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High Fatigue Strength with Better Machinability Material for Powder Forged Connecting Rod
Suzuki Hironori,Sawayama Tetsuya,Ilia Edmond,Tutton Kevin 한국분말야금학회 2006 한국분말야금학회 학술대회논문집 Vol.2006 No.1
The powder forging (PF) process is used to produce fully dense powder metallurgy (PM) parts for high performance automotive applications. PF connecting rods have been widely accepted in the US, Japan, and other countries due to higher performance and lower manufacturing costs when compared to conventionally forged steel connecting rods [1]. In order to meet and exceed requirements for higher fatigue strength and better machinability of PF connecting rods, a newly developed machinability enhancer, named KSX, was introduced [2]. A comparison study between powder forged materials prepared with 0.3% MnS and with 0.1% KSX additions showed excellent properties in the case of the mix with KSX.
Development of Optical Device Housing Compacted Using SUS304L Granulated Powders
Suzuki Hironori,Hara Toshihiro,Ogino Yukinobu,Sato Yasushi,Tomota Yo 한국분말야금학회 2006 한국분말야금학회 학술대회논문집 Vol.2006 No.1
In order to develop the SUS304L housing by powder metallurgy for an optical device useful for the FTTH communication system, the optimum compacting pressure and sintering temperature were investigated using granulated powder as the material to satisfy high air-tightness and high laser-weldability. Then the laser-welding test of specimen made under the optimum condition was carried out to observe welding sputters.
Kobayashi, Hironori,Suzuki, Yumiko,Ajimura, Kosei,Konno, Tomonori,Suzuki, Shunji,Saito, Hiroshi The Korean Society of Plant Biotechnology 2011 Plant biotechnology reports Vol.5 No.1
Vitis vinifera cv. Koshu is a traditional grape cultivar that has been grown for centuries in Japan. The Koshu grape has pink-colored skin and Koshu wines have slight astringency. We demonstrated for the first time the characterization of hydroxycinnamic acids, flavan-3-ols, and flavonoids in Koshu grape using high-performance liquid chromatography and liquid chromatography-mass spectrometry. The gross weight of phenolic compounds excluding anthocyanins and proanthocyanidins in Koshu grape at harvest was higher than those in Sauvignon Blanc, Chardonnay, and Merlot grapes. In addition, hydroxycinnamic acid and monomeric flavonol contents in Koshu grape were also higher than those in the other grape cultivars. Transcription analysis of cinnamic acid 4-hydroxylase, p-coumarate 3-hydroxylase, caffeate methyltransferase, and flavonol synthase genes indicated high accumulation of hydroxycinnamic acids and flavonols in Koshu grape skin compared with the other cultivars. These findings obtained by chemical and molecular approaches partially explained the phenolic characteristics and the peculiar astringency of Koshu grape.
Evaluation of dose effects of two types of tomotherapy couch and examination of its optimization
Suzuki Shunsuke,Inoue Tatsuya,Yamano Akihiro,Nagata Hironori 한국물리학회 2023 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.83 No.12
This study aims to evaluate the couch modeling accuracy of two types of TomoTherapy devices, namely Radixact and Hi-Art. First, we performed chamber measurement using A1SL and Cheese phantom for beams from the posterior direction to evaluate the couch modeling accuracy of the both tomotherapy units. Next, the couch model was corrected to achieve optimal dose delivery. Subsequently, patient dose verifcation for ten TomoDirect plans with only the posterior beams and ten TomoHelical plans was performed using Delta4. The gamma passing rate (γ-index) with 3 mm/3% and 2 mm/2% of Radixact (before and after couch correction modeling (CCM)) and Hi-Art (before and after CCM) were evaluated and statistically compared. Dose diferences between the measurement and calculation in Radixact ranged from−3.3% to 0%, whereas the dose diferences in Hi-Art ranged from−2.2% to 0.9%. Considerable diferences were observed in the γ-index of TomoDirect plans between Radixact before and after CCM (P<0.05) for both gamma criteria; however, these were not considerably diferent between Hi-Art before and after CCM. Moreover, no considerable diferences were noted in the γ-index of TomoHelical plans in both units. After optimizing the couch model, the γ-index for TomoDirect plans signifcantly improved for the patient dose verifcation of Radixact with Delta4. In addition, the γ-index for TomoDirect and TomoHelical plans for Hi-Art were improved after CCM despite no statistically signifcant diferences. These fndings can serve as a reference data when considering the efects of couch modeling on irradiation during TomoTherapy in clinical practice.
Optimization of TomoTherapy couch density in the RayStation treatment-planning system
Suzuki Shunsuke,Inoue Tatsuya,Yagihashi Takayuki,Nagata Hironori 한국물리학회 2023 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.83 No.12
The aim of this study is to establish the treatment couch model of TomoTherapy in a RayStation treatment-planning system. Point-dose measurements using a cylindrical solid phantom and ionizing chamber were performed to determine the optimal mass densities of the couch components by minimizing the discrepancy between the measured and calculated attenuations. To validate the efcacy of the determined mass densities, patient-specifc delivery quality assurance (DQA) of the TomoDirect plans for eight palliative spine radiotherapy (PSR), fve postmastectomy radiotherapy (PMRT), and TomoHelical plans for ten treatment sites were performed using an ionizing chamber, EBT3 flm, and Delta4 diode detector with the default couch model (DCM) and corrected couch model (CCM). The dose diferences and global gamma statistics at 3 mm/3% and at 2 mm/2% were evaluated and statistically compared between the DQA plans of DCM and CCM. When applying the default and optimal couch models for treatment planning, the mean dose diferences between the measured and calculated attenuations were − 4.8% and − 0.1%, respectively. In all DQA for PSR cases using the CCM, the dose diference and gamma statistics were statistically improved compared to those using the DCM (P<0.05). However, there was no signifcant diference in the dose diferences and gamma statistics between the PMRT and TomoHelical cases, except for the flm DQA for PMRT. The results demonstrated that the couch model in RayStation should be commissioned for TomoTherapy treatment planning when a greater dose contribution is expected from the posterior direction.
Hironori Kobayashi,Keiko Fujita,Shunji Suzuki,Tsutomu Takayanagi 한국식물생명공학회 2009 Plant biotechnology reports Vol.3 No.3
We investigated the transcriptional profiles of Japanese indigenous grape cultivar ‘Koshu’ (Vitis vinifera) leaf and berry skin during ripening. In leaf, 64 genes were abundantly transcribed at the end of ve´raison (14 weeks post-flowering), whereas the expression of 61 genes was upregulated at the end of ripening (20 weeks post-flowering). In berry skin, 67 genes were abundantly transcribed at the end of ve´raison, whereas the expression of 86 genes was upregulated at the end of ripening. Gene expression associated with biological processes was activated in both tissues at the end of ripening. The expression of genes associated with photosynthesis, sugar synthesis, anthocyanin synthesis, cinnamic acid synthesis, and amino acid metabolism was observed in leaf and berry skin during ripening, together with the accumulation of sugars, anthocyanins, cinnamic acids, and amino acids. Transcripts of AUX/IAA family proteins that repress the activities of auxin-induced proteins were expressed in berry skin at the end of ve´raison. Transcripts of genes related to the ubiquitin– proteasome system that degrades AUX/IAA family proteins were abundantly expressed in berry skin at the end of ripening, suggesting that the expansion of skin cells at ve´raison is suppressed by AUX/IAA family proteins, and that the ubiquitin–proteasome system induces the expansion of skin cells during ripening by degrading AUX/IAA family proteins. These transcriptional profiles, which provide new information on the characteristics of ‘Koshu’ grapevine during ripening, may explain the unique characteristics of ‘Koshu’ grape in comparison with those of European grapes used for winemaking, and may contribute to the improvement of ‘Koshu’ grape quality. We investigated the transcriptional profiles of Japanese indigenous grape cultivar ‘Koshu’ (Vitis vinifera) leaf and berry skin during ripening. In leaf, 64 genes were abundantly transcribed at the end of ve´raison (14 weeks post-flowering), whereas the expression of 61 genes was upregulated at the end of ripening (20 weeks post-flowering). In berry skin, 67 genes were abundantly transcribed at the end of ve´raison, whereas the expression of 86 genes was upregulated at the end of ripening. Gene expression associated with biological processes was activated in both tissues at the end of ripening. The expression of genes associated with photosynthesis, sugar synthesis, anthocyanin synthesis, cinnamic acid synthesis, and amino acid metabolism was observed in leaf and berry skin during ripening, together with the accumulation of sugars, anthocyanins, cinnamic acids, and amino acids. Transcripts of AUX/IAA family proteins that repress the activities of auxin-induced proteins were expressed in berry skin at the end of ve´raison. Transcripts of genes related to the ubiquitin– proteasome system that degrades AUX/IAA family proteins were abundantly expressed in berry skin at the end of ripening, suggesting that the expansion of skin cells at ve´raison is suppressed by AUX/IAA family proteins, and that the ubiquitin–proteasome system induces the expansion of skin cells during ripening by degrading AUX/IAA family proteins. These transcriptional profiles, which provide new information on the characteristics of ‘Koshu’ grapevine during ripening, may explain the unique characteristics of ‘Koshu’ grape in comparison with those of European grapes used for winemaking, and may contribute to the improvement of ‘Koshu’ grape quality.
Hironori Koga,Hideki Iwamoto,Hiroyuki Suzuki,Shigeo Shimose,Masahito Nakano,Takumi Kawaguchi 대한간학회 2023 Clinical and Molecular Hepatology(대한간학회지) Vol.29 No.2
Striking advances in systemic therapy for unresectable advanced hepatocellular carcinoma (HCC) have improved the average prognosis of patients with HCC. As a result, the guidelines for the treatment of HCC have changed significantly. However, various issues have emerged in clinical practice. First, there is no established biomarker that can predict response to systemic therapy. Second, there is no established treatment regimen after primary systemic therapy, including combined immunotherapy. Third, there is no established treatment regimen for intermediate-stage HCC. These points make the current guidelines ambiguous. In this review, we present the Japanese guidelines for the diagnosis and treatment of HCC based on the latest evidence; introduce various efforts mainly in Japanese real-life practice to update these guidelines; and present our perspectives on future guidelines.