http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
오늘 본 자료
A New Phenylpropanoid Glucoside from the Fruits of Illicium verum
Sung-WonLee,GaoLi,Kyong-SunLee,Dong-KeunSong,Jong-KeunSon 대한약학회 2003 Archives of Pharmacal Research Vol.26 No.8
One new phenylpropanoid glucoside (3), along with one known phenylpropanoid (1), and one known alkyl glucoside (2) were isolated from the fruits of Illicium verum and their chemical structures were elucidated on the basis of spectroscopic studies.
Han Byeol Kim,Sang-WonLee,ChinHeeMun,JiYoungYoon,JaeyoungPai,InjaeShin,Yong-BeomPark,Soo-KonLee,JinWonCho 한국당과학회 2016 한국당과학회 학술대회 Vol.2016 No.01
O-linked N-acetylglucosamine (O-GlcNAc) modification is unique glycosylations and it can occur exclusively in nucleus and cytoplasm. O-GlcNAc is attached onto a serine or threonine residue of a protein by O-GlcNAc transferase (OGT) and detached by O-GlcNAcase (OGA) under dynamic regulations by a variety of conditions. O-GlcNAcylation is associated with several clinical situations including cancers and inflammatory diseases. The effect of O-GlcNAcylation of subunits of nuclear factor-ĸB on its transcriptional activity has been reported to date. Interestingly, O-GlcNAc modification of NF-ĸB exhibited reciprocal results on its activity depending on different cell types: increased O-GlcNAcylation elevated the activity of NF-ĸB in pancreatic cancer cells, while aortic smooth muscle cells showed negative correlation between O-GlcNAcylation and NF-ĸB activity In Rheumatoid Arthirtis (RA), NF-ĸB is the novel regulator of pro-inflammatory cytokines mediating synovitis, long-term cartilage degradation and bone erosion. We hypothesize that the alteration in the activity of NF-ĸB resulting from its O-GlcNAcylation might affect the severity of RA. There was no report on the effect of O-GlcNAcylation of NF-ĸB on its activity in RA. We used in vitro synoviocytes and in vivo in mice with collagen induced arthritis (CIA) and investigated the inflammatory potential of O-GlcNAcylation of P65, one of subunits of NF-ĸB, in the pathogenesis of RA.
DNA Topoisomerases I and Il Inhibitory Activity of Constituents Isolated from Juglans mandshurica
GaoLi,Sun-YoungLee,Kyeung-SeonLee,Sung-WonLee,Sang-HyunKim,Seung-HoLee,Chong-SoonLee,Mi-HeeWoo,Jong-KeunSon 대한약학회 2003 Archives of Pharmacal Research Vol.26 No.6
Nine diarylheptanoids (1-9), one triterpene (10), one sesquiterpenoid (11), one naphthoquinone (12), four tetralones (13-16), one naphthalene carboxylic acid glucoside (17) and six naphthalenyl glycosides (18 -23) were isolated from the roots of Juglans mandshurica Maximowicz (Juglandaceae), and their structures determined from the chemical and spectral data. Here, we report the inhibitory effects, on the DNA topoisomerases I and II activities, of all these compounds. Compounds 10 and 23 showed more potent inhibitory effects, on the DNA topoisomerases I and II (94.0 and 86.0% inhibitions at the concentration of 5 mg/mL, respectively), than the positive control compounds, camptothecin and etoposide.