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Lee, Min Jae,Bhattarai, Deepak,Yoo, Jisu,Miller, Zach,Park, Ji Eun,Lee, Sukyeong,Lee, Wooin,Driscoll, James J.,Kim, Kyung Bo American Chemical Society 2019 Journal of medicinal chemistry Vol.62 No.9
<P>Over the past 15 years, proteasome inhibitors (PIs), namely bortezomib, carfilzomib (Cfz) and ixazomib, have significantly improved the overall survival and quality-of-life for multiple myeloma (MM) patients. However, a significant portion of MM patients do not respond to PI therapies. Drug resistance is present either <I>de novo</I> or acquired after prolonged therapy through mechanisms that remain poorly defined. The lack of a clear understanding of clinical PI resistance has hampered the development of next-generation PI drugs to treat MM patients who no longer respond to currently available therapies. Here, we designed and synthesized novel epoxyketone-based PIs by structural modifications at the P1′ site. We show that a Cfz analog, <B>9</B>, harboring a hydroxyl substituent at its P1′ position was highly cytotoxic against cancer cell lines displaying <I>de novo</I> or acquired resistance to Cfz. These results suggest that peptide epoxyketones incorporating P1′-targeting moieties may have the potential to bypass resistance mechanisms associated with Cfz and to provide additional clinical options for patients resistant to Cfz.</P> [FIG OMISSION]</BR>
게더타운을 활용한 2D 메타버스 졸업작품전을 위한 서비스 디자인
최수경(Choi Sukyeong),권지혜(Gwon Jihye),김해진(Kim Haejin),정은지(Jeong Eunji),이지미(Lee Jimi),원종윤(Won Jongyoun) 한국HCI학회 2022 한국HCI학회 학술대회 Vol.2022 No.2
대학 생활을 마무리 짓는 4 학년 졸업작품전을 온라인으로 진행하기 위해 서비스 디자인 프로세스를 적용한 메타버스 플랫폼인 게더타운을 선정하였고, 대학의 아이덴티티를 살린 디자인 요소들을 적용하여 졸업작품전을 구성한 서비스 디자인 경험을 공유했다.
( Eunji Jang ),( Jeunghyun Lee ),( Sukyeong Lee ),( Mi-hyun Kim ) 한국임상영양학회 2017 Clinical Nutrition Research Vol.6 No.3
This study examined the effect of convenience meals purchased at convenience stores on glycemic response and satiety in healthy college students. A total of 9 non-obese volunteers (4 males and 5 females) aged 20 to 24 years participated in this study. On 3 separate days, participants consumed a standard diet (cooked rice and side dishes), and type 2 convenience meal (sweet bread and flavored milk). Capillary blood-glucose response and satiety were measured every 30 minutes for 2 hours after consuming the 3 different test meals. Although mean fasting glucose levels were not different, glucose levels at 30 minutes and 120 minutes after the type 1 convenience meal intake were significantly higher than those in the standard meal (p < 0.05, p < 0.01). Total glucose response was higher after consumption of the type 1 convenience meal, followed by the type 2 convenience meal and standard meal (p < 0.05). Though the type 2 convenience meal contained higher calorie than the other meals, satiety of the type 2 convenience meal was lowest at 30 minutes and 60 minutes after consumption (p < 0.01, p < 0.05). This pilot study suggests that convenience meals may increase glycemic response or induce higher calorie intake with low satiety compared with nutritionally balanced Korean style meal.