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- 저자 : Shijie Dong (검색결과 2 건)
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Jie Chen,Yangjun Wu,Limin Zhang,Xiaolong He,Shijie Dong 대한기계학회 2020 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.34 No.5
Under dynamic conditions, the dynamic force between the suspended equipment and the car body is substantially increased. This increase not only affects the ride comfort but also substantially raises the likelihood of fatigue damage to the suspended equipment. A multiobjective analytical target cascading (ATC) optimization is proposed to improve the ride comfort of high-speed trains and reduce the vibration of the suspended equipment. A mathematical simulation model of the vehicle equipment system is established, and the acceleration frequency-response function expression of the car body and the suspension system is obtained. The comfort index of the car body and the acceleration root mean square (RMS) of the suspended equipment are calculated by combining the German vertical irregular track spectrum and the comfort filter function. Meanwhile, the ATC method is used to optimize the car body comfort index and the acceleration RMS of the underframe suspended equipment. Then, the availability of the optimization method is evaluated via numerical simulation. Compared with the original suspension scheme of the underframe equipment, when the running speed of the vehicle is 300 km/h, the RMS value of the vibrational acceleration of the underframe equipment after optimization decreases by 19.9 %, and the ride comfort indexes at the car body center and above the front and rear bogies are improved by 6.4 %, 0.1 %, and 1.1 %, respectively. Simulation results demonstrate that ATC optimization can improve the railway vehicle ride comfort and reduce the vibration of the suspended equipment. This paper provides a new approach to the suspension parameter design of equipment.
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Cyclooxygenase-2 Polymorphisms and Susceptibility to Colorectal Cancer: A Meta-Analysis
Jun Wang,Xufeng Guo,Jixiang Zhang,Jia Song,Mengyao Ji,Shijie Yu,Jing Wang,Zhuo Cao,Weiguo Dong 연세대학교의과대학 2013 Yonsei medical journal Vol.54 No.6
Purpose: Four polymorphisms, -765G>C, -1195G>A, 8473T>C, and Val511Ala, in the cyclooxygenase-2 (COX-2) gene were identified to be associated with colorectal cancer (CRC) risk. However, the results are inconsistent. The objective of this meta-analysis was to evaluate the association between these four polymorphisms and the risk of CRC. Materials and Methods: All eligible case-control studies published up to December 2012 on the association between the four polymorphisms of COX-2 and CRC risk were identified by searching PubMed and Web of Science. The CRC risk associated with the four polymorphisms of the COX-2 gene was estimated for each study by odds ratio (OR) together with its 95% confidence interval (CI), respectively. Results: A total of 15 case-control studies were included. Overall, no evidence has indicated that the -1195A allele, -765C allele, 8473C allele, and 511Ala allele are associated with susceptibility to CRC (-1195G>A: OR=1.11, 95% CI: 0.82-1.51, p=0.78; -765G>C: OR=1.08, 95% CI: 0.96-1.21, p=0.07; 8473T>C: OR=1.03, 95% CI: 0.89-1.18, p=0.91; Val511Ala:OR=0.71, 95% CI: 0.46-1.09, p=0.94). However, stratified analysis with ethnicity indicated that individuals with -765GC or GC/CC genotypes had an increased risk of CRC among Asian populations (GC vs. GG: OR=1.05, 95% CI: 0.87-1.28, p=0.03; GC+CC vs. GG: OR=1.08, 95% CI: 0.96-1.21, p=0.07). Conclusion: This meta-analysis indicated that -765G>C polymorphism was significantly associated with susceptibility to CRC in Asian populations.
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