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Suhyeon Ha,Shin Hwang,Lee Na Ryu 한국간담췌외과학회 2020 Annals of hepato-biliary-pancreatic surgery Vol.24 No.3
Complete resection of Todani type IV choledochal cyst (CC) is not possible, because the intrahepatic portion is not resectable. We present a case of intrahepatic cholangiocarcinoma that arose from the remnant CC portion that was located within the liver 10 years after resection. A 59-year-old female patient had undergone resection of type IV CC 10 years ago, leaving large remnant portions of CC at the liver and pancreas. Two and four years after resection of the extrahepatic CC, cholangitis with intrahepatic stones developed hence these episodes were treated with percutaneous transhepatic cholangioscopy. Ten years after the first operation, intrahepatic stones and a new mass were identified in follow-up imaging studies. Because the mass was identified as adenocarcinoma on biopsy, we performed left hepatectomy with redo hepaticojejunostomy. Pathologic examination showed a 4.5-㎝-sized moderately differentiated adenocarcinoma arising from the remnant CC with lymph node metastasis. The patient recovered uneventfully and is currently undergoing adjuvant chemotherapy. Our case indicates that the remnant intrahepatic CC can undergo malignant transformation long after resection of CC. Since the intrahepatic CC portion in type IV CC is usually unresectable, wide hepaticojejunostomy and life-long observation with regular imaging study follow-up are highly recommended for prevention and early detection of malignant transformation.
Jiwon Ha,Minjoo Kim,Suhyeon Lee,Minhee Oh,Sungjin Kim,Sojung Kim 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
Thistle has been used for traditional medicine of blood coagulation and hepatoprotection along centuries. According to recent research, It has reported to have outstanding antioxidant activity and liver protection effect. In this study, we extract three species of thistles (C. japonicum, C. nipponicum, C. setidens) using five extraction solvents (Methanol(MeOH), Dichloromethane(MC), n-Butanol(BuOH), Ethyl acetate(EA), Water), then identify antioxidant activity, total polyphenol content, total flavonoid content. DPPH radical scavenging activity of 1 mg/mL of extract is measured the highest activity at 89% in EA fraction of C. nipponicum and ABTS radical scavenging activity of 0.5 mg/mL of extract is measured the highest activity at 94% in BuOH fraction of C. nipponicum. Total polyphenol content is the highest in 320mg GAE/g from BuOH fraction of C. nipponicum. Also total flavonoid content is the highest in 600mg QE/g from BuOH fraction of C. nipponicum. Through 13 Polyphenols and Flavonoids HPLC analysis, EA and BuOH fraction have a high polyphenol contents most of which is chlorogenic acid(EA 40 mg/g, BuOH 65 mg/g), and apigenin, sylingic acid are also contained in extract.
Kim, Suhyeon,Kim, Songhee H.,Ahn, Jinsook,Jo, Inseong,Lee, Zee-Won,Choi, Sang Ho,Ha, Nam-Chul Korean Society for Molecular and Cellular Biology 2019 Molecules and cells Vol.42 No.12
The Gram-negative opportunistic pathogen, Pseudomonas aeruginosa, has multiple multidrug efflux pumps. MexT, a LysR-type transcriptional regulator, functions as a transcriptional activator of the MexEF-OprN efflux system. MexT consists of an N-terminal DNA-binding domain and a C-terminal regulatory domain (RD). Little is known regarding MexT ligands and its mechanism of activation. We elucidated the crystal structure of the MexT RD at 2.0 Å resolution. The structure comprised two protomer chains in a dimeric arrangement. MexT possessed an arginine-rich region and a hydrophobic patch lined by a variable loop, both of which are putative ligand-binding sites. The three-dimensional structure of MexT provided clues to the interacting ligand structure. A DNase I footprinting assay of full-length MexT identified two MexT-binding sequence in the mexEF-oprN promoter. Our findings enhance the understanding of the regulation of MexT-dependent activation of efflux pumps.
해양 미세플라스틱 모니터링을 위한 원격탐사 적용 가능성 검토
박수현 ( Suhyeon Park ),김창민 ( Changmin Kim ),정성우 ( Seongwoo Jeong ),장성간 ( Seonggan Jang ),김수빈 ( Subeen Kim ),하태정 ( Taejung Ha ),한경수 ( Kyung-soo Han ),양민준 ( Minjune Yang ) 대한원격탐사학회 2022 大韓遠隔探査學會誌 Vol.38 No.5
전 세계적으로 모든 해양 환경에서 발견되는 미세플라스틱이 환경 문제로 대두되면서 해양 미세플라스틱을 모니터링 하기 위한 연구가 국내외적으로 활발히 수행되고 있다. 최근 국외에서는 대규모의 실시간 관측이 가능한 원격탐사 기술을 해양 플라스틱 모니터링에 적용하기 위한 활발한 연구가 진행되고 있다. 그러나 국내에서 해양 미세플라스틱 원격탐사 관련 연구는 매우 미비한 실정이며 중대형 해양 플라스틱 원격탐사 연구만 일부 수행되고 있다. 본 논문에서는 국내와 국외에서 수행된 해양 플라스틱 원격탐사와 관련된 대표적인 연구사례를 통해 국내외 연구 동향을 파악하고, 해양 미세플라스틱 모니터링 시 원격탐사 기술의 적용 가능성에 대해 고찰하여 앞으로 국내에서의 연구 방향성에 대해 제안하고자 한다. Microplastics have arisen as a worldwide environmental concern, becoming ubiquitous in all marine compartments, and various researches on monitoring marine microplastics are being actively conducted worldwide. Recently, application of a remote detection technology that enables large-scale real-time observation to marine plastic monitoring has been conducted overseas. However, in South Korea, there is little information linking remote detection to marine microplastics and some field studies have demonstrated remote detection of medium- and large-sized marine plastics. This study introduces research cases with remote detection of marine plastics in South Korea and overseas, investigates potential feasibility of using the remote detection technology to marine microplastic monitoring, and suggests some future works to monitor marine microplastics with the remote detection.