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Shih-Feng Huang,Tze-Yun Lin 한국증권학회 2018 Asia-Pacific Journal of Financial Studies Vol.47 No.3
This study presents an example of the linearization of a complex mean-risk investment problem. The spectral risk measure is employed as a measure of risk and assets are assumed to have autocorrelation and conditionally heteroskedastic volatilities. Simulation results indicate that the proposed method saves a great deal of computational time. Empirical studies show that this strategy, implemented with certain trading frequency constraints, outperforms the equal-weighted portfolio, the classical mean-variance method, and the corresponding market index in Taiwan, the US, and Japan when considering transaction costs and different economic conditions.
Yun-Chieh Tsai,Yu-Chen Lin,Chun-Chih Huang,Oliver B. Villaflores,Tzong-Yuan Wu,Shih-Ming Huang,Ting-Yu Chin 한국식품영양과학회 2019 Journal of medicinal food Vol.22 No.5
Aging and lifestyle factors, including high-sugar and high-fat diets, promote a systemic metabolic imbalance that promotes neurodegeneration. Hericium erinaceus has long been used in traditional Chinese medicine. Recently, its functional activities, such as antimetabolic dysfunction, antineuroinflammatory activities, and stimulation of nerve growth factor (NGF) synthesis, have been revealed. This study demonstrated that Hericium erinaceus mycelium (HEM) and an isolated diterpenoid derivative, erinacine A (EA), may reverse spatial learning disabilities in aging mice (15 months old) fed with a high-fat and high-sucrose diet (HFSD). Aging mice were randomly assigned to one of four treatment groups: (1) a chow diet (control), (2) an HFSD, and an HFSD supplemented with either (3) HEM or (4) EA for 18 weeks. The Morris water maze (MWM) and Y-maze were used for behavioral assessments. Both HEM- and EA-treated mice had shorter mean daily escape latencies than HFSD-treated mice in the MWM. In addition, HEM-treated mice had a slightly increased exploratory time and frequency in the novel arm in the Y-maze. Quantitative PCR revealed that both HEM- and EA-treated mice exhibited reduced messenger RNA (mRNA) expression of tumor necrosis factor-α, interleukin-1β, and HEM-treated mice exhibited increased mRNA expression of NGF and NeuN in the hippocampus. Moreover, HEM and EA also decreased body weight, abdominal fat, plasma glucose, serum and liver total cholesterol, and liver triacylglycerol. Thus, HEM may be a potential health-promoting supplement for minimizing the progression of aging and obesity-induced neurodegeneration by reducing metabolic abnormalities and neuroinflammatory cytokines and increasing neurogenesis factors.
Load Voltage Tracking of Electric Power Systems by Using Backstepping Design
Der-Cherng Liaw,Shih-Tse Chang,Yun-Hua Huang,Jen-Tze Huang,Tzu-Chung Yenn 제어로봇시스템학회 2009 제어로봇시스템학회 국제학술대회 논문집 Vol.2009 No.8
A backstepping controller design is proposed for the load voltage tracking of electric power system. It is known that a power system might exhibit saddle-node and Hopf bifurcations as load change, which can lead to the appearance of dynamic and/or static voltage collapses. The output tracking control laws are proposed for the load voltage regulation of the electric power system via backstepping control scheme. The numerical simulations demonstrate that the proposed control scheme not only could provide the regulation of the load voltage but also prevent and/or delay the appearance of bifurcation phenomena and chaotic behavior.
Resource Management in 5G Mobile Networks: Survey and Challenges
Wei-Che Chien,Shih-Yun Huang,Chin-Feng Lai,Han-Chieh Chao 한국정보처리학회 2020 Journal of information processing systems Vol.16 No.4
With the rapid growth of network traffic, a large number of connected devices, and higher application services, the traditional network is facing several challenges. In addition to improving the current network architecture and hardware specifications, effective resource management means the development trend of 5G. Althoughmany existing potential technologies have been proposed to solve the some of 5G challenges, such as multipleinput multipleoutput (MIMO), softwaredefined networking (SDN), network functions virtualization (NFV), edge computing, millimeterwave, etc., research studies in 5G continue to enrich its function and move toward B5G mobile networks. In this paper, focusing on the resource allocation issues of 5G core networks and radio access networks, we address the latest technological developments and discuss the current challenges for resource management in 5G.
Angel Chao,Yi-Hao Lin,Lan-Yan Yang,Ren-Chin Wu,Wei-Yang Chang,Pi-Yueh Chang,Shih-Cheng Chang,Chiao-Yun Lin,Huei-Jean Huang,Cheng-Tao Lin,Hung-Hsueh Chou,Kuan-Gen Huang,Wen-Ling Kuo,Ting-Chang Chang,Ch 대한부인종양학회 2020 Journal of Gynecologic Oncology Vol.31 No.3
Objective: The characteristics of patients with metachronous breast and ovarian malignancies and the pathogenic role of BRCA1/2 mutations remain poorly understood. We investigated these issues through a review of hospital records and nationwide Taiwanese registry data, followed by BRCA1/2 mutation analysis in hospital-based cases. Methods: We retrospectively retrieved consecutive clinical records of Taiwanese patients who presented with these malignancies to our hospital between 2001 and 2017. We also collected information from the Data Science Center of the Taiwan Cancer Registry (TCR) between 2007 and 2015. Next-generation sequencing and multiplex ligation-dependent probe amplification were used to identify BRCA1/2 mutations and large genomic rearrangements, respectively. When BRCA1/2 mutations were identified in index cases, pedigrees were reconstructed and genetic testing was offered to family members. Results: A total of 12,769 patients with breast cancer and 1,537 with ovarian cancer were retrieved from our hospital records. Of them, 28 had metachronous breast and ovarian malignancies. We also identified 113 cases from the TCR dataset. Eighteen hospital-based cases underwent BRCA1/2 sequencing and germline pathogenic mutations were detected in 7 patients (38.9%, 5 in BRCA1 and 2 in BRCA2). All BRCA1/2 mutation carriers had ovarian high-grade serous carcinomas. Of the 12 patients who were alive at the time of analysis, 5 were BRCA1/2 mutation carriers. All of them had family members with BRCA1/2-associated malignancies. Conclusions: Our results provide pilot evidence that BRCA1/2 mutations are common in Taiwanese patients with metachronous breast and ovarian malignancies, supporting the clinical utility of genetic counseling.