LncRNA SNHG12/miR-494-3p/CBX3 axis in diffuse large B-cell lymphoma

Si Cheng,Zhang Wanyong,Han Qi,Zhu Bisheng,Zhan Chengzhi 대한독성 유전단백체 학회 2023 Molecular & cellular toxicology Vol.19 No.1

Background Diffuse large B-cell lymphoma (DLBCL) is the most common lymphoid malignancy in adults. Current studies have implicated that long non-coding RNAs (lncRNAs) regulate the development of DLBCL; nevertheless, the control method is dim. Here, we reconnoitered the characters of lncRNA small nucleolar RNA host gene 12 (lncRNA SNHG12) in DLBCL. Objective The pathological morphology of tumor tissues and normal tissues was perceived by hematoxylin–eosin (HE) staining. The levels of SNHG12, microRNA-494-3p (miR-494-3p), and chromobox 3 (CBX3) were detected by quantitative real-time PCR and western blot. Whereafter, MTT assay and EdU assay were enforced to validate cell proliferation. Flow cytometry assay was implemented to assess the cell cycle and cell apoptosis, respectively. Additionally, the interface between miR-494-3p with SNHG12 or CBX3 was identified by dual-luciferase reporter assay. Results SNHG12 and CBX3 were enhanced, but miR-494-3p was diminished in DLBCL. Knockdown of SNHG12 repressed cell proliferation and cell cycle, although heightened cell apoptosis in DLBCL cells. SNHG12 sponged miR-494-3p to adjust the CBX3. Additionally, miR-494-3p restrained DLBCL cells development by targeting CBX3. Conclusion SNHG12 contributed to DLBCL development by regulating miR-494-3p/CBX3. The outcomes demonstrated that SNHG12 provided a potential train of thought for DLBCL theory of targeted therapy.

Association Between Excessive Daytime Sleepiness and Functional Gastrointestinal Disorders: A Population-based Study in China

( Sicheng Wu ),( Shuqi Chen ),( Yanfang Zhao ),( Xiuqiang Ma ),( Rui Wang ),( Jia He ) 대한소화기기능성질환·운동학회(구 대한소화관운동학회) 2017 Journal of Neurogastroenterology and Motility (JNM Vol.23 No.2

Background/Aims Several studies have demonstrated that sleep problems are associated with functional gastrointestinal disorders (FGIDs): irritable bowel syndrome (IBS), functional dyspepsia, etc, but the relationship between excessive daytime sleepiness (EDS) and FGIDs has not been systematically studied in the general population. This study aims to explore the relationship between EDS and specific types of FGIDs and the effect of the number of FGIDs on EDS. Methods A sample of 3600 individuals (aged 18-80 years) was selected from 5 regions in China using a randomized, stratified, multi-stage sampling method. EDS was measured by the Epworth Sleepiness Scale, while gastroesophageal reflux disease (GERD) and other FGIDs were assessed by Reflux Disease Questionnaire and the Rome II diagnostic criteria, respectively. Results The survey was completed by 2906 individuals (response rate: 80.72%), and 644 individuals (22.16%) had EDS. EDS was significantly associated with ulcer-like dyspepsia (OR, 2.50; 95% CI, 1.08-5.79), diarrhea-predominant IBS (OR, 2.00; 95% CI, 1.09-3.66), alternating IBS (OR, 2.32; 95% CI, 1.30-4.13), functional constipation (OR, 1.68; 95% CI, 1.20-2.35), and GERD (OR, 1.72; 95% CI, 1.08-2.72). Risk of EDS increased along with the increasing numbers of FGIDs: with 1 FGID (OR, 1.72; 95% CI, 1.37-2.15); with 2 FGIDs (OR, 2.43; 95% CI, 1.63-3.62); and with 3 or more FGIDs (OR, 3.26; 95% CI, 1.37-7.78). Conclusions FGIDs, such as ulcer-like dyspepsia, diarrhea-predominant IBS, alternating IBS, functional constipation, and GERD, were significantly associated with EDS. Those who suffered from more kinds of FGIDs were more susceptible to EDS. (J Neurogastroenterol Motil 2017;23:298-305)

Online Gait Generation Method Based on Neural Network for Humanoid Robot Fast Walking on Uneven Terrain

Haoran Zhong,Sicheng Xie,Xinyu Li,Shengyu Lu,Liang Gao 제어·로봇·시스템학회 2022 International Journal of Control, Automation, and Vol.20 No.3

Advanced humanoid robots highlight the ability of fast walking and adaptability to uneven terrain. However, owing to the complexity in walking dynamics, disturbances introduced by terrain height variations can adversely affect the bipedal walking performance. Moreover, to generate periodic gaits, most methods require to solve the gait generation problem by using nonlinear optimization approaches, resulting in difficulties for online control. To solve this problem, this paper proposes an online gait generation method to find periodic gaits for fast walking on uneven terrain by using a pre-trained neural network. First, to enhance the terrain adaptability, this paper proposes an improved walking pattern that allows the robots to skip the last single support phase. Such improvement enlarges the feasible step region when stepping down. A compensation strategy is also proposed to reduce the velocity tracking error. Then the improved whale swarm algorithm (IWSA) is applied to generate various datasets that cover the ranges of target velocities and terrain height variations. A back-propagation (BP) network is employed to train these datasets offline to learn the gait dynamics, which is further used to generate the optimal trajectories. Simulation results suggest that, compared with the current methods, the proposed method can solve the walking return map in a short time, with improvements in both maximum walking speed and terrain adaptability.

Sensitive Vector Search for Logic Circuit Failure Probability based on Improved Adaptive Cuckoo Algorithm

Shuo Cai,Sicheng Wu,Weizheng Wang,Fei Yu,Lairong Yin 대한전자공학회 2022 Journal of semiconductor technology and science Vol.22 No.2

With the development of microelectronics technology, the feature size of integrated circuit continues to shrink, and circuit performance has been improved. At the same time, however, factors such as process disturbance, power noise, and particle radiation are having an increasingly serious influence on the Failure Probability of Circuits (FPC). Searching the input vectors that are sensitive to FPC can assist circuit designers in selectively reinforcing the circuit to reduce the fault-tolerant overhead and improve the fault-tolerant efficiency. In this paper, an Improved Adaptive Cuckoo Search (IACS) algorithm is proposed to search sensitive circuit vectors. The vector segmentation strategy is used to change the dimension of the input vector, the hill climbing algorithm is used to improve the quality of the initial population, and the adaptive strategy is used to control parameters such as power-law index, discovery probability and scaling factor. At the same time, a Correlation Separation Approach (COSEA) is proposed to calculate the FPC under specific vector excitation. Experimental results show that the proposed algorithm has higher accuracy and better efficiency compared with existing algorithms.

Nonlinear vibration of FG-CNTRC curved pipes with temperature-dependent properties

Mingjie Liu,Shaoping Bi,Sicheng Shao,Hadi Babaei 국제구조공학회 2023 Steel and Composite Structures, An International J Vol.46 No.4

In the current research, the nonlinear free vibrations of curved pipes made of functionally graded (FG) carbon nanotube reinforced composite (CNTRC) materials are investigated. It is assumed that the FG-CNTRC curved pipe is supported on a three-parameter nonlinear elastic foundation and is subjected to a uniform temperature rise. Properties of the curved nanocomposite pipe are distributed across the radius of the pipe and are given by means of a refined rule of mixtures approach. It is also assumed that all thermomechanical properties of the nanocomposite pipe are temperature-dependent. The governing equations of the curved pipe are obtained using a higher order shear deformation theory, where the traction free boundary conditions are satisfied on the top and bottom surfaces of the pipe. The von Kármán type of geometrical non-linearity is included into the formulation to consider the large deflection in the curved nanocomposite pipe. For the case of nanocomposite curved pipes which are simply supported in flexure and axially immovable, the motion equations are solved using the two-step perturbation technique. The closed-form expressions are provided to obtain the small- and large-amplitude frequencies of FGCNTRC curved pipes rested on a nonlinear elastic foundation in thermal environment. Numerical results are given to explore the effects of CNT distribution pattern, the CNT volume fraction, thermal environment, nonlinear foundation stiffness, and geometrical parameters on the fundamental linear and nonlinear frequencies of the curved nanocomposite pipe.

Influence of Electrical Aging on Space Charge Dynamics of Oil-Impregnated Paper Insulation under AC-DC Combined Voltages

Yan Wang,Jian Li,Sicheng Wu,Peng Sun 대한전기학회 2013 Journal of Electrical Engineering & Technology Vol.8 No.6

Oil-impregnated paper is a major type of insulation used in oil-filled converter transformers for both traditional and new energy systems. This paper presents and analyzes the results of the experiment conducted on the electrical aging of oil-impregnated paper under AC-DC combined voltages using the pulsed electro-acoustic (PEA) technique. The formation and dynamics of space charge affected the performance of insulation material. The electrical aged oil-paper insulation was obtained through electrical aged experiments under the voltages. Based on the PEA technique, measurements were carried out when the oil-paper insulation system was subjected to different stressing and aging times. The space charge dynamics in the bulk of the oil-paper insulation system with different aging times were measured and analyzed. Characteristic parameters such as the total charge injection amount, the total charges of fast moving and slow moving, and the distortion factor of electric field were calculated and discussed. Results show that the longer electrical aging time, the more charges trapped in the bulk of aging sample. It leads to larger distortion factor of electric field in the bulk of aging samples and accelerate degradation of oil-paper insulation under AC-DC combined voltages.

Alloying Behavior and Properties of FeSiBAlNiCox High Entropy Alloys Fabricated by Mechanical Alloying and Spark Plasma Sintering

Wen Wang,Boyu Li,Sicheng Zhai,Juan Xu,Zuozhe Niu,Jing Xu,Yan Wang 대한금속·재료학회 2018 METALS AND MATERIALS International Vol.24 No.5

In this paper, FeSiBAlNiCo x ( x = 0.2, 0.8) high-entropy alloy (HEA) powders were fabricated by mechanical alloying process,and the powders milled for 140 h were sintered by spark plasma sintering (SPS) technique. The microstructures andproperties of as-milled powders and as-sintered samples were investigated. The results reveal that the fi nal milling products(140 h) of both sample powders present the fully amorphous structure. The increased Co contents obviously enhance theglass forming ability and thermal stability of amorphous HEA powders, which are refl ected by the shorter formation time offully amorphous phase and the higher onset crystallization temperature, respectively. According to coercivity, the as-milledFeSiBAlNiCo x ( x = 0.2, 0.8) powders (140 h) are the semi-hard magnetic materials. FeSiBAlNiCo 0.8 HEA powders possessthe highest saturation magnetization and largest remanence ratio. The SPS-ed products of both bulk HEAs are composedof body-centered cubic solid solution, and FeSi and FeB intermetallic phases. They possess the high relative density above97% and excellent microhardness exceeding 1150 HV. The as-sintered bulks undergo the remarkable increase in saturationmagnetization compared with the as-milled state. The SPS-ed FeSiBAlNiCo 0.8 HEA exhibits the soft magnetic properties. The electrochemical corrosion test is carried out in 3.5% NaCl solution. The SPS-ed FeSiBAlNiCo 0.2 HEA reveals the betterpassivity with low passive current density, and the higher pitting resistance with wide passive region.

Effect of different dielectrics on performance of sub-5.1 nm blue phosphorus Schottky barrier field-effect transistor from quantum transport simulation

Chen Wen,Jing Sicheng,Wang Yu,Pan Jinghua,Li Wei,Bian Baoan,Liao Bin 한국물리학회 2022 Current Applied Physics Vol.43 No.-

Two-dimensional materials have attracted great attention because of their ultra-thin atomic layer thickness and high carrier mobility. In this work, we investigated the electronic transport of in-plane (IP) heterojunction based on Cu/Blue Phosphorus (BlueP), and the results suggest the metallization at the IP Cu/BlueP contact interface and a small Schottky barrier. Then, we investigated the performance of 5.1 nm IP BlueP Schottky barrier field-effect transistors (SBFET) with different dielectrics (SiO2, Al2O3, Y2O3, and La2O3) using quantum transport simulations. The results show that IP BlueP SBFETs with four dielectrics satisfy the off-state requirement of the International Technology Roadmap for Semiconductors (ITRS) for the high-performance (HP) device. However, the on-state current of only IP BlueP SBFET with La2O3 satisfies the requirements of ITRS. This will provide a reference for designing BlueP SBFETs.

Influence of Electrical Aging on Space Charge Dynamics of Oil-Impregnated Paper Insulation under AC-DC Combined Voltages

Wang, Yan,Li, Jian,Wu, Sicheng,Sun, Peng The Korean Institute of Electrical Engineers 2013 Journal of Electrical Engineering & Technology Vol.8 No.6

Oil-impregnated paper is a major type of insulation used in oil-filled converter transformers for both traditional and new energy systems. This paper presents and analyzes the results of the experiment conducted on the electrical aging of oil-impregnated paper under AC-DC combined voltages using the pulsed electro-acoustic (PEA) technique. The formation and dynamics of space charge affected the performance of insulation material. The electrical aged oil-paper insulation was obtained through electrical aged experiments under the voltages. Based on the PEA technique, measurements were carried out when the oil-paper insulation system was subjected to different stressing and aging times. The space charge dynamics in the bulk of the oil-paper insulation system with different aging times were measured and analyzed. Characteristic parameters such as the total charge injection amount, the total charges of fast moving and slow moving, and the distortion factor of electric field were calculated and discussed. Results show that the longer electrical aging time, the more charges trapped in the bulk of aging sample. It leads to larger distortion factor of electric field in the bulk of aging samples and accelerate degradation of oil-paper insulation under AC-DC combined voltages.

Ballistic transport in 5.1 nm monolayer boron phosphide transistors for high-performance applications

Wang Yu,Chen Wen,Jing Sicheng,Pan Jinghua,Wang Danni,Ma Zelong,Bian Baoan 한국물리학회 2023 Current Applied Physics Vol.52 No.-

Boron Phosphide is reported to be a semiconductor material with anisotropy, tunable bandgap, and high carrier mobility. We study the performance of 5.1 nm metal–oxide–semiconductor field-effect transistors (MOSFETs) based on boron phosphide using quantum transport simulation. The calculated results show that the on-state current can fulfill the requirements of the International Semiconductor Technology Roadmap (ITRS) for high-performance (HP) devices at the optimal doping concentration, but the gate control capability is not ideal. Furthermore, it is found that the gate control capability and on-state current can be significantly improved with the length being 1 nm by using the underlap (UL) structure. We also study the performance of boron phosphide MOSFET with different gate lengths (5–8 nm), and the results suggest that the shorter the gate length, the worse the gate control capability. Interestingly, the p-type boron phosphide MOSFET always outperforms the n-type MOSFET. This work will provide a new reference for the development of two-dimensional (2D) semiconductor devices.