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( Sang Muk Oh ),( Chang Gyo Park ),( Joo Hee Kang ),( Eun Jung Kim ),( Hee Youn Chee ),( Bong Ho Lee ),( Kyung Bok Lee ) 한국응용생명화학회 2011 Applied Biological Chemistry (Appl Biol Chem) Vol.54 No.3
Dieckol, a polyphenol compound extracted from Brown algae, Ecklonia cava, is known to have anti-inflammatory and anti-tumorigenic activities. However, the underlying molecular mechanism by which dieckol regulates cancer cell growth and proliferation remains elusive. Here we report that dieckol extracted from Ecklonia cava inhibited 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced human hepatocellular carcinoma SK-Hep1 cell motility, and that dieckol decreased extracellular signal-regulated kinases 1/2 and c-Jun N-terminal kinases (JNKs) activities, but not p38 Mitogen-Activated Protein Kinase (MAPK), in dose-dependent manner. Dieckol reduced TPA-induced activator protein-1 transcriptional activity. TPA-induced matrix metalloproteinase-9 (MMP-9) activity was greatly reduced in SK-Hep1 cells by treatment of dieckol. These findings suggest that dieckol functions as a potent inhibitor for tumor promoter-mediated MAPK signaling pathways leading to AP-1 and MMP-9 activation thereby regulates cancer cell motility.
Kim, Dong-Ha,Lim, Yun-Young,Kim, Hyeong-Mi,Kim, So-Young,Kim, Beom-Joon,Park, Sung-Gil,Lee, Tae-Hoon,Cho, Soo-Muk Korean Society of ToxicologyKorea Environmental Mu 2012 Toxicological Research Vol.28 No.1
A novel synthetic hexapeptide (SFKLRY-$NH_2$) that displays angiogenic activity has been identified by positional scanning of a synthetic peptide combinatorial library (PS-SPCL). This study was carried out to investigate the irritation of the SFKLRY-$NH_2$ on the skin. The tests were performed on the basis of Korea Food and Drug Administration (KFDA) guidelines. In results, cell toxicity is not appeared for SFKLRY-$NH_2$ in HaCaT cells and B16F10 cells. SFKLRY-$NH_2$ induced no skin irritation at low concentration ($10{\mu}m$), mild irritation at high concentration (10mM). We consider that this result is helpful for saying about the safety of SFKLRY-$NH_2$ in clinical use.
Identification of tumor antigens in malignant mesothelioma
Kim, Ye-Rin,Song, Myung-Ha,Lee, Jun-Won,Bae, Jae-Ho,Kim, Jong-Eun,Kang, Dong-Muk,Lee, Sang-Yull D.A. Spandidos 2017 Oncology letters Vol.14 No.4
<P>Serological analysis of recombinant tumor cDNA expression library (SEREX) is a powerful and widely used method to explore the cancer immune environment. In the present study, immunoscreening of normal testicular tissues and malignant mesothelioma (MM) cancer MSTO-211H cell line cDNA libraries with sera from 5 MM patients led to the isolation of 16 independent antigens, which were designated ‘Korea Pusan-Malignant Mesothelioma’ (KP-MM)-1 to −16. In total, 3/16 antigens were identified using the results of previous SEREX analyses, and 13 were newly identified. Of these, KP-MM-8, which was subsequently identified as amyotrophic lateral sclerosis 2 chromosome region candidate 11, was shown to be tissue-restricted. Reverse transcription-polymerase chain reaction demonstrated KP-MM-8 to be expressed strongly only in the normal testis, and weakly in the spleen, prostate, ovary, heart and skeletal muscle. In addition, KP-MM-8 mRNA was identified in MM cell lines, and in various other cancer cell lines, including MM (3/4), lung cancer (5/7), melanoma (5/7) and liver cancer (5/5) cell lines. Additionally, 2/16 antigens (KP-MM-2 and KP-MM-6) exclusively reacted with sera from cancer patients. However, KP-MM-8 reacted with 1 of 8 MM sera. Notably, 8/8 patients with MM and 8/8 normal individuals exhibited antibodies reactive to KP-MM-5, which was identified as cell division cycle 25B, a known oncogene. Overall, this data suggests that KP-MM-8 may be considered as a cancer/testis-like antigen and KP-MM-5 as an immunogenic tumor antigen in MM patients.</P>
Kim, Hyun-Woo,Lim, Jun-Muk,Lee, Hyeon-Ji,Eom, Seung-Wook,Hong, Young Taik,Lee, Sang-Young The Royal Society of Chemistry 2016 Journal of materials chemistry. A, Materials for e Vol.4 No.10
<▼1><P>Artificially engineered, bicontinuous anion-conducting/-repelling polymeric phases were demonstrated as a selective ion transport channel to bring separator membrane-driven performance benefits for rechargeable Zn–air batteries.</P></▼1><▼2><P>Zinc (Zn)–air batteries have recently attracted a great deal of attention as a promising energy storage system to fulfill our ever-increasing demand for higher energy density power sources. Despite commercial success of primary Zn–air batteries, performances of rechargeable Zn–air batteries are still far below practically satisfactory levels. Among critical challenges facing the electrochemical rechargeability, the crossover of zincate (Zn(OH)4<SUP>2−</SUP>) ions from the Zn anode to the air cathode (<I>via</I> separator membranes) is a formidable bottleneck. Here, as a facile and scalable polymer architecture strategy to address this ion transport issue, we demonstrate a new class of polymer blend electrolyte membranes with artificially engineered, bicontinuous anion-conducting/-repelling phases (referred to as “PBE membranes”). As an anion-conducting continuous phase, an electrospun polyvinyl alcohol (PVA)/polyacrylic acid (PAA) nanofiber mat is fabricated. Into the PVA/PAA nanofiber mat, Nafion bearing pendant sulfonate groups is impregnated to form an anion-repelling continuous phase. Such bicontinuous phase-mediated structural uniqueness enables the PBE membrane to act as a selective ion transport channel, <I>i.e.</I>, effectively suppresses Zn(OH)4<SUP>2−</SUP> crossover (by a continuous Nafion phase offering the Donnan exclusion effect) with slightly impairing OH<SUP>−</SUP> conduction (predominantly through the PVA/PAA nanofiber mat), eventually improving the cycling stability (cycle time = over 2500 min for the PBE membrane <I>vs.</I> 900 min for a conventional polypropylene separator). The PBE membrane featuring the selective transport of OH<SUP>−</SUP> and Zn(OH)4<SUP>2−</SUP> ions is anticipated to pave a new route that leads us closer toward rechargeable Zn–air batteries.</P></▼2>
Kim, Ju-Myung,Kim, Chanhoon,Yoo, Seungmin,Kim, Jeong-Hoon,Kim, Jung-Hwan,Lim, Jun-Muk,Park, Soojin,Lee, Sang-Young The Royal Society of Chemistry 2015 Journal of Materials Chemistry A Vol.3 No.20
<▼1><P>We demonstrated an agarose-biofunctionalized, dual-electrospun heteronanofiber mat as a new class of chemically active (specifically, metal-ion chelating) separator membranes for high-performance Li-ion batteries.</P></▼1><▼2><P>A facile and efficient way to impart compelling chemical functionality is the utilization of bio-related materials that are easily accessible from natural products. Here, inspired by anomalous physicochemical features and natural abundance of agarose, we demonstrate a new class of agarose-biofunctionalized, dual-electrospun heteronanofiber mats as a chemically active separator membrane for high-performance lithium-ion batteries. The agarose-enabled metal ion chelation effect of the separator membrane, in combination with its highly porous structure and superior electrolyte wettability, provides unprecedented improvement in cell performance far beyond those accessible with conventional battery separator membranes.</P></▼2>