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제초제 2,4-D가 흰쥐 소장 점액질에 미치는 영향에 관한 조직화학적 연구
신인성,정길남,조운복 부산대학교 사범대학 과학교육연구소 2007 科學敎育硏究報 Vol.34 No.-
제초제인 2,4-D가 십이지장샘, 십이지장, 회장 및 공장 술잔세포내 점액질에 미치는 영향을 규명하기 위하여, 성숙한 흰쥐에 제초제 2,4-D 액제를 경구적으로 투여하며 중독시킨 후 3시간군, 6시간군, 12시간군, 24시간군, 48시간군, 72시간군, 96시간군 및 120시간군 별로 나누어 점액샘 및 술잔세포내 점액질 성상을 alcian blue pH 2.5 염색법, alcian blue pH 1.0 염색법, PAS 염색법, alcian blue pH 2PAS 염색법, alcian blue pH 1.0-PAS 염색법 및 aldehyde fuchsin pH 1.7-alcian blue pH 2.5 염색법으로 검색하여 관찰하였다. 십이지장샘내 중성점액질 양은 농약투여 후 12시간군부터 96시간군까지 현저한 감소를 보였으며, 감소된 중성점액질 양은 농약투여 후 120시간군에서 회복되었다. 농약투여 후 소장 술잔세포내 점액질 감량은 음모상부 및 은와저부 쪽에서 더 심하였고, 산성점액질의 감량이 중성점액질의 감량보다 매우 더 심하였고, 회복도 산성점액질보다는 중성점액질쪽에서 더 빨랐다. 장기별로는 십이지장 술잔세포가 제일 심한 영향을 받았고, 다음 공장 배상세포이었으나 회장에서는 현저하지 않았다. 소장에 있어서 산성점액질의 가장 현저한 감소는 십이지장에서 농약투여 추 12시간군, 24시간군 및 48시간군 또는 공장에서 농약투여 후 24시간군과 48시간군이었으며 현저한 감소는 십이지장에서 농약투여 추 3시간군과 6시간군, 공장에서 농약투여 후 12시간군 그리고 다소 현저한 감소는 회장에서 농약투여 후 12시간군, 24시간군, 48시간군 및 72시간군이었다. 감소된 산성점액질 양은 십이지장 및 공장에서 농약투여 후 72시간군 또는 회장에서 농약투여 후 96시간군에서 점차적으로 회복되는 경향을 나타내었다. 중성점액질 양의 감소는 십이지장에서만 농약투여 후 12시간군, 24시간군 및 48시간군에서 현저한 감소를 나타내었으나 공장 및 회장에서는 중성점액질의 감소가 현저하지 않았으며, 감소된 중성점액질 양은 농약 투여 후 십이지장 및 공장에서 72시간군 또는 회장에서 96시간군에서 점차 회복되는 경향을 나타내었다. 소장융모 및 은와내 강 sulfated mucin을 분비하는 술잔세포와 sialomucin을 분비하는 배상세포가 농약투여 후 다같이 그 염색성이 감희되었고, 전자가 후자보다 더 심한 영향을 받았으며 회복되는 경향도 늦었다. 특히 공장에서는 sialomucin을 분비하는 술잔세포가 농약투여 후 12시간군, 24시간군 및 48시간군에서 증가되는 경향을 나타내었다. This experiment was performed to observe the effect of herbicide, 2,4-D, on the production, secretion and histochemical properties of the mucosubstances of the duodenal glands and goblet cells in the small intestine. Healthy adult rats weighing about 250~300g were divided into two groups normal and experimental. Each animal of experimental groups was administrated 2,4-D (187.5mg/kg) orally and sacrificed in 3, 6, 12, 24, 48, 72, 96 and 120 hours after 2,4-D administration. The mucous glands and the goblet cells of the small intestine were stained with alcian blue(AB) PH 2.5, AB pH 1.0, periodic acid Schiff (PAS), AB pH 2.5-PAS, AB pH 1.0-PAS and aldehyde fuchsin AF pH 1.7-AB pH 2.5. The obtained results were as follows : Marked diminution of neutral mucosubstances in the duodenal glands was noted up from 12 hours to 96 hours, and recovered gradually from 120 hours after 2,4-D administration. Decrease of both acid and neutral mucosubstances was noted to be considerable in the goblet cells of the small intestine after 2,4-D administration, especially of the upper willi and the basal regions of the crypts, and add mucins became more markedly diminished than neutral ones, while neutral mucins more strikingly recovered than add ones. In comparison with organs, e goblet cells of duodenum seemed to be most strikinly affected, next those of the ileum, but those of jejunum not affected markedly. The most remarkable decrease of acid mucosubstances was observed in the duodenum 12, 24 and 48 hours, in the jejunum 24 and 48 hours. Remarkable decrease of those observed in the duodenum 3 and 6 hours, in the jejunum 12 hours. Slight decrease of those observed in the ileum 12, 24,m 48 and 72 hours after 2,4-D administration. the decreased amount of acid mucins tended to be gradually recovered in the duodenum and jejunum 72 hours, in the ileum 96 hours after 2,4-D administration. The amount of neutral mucins was markedly diminished only in the duodenum 12, 24 and 48 hours after the administration, but neutral mucins was not diminished in the jejunum and ileum. The decreased amount of neutral mucins tended to be gradually recovered in the duodenum and jejumin 72 hours and in the ileum 96 hours after the administration. Stainability of the goblet cells with strong sulfated mucins and with sialomucins both in the intestinal villi and crypts was generally decreased after the administration. However, the former was more markedly affected than the latter. The tendency of recover appeared to be slow, especially the goblet cells with sialomucins in the jejunum 12, 24 and 48 hours tended to be increased after the administration.
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신길수,김조은 한국스포츠리서치 2003 한국 스포츠 리서치 Vol.14 No.2
Dance have related with human beings since the beginning of human history and its power on human beings has the same importance in the past and present. Human history and leisure have coexisted. Leisure in ancient times is closely related with the manners of religious service, festivals, arts. It is expressed as a biological drive and instinct in dance and has been standardized as a systematic art with aesthetic elements. Based on the above background, obtained the conclusions as follows. First, the aspects of time and space in leisure coexist. The aspect of space in leisure agrees to the simultaneous aspect of dance in vertical aspect which is from the ancient times to the present or static aspect which offers a stage for a performance art. Second, leisure affected human beings directly through a sense of religious ceremonies or a sense of medical treatment, or personal or group dance and, as a result of, human beings could overcome anxiety or difficult reality and enter into a hopeful world. Third, dance, as the result of leisure instinct, is closely related with music which used repeated rhythm standardized and developed as a means of aesthetic expression with an artistic form of dance in all creative activities. Fourth, from an educational view, present dance offers students artistic experience in intellectual, emotional, creative aspects rather than practical utility such as physical development or enhancement of sports function and enables them to regard it as an educational means contributing to the establishment and cultivation of model image of man. Considering the history of dance, we can expect the best unfoldment of its past beauty and form, and an educational value contributes to the revival of remarkable artistic dance and to the establishment and cultivation of the model image of man.
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大防風湯의 LPS誘發 關節炎 緩和效果에 관한 實驗的 硏究
田元準,辛吉祚,李源哲 동국대학교 한의학연구소 2000 東國韓醫學硏究所論文集 Vol.9 No.-
본 실험은 大防風湯이 혈관생성과 세포유착인자발현 억제를 통해 LPS(lipopolysaccharide)유발 관절염 완화에 미치는 영향을 조사하기 위해 LPS주사로 관절염이 유발된 생쥐에게 大防風湯 추출액을 음용 투여하였다. 실험동물은 20g된 female Balb/c계 생쥐암컷을 선별하여 아무런 처치를 하지 않은 대조군, 무릎관절에 LPS를 주사한 LPS군, LPS주사후 大防風湯 추출액을 투여한 DBP군으로 나누어, 다시 LPS와 DBP군을 LPS처리 후 시간의 경과에 따라 3, 7, 14일로 구분하였으며, 실험군 각각에는 실험동물을 10마리씩 배정하였다. 광학 현미경(BX50)으로 大防風湯 추출액 투여가 LPS주사 후 증가된 윤할 관절막내 혈관분포 증가에 미치는 영향과 아울러 윤활세포, 섬유화 및 섬유모세포, 비만세포와 염증관여세포, 세포유착인자 등의 윤활 관절막에서의 형태변화를 관찰하였다. DBP군에서는 자유면에서 윤활세포과형성의 억제와 침윤 림프구의 감소, 낮은 섬유화 양상과 침적 섬유모세포의 감소, 모세혈관 주변의 림프구 침적 감소와 비만세포 분포감소, 자유면과 섬유지지역분포 ICAM과 혈관주변분포VCAM 등과 같은 세포유착인자의 감소 등이 관찰되었다. 이상의 결과로 볼 때 大防風湯은 관절염 유발시 발생되는 혈관생성과 세포유착인자의 발현증가 등을 억제함으로써 이후 발생되는 윤활 관절막 손상을 완화하는 것으로 사료된다. Purpose : This study is to investigate the alleviation effects of Daebangpoongtang in LPS induced arthritis in mice knee joint. Methods : Daebangpoongtang was chosen to treat the arthritis caused by injecting 300 μg/kg LPS to mice knee joint. The control group had no treatment, while the LPS group was injected 300μg/kg LPS to mice knee joint and the DBP group was oral administrated of Daebangpoongtang. After injection of 300μg/kg LPS to mice knee joint, the alteration of synovial lining cell, vessel, fibrosis, distribution of collagen fiber, fibroblast, mast cell, infiltration of inflammation component cell and distribution of ICAM and VCAM was observed by light microscope(BX50). Results : In the DBP extract treatment group, the distribution of vessel, the enlargement of synovial lining cell layer, the synovial lining cells with filopodia, the fibrosis, the distribution of fibroblast in synovial membrane, the distribution of ICAM and VCAM on the knee joint was less than that of LPS group. Infiltrated lymphocyte into the apical surface had not observed in the DBP extract treatment group. The distribution of mast cell was as same as control group(no treatment group) and it showed granulated type. Conclusion : According to the above results, it might be considered that the administration of Daebangpoongtang has a curative effect on synovial membrane injury in arthritis by inhibiting increase of vessel, cell adhesion molecule(1CAM and VCAM) in LPS induced arthritis.
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李東垣,辛吉祚,李源哲 동국대학교 한의학연구소 1995 東國韓醫學硏究所論文集 Vol.4 No.-
This study was done in order to investigate the treatment of occidental and oriental medicine on dementia(mainly senile dementia and cerobrovascular dementia). The results were as fellows ; 1. Dementia must treat a direct causes, but uncountable dementia(senile dementia) and cerobrovascular dementia can't treat at present. 2. Sciopsychological treatment in very important in dementia patient : maintance of appropriate stlmulation psychological rest, physical examination, dietary cure and safety device is needed. On secondary mental disorder antipsychotics, anxiolytics and antidepressants have to proscribe properly. 3. Treatments of Senile dementia(uncountable cerebral degenerative disease) prescribed hydergine which is peripheral vasodilator and physostigmine which increase cholinergic activity (of brain, but this have slight effort on some patients. On treatments of cerobrovascular dementia, the medication that improved the cell metabolism and circulation of brain, this improved only a subjective symptom, but isn't foundamental treatment. 4. A tonic medicine is used basically, the methods are as folllows. 1) Kenwihwadam(建胃化痰) - Sesimtang(洗心湯) 2) Bosiniksu(補腎益髓) - Hwansodan(還少丹) 3) Bosimiksin(補心益腎) -- Gyuibitang(歸脾湯), Singyuo(神交湯) 4) Boheoansin(補虛安神) - Cilbokem(七福飮), sanggitang(生氣湯) 5) geoeohwalhyel(祛瘀活血) -tonggyuhwalhyeltang(通竅活血湯). 5. Acupuncture therapy on dementia used follow acupuncture point : Yamen(啞門 GV15), Laokung(勞宮 HC8), Tsusanli(足三里 ST36), Shenshu(腎兪 BL23), Tachui(大?? GVl4), Chiuwei(鳩尾 CV15). Sanyinchiao(三除交 SP6), Yungchuan(??泉 KIl), Shipsun(十宣), Shousanli(手三里 LI1O), Taichong(太衡 LV3) In moxibustion therapy, Dachui(大?? GVl4) point is used.
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Shin, Seul-Mee,Kim, Seul-Ah,Oh, Hee-Eun,Kong, Hyun-Seok,Shin, Eun-Ju,Do, Seon-Gil,Jo, Tae-Hyung,Park, Young-In,Lee, Chong-Kil,Kim, Kyung-Jae The Korean Association of Immunobiologists 2012 Immune Network Vol.12 No.3
Obesity-induced disorders contribute to the development of metabolic diseases such as insulin resistance, fatty liver diseases, and type 2 diabetes (T2D). In this study, we evaluated whether the Aloe QDM complex could improve metabolic disorders related to blood glucose levels and insulin resistance. Male C57BL/6 obese mice fed a high-fat diet for 54 days received a supplement of Aloe QDM complex or pioglitazone (PGZ) or metformin (Met) and were compared with unsupplemented controls (high-fat diet; HFD) or mice fed a regular diet (RD). RT-PCR and western blot analysis were used to quantify the expression of obesity-induced inflammation. Dietary Aloe QDM complex lowered body weight, fasting blood glucose, plasma insulin, and leptin levels, and markedly reduced the impairment of glucose tolerance in obese mice. Also, Aloe QDM complex significantly enhanced plasma adiponectin levels and insulin sensitivity via AMPK activity in muscles. At the same time, Aloe QDM decreased the mRNA and protein of $PPAR{\gamma}/LXR{\alpha}$ and scavenger receptors in white adipose tissue (WAT). Dietary Aloe QDM complex reduces obesity-induced glucose tolerance not only by suppressing $PPAR{\gamma}/LXR{\alpha}$ but also by enhancing AMPK activity in the WAT and muscles, both of which are important peripheral tissues affecting insulin resistance. The Aloe QDM complex could be used as a nutritional intervention against T2D.
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강알칼리 중독에서 약산을 이용한 중화요법의 유용성에 대한 실험적 연구 : In-vivo Study
조유환,조익준,신중호,이중의,서길준,윤여규 대한응급의학회 2003 대한응급의학회지 Vol.14 No.1
Purpose: This study was designed to prove the efficacy of neutralization with weak acid against strong alkali ingestion and to evaluate exothermic reaction of neutralization therapy. Methods: 30 New Zealand White rabbits were anesthetized with intravenous injection of ketamine and xylazine. After gastric lavage was done, a oro-gastric catheter and a electric thermometer probe were inserted into stomach. And then the rabbits were divided into six groups. The first group was given 3M NaOH 16.5 mL only. The second and third groups were given 3M NaOH 16.5 mL and then 1M CH₃COOH 52.14 mL one and three minutes later, respectively. The fourth and fifth groups were given tap water instead of CH₃COOH, and the sixth group was given CH₃COOH only. We monitored intra-gastric temperature continuously, compared arterial pHs before alkali infusion and 15 minutes later, measured gastric pH 15 minutes later, and examined pathologic findings of stomach after sacrificing. Results: There was no significant thermal effect in all groups, and gastric pH of neutralization groups was much lower than alkali alone or dilution groups. Changes of arterial pH after 15 minutes were greater in alkali alone and dilution groups than neutralization groups. In gross and microscopic findings of stomach, only mucosal injuries were observed in neutralization groups, especially in one minute group. But all stomach layers were destroyed in alkali alone and dilution groups. Conclusion: Neutralization therapy never makes additional thermal injury, and has protective effects against local tissue destruction and systemic alkalemia. Dilution therapy shows little or no effects.
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서울지역 대기오염과 급성관상동맥증후군 환자의 흉통 발생의 관계에 대한 연구
조익준,신중호,정성구,서길준,이중의,정연권,이창현,윤여규 대한응급의학회 2002 대한응급의학회지 Vol.13 No.3
Purpose: There have been some studies on the hazardous effects of air pollution for patients with cardiovascular diseases. This study was designed to evaluate the possible relationship between air pollution and development of chest pain in acute coronary syndrome patients. Methods: The medical records of 109 acute coronary syndrome patients, who visited two university hospital emergency rooms in the Seoul area between January 1999 and July 2001, were reviewed. Hourly concentrations of particulate mass< 10 μm and of four gaseous air pollutants were measured at 19 different points in the Seoul area. The data were analyzed using a case-crossover approach. Results: The analysis of the data showed no definite relationship between chest pain development and either the concentrations of particulate mass<10 μm(PM_10) or of four gaseous air pollutants; namely, carbon monoxide (CO), nitrogen dioxide(NO₂), ozone (O₃), and sulfur dioxide (SO₂). However, increases in the concentrations of particulate matter, gaseous NO₂and gaseous O₃showed a positive correlation, but without statistical significance. Conclusion: This study shows no relationship between the concentrations of PM10 and other air pollutants with the development of chest pain in acute coronary syndrome patients. However, for particulate mass<2.5μm, which is currently not measured in the Seoul area, the possibility of a relationship between development of chest pain in acute coronary syndrome patients and particulate air pollutants still exists.
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