 10.06 MeV were calculated using the R-matrix analysis, and a new state of 18Ne at Ex = 12.0 MeV was found in this experiment.
SINGLE PHASE PWM INVERTER WITH CURRENT MINOR CONTROL LOOP
Y.Shikano,T.Kawabata,T.Furuno,K.Honjo,N.Sashida,Y.Yamamoto 전력전자학회 1989 ICPE(ISPE)논문집 Vol.- No.-
This paper proposes a single phase sinusoidal voltage inverter with current minor loop using high speed switching devices such as Bi-MOS or IGBT.<br/> Following new methods are successfully combined and adopted to get high performance:<br/> (a) A high speed current minor control loop is given for the Inverter to constrain inverter current within SOA of switching devices, and as the reference of this current loop, following signals are given to get sinusoidal output voltage.<br/> (1) Current for the parallel element of the<br/> output filter<br/> (ii) Feedforward of the load current (iii) Voltage adjusting and stabilizing signal which is the output of voltage controller<br/> (b) Micro processor control using the dead beat algorithm is developed for sinusoidal output voltage Inverter. This system consists of two dead beat controllers for current and voltage. By using the dead beat control, the inverter current and the output voltage settle with one sampling period.
OPTICAL-INFRARED AND HIGH-ENERGY ASTRONOMY COLLABORATION AT HIROSHIMA ASTROPHYSICAL SCIENCE CENTER
UEMURA, MAKOTO,YOSHIDA, MICHITOSHI,KAWABATA, KOJI S.,MIZUNO, TSUNEFUMI,TANAKA, YASUYUKI T.,AKITAYA, HIROSHI,UTSUMI, YOUSUKE,MORITANI, YUKI,ITOH, RYOSUKE,FUKAZAWA, YASUSHI,TAKAHASHI, HIROMITSU,OHNO, MA The Korean Astronomical Society 2015 天文學論叢 Vol.30 No.2
The Hiroshima Astrophysical Science Center (HASC) was founded in 2004 at Hiroshima University, Japan. The main mission of this institute is the observational study of various transient objects including gamma-ray bursts, supernovae, novae, cataclysmic variables, and active galactic nuclei by means of multi-wavelength observations. HASC consists of three divisions; the optical-infrared astronomy division, high-energy astronomy division, and theoretical astronomy division. HASC is operating the 1.5m optical-infrared telescope Kanata, which is dedicated to follow-up and monitoring observations of transient objects. The high-energy division is the key operation center for the Fermi gamma-ray space telescope. HASC and the high-energy astronomy group in the department of physical science at Hiroshima University are closely collaborating with each other to promote multi-wavelength time-domain astronomy. We report the recent activities of HASC and some science topics pursued by this multi-wavelength collaboration.