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Shao-Mei Yang,Fu-Nan Li,Zhi-Ning Huang,Zhong-Shi Zhou,Jin Hou,Man-Yi Zheng,Li-Juan Wang,Yu Jiang,Xin-Yi Zhou,Qiu-Yue Chen,Shan-Hua Li 대한약학회 2015 Archives of Pharmacal Research Vol.38 No.10
To identify novel therapeutic agents to treatcancer, we synthesized a series of diaryl ether derivatives. Structure–activity relationship studies revealed that thepresence of a chlorine or hydroxyl at the para-position onthe phenyl ring (5h or 5k) significantly enhanced antitumoractivity. Compound 5h had stronger growth inhibitory activityin HepG2, A549, and HT-29 cells than compound 5k,with IC50 values of 2.57, 5.48, and 30.04 lM, respectively. Compound 5h also inhibited the growth of other cells lines,including Hep3B, PLC/PRF5, SMMC-7721, HeLa, andA375, with IC50 values of 2.76, 4.26, 29.66, 18.86, and10.21 lM, respectively. The antitumor activity of compound5h was confirmed by a colony forming assay. Further,our results indicated that the antitumor activity ofcompound 5h may be mediated by enhancing expression ofp21 and cl-caspase3, and leading to apoptosis of cancercells.
Hui Shao,Tian-hong Liu,Cong-Fu Ran,Li-Qun Li,Jing Yu,Xin Gao,Xue-Jun Li 한국유전학회 2015 Genes & Genomics Vol.37 No.1
High molecular weight glutenin subunits(HMW-GS) play a significant role in determining breadmakingqualities of common wheat flour. The study presentedin the paper identified two novel HMW-GS (designatedas 1Bx14* and 1By15*) at the Glu-B1 locus inChinese wheat (Triticum aestivum L.) landrace Banjiemangby SDS-PAGE. The open reading frames (ORFs) of thegenes were amplified and cloned with designed specificprimers. Both of them had sequences highly similar tothose of other HMW-GS genes, but displayed minormodification. The ORF of 1Bx14* was 2367 bp long andencoded 789 aa with 4 cysteines, which included 25nanopeptides, 65 hexapeptides and 7 tripeptides motifs. The ORF of 1By15* was 2106 bp long and encoded 702 aawith 7 cysteines, which included 23 nanopeptides and 53hexapeptides motifs. The predicted molecular weights ofthe mature proteins encoded by 1Bx14* and 1By15* geneswere 83.1 and 73.2 k Da, respectively. The presence andauthenticity of the two genes in Banjiemang were confirmedby bacterial expression and liquid chromatographyelectrosprayionization mass spectrometry (LC–ESI–MS). By phylogenetic analysis, the 1Bx14* was clustered withx-type subunits but had a high divergence with other 1Bxsubunits, whereas the 1By15* was clustered with y-typesubunits and closely related to subunit 1By15. The studyconcluded that 1Bx14* and 1By15* from Banjiemang werenovel allelic variations of HMW-GS at Glu-B1 locus,which were probably exploitable as new resources forwheat quality improvement.
Li, Jie,Yang, Chun-Xu,Mei, Zi-Jie,Chen, Jing,Zhang, Shi-Min,Sun, Shao-Xing,Zhou, Fu-Xiang,Zhou, Yun-Feng,Xie, Cong-Hua Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.10
Cancer patients often suffer from local tumor recurrence after radiation therapy. Cell cycling, an intricate sequence of events which guarantees high genomic fidelity, has been suggested to affect DNA damage responses and eventual radioresistant characteristics of cancer cells. Here, we established a radioresistant lung cancer cell line, A549R, by exposing the parental A549 cells to repeated ${\gamma}$-ray irradiation with a total dose of 60 Gy. The radiosensitivity of A549 and A549R was confirmed using colony formation assays. We then focused on examination of the cell cycle distribution between A549 and A549R and found that the proportion of cells in the radioresistant S phase increased, whereas that in the radiosensitive G1 phase decreased. When A549 and A549R cells were exposed to 4 Gy irradiation the total differences in cell cycle redistribution suggested that G2-M cell cycle arrest plays a predominant role in mediating radioresistance. In order to further explore the possible mechanisms behind the cell cycle related radioresistance, we examined the expression of Cdc25 proteins which orchestrate cell cycle transitions. The results showed that expression of Cdc25c increased accompanied by the decrease of Cdc25a and we proposed that the quantity of Cdc25c, rather than activated Cdc25c or Cdc25a, determines the radioresistance of cells.
Growth and Differentiation Effects of Homer3 on a Leukemia Cell Line
Li, Zheng,Qiu, Hui-Ying,Jiao, Yang,Cen, Jian-Nong,Fu, Chun-Mei,Hu, Shao-Yan,Zhu, Ming-Qing,Wu, De-Pei,Qi, Xiao-Fei Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.4
The Homer protein family, also known as the family of cytoplasmic scaffolding proteins, which include three subtypes (Homer1, Homer2, Homer3). Homer3 can regulate transcription and play a very important role in the differentiation and development for some tissues (e.g. muscle and nervous systems). The current studies showed that Homer3 abnormal expression changes in acute myeloid leukemia (AML). Forced expression of Homer3 in transfected K562 cells inhibited proliferation, influenced the cell cycle profile, affected apoptosis induced by $As_2O_3$ through inhibition of Bcl2 expression, and also promoted cell differentiation induced by 12-O-tetra decanoylphorbol-acetate (TPA). These results showed that Homer3 is a novel gene which plays a certain role in the occurrence and development of AML.
The Study of Criteria Weight for Taiwan National Quality Award by Fuzzy Hierarchical Analysis
Li, Shao-Chang,Fu, Hsin-Pin The Korean Society for Quality Management 2006 The Asian Journal on Quality Vol.7 No.2
In this paper, fuzzy hierarchical analysis (FHA) is used to explore the process by which the criteria weights of the Taiwan National Quality Award (TNQA) are assigned by TNQA committee members. Each member is allowed to employ fuzzy scales in place of exact scales. Each pairwise comparison of criteria is made through a questionnaire from each TNQA committee member. The membership function of trapezoidal fuzzy numbers is introduced to specify TNQA committee members' intentions. After FHA, the reasonable range of each criterion weight of TNQA is determined. The current criteria weights of TNQA are properly verified.
한영택,Shao-Mei Yang,Xiao-Yuan Wang,Fu-Nan Li 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.4
Design, synthesis and biological evaluation ofB-region, known to be a dipolar interacting pharmacophore,modified diarylalkyl amide analogues for novelTRPV1 (transient receptor potential channel, vanilloidsubfamily member 1) antagonists was described. A varietyof moieties including guanidines, heterocyclic rings, cinnamides,and a-substituted acetamides were introduced atthe B-region. TRPV1 antagonistic activities of these analogueswere evaluated by 45Ca2? uptake assay in rat DRGneuron. In particular, a,a-difluoroamide 53 exhibited3-fold more potent TRPV1 antagonistic activity (IC50 =0.058 lM) than the parent amide analogue 6.
Zhong-fu Liu,Jun-xing Zhang,Shao-min Li 보안공학연구지원센터 2016 International Journal of Smart Home Vol.10 No.8
Intelligent greenhouse monitoring technique is an efficient agricultural control technique emerging recently. The threshold value control of the switching value is the most-adopted greenhouse control method. Due to unique characteristics of greenhouse, the existing monitoring style cannot meet the great demand of greenhouse for intensive monitoring. Concerning the monitoring demands of the greenhouse and based on the technique of Internet of Things, this paper introduces the multisensory fusion technique to the intelligent greenhouse monitoring system. The greenhouse environmental monitoring system based on ZigBee is built, and a two-layer fusion method of “sensor+aggregation node” is put forward. The Kalman filtering method and the weighted average method are employed to conduct sensor node fusion and aggregation node fusion, respectively. An experiment is carried out to verify the built model with the experimental results suggesting that the two-layer fusion method can improve the measurement accuracy and stability of the greenhouse environmental monitoring system.
Chuanhe Li,Ruiqi Shao,Chunhong Wang,Guangwei Fu,Bingjie Yang 한국섬유공학회 2023 Fibers and polymers Vol.24 No.10
Quality characteristics of blended yarns, which play an important role in textile quality, are continually assessed by softness, breaking strength, breaking elongation, hairiness, irregularity, etc. In this study, hemp was softened and blended with other cellulose fibers with better softness to produce yarns. The softness of hemp is obviously lower than that of the other two fibers. With the increase of hemp fiber percentage content, the yarn properties deteriorated. Therefore, the softening treatment of hemp fiber is very necessary. Moreover, the blending hemp, cotton, and viscose in the yarn structure provided synergies, improving the weak properties of ternary fibers. Results show that softening treatment and lower percentage content of the hemp fiber will result in better yarn quality, which is consistent with the derivation result of the bending theoretical model. When the percentage content of treated hemp is 40 wt%, the overall performance of blended yarn is the best. Compared with the untreated hemp-based ternary blended yarns, the hairiness of blended yarn is significantly less (3.65 ends/m, compared to 12.23 ends/m), and the irregularity of yarn is lower (27.33% and 27.70%, respectively), yarn quality improved considerably. In addition, the resulting hemp yarn showed antibacterial activity against Escherichia coli and Staphylococcus aureus.