성인에서 Mycoplasma pneumoniae 페렴과 동반된 Stevens-Johnson 증후군 1예

이정현,엄영실,한우진,윤규현,이서영,서종구,김진용,김수연,박윤수,서일혜,조용균 대한감염학회 2008 감염과 화학요법 Vol.40 No.6

Stevens-Johnson syndrome is an acute mucocutaneous syndrome that is related to drugs and infections. Mycoplasma pneumonias infection is known as one of the causes of Stevens-Johnson syndrome in children and young adults, In Korea, Mycoplasma pneumoniae infection is rarely reported as a cause of Stevens-Johnson syndrome in adults. We report a case of Stevens-Johnson syndrome associated with Mycoplasma pneumoniae pneumonia in an adult patient. A 34-years old woman was admitted to our hospital and was diagnosed with mycoplasma pneumonia. At the time of admission, she had hemorrhagic crusts on her lips. On the 2nd day of admission, target lesions also developed on her skin. We diagnosed her disease as Stevens-Johnson syndrome associated with Mycoplasma pneumoniae pneumonia. She completely recovered from pneumonia and Stevens-Johnson syndrome after treatment with antibiotics and conservative management.

디티옥시 아미드 치환체의 백금 착물 합성

李承熙,金廷修 홍익대학교 산업기술연구소 1997 産業技術 Vol.7 No.-

Few square planar Pt(Ⅱ) complexes hows photoluminescence due to effective radiationless decay. The luminescence assures by an intraligand excitation (^3IL)π-π^*, a metal-ligand charge transfer (^3MLCT) d-π^*, or both of the above. It seems to depend on the ligand of the complex. Pt(Ⅱ)-dithioxamide complexes show photoluminescence at room temperature and depending on the substituents of dithioxamide the absorption and luminescence bands are different. It has been reported that the bulkiness of a substituent affected the distances between Pt(Ⅱ) complex pair ions and thus π orbitals of the ligands. On the way of studying the electronic effect of the substituents in the ligands, we have synthesized N,N'-bis(2'-chlorophenyl)dithiozamide and N,N'-biphenyldithiozamide and reported ^1H-nmr and FT-IR data.

석회유담즙증 1예

이지아,김도영,정혜경,문일환,신수연,곽재진 梨花女子大學校 醫科大學 醫科學硏究所 2003 EMJ (Ewha medical journal) Vol.26 No.1

Milk of calcium bile or limy bile is a rare disorder in which the gallbladder lumen is filled with a thick, paste-like, radio-opaque material. Churchman first reported a case of curious deposition of calcium salts within the gallbladder in 1911. Volkmann first used the term Kalkmilchgalle or "milk of calcium bile" in 1926. The radio-opaque material is almost entirely composed of calcium carbonate by weight. The mechanisms by which bile turns limy and radio-opaque or the time required for this biochemical alteration to occur are not well understood. The limy bile is found mostly in a gallbladder complicated by cholecystitis. Recently, we experienced a 33 year old woman who had a milk of calcium bile in the gallbladder lumen. We report this case with a review of literature.

Streptococcus anginosus 균혈증에 동반된 상완 골수염 및 주변부 연조직 농양 1예

한우진,조문숙,이정현,안홍대,윤규현,서종구,김진용,김수연,박윤수,서일혜,조용균 대한감염학회 2008 감염과 화학요법 Vol.40 No.5

Streptococcus anginosus is a normal flora found in multiple body sites and belongs to the Streptococcus milleri group, It has often been associated with pyogenic infection, such as periodontitis, endocarditis, pulmonary abscess and abdominal or cerebral abscess. Also uncommonly, it can cause osteomyelitis. A 42-year-o1d man was admitted due to gastric ulcer perforation. At 12th hospital day, left humeral osteomyelitis and soft tissue abscess developed, Streptococcus anginosus grew in blood culture, He was treated with intravenous penicillin and surgical debridement of the necrotic tissue which lead to a satisfactory result. We report a rare case of Streptococcus anginosus-induced humeral osteomyelitis and soft tissue abscess.

급성 신우신염이 선행된 Escherichia coli 농흉 1예

차치운,조준형,김미진,오윤정,연재우,이성규,오미정,채지영,김수연 대한감염학회 2009 감염과 화학요법 Vol.41 No.5

We experienced a case of acute pyelonephritis which progressed to Escherichia coli bacteremia and later complicated by empyema in a 65-year-old female. She was successfully treated with intravenous antibiotic therapy and percutaneous drainage of empyema.

2개월 남아에서 발병한 Malignant Ectomesenchymoma

황지영,서지현,김점수,김용숙,이수진,박찬후,김유경,박선후,이정희,안인옥,정기현,박병규 대한소아과학회 2001 小兒科 Vol.44 No.8

Spider Community of River basin from Korea

Sue Yeon Lee,Jong Kook Jung,Jung Sun Yoo,Joon Ho Lee,Seung Tae Kim 한국응용곤충학회 2013 한국응용곤충학회 학술대회논문집 Vol.2013 No.10

Spider community was surveyed at Nakdonggang River which is the longest river (525 km and 23,384 km2) located East-south part of Korea. Nakdonggang river is developing for water management and environmental conservation including restoration of river ecosystem under “The Four-River Restoration Project”. Sampling was made 3 occasions from June to August in 2009. Eight survey sites were selected from both sides of river in Andong, Sangju, Gumi and Seongju prefectures. Spiders were collected with sweep net for on the plants above ground and pitfall traps for on the ground. A total of 94 species of 71 genera in 24 families were identified from 805 collected spiders. Species richness was high in Salticidae (18 species, 19.1%), Araneidae (12 species, 12.8%), Lycosidae (9 species, 9.6%) in order. Wandering spiders (55 species occupied 58.5%, 493 individuals occupied 61.2%) were higher than webbing spiders (39 species occupied 41.5%, 493 individuals occupied 61.2%) in species richness and abundance. Dominant species were Tetragnatha praedonia (Tetragnathidae) and Neoscona adianta (Araneidae) in webbing spiders, and Anahita fauna (Ctenidae), Pirata procurvus (Lycosidae) and Gnaphosa kompirensis (Gnaphosidae) in wandering spiders with abundance. Collectively, most spiders collected from this study were water preferring spiders and showed different community structure compared to other reports from terrestrial spider fauna. Present result will bevaluable to compare the effect of development on the arthropod fauna after completion of the project.

In Situ Forming Gelatin Hydrogels-Directed Angiogenic Differentiation and Activity of Patient-Derived Human Mesenchymal Stem Cells

Lee, Yunki,Balikov, Daniel A.,Lee, Jung Bok,Lee, Sue Hyun,Lee, Seung Hwan,Lee, Jong Hun,Park, Ki Dong,Sung, Hak-Joon MDPI 2017 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.18 No.8

<P>Directing angiogenic differentiation of mesenchymal stem cells (MSCs) still remains challenging for successful tissue engineering. Without blood vessel formation, stem cell-based approaches are unable to fully regenerate damaged tissues due to limited support for cell viability and desired tissue/organ functionality. Herein, we report in situ cross-linkable gelatin−hydroxyphenyl propionic acid (GH) hydrogels that can induce pro-angiogenic profiles of MSCs via purely material-driven effects. This hydrogel directed endothelial differentiation of mouse and human patient-derived MSCs through integrin-mediated interactions at the cell-material interface, thereby promoting perfusable blood vessel formation in vitro and in vivo. The causative roles of specific integrin types (α<SUB>1</SUB> and α<SUB>v</SUB>β<SUB>3</SUB>) in directing endothelial differentiation were verified by blocking the integrin functions with chemical inhibitors. In addition, to verify the material-driven effect is not species-specific, we confirmed in vitro endothelial differentiation and in vivo blood vessel formation of patient-derived human MSCs by this hydrogel. These findings provide new insight into how purely material-driven effects can direct endothelial differentiation of MSCs, thereby promoting vascularization of scaffolds towards tissue engineering and regenerative medicine applications in humans.</P>

Structural characteristics of a red ginseng acidic polysaccharide rhamnogalacturonan I with immunostimulating activity from red ginseng

Lee, Sue Jung,In, Gyo,Han, Sung-Tai,Lee, Mi-Hyang,Lee, Jong-Won,Shin, Kwang-Soon The Korean Society of Ginseng 2020 Journal of Ginseng Research Vol.44 No.4

Background: Many researchers reported that the various immune activities of red ginseng are due to acid polysaccharides. But, the exact structural characteristics of the acidic polysaccharide in red ginseng have not been fully elucidated. Therefore, we isolated the acidic polysaccharide from red ginseng and characterized the structural property of the active moiety of this polysaccharide, which contributes to the immunostimulatory activity of red ginseng. Methods: A polysaccharide (RGP-AP-I) was purified from red ginseng via size-exclusion chromatography using Sephadex G-100. Immunostimulatary activity of RGP-AP-I was investigated via anti-complementory and macrophage stimulatory activity. The structure of RGP-AP-I was characterized by HPLC, sugar composition, β-glucosyl Yariv reagent and methylation analysis. Results: Peritoneal macrophages stimulated using RGP-AP-I significantly augmented the production of various cytokines such as interleukin (IL)-6, IL-12, and tumor necrosis factor (TNF)-α. The primary structure of RGP-AP-I was elucidated by assessing its sugar composition and methylation analysis. RGP-AP-I is a 96 kDa acidic polysaccharide, and comprises nine different monosaccharides, which mainly include sugars such as rhamnose (Rha, 9.5%), galacturonic acid (GalA, 18.4%), galactose (Gal, 30.4%), and arabinose (Ara, 35.0%). RGP-AP-I exhibited an considerable reaction with the β-glucosyl Yariv reagent, revealing the presence of arabino-β-3,6-galactan. Methylation analysis indicated that RGP-AP-I comprises 21 different glycosyl linkages, such as 3-, 4-, 6- and 3,6-linked Galp; 5-linked Araf; 2,4-linked Rhap; and 4-linked GalAp, which are characteristics of rhamnogalacturonan I (RG-I). Conclusion: we assumed that the immunostimulatory activity of RGP-AP-I may be due to the RG-I structure, which comprises a main chain with a repeating linkage unit, [→2)-Rhap-(1→4)-GalAp-(1→] and three groups of side chains such as (1→5)-linked arabinan, (1→4)-linked galactan, and arabino-β-3,6-galactan, which branch at the C(O)4 positions of Rha residues in the main chain of RGP-AP-I.

Study on the influence of sewer network simplification on urban inundation modelling results

Lee, Seung-Soo,Pakdimanivong, Mary,Jung, Kwan-Sue,Kim, Yeonsu 한국수자원학회 2018 한국수자원학회논문집 Vol.51 No.4

도시유역에서 발생한 유출은 지표면뿐만 아니라 하수관망을 통해 배수되며, 도시침수 모의 수행시 하수관망을 수문학적 배수 시스템의 한 구성요로서 고려하는 것은 매우 중요하다. 그러나 도시 침수 모의를 수행하는 대부분의 연구자들이 적절한 기준에 준하지 않고 직관적으로 하수관망을 단순화시켜 모의를 수행하는 실정이다. 따라서 본 연구에서는 1D-2D 결합 도시침수 해석 모형을 이용하여 수지상 구조에 구분법에 기반하여 단순화 된 하수관망의 도시침수 해석 결과에 미치는 영향을 분석하였다. 하수관망 해석을 위한 1차원 모델은 Lee et al. (2017)에 의해 소개된 모형으로서 지표면과 하수관망 사이의 유입과 역류를 동시에 모의할 수 있고, 2차원 지표면 모델은 불규칙 삼각망을 이용하여 지표수 흐름을 모의하며 1차원 하수관망 해석모형과 연계되어 도시침수를 모의할 수 있다. 하수관망은 수지상 구조 구분법에 기반하여 2차, 3차 그리고 단순화 하지 않은 경우로 구분할 수 있으며, 구분된 각 하수관망은 서울시 사당역 인근에 많은 침수 피해를 발생시킨 2011년 7월 27일 강우 사상에 적용하여 제안된 방법의 적용성을 평가하였다. 모든 케이스에 대하여 침수면적, 지표면에서 하수관망으로의 유입 유량, 하수관망에서 지표면으로의 역류 유량 등을 비교하였으며, 마지막으로 하수관망 단순화를 위한 적절한 기준 제시에 대한 논의를 수행하였다. In urban areas, runoff flow is drained through sewer networks as well as surface areas. Therefore, it is very important to consider sewer networks as a component of hydrological drainage processes when conducting urban inundation modelling. However, most researchers who have implemented urban inundation/flood modelling, instinctively simplified the sewer networks without the appropriate criteria. In this research, a 1D-2D fully coupled urban inundation model is applied to estimate the influence of sewer network simplification on urban inundation modelling based on the dendritic network classification. The one-dimensional (1D) sewerage system analysis model, which was introduced by Lee et al. (2017), is used to simulate inlet and overflow phenomena by interacting with surface flow. Two-dimensional (2D) unstructured meshes are also applied to simulate surface flow and are combined with the 1D sewerage analysis model. Sewer network pipes are simplified based on the dendritic network classification method, namely the second and third order, and all cases of pipes are conducted as a control group. Each classified network case, including a control group, is evaluated through their application to the 27 July 2011 extreme rainfall event, which caused severe inundation damages in the Sadang area in Seoul, South Korea. All cases are compared together regarding inundation area, inflow discharge and overflow discharge. Finally, relevant criterion for the simplification method is recommended.