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Baek, Seung Hoon,Roh, Jihyeok,Park, Chan Yeong,Kim, Min Woo,Shi, Rongjia,Kailasa, Suresh Kumar,Park, Tae Jung Elsevier 2020 Materials Science and Engineering C Vol.107 No.-
<P><B>Abstract</B></P> <P>A novel electrospinning approach is proposed for the fabrication of copper (Cu)-nanoflower decorated gold nanoparticles (AuNPs)-graphene oxide (GO) nanofiber (NF) as an electrochemical biosensor for the glucose detection. In this study, GO was mixed with poly(vinyl alcohol) (PVA) and used as a fiber precursor, which greatly improves the electrochemical properties. The above solution was uniformly coated onto the surfaces of gold chip to form GO NFs <I>via</I> electrospinning. AuNPs were coated onto the surface of GO NFs and then incorporated organic-inorganic hybrid nanoflower [Cu nanoflower-glucose oxidase (GOx) and horseradish peroxidase (HRP)]. The electrochemical experiments revealed that Cu-nanoflower@AuNPs-GO NFs exhibited outstanding electrochemical catalytic nature, and selectivity for the conversion of glucose to gluconic acid in the presence of GOx-HRP-Cu nanoflower. The Cu-nanoflower@AuNPs-GO NFs coated Au chip exhibited good linear range 0.001–0.1 mM, with a detection limit of 0.018 μM. The Cu-nanoflower@AuNPs-GO NFs modified Au chip exhibited higher catalytic properties, which are attributed to the coating of unique organic-inorganic nanostructured materials on the surfaces of Au chip. These results indicate that the nano-bio hybrid materials can be applied as a promising electrochemical biosensor to monitor glucose levels in biofluids.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Graphene oxide (GO)/polyvinyl alcohol nanofiber (NF) as an electrochemical sensor. </LI> <LI> One-step synthesis of organic-inorganic hybrid nanoflower for glucose detection. </LI> <LI> Cu-nanoflower@gold nanoparticles-GO NFs for electrochemical biosensing of glucose. </LI> <LI> The modified gold chip exhibited a low detection limit of 0.018 μM for glucose. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
나노-바이오기술 기반의 바이오인터페이스 센서 산업 동향
백승훈(Seung Hoon Beak),김민우(Min Woo Kim),박찬영(Chan Yeong Park),노지혁(Jihyeok Roh),박태정(Tae Jung Park) 한국진공학회 2020 진공 이야기 Vol.6 No.3
A nano-biosensor is a kind of analytical device able to recognize a specific target molecule after the biological interaction then generate a specific signal in the form of an electrical, optical, or mechanical response. Since these types of interactions demonstrate high specificity and selectivity, they have been contributed to various fields including food hygiene, environmental monitoring, management, drug discovery research, and disease diagnosis. Moreover, it realized the miniaturization of instruments like as wearable biosensors due to requiring a small volume of sample. In the case of wearable biosensors, especially, it has been focused on substantial interest in many studies due to various properties such as continuous reflection of conditions and its mobility. As these types of monitoring approaches are well-matched with future needs, these strategies have a prospect, and this technology would have a broad impact on our daily lives.