Exposure to Extremely Low Frequency Magnetic Fields Enhances Locomotor Activity via Activation of Dopamine D₁-Like Receptors in Mice

Shin, Eun-Joo,Jeong, Ji Hoon,Kim, Hyun Ji,Jang, Choon-Gon,Yamada, Kiyofumi,Nabeshima, Toshitaka,Kim, Hyoung-Chun The Japanese Pharmacological Society 2007 Journal of pharmacological sciences Vol.105 No.4

<P>We demonstrated that exposure to extremely low frequency magnetic fields (ELF-MF) enhanced dopamine levels in the rat striatum. To extend our understanding, we examined the role of dopaminergic receptors in ELF-MF–induced behavioral changes. Exposure to ELF-MF (2.4 mT, 1 h/day, for one or seven days) enhanced locomotor activity in a time-dependent manner. This hyperlocomotor activity paralleled an increase in c-Fos-like immunoreactivity (c-Fos-IR). Pretreatment with SCH23390, a dopaminergic D<SUB>1</SUB>-like receptor antagonist, but not with sulpiride, a dopaminergic D<SUB>2</SUB>-like receptor antagonist, inhibited ELF-MF–induced increased locomotor activity and c-Fos-IR. Thus, our results suggest that ELF-MF–induced behavioral responses are, at least in part, mediated by activation of dopamine D<SUB>1</SUB>-like receptors.</P>

Association between Pelvic Parameters and Vaginal Delivery

Yamada Tomohiro,Yamato Yu,Hasegawa Tomohiko,Yoshida Go,Yasuda Tatsuya,Banno Tomohiro,Arima Hideyuki,Oe Shin,Mihara Yuki,Ushirozako Hiroki,Ide Koichiro,Watanabe Yuh,Hosino Hironobu,Matsuyama Yukihiro 대한척추외과학회 2022 Asian Spine Journal Vol.16 No.2

Study Design: Cross-sectional study. Purpose: To investigate the association between vaginal delivery and pelvic parameters and clarify the effect of parity on parameter fluctuations. Overview of Literature: During vaginal delivery, the sacroiliac joint widens and the sacrum nutates (nods). However, the association between these pelvic parameters and parity is unknown. Methods: As part of a 2016 health screening, 320 female volunteers underwent whole-spine radiographs. Age-matched healthy women were grouped according to the number of vaginal deliveries (0, 1–2, or ≥3). Demographic variables and spinopelvic parameters were compared among the three groups. Results: Of the 320 volunteers, 213 were enrolled (mean age, 71.1±7.2 years). The mean number of vaginal deliveries was 2.2. The average pelvic incidence (PI) was 55.6°±11.1° and was significantly higher in the 90 women with three or more vaginal deliveries than in the other two groups (p<0.001). The average sacral slope was 33.4°±11.1° and was significantly higher in the women with three or more vaginal deliveries than in the 18 who did not deliver vaginally (p<0.001). The 105 women with one or two vaginal deliveries had significantly higher PIs and sacral slopes than did those who did not deliver vaginally (p<0.001). Conclusions: This is the first study documenting an association between vaginal delivery and pelvic parameters. Bony birth canal realignment during vaginal delivery can affect postnatal PI. Our study helps in understanding the PI changes over a woman’s life span.

Role of microsomal epoxide hydrolase in methamphetamine-induced drug dependence in mice

Shin, Eun-Joo,Bing, Guoying,Chae, Jong Seok,Kim, Tae Woo,Bach, Jae-Hyung,Park, Dae Hun,Yamada, Kiyofumi,Nabeshima, Toshitaka,Kim, Hyoung-Chun Wiley Subscription Services, Inc., A Wiley Company 2009 Journal of neuroscience research Vol.87 No.16

<P>Microsomal epoxide hydrolase (mEH) and cytochrome P-450 (CYP) ensure the rapid detoxification of epoxides generated during the oxidative metabolism of xenobiotics. Although CYP has been demonstrated to modulate methamphetamine (METH)-induced behavioral effects, little is known about the role of the mEH gene on these effects. We examined the role of mEH gene expression in METH-induced conditioned place preference and behavioral sensitization by using mEH<SUP>–/–</SUP> and wild-type (WT) mice. Extracellular dopamine (DA) levels and DA uptake into synaptosomes were assessed by using an in vivo microdialysis and [<SUP>3</SUP>H]DA uptake assay. We applied double-label immunocytochemistry to characterize mEH-positive cellular types. METH-induced behavioral responses paralleled striatal c-Fos-like immunoreactivity. METH treatment resulted in increased extracellular DA levels in the nucleus accumbens but decreased synaptosomal DA uptake in the striatum. These behavioral and neurochemical changes were more pronounced in the mEH<SUP>–/–</SUP> mice than in WT mice. In WT mice, mEH-like immunoreactivity was expressed in astrocytes labeled by GFAP or S100B after METH treatment. The results suggest that epoxide intermediates mediate METH drug dependence and that astrocytic reactions of mEH protein are important in the endogenous modulation in response to METH drug dependence. © 2009 Wiley-Liss, Inc.</P>

Applying Word Embeddings to Measure the Semantic Adaptation of English Loanwords in Japanese and Korean

Akihiko Yamada,Hyopil Shin 서울대학교 언어교육원 2017 語學硏究 Vol.53 No.3

With the internationalization of English, many English words are used as loanwords around the world. These English loanwords can bring about confusion, however, as the semantic usage of a loanword often differs from region to region. Therefore, it is important to examine how the semantic adaptation of a given English loanword has occurred when it is introduced into the lexicon of a country. The word vector model has been used to study semantic changes. In this paper, using these techniques, we investigate the semantic adaptation of English loanwords in Japanese and Korean. In addition, we investigate the correlation between the number of meanings of original English words and cosine similarity. As a result, we have brought a new insight into the computational contrastive semantics.

Spinal Sagittal Alignment, Hospital Anxiety and Depression Scale Scores, and Patient-Reported Outcome among People with Sporting Activity

Oe Shin,Yamato Yu,Hasegawa Tomohiko,Yoshida Go,Kobayashi Sho,Yasuda Tatsuya,Banno Tomohiro,Arima Hideyuki,Mihara Yuki,Ushirozako Hiroki,Yamada Tomohiro,Ide Koichiro,Watanabe Yuh,Haruo Niwa,Matsuyama Y 대한척추외과학회 2020 Asian Spine Journal Vol.14 No.3

Study Design: Retrospective cohort study.Purpose: This study aimed to investigate how participation in sporting activity affects patient-reported outcome (PRO), including Neck Disability Index (NDI), in males and females.Overview of Literature: Previously, our study reported that factors with a negative influence on the NDI in females were a lack of sporting activities. However, it was still unclear why it affected poor scores of NDI.Methods: The subjects were 473 volunteers. They were divided into two groups (activity and non-activity) according to participation or non-participation in sporting activities using a self-filled questionnaire. The evaluation items were height, weight, grip strength, bone density, Hospital Anxiety and Depression Scale (HADS) score, standing radiographic parameters, PRO (evaluated by EuroQol-5 dimension [EQ-5D], Oswestry Disability Index [ODI]), and NDI.Results: There were 101 males in the non-activity group and 69 in the activity group and 178 females in the non-activity group and 125 in the activity group. For the males, the evaluation items with significant influence were cervical lordosis (non-activity group:activity group, 17°:22°) and T1 slope minus cervical lordosis (10°:6°, <i>p</i> <0.05). For the females, the evaluation items with significant influence were sagittal vertical axis (28:14 mm), HADS (10.4:8.4), EQ-5D (0.79:0.86), ODI (17:12), and NDI (12:9, <i>p</i> <0.01). HADS and PRO in the females were significantly correlated with the EQ-5D (−0.40), ODI (0.43), and NDI (0.55).Conclusions: Males who participated in sporting activities had better cervical spine alignment but no effect on PRO. Females with sporting activities had better spinal global alignment and less mental stress. It is suggested that sporting activity in females might be associated with PRO because HADS highly correlates with PRO.

Conclusions and Suggestions on Low-Dose and Low-Dose Rate Radiation Risk Estimation Methodology

Sakai, Kazuo,Yamada, Yutaka,Yoshida, Kazuo,Yoshinaga, Shinji,Sato, Kaoru,Ogata, Hiromitsu,Iwasaki, Toshiyasu,Kudo, Shin'ichi,Asada, Yasuki,Kawaguchi, Isao,Haeno, Hiroshi,Sasaki, Michiya The Korean Association for Radiation Protection 2021 방사선방어학회지 Vol.46 No.1

Background: For radiological protection and control, the International Commission on Radiological Protection (ICRP) provides the nominal risk coefficients related to radiation exposure, which can be extrapolated using the excess relative risk and excess absolute risk obtained from the Life Span Study of atomic bomb survivors in Hiroshima and Nagasaki with the dose and dose-rate effectiveness factor (DDREF). Materials and Methods: Since it is impossible to directly estimate the radiation risk at doses less than approximately 100 mSv only from epidemiological knowledge and data, support from radiation biology is absolutely imperative, and thus, several national and international bodies have advocated the importance of bridging knowledge between biology and epidemiology. Because of the accident at the Tokyo Electric Power Company (TEPCO)'s Fukushima Daiichi Nuclear Power Station in 2011, the exposure of the public to radiation has become a major concern and it was considered that the estimation of radiation risk should be more realistic to cope with the prevailing radiation exposure situation. Results and Discussion: To discuss the issues from wide aspects related to radiological protection, and to realize bridging knowledge between biology and epidemiology, we have established a research group to develop low-dose and low-dose-rate radiation risk estimation methodology, with the permission of the Japan Health Physics Society. Conclusion: The aim of the research group was to clarify the current situation and issues related to the risk estimation of low-dose and low-dose-rate radiation exposure from the viewpoints of different research fields, such as epidemiology, biology, modeling, and dosimetry, to identify a future strategy and roadmap to elucidate a more realistic estimation of risk against low-dose and low-dose-rate radiation exposure.

Change in Line of Sight after Corrective Surgery of Adult Spinal Deformity Patients: A 2-Year Follow-up

Magcalas Ken Jeffrey,Oe Shin,Yamato Yu,Hasegawa Tomohiko,Yoshida Go,Banno Tomohiro,Arima Hideyuki,Mihara Yuki,Ushirozako Hiroki,Yamada Tomohiro,Ide Koichiro,Watanabe Yuh,Matsuyama Yukihiro 대한척추외과학회 2023 Asian Spine Journal Vol.17 No.2

Study Design: Cohort study.Purpose: There is currently no published study that focuses on the spinal corrective surgery effects with cranial parameters in adult spinal deformity (ASD) patients. It is an important factor to measure since it plays a critical role in maintaining the line of sight. The objective is to determine the change in cranial parameters using the slope of McGregor’s line (McGS) after ASD surgery after 2 years of follow-up.Overview of Literature: A study concluded that cervical spine alignment (C2–C7 lordosis) is strongly affected by thoracic kyphosis (TK). Another study showed that patients with ascending gaze had significantly more thoracolumbar malalignment.Methods: This retrospective study includes 295 corrective surgery patients with ASD. Subjects were divided into two groups after propensity age matching analysis: cranial malalignment (McGS <−8 or >13) and normal cranial alignment (−8≤ McGS ≤13). Lumbar lordosis (LL), pelvic tilt (PT), TK, cervical lordosis (CL), and sagittal vertical axis (SVA) were evaluated between the two groups.Results: SVA (95–56 mm) and PT (34°–25°) decreased and LL (19°–41°) increased 2 years after surgery (p <0.05), but McGS (−1.1° to −0.5°) and CL (21°–19°) did not change. Conversely, in the group with cranial malalignment, SVA (120–64 mm), PT (35°–26°), and LL (12°–41°) showed similar results to the normal cranial parameter group 2 years after surgery, but in contrast, McGS (−13° to −2°) and CL (24°–18°) improved significantly.Conclusions: Severe ASD adversely affects to maintain horizontal gaze but can be improved by spinal corrective surgery.

Beta-Tricalcium Phosphate Block for Donor Site Morbidity of the Patella in Anterior Cruciate Ligament Reconstruction Using Bone-Patellar Tendon-Bone Graft

Yuki Kato,Joverienne Chavez,Shin Yamada,Soichi Hattori,Shuzo Takazawa,Hiroshi Ohuchi 대한슬관절학회 2019 대한슬관절학회지 Vol.31 No.2

Purpose: This study aimed to investigate anterior knee symptoms in patients who underwent anterior cruciate ligament (ACL) reconstruction using bone­patellar tendon­bone (BPTB) graft followed by implantation of a beta­tricalcium phosphate (β­TCP) block as a bone void filler.Materials and Methods: We retrospectively reviewed 84 cases of synthetic bone grafting using a β­TCP block for the patellar bone defect in ACL reconstruction with a BPTB autograft. Computed tomography of the operated knee was performed immediately after the surgery to evaluate whether the grafted β­TCP block protruded forward from the anterior surface of the patella. On the basis of the results, the cases were divided into a protrusion group (n=31) and a non­protrusion group (n=53). Anterior knee symptoms at 12 months postoperatively and absorption of the grafted β­TCP block were compared between the two groups.Results: Except for patellofemoral crepitus, there was no significant difference in anterior knee symptoms between the two groups (p>0.05). The incidence of patellofemoral crepitus was significantly lower in the protrusion group than in the non­protrusion group (p=0.027). The groups showed no significant difference in β­TCP absorption.Conclusions: The present study demonstrated that the protrusion of β­TCP that was used as a bone void filler had no adverse effects.

Fustin flavonoid attenuates β-amyloid (1–42)-induced learning impairment

Jin, Chun-Hui,Shin, Eun-Joo,Park, Jae-Bong,Jang, Choon-Gon,Li, Zhengyi,Kim, Min Soo,Koo, Kyo Hwan,Yoon, Hyoung-Jong,Park, Sang-Jae,Choi, Won-Cheol,Yamada, Kiyofumi,Nabeshima, Toshitaka,Kim, Hyoung-Chu Wiley Subscription Services, Inc., A Wiley Company 2009 Journal of neuroscience research Vol.87 No.16

<P>Natural flavonoids ameliorate amyloid-β peptide (Aβ)-induced neurotoxicity. We examined whether the fustin flavonoid affects Aβ-induced learning impairment in mice. Repeated treatment with fustin significantly attenuated Aβ (1–42)-induced conditioned fear and passive avoidance behaviors. This effect was comparable to that of EGb761, a standard extract of ginkgo. Fustin treatment significantly prevented decreases in acetylcholine (ACh) levels, choline acetyltransferase (ChAT) activity, and ChAT gene expression induced by Aβ (1–42). Fustin also consistently suppressed increases in acetyl cholinesterase (AChE) activity and AChE gene expression induced by Aβ (1–42). In addition, fustin significantly attenuated Aβ (1–42)-induced selective decreases in muscarinic M1 receptor gene expression and muscarinic M1 receptor binding activity (as determined by [<SUP>3</SUP>H]pirenzepine binding) by modulating extracellular signal-regulated kinase 1/2 (ERK 1/2) and cAMP response-element binding protein (CREB) phosphorylation and brain-derived neurotrophic factor (BDNF) expression. These effects of fustin were reversed by treatment with dicyclomine, a muscarinic M1 receptor antagonist, and SL327, a selective ERK inhibitor, but not by chelerythrine, a pan-protein kinase C (PKC) inhibitor. Taken together, our results suggest that fustin attenuates Aβ (1–42)-impaired learning, and that the ERK/CREB/BDNF pathway is important for the M1 receptor-mediated cognition-enhancing effects of fustin. © 2009 Wiley-Liss, Inc.</P>

Arthroscopic Transosseous-Equivalent Repair for Rotator Cuff Tear by Double Anchor Footprint Fixation (DAFF) Technique

Minoru Yoneda,Shinsuke Nonaka,Shin-ichi Yamada 대한견주관절의학회 2009 대한견주관절학회 학술대회논문집 Vol.2009 No.5