Investigating the Performance and Customer Satisfaction on Free Economic Zone?

( Sunhye Lee ),( Yoon C. Cho ) 서암순창장학회 2016 Journal of Marketing Thought Vol.3 No.2

By applying the extended expectancy confirmation model (1980), this study examined the relationships between awareness, expectation, performance, confirmation/disconfirmation, and satisfaction for special economic zone. This study measured the effects of each element of customer satisfaction as follows: i) impact of awareness of free economic zone on expectation; ii) impact of expectation of free economic zone on perceived performance and confirmation; iii) impact of perceived performance of free economic zone on confirmation and satisfaction; and iv) impact of confirmation on satisfaction. This study conducted both qualitative and quantitative research and provides managerial and policy implications for expectation and performance of free economic zone.

Human Long Noncoding RNA Regulation of Stem Cell Potency and Differentiation

Lee, Seahyoung,Seo, Hyang-Hee,Lee, Chang Youn,Lee, Jiyun,Shin, Sunhye,Kim, Sang Woo,Lim, Soyeon,Hwang, Ki-Chul Hindawi 2017 Stem cells international Vol.2017 No.-

<P>Because of their capability of differentiation into lineage-specific cells, stem cells are an attractive therapeutic modality in regenerative medicine. To develop an effective stem cell-based therapeutic strategy with predictable results, deeper understanding of the underlying molecular mechanisms of stem cell differentiation and/or pluripotency maintenance is required. Thus, reviewing the key factors involved in the transcriptional and epigenetic regulation of stem cell differentiation and maintenance is important. Accumulating data indicate that long noncoding RNAs (lncRNAs) mediate numerous biological processes, including stem cell differentiation and maintenance. Here, we review recent findings on the human lncRNA regulation of stem cell potency and differentiation. Although the clinical implication of these lncRNAs is only beginning to be elucidated, it is anticipated that lncRNAs will become important therapeutic targets in the near future.</P>

Spindle epithelial tumor with thymus-like differentiation of the thyroid in a 70-year-old man

Sunhye Lee,Yon Seon Kim,Jeong Hyeon Lee,Sung Ho Hwang,Yu-Hwan Oh,Byung Kyun Ko,Soo-Youn Ham 대한외과학회 2018 Annals of Surgical Treatment and Research(ASRT) Vol.94 No.6

Spindle epithelial tumor with thymus-like differentiation (SETTLE) is a very rare tumor of the thyroid gland mostly occurring in young patients. The imaging findings of SETTLE tumors are yet to be defined. However, they are usually described as well-defined heterogeneously enhanced masses on CT scan. The current case has the potential growth as compared with a 2009 chest radiography. We took into account the possibility of SETTLE in the case of a bulky mass in patients over 70 years old, particularly in the lower neck. Herein, we report a case of the oldest patient so far. The patient underwent a right lobectomy of the thyroid and mass excision. Follow-up CT scans after 6 months revealed no local recurrence. Surgery is the gold standard treatment for SETTLE. Chemotherapy and radiotherapy could be another possible option for patients with advanced stage SETTLE.

MicroRNA-Mediated Down-Regulation of Apoptosis Signal-Regulating Kinase 1 (ASK1) Attenuates the Apoptosis of Human Mesenchymal Stem Cells (MSCs) Transplanted into Infarcted Heart

Lee, Chang Youn,Shin, Sunhye,Lee, Jiyun,Seo, Hyang-Hee,Lim, Kyu Hee,Kim, Hyemin,Choi, Jung-Won,Kim, Sang Woo,Lee, Seahyung,Lim, Soyeon,Hwang, Ki-Chul MDPI 2016 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.17 No.10

<P>Stem cell therapy using adult stem cells, such as mesenchymal stem cells (MSCs) has produced some promising results in treating the damaged heart. However, the low survival rate of MSCs after transplantation is still one of the crucial factors that limit the therapeutic effect of stem cells. In the damaged heart, oxidative stress due to reactive oxygen species (ROS) production can cause the death of transplanted MSCs. Apoptosis signal-regulating kinase 1 (ASK1) has been implicated in the development of oxidative stress-related pathologic conditions. Thus, we hypothesized that down-regulation of ASK1 in human MSCs (hMSCs) might attenuate the post-transplantation death of MSCs. To test this hypothesis, we screened microRNAs (miRNAs) based on a miRNA-target prediction database and empirical data and investigated the anti-apoptotic effect of selected miRNAs on human adipose-derived stem cells (hASCs) and on rat myocardial infarction (MI) models. Our data indicated that miRNA-301a most significantly suppressed ASK1 expression in hASCs. Apoptosis-related genes were significantly down-regulated in miRNA-301a-enriched hASCs exposed to hypoxic conditions. Taken together, these data show that miRNA-mediated down-regulation of ASK1 protects MSCs during post-transplantation, leading to an increase in the efficacy of MSC-based cell therapy.</P>

Supplementation of non‑fermented and fermented goji berry (Lycium barbarum) improves hepatic function and corresponding lipid metabolism via their anti‑inflammatory and antioxidant properties in high fat‑fed rats

Lee Sunhye,Jeong Soyeon,Park Yeongju,Seo Hyunji,You Cheongbin,Hwang Unsik,Park Hoon,Suh Hee-jae 한국응용생명화학회 2021 Applied Biological Chemistry (Appl Biol Chem) Vol.64 No.5

Development of obesity is associated with excessive fat accumulation and oxidative stress along with chronic inflammation. Goji berries (Lycium barbarum) are high in polyphenolic compounds and have anti-inflammatory, anti-oxidant, and hypolipidemic properties that may alleviate the pathogenesis of obesity and related metabolic complications. Thus, the aim of this study was to investigate potential metabolic benefits of GB supplementation against high fat (HF) diet-induced obesity and its comorbidities in HF diet-fed rats (male Sprague–Dawley, n = 8/group, 6 weeks old). We also sought to examine the potential metabolic benefits of fermented GB (FGB) with L. plantarum CB3 and possible distinctions in the degree and/or mechanism of action compared to GB. GB and FGB supplementation suppressed the gene expression of inflammation indices at the local (adipose tissues) and systemic (liver) levels. In addition, GB and FGB supplementation upregulated the gene expression of antioxidant enzymes compared to the HF and/or even low fat (LF) group with more remarkable antioxidant effects by GB supplementation. Also, GB and FGB supplementation protected from HF-induced damages of the liver and dyslipidemia. In conclusion, we demonstrated that GB and FGB supplementation protected from HF-induced metabolic complications primarily by improving hepatic function and corresponding lipid metabolism via their anti-inflammatory and antioxidant properties. To our knowledge, this is the first in vivo study confirming metabolic benefits of GB in a fermented form. Thus, these findings support the potential application of both GB and FGB to ameliorate obesity-associated metabolic abnormalities.

Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014)

Lee, Yoonji,Hong, Sunhye,Cui, Minghua,Sharma, Pankaz K,Lee, Jeewoo,Choi, Sun Informa UK, Ltd. 2015 Expert opinion on therapeutic patents Vol.25 No.3

<P>Introduction: Transient receptor potential vanilloid type 1 (TRPV1) is a nonselective cation channel that can be activated by noxious heat, low pH and vanilloid compounds such as capsaicin. Since TRPV1 acts as an integrator of painful stimuli, TRPV1 antagonists can be used as promising therapeutics for new types of analgesics. Areas covered: This review article covers the patents that claim TRPV1 antagonists and were published during 2011 - 2014. The patent evaluation is organized according to the applicant companies, and the representative chemical entities with important in vitro and in vivo data are summarized. Expert opinion: Many pharmaceutical companies showed promising results in the discovery of potent small molecule TRPV1 antagonists, and recently, a number of small molecule TRPV1 antagonists have been advanced into clinical trials. Unfortunately, several candidate molecules showed critical side effects such as hyperthermia and impaired noxious heat sensation in humans, leading to their withdrawal from clinical trials. Some TRPV1 antagonists patented in recent years (2011 - 2014) overcame these undesirable side effects, making the development of TRPV1 antagonists much more promising.</P>

microRNA-133a attenuates cardiomyocyte hypertrophy by targeting PKCδ and Gq

Lee, Se-Yeon,Lee, Chang Youn,Ham, Onju,Moon, Jae Yoon,Lee, Jiyun,Seo, Hyang-Hee,Shin, Sunhye,Kim, Sang Woo,Lee, Seahyoung,Lim, Soyeon,Hwang, Ki-Chul Springer-Verlag 2018 MOLECULAR AND CELLULAR BIOCHEMISTRY - Vol.439 No.1

세계시민교육을 위한 그림책 활용 미술교육에 관한 실행연구 : 초등학교 1학년 대상 공감능력 중심으로

이선혜(Sunhye LEE),김선아(Sunah KIM) 한국조형교육학회 2021 造形敎育 Vol.- No.80

본 연구는 공감과 실천을 학습 영역으로 하는 새로운 관점에서의 세계시민교육의 필요성을 가지고, 세계시민교육을 위한 그림책 활용 미술교육에 관한 프로그램을 개발하여 실행수업을 통해 학생들과 교사의 세계시민의식에 어떻게 영향을 주는지 변화 상에 대해 알아보고자 하였다. 프로그램의 실행은 초등학교 1학년 대상 공감능력 중심으로 제안하였다. 공감능력의 향상을 위해 공감의 대상을 ‘타인’을 넘어 주변의 현상이나 환경에까지 확장하여 실행하였다. 프로그램의 실행 후 학생의 경우 타인에 대한 이해 능력에서의 변화와 교사는 실천적 공감의 이해 능력의 측면에서 변화가 일어났다. 본 연구의 세부 연구문제는 다음과 같다. 공감능력 향상을 위한 세계시민교육 프로그램을 통해 초등학교 1학년 학생들의 세계시민의식은 어떻게 변화하는가? 프로그램 실행 과정에서 세계시민교육을 가르치는 교사의 전문성과 역할은 무엇인가? 이에 대한 결론은 다음과 같다. 학생들은 입장 바꿔보기를 통한 공감과 시각화 활동을 통한 공감의 경험으로 세계시민의식의 변화를 가져왔다. 교사 또한 실천적 공감의 이해 능력의 변화를 가져오고, 모델링 제공자의 역할과 세계시민교육 전문가의 역할을 통해 학생의 공감능력 향상이 이루어질 수 있을 것이라는 교육적 의미를 가지게 되었다. 본 연구는 학생과 교사의 정서적 공감이 긍정적인 역할을 수행하고, 세계화 시대에서 공감능력을 함양하는 데 미술교육이 중심이 될 수 있다는 방안을 모색하였다는 데 의의가 있다. This study aims to develop a program on art education using picture books for global citizenship education with the need for global citizenship education from a new perspective of empathy and practice as a learning area and to find out how students and teachers influence global citizenship. The implementation of the program was proposed focusing on empathy ability for first graders in elementary school. In order to improve empathy ability, the object of empathy was extended beyond other to surrounding phenomena and environments. After the implementation of the program, in the case of students, changes in the ability to understand others and teachers in terms of the ability to understand practical empathy occurred. The detailed research problems of this study are as follows. How does the global citizenship of first-year elementary school students change through the global citizenship education program to improve their empathy? What is the professionalism and role of teachers who teach global civic education in the process of program execution? The conclusion on this is as follows. Students brought about a strong change in citizenship through empathy through changing positions and experience of empathy through visualization activities. Teachers also brought about changes in the understanding ability of practical empathy, and had an educational meaning that students empathy ability could be improved through the role of modeling providers and global civic education experts. This study is meaningful in that it sought ways that the emotional empathy of students and teachers plays a positive role and art education can be centered on cultivating empathy skills in the era of globalization.

소통능력 신장을 위한 동영상 활용 시각 문화 미술교육에 관한 실행연구: 초등학교 3학년 중심으로

이선혜(Sunhye LEE) 한국조형교육학회 2023 造形敎育 Vol.- No.87

Anticholinergic Cognitive Burden as a Predictive Factor for In-hospital Mortality in Older Patients in Korea

Jae Hyun Lee,정희원,Il-Young Jang,문성도,Sunhye Lee,Seung Jun Han 대한노인병학회 2020 Annals of geriatric medicine and research Vol.24 No.1

Background: With the increasing prevalence of chronic disease due to aging, many older adults experience multimorbidity and polypharmacy. Medications with anticholinergic properties are particularly associated with adverse cognitive outcomes, including functional decline and mortality. We assessed the clinical impact of anticholinergic cognitive burden (ACB) on clinical outcomes of older patients acutely admitted to a single, hospitalist-operated medical unit of a tertiary hospital in Korea. Methods: This retrospective study reviewed electronic medical records of 318 patients aged 65 years or older admitted to the hospitalist-operated medical unit through the emergency department of Seoul National University Hospital. The analyzed clinical outcomes were the length of hospital stay, in-hospital mortality, unplanned intensive care unit admission, and unexpected readmission within 30 days. Results: The clinical outcomes did not differ between patients who took five or more drugs and those who did not. Patients with an ACB score of 3 or higher had a higher in-hospital mortality rate and longer hospital stay than those who did not. After adjusting for confounding factors, an ACB score of 3 or higher was an independent predictive factor for in-hospital mortality (odds ratio=3.09; 95% confidence interval, 1.18–8.06). Conclusion: ACB rather than the number of medications was associated with in-hospital mortality in acutely ill older patients. Further analytic and interventional studies are required to assess potentially inappropriate medication use and ACB in older inpatients.