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Wearable, Luminescent Oxygen Sensor for Transcutaneous Oxygen Monitoring
Lim, Chang-Jin,Lee, Soyeon,Kim, Jin-Hoon,Kil, Hye-Jun,Kim, Yu-Chan,Park, Jin-Woo American Chemical Society 2018 ACS APPLIED MATERIALS & INTERFACES Vol.10 No.48
<P>We present a new concept for a wearable oxygen (O<SUB>2</SUB>) sensor for transcutaneous O<SUB>2</SUB> pressure (tcpO<SUB>2</SUB>) monitoring by combining the technologies of luminescent gas sensing and wearable devices. O<SUB>2</SUB> monitoring has been exhaustively studied given its central role in diagnosing various diseases. The ability to quantify the physiological distribution and real-time dynamics of O<SUB>2</SUB> from the subcellular to the macroscopic level is required to fully understand mechanisms associated with both normal physiological and pathological conditions. Despite its profound biological and clinical importance, few effective methods exist for noninvasively quantifying O<SUB>2</SUB> in a physiological setting. The wearable sensor developed here consists of three components: a luminescent sensing film attached onto skin by a carbon tape, an organic light-emitting diode (OLED) as a light source, and an organic photodiode (OPD) as a light detector. All the components are solution-processable and integrated on a plane in a bandage-like configuration. To verify the performance, tcpO<SUB>2</SUB> variations by pressure-induced occlusion were measured in the lower arm and a thumb by the wearable sensor, and the results were comparable to those measured by a commercial instrument. In addition to its flexibility, other features of this sensor render it a potential low-cost solution for the simultaneous monitoring of tcpO<SUB>2</SUB> in any part of a body.</P> [FIG OMISSION]</BR>
Soyeon Park,Yeojin Kim,Sunwoo Yoon,You Jin Nam,Sunhwa Hong,Yong Hyuk Cho,Sang Joon Son,Chang Hyung Hong,Jai Sung Noh,Hyun Woong Roh 대한신경정신의학회 2024 PSYCHIATRY INVESTIGATION Vol.21 No.3
Objective The impact of the government-initiated senior employment program (GSEP) on geriatric depressive symptoms is underexplored. Unearthing this connection could facilitate the planning of future senior employment programs and geriatric depression interventions. In the present study, we aimed to elucidate the possible association between geriatric depressive symptoms and GSEP in older adults.Methods This study employed data from 9,287 participants aged 65 or older, obtained from the 2020 Living Profiles of Older People Survey. We measured depressive symptoms using the Korean version of the 15-item Geriatric Depression Scale. The principal exposure of interest was employment status and GSEP involvement. Data analysis involved multiple linear regression.Results Employment, independent of income level, showed association with decreased depressive symptoms compared to unemployment (p<0.001). After adjustments for confounding variables, participation in GSEP jobs showed more significant reduction in depressive symptoms than non-GSEP jobs (β=-0.968, 95% confidence interval [CI]=-1.197 to -0.739, p<0.001 for GSEP jobs, β=-0.541, 95% CI=-0.681 to -0.401, p<0.001 for non-GSEP jobs). Notably, the lower income tertile in GSEP jobs showed a substantial reduction in depressive symptoms compared to all income tertiles in non-GSEP jobs.Conclusion The lower-income GSEP group experienced lower depressive symptoms and life dissatisfaction compared to non-GSEP groups regardless of income. These findings may provide essential insights for the implementation of government policies and community-based interventions.
Development of Cellulose Hydrogel Microspheres for Lipase Immobilization
Soyeon Jo,Sae-Rom Park,Yujin Oh,Jiyeon Hong,Hyung Joo Kim,Kwang Jin Kim,Kyeong Keun Oh,이상현 한국생물공학회 2019 Biotechnology and Bioprocess Engineering Vol.24 No.1
Cellulose hydrogel microspheres were prepared by sol-gel transition using an ionic liquid-in-oil emulsion. Factors that influenced the formation of these microspheres, including the ratio of ionic liquid to oil, surfactant concentration, and stirring speed, were optimized for lipase immobilization. Using the optimized method, Candida rugosa lipase was efficiently immobilized on the microspheres by physical adsorption. As compared with the free lipase, the specific activity of the immobilized lipase was 1.4 times higher, its half-life at 45°C was 41 times longer, and it showed an enhanced stability over a wide pH range. The lipase immobilized on cellulose microspheres showed a much higher loading efficiency, immobilization yield, and specificity constant than lipase immobilized on microcrystalline cellulose or millimeter-sized hydrogel beads. To increase the reusability of cellulose microspheres as an enzyme support material, magnetic cellulose microspheres were also prepared by adding Fe3O4. The lipase immobilized on magnetic cellulose microspheres was simply recovered using a magnet and continuously reused with a minimal loss of activity.
Cannabidiol-induced apoptosis is mediated by activation of Noxa in human colorectal cancer cells
Jeong, Soyeon,Yun, Hye Kyeong,Jeong, Yoon A,Jo, Min Jee,Kang, Sang Hee,Kim, Jung Lim,Kim, Dae Yeong,Park, Seong Hye,Kim, Bo Ram,Na, Yoo Jin,Lee, Sun Il,Kim, Han Do,Kim, Dae Hyun,Oh, Sang Cheul,Lee, Da Elsevier 2019 Cancer letters Vol.447 No.-
<P><B>Abstract</B></P> <P>Cannabidiol (CBD), one of the compounds present in the marijuana plant, has anti-tumor properties, but its mechanism is not well known. This study aimed to evaluate the apoptotic action of CBD in colorectal cancer (CRC) cells, and focused on its effects on the novel pro-apoptotic Noxa-reactive oxygen species (ROS) signaling pathway. CBD experiments were performed using the CRC cell lines HCT116 and DLD-1. CBD induced apoptosis by regulating many pro- and anti-apoptotic proteins, of which Noxa showed significantly higher expression. To understand the relationship between Noxa and CBD-induced apoptosis, Noxa levels were downregulated using siRNA, and the expression of apoptosis markers decreased. After ROS production was blocked, the level of Noxa also decreased, suggesting that ROS is involved in the regulation of Noxa, which along with ROS is a well-known pro-apoptotic signaling agents. As a result, CBD induced apoptosis in a Noxa-and-ROS-dependent manner. Taken together, the results obtained in this study re-demonstrated the effects of CBD treatment <I>in vivo</I>, thus confirming its role as a novel, reliable anticancer drug.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Our results strongly suggest, for the first time, that CBD can cause Noxa-induced cell death. </LI> <LI> CBD induced apoptotic cell death via ROS/Endoplasmic Reticulum stress-regulated Noxa activation in colorectal cancer cells. </LI> <LI> These results suggest that CBD has important implications for the potential treatment of human CRC. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
사용자가 원하는 사용성 요소의 충족이 만족도에 미치는 영향
백소연(Soyeon Baik),진범석(Beomsuk Jin),지용구(Yonggu Ji) 한국HCI학회 2009 한국HCI학회 학술대회 Vol.2009 No.2
본 연구는 실제 사용자 언어로서의 사용성 평가를 시도하기 위해 진행되었다. 기존의 획일화 된 잣대로서의 평가가 아닌, 사용자가 원하는 사용성 요소가 충족되었을 때의 지각되는 사용성에 대한 만족도를 알아보고자 한 것이다. 이에 본 연구에서는 사용자의 유형에 따라 제품 및 서비스의 인터페이스에 중요하다고 생각하는 사용성 요소가 다를 것이라고 가정한 뒤, 그 사용성 요소의 충족여부에 따라서 사용자의 주관적인 만족도가 다르게 나타날 것이라고 예상하였다. 이 연구문제를 위하여 혁신 수용의 사용자 유형 별로 가장 중요하다고 생각하는 사용성 요소를 추출하였다. 조기사용자는 사용성 요소 중 Affect 의 사용성 요소를 가장 중요하다고 평가하였으며 후기사용자는 사용성 요소 중 Productivity 의 사용성 요소를 가장 중요하다고 평가하였다. 이후 각각의 사용자 유형에 중요평가된 사용성 요소가 충족되거나 충족되지 않은 프로토타입을 제시한 뒤, 사용 경험의 만족도를 조사한 결과, 각 사용자 유형내에서의 만족도는 충족여부에 따라 통계적으로 유의미한 차이를 보였으나, 각 사용자 유형간의 만족도는 충족여부에 따른 통계적으로 유의미한 차이를 나타내지 않았다. 본 연구의 결과는 사용성평가를 평가자의 언어가 아닌 사용자의 언어로 측정하는 새로운 평가방식 개발의 기초자료로 활용될 수 있다. 또한 본 연구는 사용자 유형 별 중요하게 기대하는 사용성 요소의 결과를 제시함으로써 제품 및 서비스의 인터페이스의 개발에 있어 사용자 군 별 중요하게 고려되어야 할 속성들의 판단자료를 제공할 수 있다는 점에서 의의를 갖는다.