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DNA Topoisomerases I and Il Inhibitory Activity of Constituents Isolated from Juglans mandshurica
GaoLi,Sun-YoungLee,Kyeung-SeonLee,Sung-WonLee,Sang-HyunKim,Seung-HoLee,Chong-SoonLee,Mi-HeeWoo,Jong-KeunSon 대한약학회 2003 Archives of Pharmacal Research Vol.26 No.6
Nine diarylheptanoids (1-9), one triterpene (10), one sesquiterpenoid (11), one naphthoquinone (12), four tetralones (13-16), one naphthalene carboxylic acid glucoside (17) and six naphthalenyl glycosides (18 -23) were isolated from the roots of Juglans mandshurica Maximowicz (Juglandaceae), and their structures determined from the chemical and spectral data. Here, we report the inhibitory effects, on the DNA topoisomerases I and II activities, of all these compounds. Compounds 10 and 23 showed more potent inhibitory effects, on the DNA topoisomerases I and II (94.0 and 86.0% inhibitions at the concentration of 5 mg/mL, respectively), than the positive control compounds, camptothecin and etoposide.