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한국인 알코올 의존 환자에서 알코올 대사 효소 유전자형 빈도의 남녀 차이
김성곤,김철민,이덕기,황인복,이현숙,김성연,전은숙,송영상,박제민,최병무,김명정 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.2
Objectives : There are a number of preceding epidemiological studies reporting gender differences in the genetic etiology of alcohol dependence. The author investigated gender difference in the frequencies of ADH2 and ALDH2 genoypes between the patients with alcohol dependence and normal control. Methods : The subjects were 141 alcohol dependent patients (104 males, 37 females) and 138 normal control (79 males, 59 females). The frequencies of 1/1 and 1/2+2/2 (2+ afterward) genotypes for ADH2 and ALDH2 were investigated in male and female between alcohol dependence and normal control group. DNA was extracted from WBC in peripheral venous blood and PCR-RFLP method was used out for genotyping. Results : First, the frequency of ADH2 1/1 genotype was significantly higher in alcohol dependent patients than normal control in both genders. Second, while there was no gender difference in the frequency of ADH2 1/1 genotype in normal controls, in the patient group however, the frequency was significantly higher in females than males. Third, in male subjects with alcohol dependence, the frequency of ALDH2 1/1 genotype was significantly higher than in male normal control subjects. On the other hand, in female subjects with alcohol dependence, the frequency of ALDH2 2+ genotype was significantly higher than in female normal control subjects. Conclusion : These results suggest that while the risk of alcohol dependence is predominantly affected by ALDH2 1/1 geno-type in male, the female ADH2 1/1 genotype is mainly associated with the risk of alcohol dependence. This means that there are gender differences in the genetic etiology of alcohol dependence.
김재홍,윤기범,박평원,김영진,전경민,김영태,김중환,곽호,구상완,송민석,유옥,지혜구,김동원,문상은,박영립,정승호,성범진,성순제,엄주용,황정열,이기홍,이주협,전태진 대한화학요법학회 1994 대한화학요법학회지 Vol.12 No.1
The prevalence of PPNG among pretreated gonorrhea cases isolated at the STD clinic of Choong-Ku Public Health Center in Seoul has been studied and reported annually since 1981. In 1991, 123 strains of N.gonorrhoeae were isolated, among which 58(47.1%) were PPNG. In 1992, 98 starains of N.gonorrhoeae were isolated, among which 51(52.0%) were PPNG. In all, 109(49.3%) strains were found to be PPNG among 221 strains isolated between 1991-1992. The prevalence of PPNG in Seoul showed increased tendency till 1989, thereafter, it has been stationary or slightly decreasing.
Kim, Hoyeun,Na, Sang ,Hyeon,Lee, So-Young,Jeong, Young-Min,Hwang, Hyun-Ju,Hur, Jae ,Young,Park, Sang-Hyun,Woo, Je-Chang,Kim, Sang-Gu Portland Press Ltd. 2012 The Biochemical journal Vol.443 No.1
<P>TDP1 (tyrosyl-DNA phosphodiesterase 1), a member of the PLD (phospholipase D) superfamily, catalyses the hydrolysis of a phosphodiester bond between a tyrosine residue and the 3′-phosphate of DNA. We have previously identified and characterized the <I>AtTDP</I> gene in <I>Arabidopsis thaliana</I>, an orthologue of yeast and human <I>TDP1</I> genes. Sequence alignment of TDP1 orthologues revealed that AtTDP has both a conserved C-terminal TDP domain and, uniquely, an N-terminal SMAD/FHA (forkhead-associated) domain. To help understand the function of this novel enzyme, we analysed the substrate saturation kinetics of full-length AtTDP compared with a truncated AtTDP mutant lacking the N-terminal FHA domain. The recombinant AtTDP protein hydrolysed a single-stranded DNA substrate with <I>K</I><SUB>m</SUB> and <I>k</I><SUB>cat</SUB>/<I>K</I><SUB>m</SUB> values of 703±137 nM and (1.5±0.04)×10<SUP>9</SUP>M<SUP>−1</SUP>·min<SUP>−1</SUP> respectively. The AtTDP-(Δ1–122) protein (TDP domain) showed kinetic parameters that were equivalent to those of the full-length AtTDP protein. A basic amino acid sequence (RKKVKP) within the AtTDP-(Δ123–605) protein (FHA domain) was necessary for nuclear localization of AtTDP. Analysis of active-site mutations showed that a histidine and a lysine residue in each of the HKD motifs were critical for enzyme activity. Vanadates, inhibitors of phosphoryl transfer reactions, inhibited AtTDP enzymatic activity and retarded the growth of an <I>Arabidopsis tdp</I> mutant. Finally, we showed that expression of the <I>AtTDP</I> gene could complement a yeast <I>tdp1</I>Δ<I>rad1</I>Δ mutant, rescuing the growth inhibitory effects of vanadate analogues and CPT (camptothecin). Taken together, the results of the present study demonstrate the structure-based function of AtTDP through which AtTDP can repair DNA strand breaks in plants.</P>
Stabilization of the surface of nitinol stent for cerebral aneurysm prevention
Chang-Min.Yoo(유창민),Hyo-Geun Nam(남효근),Je-Hee Shin(신재희),Min-Ho Hwang(황민호),Seung-Min Baek(백승민),Hyeong-Guk Son(손형국),Jeong-Hun Park(박정훈),Jin-Su Jeong(정진수),Jae-Won Lee(이재원),Hyuk Choi(최혁) 대한전자공학회 2016 대한전자공학회 학술대회 Vol.2016 No.6
Nikel titanium shape memory alloys (NiTi) are promising materials due to their shape memory effect. The disadvantage of the nickel is the toxicity, there are too many restrictions on the use of the human body. Hence, if the proper surface modification is chosen, the surface of NiTi can be tranquilized and smooth. Also, toxic chemicals can be protected by oxide film. The polishing method we have used is electro-polishing which is simple enough, economical and can handle wide range at once. In this study, we are surface modification NiTi by surface electro-polishing. The polishing method we have used is electro-polishing which is simple enough, economical and can handle wide range at once. We have used AFM(atomic force microscopy), SEM(scanning electron microscopy), OM(optical microscope) to analyze the roughness, and formation of surface of NiTi stent. To measure corrosion resistance, steady potentiostat was used to corrosion test. Our study group have concluded that condition of 40V 10seconds of electro-polishing showed the optimal stabilization of the surface.
동씨침을 이용한 양성 발작성 체위성 현훈환자 치험 1례
박민제(Min Je Park),김정욱(Jung Uk Kim),김은걸(Eun Geol Kim),이원희(Won Hui Lee),황민섭(Min Seop Hwang),윤종화(Jong Hwa Yoon) 대한의료기공학회 2007 醫療氣功 Vol.10 No.1
Benign Paroxysmal Positional Vertigo(BPPV) is a common disorder that peripheral vertigo in clinic, it is provoked Paroxysmal vertigo according to positional change. A man, aged 75, suffered from attacks of vertigo when get out of bed, He complained vertigo, nausea and walking trouble So he visited our clinic. Based upon the case history and position-provoked vertigo with characteristic findings on the Dix-Hallpike maneuver, we diagnosed as BPPV. Through only Shang-San-Huang(上三黃) of Dong Shi Xue(董氏穴) acupuncture therapy symptoms were vanished completely. This study was showed effect that operating only Dong-Shi acupuncture therapy without maneuver therapy and the other therapies to patient can not tolerate the Dix-Hallpike Maneuver. We need additional researches with methodological improvement and many clinical cases.
Min Je Kim,Hyeon Gyu Hwang,Jae Hwa Lee,Jooha Kim,박정목,Ginseok Song 대한기계학회 2022 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.36 No.9
In the present study, the aerodynamic performance and flight stability of a twodimensional (2D) canopy in a paraglider are optimized using a combination of response surface methodology (RSM) and a multi-objective genetic algorithm (MOGA) coupled with the unsteady Reynolds-averaged Navier-Stokes (URANS) equations solver. Compared to a 2D base case, an optimized canopy, featured by reduced airfoil thickness, shows an increase in the aerodynamic performance up to 18.9 % based on lift-to-drag ratio, while the flight stability is similar between them. An optimized three-dimensional (3D) canopy is constructed by duplicating the 2D canopy along the arc direction to identify the effects of the optimization on an actual 3D canopy. Based on large-eddy simulation (LES) data of the optimized 3D canopy and base 3D canopy, we show an improvement of the aerodynamic performance and stability of the optimized 3D canopy, consistent with our results from the 2D canopies.