Vitis vinifera 적포도의 알콜발효중 화학성분의 변화

심기환,최상도,이용수,최진상 慶尙大學校 1992 論文集 Vol.31 No.2

Vitis vinifera 적포도의 발효중 총당, 알콜, 총산, pH, 유기산, 유리아미노산 및 총질소 함량등을 HPLC 등의 기기를 이용하여 분석한 결과는 다음과 같다. 발효중 총산은 초기에 약간의 증가를 보이다가 발효가 활발하게 진행되어 알콜의 농도가 증가하여 발효 후 품종에 따라 Cabernet sauvignon 15.6%, Cabernet franc 18.5% 및 Malbec 28.3% 감소하였다. 발효중 pH는 5일까지 감소현상을 보이다가 발효 후반기에 증가하여 발효완료 후 초기의 pH보다 높게 나타났다. Malic acid와 tartaric acid는 알콜의 농도가 증가함에 따라 감소하였으며, lactic acid는 발효초기에 측정되지 않았으나 발효가 진행됨에 따라 생성되어 succinic acid와 함께 발효시간의 경과에 함량변화가 없었다. 또한 유리아미노산은 발효초기에 급격한 감소를 보여 발효진행 5일 후의 농도가 Cabernet sauvignon 57.5%, cabernet franc 59.0% 및 Malvec 48.8%까지 감소하였으나, proline, glycine 및 serine은 발효중 변화가 적었으며, 알콜발효가 끝나는 시점부터 증가하였다. 총질소의 함량은 발효초기에 급격히 감소하였고, 알콜생성이 완료되고 2∼3일 경과 후 증가하는 현상을 보였으며, 발효최성기에는 초기농도의 약 13.5∼17.6%만이 발효액중에 남아있었고, 발효가 끝난 후에는 초기농도의 31∼38%정도였다. In order to investigate the changes of some chemical components during the alcoholic fermentation of Vitis vinifera red grapes, total sugar, alcohol, total acid, pH, organic acid, free amino acids and total nitrogen contents were analyzed with HPLC etc., the results are as follows. Total acid during the fermentation which increased slightly at the early time of fermentation decreased in Cabernet sauvignon 15.6% Cabernet franc 18.5% and Malbec 28.3% according to increasing the concentration of alcohol when fermentation was actively progress. PH during the fermentation showed decreasing phenomenon was actively progress. pH during the fermentation showed decreasing phenomenon until 5 days but showed higher at finished time of fermentation than initial time. Malic acid and tar-taric acid were decreased in proportion to increase of alcohol concentration, and lactic acid was not detected at the early time of fermentaation but the progress time of fermentation did not change the content with succinic acid. Free amino acids were rapidly decreased at the early time of fermentation when the concentration was decrased in Cabernet sauv-ignon 33.3%, Cabernet franc 55.5% and Malbec 54.2% at that time after 5 days, but the change was little in proline, glycine and serine during fermentation, and increased slightly until the finished time of fermentation. The content of total nitrogen was decreased rap-idly at the early time of fermentation of alcohol, and the concentration of total nitrogen in the height of prosperity of fermentation was exst only about 13.5∼17,6% in the liquid of fermentation than that of initial concentration, and was about 31∼38% of initial concent-ration after finished fermentation.

유자과즙을 이용한 식초제조

김용택,서권일,정용진,이용수,심기환 동아시아식생활학회 1997 동아시아식생활학회지 Vol.7 No.3

To enhance the utility value of citron, vinegars were made of citron juice, their properities were investigated, the results are as following. Optimum bacteria was Acetobacter sp. PA 97 for the citron vinegar fermentation, optimum temperature, initial acidity and alcohol concentration were 30℃, 1.5% and 8%, respectively. The lower citron juice was added, the more citric acid was produced, the acidity of sample added sub-nutrition source was higher than that of sample no added. In samples added citron juice of 10, 20 and 30%, and sub-nutrition source, total acidity were 5.42, 5.36 and 5.04%, pure acetic acid yields were 52.69, 45.25 and 35.10%, respectively. Remained alcohol of sample no added sub-nutrition source was more than that of added. In the sensory test, the most suitable concentration of citron juice for vinegar fermentation was 30%.

밤꽃의 화학성분

이용수,서권일,심기환 동아시아식생활학회 1997 동아시아식생활학회지 Vol.7 No.3

To obtain fundamental data from chestnut flower, chemical properties were investigated. The results are as follows. The contents of total sugar, reducing sugar, crude protein, crude fat and ash in prebloomed chestnut flower were 10.44, 4.91, 8.80, 1.42 and 0.87%, in the postbloomed were 11.75, 7.04, 7.71, 2.26 and 0.66%, respectively. The browning degree of the extracts from the prebloomed sample was higher than that of the postbloomed. The contents of flavonoids and nonflavonoids in the prebloomed sample were 7.05 and 0.52%, in the postbloomed were 2.08% and 0.22%, respectively. The contents of free sugars such as sucrose, fructose and glucose in the prebloomed sample were 2.90, 0.72 and 0.71%, in the postbloomed were 2.65, 2.10 and 2.20%, respectively. The major amino acids in the prebloomed sample were threonine, proline and cystine and its contents were 28.96, 12.49 and 11.43%. But aspartic and glutamic acid were major amino acids in the postbloomed and its contents were 16.19 and 11.90%, respectively.

유전율이 다른 두 마이크로스트립 기판 접합에 의한 불연속의 해석 : 3차원 유한차분-시간영역 방법에 의한 접근

이용택,전중창,심재륜,김태수 위덕대학교 부설 전자기술연구소 1999 전자기술연구소 논문집 : 위덕대 Vol.3 No.1

본 논문에서는 3차원 유한차분 시간영역 방법을 사용하여 유전율이 서로 다른 마이크로스트립 기판의 접합 불연속 효과를 해석하였다. 본 논문에서 구현된 FDTD 알고리듬의 정확성을 검증하기 위해서, step-in-width 불연속 해석 결과를 상용 CAD 소프트웨어 시뮬레이션 결과와 비교였으며, 18 GHz까지의 주파수 범위에서 두 결과가 잘 일치하였다. 유전율이 서로 다르더라도 특성 임피던스가 동일하도록 도체 폭이 조절되면 반사계수가 -33 dB이하로 매우 낮아지며, 유전율이 서로 다르면서 도체 폭이 균일 한 경우에는 step-in-width 불연속 효과와 비슷한 결과가 얻어졌다. 유전율이 서로 다른 마이크로스트립 기판 접합에 의한 불연속 효과는 마이크로파 회로 모듈 패키징(packaging), 안테나 피더(feeder) 등의 설계에 적용될 수 있다. In this paper, we have analysed the junction of microstrip substrates having different permittivities using the 3-dimensional finite-difference time-domain (FDTD) method The accuracy of the FDTD application is validated by the comparison between FDTD results and commercial CAD software simulation results for a conventional step-in-width discontinuity. The FDTD results for the junction of microstrip substrates having different permittivities reveal that the reflection coefficient can be very small as below -33 dB only if the widths of metal strips are adjusted so that characteristic impedances of both sides are uniform. Also, it is shown that the junction with a uniform strip width has a similar characteristics as a step-in-width discontinuity. The simulation results presented at this paper can be applied to microwave circuit packaging and antenna feeder circuits.

정신분열병 환자 가족을 위한 한 정신교육적 가족치료 모형의 효과

이영호,심주철,이상경,서영수,김용관,김규수,김영훈 大韓神經精神醫學會 2000 신경정신의학 Vol.39 No.3

연구목적 : 본 교실에서 정신분열병 환자 가족을 대상으로 시행 중인 장기 정신교육적 가족치료모형을 소개하고, 이모형이 가족의 대처방식과 우울증상, 환자가 자각하는 가족의 정서적 지지와 우울증상, 재입원율 및 사회재활상태에 미치는 영향을 평가하였다. 방 법 : 연구대상은 DSM-IV 진단기준에 의해 정신분열병으로 진단받고 외래 통원치료를 받고 있는 환자와 그 보호자였다. 교육군은 전체 19회 교육 중 최소 ⅔이상 참여한 11명의 환자와 가족이었고 비교육군은 부산소재의 종합병원에서 가족교육을 받지 않고 통원치료만을 받았던 11명의 환자와 가족이었다. 정신교육적 가족치료 모형의 효과는 가족의 대처방식과 우울증상, 환자가 자각하는 가족의 정서적 지지와 우울증상, 재입원율, 사호재활 실태로 나누어 평가했다. 평가도구는 The Ways of Coping Checklist의 국내번안용, Family Emotional Support Questionnaire for Transaction. Beck Depression Inventory를 이용했다. 재입원율 및 사회재활 실태에 대한 평가는 환자 및 가족과의 면담을 통해 조사했다. 결 과 : 본 연구의 정신교육적 가족치료 모형 실시 후 가족의 대처방식 중 적극적 대처는 교육군운 의미있게 증가한 반면 비교육군에서는 변화가 없었다. 소극적 대처 교육군은 의미있게 감소했으나 비교육군에서는 변화가 없었다. 가족치료모형 실시 전 가족들은 양군 모두 심한 우울증상을 갖고 있었다. 가족치료모형 실시 후 가족의 우울증상은 교육군에서 감소, 비교육군은 증가를 보였으나 통계적 유의성은 없었다. 환자가 지각하는 가족의 정서적 지지 평가척도점수는 교육군은 의미있는 증가를 보였으나 비교육군에서는 변화가 없었다. 환자의 우울증상의 교육군에서는 현저한 감소를 보인 반면 비교육군은 상반되게 증가했다. 가족의 적극적 대처가 환자가 자각하는 정서적 지지의 증가 및 우울증상 감소와 의미있는 상관관계를 나타냈다. 또한 교육군의 환자들이 비교육군의 환자들보다 장기가족교육 종료시점과 9개월 경과 후의 추적 평가에서 재입원율이 현저히 낮았고, 사회재활상태도 좋았다. 결 론 : 본 연구에서 실시된 장기 가족교육모형은 가족의 대처방식을 향상시키고, 우울증상의 감소를 가져오며, 환자가 자각하는 가족의 정서적 지지 향상 및 우울증상의 호전을 가져오고, 재입원율의 저하 및 사회재활의 향상을 보이는 것으로 나타났다. Objectives : This study was performed to introduce a psychoeducational family therapy model for the families of schizophrenic patient and to investigate the effect of this model on the changes in coping style and depressive symptoms of the family members, and in perception of emotional support by families and depressive symptoms of patients. Methods : Subjects were schizophrenic out-patients, who fufilled DSM-IV diagnostic criteria, and their families. The members of "education group" were 11 families and patients who participated in more than two thirds of 19 sessions of the program. The members of "non-education group" were 11 families and patients who had no experience of family education and were treated in a general hospital in Pusan. Clinical ratings were performed using by The Ways of Coping Checklist, Family Emotional Support Questionnaire for Transactions, and Beck Depression Inventory. Results : Coping style was changed positively, in education group but not in non-education group. The depressive symptoms of families were decreased in educated group and increased in non-educated group, although there were no statistical significance. In education group, patients felt much better emotional support by their families than patients in non-education group did. At the same time, their depressive symptoms were significantly reduced. The patients from education group were on more successful rehabilitation than those from non-education group were. Conclusion : Our results suggest that this psychoeducational family therapy model would be helpful to induce the positive changes in coping styles and reduce the depressive symptoms of family members, and it could also induce the reduction of depressive symptoms of schizophrenic patients and help their rehabilitation.

Cefatrizine (Cefatrin^(�))의 임상적 연구

권오정,심영수,한용철 최신의학사 1984 最新醫學 Vol.27 No.7

DAF에서 압력에 따른 미세기포의 크기특성

한무영,박용효,이준,심재수 대한상하수도학회 2002 상하수도학회지 Vol.16 No.2

Although DAF (Dissolved Air Rotation) has been successfully accepted for water and wastewater treatment, the fundamental characteristics of the process have not been fully investigated. According to recent theoretical work on DAF, bubble size is one of the most important factors that affect the DAF efficiency. It is well known that the size of bubbles in DAF is mostly affected by applied pressure. In this study, a newly developed Particle Counter Method (PCM) is introduced and compared with image analysis and verified. Using this PCM, the size of bubbles in DAF is measured under various pressure conditions from 2-6atm. Through a set of experiments, it was found that bubble size decreases as the pressure increases up to 3.5atm. This is a critical pressure after which bubble size does not decrease. According to the experimental results, it is not only costly but also unnecessary to maintain pressure more than 3.5atm if the goal is only to generate smaller bubbles for better removal efficiency in DAF operational practice.

한국인 두경부암종 환자에서 Cytochrome P450 1A1,2E1 및 N-acetyltransferase 2 효소의 다형성 분석에 따른 유전적 감수성에 대한 연구

심광섭,김태균,우순섭,이영수,공구 대한악안면성형재건외과학회 2000 Maxillofacial Plastic Reconstructive Surgery Vol.22 No.4

Individual genetic susceptibilities to cancers may result from several factors including differences in xeno-biotics metabolism to chemical carcinogens, DNA repair, altered oncogenes and suppressor genes, and environmental carcinogen exposures. Among them, genetic polymorphisms of metabolizing enzymes to chemical carcinogens have been recognized as a major important host factors in human cancers. They have two main types of enzymes: the· phase I cytochrome P-450 mediating enzymes (CYPs) and phase Ⅱ conjugating enzymes. The purpose of this study is to determine the frequencies of genotypes of phase I (CYP1A1 and CYP2E1) and phase Ⅱ (NAT2) metabolizing enzymes in healthy control and head and neck cancer patients of Korean and to identify the relative high risk genotypes of these metabolizing enzymes to head and neck cancer in Korean. The author has analyzed 132 head and neck cancer patients and 113 healthy controls using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) . The results were as following; 1.The frequencies of genotypes of CYP1A1, CYP2El and NAT2 in healthy control were as following; CYP1A1 exon 7 polymorphism; Ile / Ile: Ile/Val: Va1/Va1 = 59.3%: 36.3%: 4.4% CYP2El Pst I polymorphism, C1/Cl: C1/C2: C2/C2 = 61.1%: 32.1%: 6.2% NAT2 polymorphism; F/F: F/S: S/S = 43.4%: 48.7%: 8.0% 2.In analysis of phase I enzyme, Val/Val genotype in CYP1A1 exon 7 polymorphism and C2/C2 genotype in CYP2El Pst I polymorphism were associated with relative high risks to head and neck cancers (Odds' ratio: 2.09 and 1.37, respectively). 3.Among the genotypes of NAT2 enzyme polymorphism, S/S genotype of NAT2 enzyme had 1.03 times of relative risk to head and neck cancers. 4.In combined genotyping of CYP1A1, CYP2El, and NAT2 enzymes polymorphisms, the patients with Va1/Va1 and Cl/Cl, C2/C2 and fast acetylator, and Va1/Va1 and fast acetylator had higher relative risks than the patients with each baseline of combined genotypes (Odds' ratio: 2.82, 1.98 and 2.1, respectively) . These results suggest the combined genotypes of Va1/Va1 and Cl/Cl , C2/C2 and fast acetylator, and Val/Val and fast acetylator were more susceptible to head and neck cancers in Korean. And genotyping of metabolizing enzymes could be useful for predicting individual susceptibility to head and neck cancer.

전어의 보존중 겨자의 처리 효과

서권일,강갑석,이용수,정용진,김용택,심기환 동아시아식생활학회 1996 동아시아식생활학회지 Vol.6 No.2

Effects of mustard seed(Brassica juncea) on the preservation of raw gizzard-shad slice were investigated, morphological change of Vibrio parahaemolyticus treated with water-extract of mustard seed was examined, the results are as following. The pH of raw gizzard-shad slice soaked in water with mustard seed slightly increased during preservation, and the pH was in inverse proportion to the added amount of mustard seed. The number of bacteria and Vibrio of raw gizzard-shad slice treated with mustard seed were lower than control, and the higher the mustard seed concentration, the lower the number of bacteria and Vibrio. The TMA-N content of raw gizzard-shad slice gradually increased during preservation, and the TMA-N was in inverse proportion to the added amount of mustard seed. Scanning electron microscopy of Vibrio parahaemolyticus treated with water extract of mustard seed showed that surface membrane was destroyed with expended ellipsoidal shape.

수면-무호흡 중후군 증례보고

최동주,김영환,심영수,김건열,한용철,유빈,송재훈,한성구 대한내과학회 1987 대한내과학회지 Vol.32 No.4

Sleep apnea syndrome is characterized by loud snoring, excessive daytime somnolence and multiple attack of apnea during sleep which can cause sudden nocturnal death, cor pulmonale, hypertension, personality change and morning headache. We report a typical case of obstructive sleep apnea syndrome in a 30 year old Korean woman. She was very obese and complained loud snoring, daytime hypersomnolence. Nocturnal sleep study showed repetitive attack of apnea and fall of arterial oxygen tension and saturation. Bilateral severe tonsilar hypertrophy was thought to be the mechanism of obstruction.