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Joo‑Youl Huh,Min‑Je Hwang,Seung‑Woo Shim,Tae‑Chul Kim,Jong‑Sang Kim 대한금속·재료학회 2018 METALS AND MATERIALS International Vol.24 No.6
The reactive wetting behaviors of molten Zn–Al–Mg alloys on MnO- and amorphous (a-) SiO2-covered steel sheets wereinvestigated by the sessile drop method, as a function of the Al and Mg contents in the alloys. The sessile drop tests werecarried out at 460 °C and the variation in the contact angles (θc) of alloys containing 0.2–2.5 wt% Al and 0–3.0 wt% Mg wasmonitored for 20 s. For all the alloys, the MnO-covered steel substrate exhibited reactive wetting whereas the a-SiO2-coveredsteel exhibited nonreactive, nonwetting (θc > 90°) behavior. The MnO layer was rapidly removed by Al and Mg contained inthe alloys. The wetting of the MnO-covered steel sheet significantly improved upon increasing the Mg content but decreasedupon increasing the Al content, indicating that the surface tension of the alloy droplet is the main factor controlling its wettability. Although the reactions of Al and Mg in molten alloys with the a-SiO2 layer were found to be sluggish, the wettabilityof Zn–Al–Mg alloys on the a-SiO2 layer improved upon increasing the Al and Mg contents. These results suggest that thewetting of advanced high-strength steel sheets, the surface oxide layer of which consists of a mixture of MnO and SiO2,withZn–Al–Mg alloys could be most effectively improved by increasing the Mg content of the alloys.
Biomimetic Superoxide Disproportionation Catalyst for Anti-Aging Lithium-Oxygen Batteries
Hwang, Chihyun,Yoo, JongTae,Jung, Gwan Yeong,Joo, Se Hun,Kim, Jonghak,Cha, Aming,Han, Jung-Gu,Choi, Nam-Soon,Kang, Seok Ju,Lee, Sang-Young,Kwak, Sang Kyu,Song, Hyun-Kon American Chemical Society 2019 ACS NANO Vol.13 No.8
<P>Reactive oxygen species or superoxide (O<SUB>2</SUB><SUP>-</SUP>), which damages or ages biological cells, is generated during metabolic pathways using oxygen as an electron acceptor in biological systems. Superoxide dismutase (SOD) protects cells from superoxide-triggered apoptosis by converting superoxide to oxygen and peroxide. Lithium-oxygen battery (LOB) cells have the same aging problems caused by superoxide-triggered side reactions. We transplanted the function of SOD of biological systems into LOB cells. Malonic acid-decorated fullerene (MA-C<SUB>60</SUB>) was used as a superoxide disproportionation chemocatalyst mimicking the function of SOD. As expected, MA-C<SUB>60</SUB> as the superoxide scavenger improved capacity retention along charge/discharge cycles successfully. A LOB cell that failed to provide a meaningful capacity just after several cycles at high current (0.5 mA cm<SUP>-2</SUP>) with 0.5 mAh cm<SUP>-2</SUP> cutoff survived up to 50 cycles after MA-C<SUB>60</SUB> was introduced to the electrolyte. Moreover, the SOD-mimetic catalyst increased capacity, <I>e</I>.<I>g</I>., more than a 6-fold increase at 0.2 mA cm<SUP>-2</SUP>. The experimentally observed toroidal morphology of the final discharge product of oxygen reduction (Li<SUB>2</SUB>O<SUB>2</SUB>) and density functional theory calculation confirmed that the solution mechanism of Li<SUB>2</SUB>O<SUB>2</SUB> formation, more beneficial than the surface mechanism from the capacity-gain standpoint, was preferred in the presence of MA-C<SUB>60</SUB>.</P> [FIG OMISSION]</BR>
Sang-Yoon Lee,Hoon Joo Yang,Jeong-Joon Han,Soon Jung Hwang 대한구강악안면외과학회 2013 대한구강악안면외과학회지 Vol.39 No.5
Objectives: Buccal fracture of the mandibular proximal bone segment during bilateral sagittal split ramus osteotomy (SSRO) reduces the postoperative stability. The primary aim of this study is to evaluate the effect of this type of fracture on bone healing and postoperative stability after mandibular setback surgery. Materials and Methods: Ten patients who experienced buccal fracture during SSRO for mandibular setback movement were evaluated. We measured the amount of bone generation on a computed tomography scan, using an image analysis program, and compared the buccal fracture side to the opposite side in each patient. To investigate the effect on postoperative stability, we measured the postoperative relapse in lateral cephalograms, immediately following and six months after the surgery. The control group consisted of ten randomly-selected patients having a similar amount of set-back without buccal fracture. Results: Less bone generation was observed on the buccal fracture side compared with the opposite side (P<0.05). However, there was no significant difference in anterior-posterior postoperative relapse between the group with buccal fracture and the control group. The increased mandibular plane angle and anterior facial height after the surgery in the group with buccal fracture manifested as a postoperative clockwise rotation of the mandible. Conclusion: Bone generation was delayed compared to the opposite side. However, postoperative stability in the anterior-posterior direction could be maintained with rigid fixation.
( Joo Hyun Lim ),( Sang Gyun Kim ),( Ji Hyun Song ),( Jae Jin Hwang ),( Dong Ho Lee ),( Jae Pil Han ),( Su Jin Hong ),( Ji Hyun Kim ),( Seong Woo Jeon ),( Gwang Ha Kim ),( Ki-Nam Shim ),( Woon Geon Sh 대한소화기학회 2017 Gut and Liver Vol.11 No.2
Background/Aims: The resistance rate of Helicobacter pylori is gradually increasing. We aimed to evaluate the ef-ficacy of levofloxacin-based third-line H. pylori eradication in peptic ulcer disease. Methods: Between 2002 and 2014, 110 patients in 14 medical centers received levofloxacin-based third-line H. pylori eradication therapy for peptic ulcer disease. Of these, 88 were included in the study; 21 were excluded because of lack of follow-up and one was excluded for poor compliance. Their eradication rates, treatment regi-mens and durations, and types of peptic ulcers were ana-lyzed. Results: The overall eradiation rate was 71.6%. The adherence rate was 80.0%. All except one received a proton-pump inhibitor, amoxicillin, and levofloxacin. One received a proton-pump inhibitor, amoxicillin, levofloxacin, and clarithro-mycin, and the eradication was successful. Thirty-one were administered the therapy for 7 days, 25 for 10 days, and 32 for 14 days. No significant differences were observed in the eradication rates between the three groups (7-days, 80.6% vs 10-days, 64.0% vs 14-days, 68.8%, p=0.353). Additionally, no differences were found in the eradiation rates according to the type of peptic ulcer (gastric ulcer, 73.2% vs duode-nal/ gastroduodenal ulcer, 68.8%, p=0.655). Conclusions: Levofloxacin-based third-line H. pylori eradication showed ef-ficacy similar to that of previously reported first/second-line therapies. (Gut Liver 2017;11:226-231)
A case of cervical chondrocutaneous branchial remnants
( Sang Hyeon Hwang ),( Jae Yun Lim ),( Ju Yeon Choi ),( Han Saem Kim ),( Jung In Kim ),( Jung Min ),( Hyun Min Seo ),( Ho Joo Jung ),( Jae Hui Nam ),( Ga Young Lee ),( Won Serk Kim ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.1
Cervical chondrocutaneous branchial remnants are rare developmental anomalies of the brachial apparatus which appear as a firm, protruding papule or nodule on the neck along the line of anterior border of the sternocleidomastoid muscle. Primitive branchial embryonic tissues migrate into the final lateral facial position to form the adult derivatives of head and neck. However, failure of proper migration, fusion, or maturation of the branchial apparatus components results in a variety of congenital defects. Most branchial cysts and fistulae are considered to be derived from the first and second branchial clefts. Of these, cervical chondrocutaneous branchial remnants are infrequent, whereas branchial cysts and sinuses are relatively more common. Our patient, a 9-month-old girl, presented with a solitary skin-colored about 0.4 cm sized soft papule on the lower third of the left neck. The lesion had been presented at birth and physical examination revealed no remarkable findings except for the skin lesion. The histopathologic examination revealed normal epidermis and characteristic cartilage core in the dermis without connection to the epidermis. The histopathological features were consistent with cervical chondrocutaneous branchial remnants.
Hwang, Heeyoun,Park, Gun Wook,Park, Ji Yeong,Lee, Hyun Kyoung,Lee, Ju Yeon,Jeong, Ji Eun,Park, Sung-Kyu Robin,Yates, John R.,Kwon, Kyung-Hoon,Park, Young Mok,Lee, Hyoung-Joo,Paik, Young-Ki,Kim, Jin Yo American Chemical Society 2017 Journal of proteome research Vol.16 No.12
<P>Human Proteome Project aims to map all human proteins including missing proteins as well as proteoforms with post translational modifications, alternative splicing variants (ASVs), and single amino acid variants (SAAVs). neXtProt and Ensemble databases are usually used to provide curated information on human coding genes. However, to find these proteoforms, we (Chr #11 team) first introduce a streamlined pipeline using customized and concatenated neXtProt and GENCODE originated from Ensemble, with controlled false discovery rate (FDR). Because of large sized databases used in this pipeline, we found more stringent FDR filtering (0.1% at the peptide level and 1% at the protein level) to claim novel findings, such as GENCODE ASVs and missing proteins, from human hippocampus data set (MSV000081385) and ProteomeXchange (PXD007166). Using our next generation proteomic pipeline (nextPP) with neXtProt and GENCODE databases, two missing proteins such as activity-regulated cytoskeleton-associated protein (ARC, Chr 8) and glutamate receptor ionotropic, kainite 5 (GRIK5, Chr 19) were additionally identified with two or more unique peptides from human brain tissues. Additionally, by applying the pipeline to human brain related data sets such as cortex (PXD000067 and PXD000561), spinal cord, and fetal brain (PXD000561), seven GENCODE ASVs such as ACTN4–012 (Chr.19), DPYSL2–005 (Chr.8), MPRIP-003 (Chr.17), NCAM1–013 (Chr.11), EPB41L1–017 (Chr.20), AGAP1–004 (Chr.2), and CPNE5–005 (Chr.6) were identified from two or more data sets. The identified peptides of GENCODE ASVs were mapped onto novel exon insertions, alternative translations at 5′-untranslated region, or novel protein coding sequence. Applying the pipeline to male reproductive organ related data sets, 52 GENCODE ASVs were identified from two testis (PXD000561 and PXD002179) and a spermatozoa (PXD003947) data sets. Four out of 52 GENCODE ASVs such as RAB11FIP5–008 (Chr. 2), RP13–347D8.7–001 (Chr. X), PRDX4–002 (Chr. X), and RP11–666A8.13–001 (Chr. 17) were identified in all of the three samples.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jprobs/2017/jprobs.2017.16.issue-12/acs.jproteome.7b00223/production/images/medium/pr-2017-00223z_0006.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/pr7b00223'>ACS Electronic Supporting Info</A></P>
Current Status of Endoscopic Ultrasonography in Gastrointestinal Subepithelial Tumors
Sang Gyun Kim,Ji Hyun Song,Joo Ha Hwang 대한소화기내시경학회 2019 Clinical Endoscopy Vol.52 No.4
Gastrointestinal subepithelial tumors (GSTs) are usually detected incidentally on endoscopic or radiologic examinations. In conventional endoscopy, a GST usually presents as a protuberant lesion with an intact mucosal surface. As the lesion is located beneaththe mucosal layer of the gastrointestinal tract, conventional biopsy typically does not reveal the pathologic diagnosis. First, a GSTshould be differentiated from an extrinsic compression through the positional change of the patient during conventional endoscopicexamination. In cases of GSTs originating from the gastrointestinal wall, endoscopic ultrasonography (EUS) can be beneficial fornarrowing the differential diagnosis through delineation of echo findings and by determining the layer of origin. EUS findings can alsohelp determine the management strategies for GSTs by making a differential diagnosis according to malignant potential.