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오늘 본 자료
YongRokLee,DoHoonKim,Jae-JinShim,SeogK.Kim,JungHagPark,JinSoonCha,Chong-SoonLee 대한화학회 2002 Bulletin of the Korean Chemical Society Vol.23 No.7
An efficient synthesis of 2H-pyrans is achieved by indium (III) chloride-catalyzed reactions of 1,3-dicarbonyl compounds with a variety of α,β-unsaturated aldehydes in moderate yields. This method has been applied to the synthesis of pyranocoumarins, pyranophenalenones, and pyranoquinolinone alkaloids.
DNA Topoisomerases I and Il Inhibitory Activity of Constituents Isolated from Juglans mandshurica
GaoLi,Sun-YoungLee,Kyeung-SeonLee,Sung-WonLee,Sang-HyunKim,Seung-HoLee,Chong-SoonLee,Mi-HeeWoo,Jong-KeunSon 대한약학회 2003 Archives of Pharmacal Research Vol.26 No.6
Nine diarylheptanoids (1-9), one triterpene (10), one sesquiterpenoid (11), one naphthoquinone (12), four tetralones (13-16), one naphthalene carboxylic acid glucoside (17) and six naphthalenyl glycosides (18 -23) were isolated from the roots of Juglans mandshurica Maximowicz (Juglandaceae), and their structures determined from the chemical and spectral data. Here, we report the inhibitory effects, on the DNA topoisomerases I and II activities, of all these compounds. Compounds 10 and 23 showed more potent inhibitory effects, on the DNA topoisomerases I and II (94.0 and 86.0% inhibitions at the concentration of 5 mg/mL, respectively), than the positive control compounds, camptothecin and etoposide.