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Baek, Seung Hoon,Roh, Jihyeok,Park, Chan Yeong,Kim, Min Woo,Shi, Rongjia,Kailasa, Suresh Kumar,Park, Tae Jung Elsevier 2020 Materials Science and Engineering C Vol.107 No.-
<P><B>Abstract</B></P> <P>A novel electrospinning approach is proposed for the fabrication of copper (Cu)-nanoflower decorated gold nanoparticles (AuNPs)-graphene oxide (GO) nanofiber (NF) as an electrochemical biosensor for the glucose detection. In this study, GO was mixed with poly(vinyl alcohol) (PVA) and used as a fiber precursor, which greatly improves the electrochemical properties. The above solution was uniformly coated onto the surfaces of gold chip to form GO NFs <I>via</I> electrospinning. AuNPs were coated onto the surface of GO NFs and then incorporated organic-inorganic hybrid nanoflower [Cu nanoflower-glucose oxidase (GOx) and horseradish peroxidase (HRP)]. The electrochemical experiments revealed that Cu-nanoflower@AuNPs-GO NFs exhibited outstanding electrochemical catalytic nature, and selectivity for the conversion of glucose to gluconic acid in the presence of GOx-HRP-Cu nanoflower. The Cu-nanoflower@AuNPs-GO NFs coated Au chip exhibited good linear range 0.001–0.1 mM, with a detection limit of 0.018 μM. The Cu-nanoflower@AuNPs-GO NFs modified Au chip exhibited higher catalytic properties, which are attributed to the coating of unique organic-inorganic nanostructured materials on the surfaces of Au chip. These results indicate that the nano-bio hybrid materials can be applied as a promising electrochemical biosensor to monitor glucose levels in biofluids.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Graphene oxide (GO)/polyvinyl alcohol nanofiber (NF) as an electrochemical sensor. </LI> <LI> One-step synthesis of organic-inorganic hybrid nanoflower for glucose detection. </LI> <LI> Cu-nanoflower@gold nanoparticles-GO NFs for electrochemical biosensing of glucose. </LI> <LI> The modified gold chip exhibited a low detection limit of 0.018 μM for glucose. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>