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      • 상기도 감염의 세균학적 연구

        김숙자,정용헌 충남대학교 의과대학 지역사회의학연구소 1986 충남의대잡지 Vol.13 No.1

        For bacteriological studies on upper respiratory infection in pediatric age, samples by nasopharyngeal swabs in 60 cases of rhinitis group, oropharyngeal swabs in 59 cases of pharyngitis-ton-sillitis group and 46 cases of laryngitis group and naso-and oropharyngeal swabs in 59 cases of control group were collected at the outpatient departmrnt of pediatrics, Chung-Buk Medical Center and Chung-Nam National University Hospital from January, 1982 to October, 1982. Bacteriological studies according to each clinical group and age were made. Antibiotics sensitivity test and clinical manifestation according to potential pathogenic bacteria were evaluated. The results are summarized as follows: 1. Incidence of significant potential bacterial pathogen was 32% in URI patients and 17% in the control group. 2. The order of potential bacteria isolated from rhinitis patients was Staphylococcus aureus, Pneumococcus. H. influenza, and H. aphrophilus. Staphylococcus aureus were cultured more in the younger age group. H. influenza were cultured highly in ages of 2-5years, and Pneumococcus were cultured from children over 2 years of age. 3. The order of potential bacteria isolated from phayngitis tonsillitis group was beat-hemolytic Streptococcus and Pneumococcus. Beta-hemolytic Streptococcus were cultured highly over 2years of age, but Pneumococcus had no difference according to age. 4. Main potential bacteria isolated from laryngitis was H. influenza which was cultured highly in the 2-5year old group. 5. Symptoms of rhinitis and pharyngotonsillitis in Staphylococcus and Pneumococcus, of pharyngitis-tonillitis accmopanied with high fever in beta-hemolytic Steptococcus and of laryngitis and rhinitis H. influenza were noted. 6. Antibiotics sensitivity by the disc method showed as follows : Novobiocin, CM, Neomycin & Cephalosporin in Staphylococcus aureus : CM in Staphylococcus epidemidis : Penicillin, EM, Novobiocin, CM and Lincomycin in beta-hemolytic Streptococcus; CM in Strepteptococcus viridans : Penicillin, Ampicillin, Doxicycline in Pneumococcus and Penicillin, Novobiocin and CM in Neisseria were highly sensitive antibiotics.

      • 영아 성장에 대한 종단적 연구

        김숙자,정용헌 충남대학교 의과대학 지역사회의학연구소 1986 충남의대잡지 Vol.13 No.1

        This is a study on physical growth during infancy, to evaluate normal growth patterns and to clarify if there is any difference between the results studied by longitudinal and by cross-sectional study and influencing factors on growth, carried out during the period of March 1983 through August 1985. The results were as follows: 1. Considerable differences of weight, height and head circumference were noted according to sex and age differences(Table 1-a). 2. Growth rates were decreased with age and shown comparable patterns in groups below 4 month, 5-8 month and 9-12 month of age(Table 1-a, b, 2-a, b, c and Fig. 1∼6). 3. Incremental rates of weight and height were decreased rapidly during first several months and thereafter decreased slowly in both sexes, but those of head circumference decreased throughout infancy(Table 3-a, b, c and Fig. 7∼9). 4. There were significant differences of growth between two studies by longitudinal and by cross-sectional method in both sexes and in most age groups(Table 2-a, b, c). 5. Infant growth was influenced by the parent's physiques, birth weight and illness but not by the types of milk.

      • 10 year follow up of a boy with Lesch Nyhan Syndrome

        Kim, Sook Za,Song, Wung Ju 대한유전성대사질환학회 2011 대한유전성대사질환학회지 Vol.11 No.1

        Lesch-Nyhan syndrome is a X-linked recessive disorder caused by a deficiency of the enzyme hypoxanthine-guanidine phosphoribosyltransferase (HPRT), enzyme to recycle purines. Case history: born induced vaginal delivery at 40 weeks complicated by premature membrane ruputure, body weight 2.820 gm. He showed failure to thrive showing severe protein aversion like milk products and pink daper. Developmental delay revealing rolling over at 10.5 month, followed by regression. Seizure at 2 months, His poor oral feeding was lifelong problem. Weak crying, spastic, choreoathetoid movement. Self mutilating behavior noted and diagnosed at age 3 years. No family history of consanguinity and neurological disorders. Method: Laboratory test, physical exam, imaging study and molecular. Clinical follow up Treat ment with allopurinol. Result: uric acid 10.5 mg/dL (N 3.5-7.9), APRT 151.1uM/ min/ml pro(25.7-101), HPRT 7.6 (N 233.5-701) and c.151C>T hemizygote (p,Arg51X). Abdominal sonogram showed staghorn calculi in both kidneys, brain MRI brain atrophy. Clinical follow up showed, seizure at 2 mo, developmental delay (head control and, rolling over at at 11mo, pointing body part at 2 yr 7 mo, eye hand coordination at 2 y 11mo,creeping at 3 y 7 mo, speaking words at 6 y 6 mo ),and developmental regression at 3 yr of age. Sleeping problem including insomnia and severe constipation. Self mutilating behavior (lip bite) started at 2.5 yr, neurologic sx including intermittent upward gaze accompanied by swallowing difficulty at 3 y 7 mo grand mal seizure at 4.5 yr and spastic extremity and trunchal hypotonia and choleoathetoid movement and ataxia at 6.5 yr. Scoliosis with severe spasticity at 9 yr 9 mo. Acute life threatening episode with irregular breathing at 9 yr and 9 mo, Emaciation and nephrolithiasis and recurrent pneumonia. Died suddenly at 10 yr 3 mo. Conclusion: life long feeding problem, chronic gut motility dysfunction, sleeping difficulty and progressing neurologic deterioration and nephrolithiasis despite normal serum uric acid maintence by allopurinol treatment.

      • KCI등재

        A neonate with hyperornithinemia-hyperammonemia-homocitrullinuria syndrome from a consanguineous Pakistani family

        Kim, Yoo-Mi,Lim, Han Hyuk,Gang, Mi Hyeon,Lee, Yong Wook,Kim, Sook Za,Kim, Gu-Hwan,Yoo, Han-Wook,Ko, Jung-Min,Chang, Meayoung Korean Society of Medical Genetics and Genomics 2019 대한의학유전학회지 Vol.16 No.2

        Hyperornithinemia-hyperammonemia-homocitrullinuria (HHH) syndrome is a rare autosomal recessive urea cycle disorder. HHH is caused by a deficiency of the mitochondrial ornithine transporter protein, which is encoded by the solute carrier family 25, member 15 (SLC25A15) gene. Recently, government supported Korean newborn screening has been expanded to include a tandem mass spectrometry (MS/MS) measurement of ornithine level. We report a case of a neonate with HHH syndrome showing a normal MS/MS measurement of ornithine level. A female newborn was admitted to neonatal intensive unit due to familial history of HHH syndrome. Her parents were consanguineous Parkistani couple. The subject's older sister was diagnosed with HHH syndrome at age of 30 months based on altered mental status and liver dysfunction. Even though the subject displayed normal ammonia and ornithine levels based on MS/MS analysis, a molecular test confirmed the diagnosis of HHH syndrome. At 1 month of age, amino acid analysis of blood and urine showed high levels of ornithine and homocitrulline. After 11 months of follow up, she showed normal growth and development, whereas affected sister showed progressive cognitive impairment despite no further hyperammonemia after protein restriction and standard therapy. Our report is in agreement with a previous Canadian study, which showed that neonatal samples from HHH syndrome patients demonstrate normal ornithine levels despite having known mutations. Considering the delayed rise of ornithine in affected patients, genetic testing, and repetitive metabolic testing is needed to prevent patient loss in high risk patients.

      • KCI등재

        사회체육지도자의 직장만족도에 관한 연구

        김경숙(Kyung Sook Kim),김숙자(Sock Za Kim),허현미(Hyun Mi Heo) 한국사회체육학회 1995 한국사회체육학회지 Vol.3 No.-

        To investigate and analyze job-satisfaction of sport for all leaders, the present study was in tended (1) to evaluate thf. reliability and validity of the research tool to be used and (2) to identify clearly the relationship between factors related to the job-satisfaction of sport for leaders using this research tool. Hence, the crucial purpose of the present study consists in suggesting the direction for the establish;nent and development of sport for all leaders as a firm profession and providing the basic materi-l for the rationalized operations of sport for all leaders. In this research 23 places were randomly sampled among the sports centers registered as the complex sports facilities in Seoul and Kyunggi province, and 243 sport for all leaders who were in full-time employment at there were selected as subjects. The research tool was the questionnaire consisting of a total of 40 questions which were grouped into the question on importance (20 questions) and the question on actuality (20 questions) to show the gap between the importance and actuality of job, perceived by sport for all leaders. And responses on those questions were measured on a 5-point scale. The collected questionnaires, after coding and punching, were analyzed by using SPSS statistics software program. Chrombach α-value was analyzed for the reliability of the research tool, and a correlational analysis was performed to the degree of sport for all leaders` job-satisfaction with the overall life for validity to determine construct validity. A descriptive analysis was made of frequency, percentage, me n, and standard deviation relating to the distribution of responses for their job-satisfaction. As the result of analyzing the reliability and validity for evaluating the availability of research tool, it was revealed that the coefficient of reliability for 20 questions on job-satisfaction was. 9196 and the coefficient of reliability for 20 questions on actuality was.9203. The reliability of whole question was shown to be high. As the result of testing construct validity based on the overall life-satisfaction, it was shown that the correlational coefficient between `the gap in importance and actuality` and `the overall life-satisfaction` was.3665 and it was significant statistically at the level of α= -.001. The main findings from the study on the job-satisfaction of sport for all leaders were as follows; 1. It was revealed that the expected distribution of importance on the job was very high(M=4. 21, SD=0.54). 2. It was found that the experientially cognitive distribution of actuality on the job was more than usual(M=3.26, SD=0.59). 3. It can be seen that the job-satisfaction expressed as `the gap between importance and actuality` on job indicates that the actual. experiential cognition of all the factors does not reach the expected level(M= -0.95, SD=0.62). 4. In relation to each area of job-satisfaction, individual need, human relations, personnel management policy, and incentive condition were revealed as -0.76, -0.80, -1.12, and -1.43, respectively. It was shown that the area of individual need was most satisfactory while the area of incentive condition was most dissatisfactory. 5. In point of subfactor of each area, it was shown that co-workers relationship(-0.67) were most satisfactory white wage policy(-1.60) was most dissatisfactory.

      • KCI등재

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