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      • KCI등재

        Phytochemical composition, protective and therapeutic effect on gastric ulcer and a-amylase inhibitory activity of Achillea biebersteinii Afan.

        Howaida I. Abd-Alla,Nagwa M. M. Shalaby,Manal A. Hamed,Nagy Saba El-Rigal,Samira N. Al-Ghamdi,Jalloul Bouajila 대한약학회 2016 Archives of Pharmacal Research Vol.39 No.1

        Three sesquiterpene lactones [two germacranolides (micranthin and sintenin) and one guaianolide (4b,10adihydroxy- 5b,7b,8bH-guaia-1,11(13)dien-12,8a-olide)] and four derivatives of 3-methoxy flavones (santin, quercetagetin- 3,6,30-trimethyl ether, quercetagetin-3,6-dimethyl ether, and 5,7 dihydroxy 3,30,40-trimethoxy flavone) were isolated from the ethyl acetate extract (EAE) of the aerial parts of Achillea biebersteinii Afan. (Asteraceae). Evaluation of protective and therapeutic effects of EAE against ethanol-induced gastric ulcer in rats was carried. Antiulcer activity evaluation was done through measuring ulcer indices, stomach acidity, gastric volume and lesion counts. Oxidative stress markers; malondialdehyde, glutathione and superoxide dismutase were also estimated. The work was extended to determine the histopathological assessment of the stomach. Gastric ulcer exhibited a significant elevation of the ulcer index and oxidative stress markers. The extract attenuated these increments and recorded protective and therapeutic effects against gastric ulcer. Hyperglycaemia increases the mucosal susceptibility to ulcerogenic stimuli and predisposes gastric ulceration. In vitro a-amylase inhibitory assay was applied to evaluate the post prandial antihyperglycaemia activity. The result showing that the EAE has the ability to reduce starch-induced postprandial glycaemic excursions by virtue of potent intestinal a-amylase inhibitory activity. These findings demonstrated the remarkable potential of A. biebersteinii as valuable source of antiulcer agent with post prandial hyperglycaemia lowering effect.

      • KCI등재

        Parametric study of shear strength of CFRP strengthened end-web panels

        Haitham A. Shalaby,Maha M. Hassan,Sherif S. Safar 국제구조공학회 2019 Steel and Composite Structures, An International J Vol.31 No.2

        Strengthening of civil infrastructure with advanced composites have recently become one of the most popular methods. The use of Fiber Reinforced Polymer (FRP) strips plates and fabric for strengthening of reinforced concrete structures has well established design guidelines and standards. Research on the application of FRP composites to steel structures compared to concrete structures is limited, especially for shear strengthening applications. Whereas, there is a need for cost-effective system that could be used to strengthen steel high-way bridge girders to cope with losses due to corrosion in addition to continuous demands for increasing traffic loads. In this study, a parametric finite element study is performed to investigate the effect of applying thick CFRP strips diagonally on webs of plate girders on the shear strength of end-web panels. The study focuses on illustrating the effect of several geometric parameters on nominal shear strength. Hence, a formula is developed to determine the enhancement of shear strength gained upon the application of CFRP strips.

      • Increasing Antimicrobial Resistance Monitored in Surveillance Analysis of Blood Stream Infections in Febrile Neutropenic Pediatric Oncology Patients

        El-Mahallawy, Hadir A,Hassan, Safaa Shawky,El-Wakil, Mohamed,Moneer, Manar M,Shalaby, Lobna Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.14

        Background: Continuous surveillance of pattern of blood stream infection is necessary in febrile neutropenia (FN)especially with the recent escalating trend in the management of pediatric cancer patients towards intensified regimens and with the increase in infections caused by resistant organisms limiting the choice of antibiotics. Aim: To monitor change in pattern of blood stream infections (BSI) in FN pediatric cancer patients. Materials and Methods: Surveillance of FN episodes with positive BSI was prospectively monitored and compared to a previous surveillance in the same pediatric oncology unit. Results: A total of 232 BSI positive episodes were documented in 192 patients during a 6 months period. The results of recent surveillance analysis showed an increase in intensified regimens of chemotherapy, antimicrobial resistance, fungal infections, and prolonged duration of episodes when compared to previous surveillance, with p value sof <0.001, 0.005, 0.021, and <0.001, respectively. There was an apparent decrease in the crude mortality but this was not statistically significant, to 6% in 2011 from 10 % in 2006. Conclusions: The pattern of BSI at our institution is still inclining towards gram positive organisms but is showing a shift towards more antibiotic resistance and fungal infections.

      • KCI등재후보

        The role of type II FB (I):Tl+ defect in laser light generation and color image formation at the low coordination surface sites of AgBr: ab initio calculations

        A.S. Shalabi,A.S. Algaber,N.K. Madi,Kh.M. Eid,Z.M. Fathy 한국물리학회 2006 Current Applied Physics Vol.6 No.1

        The role of type IIFB (I):Tl+ color center at low coordination surface sites of AgBr thin lms in providing tunable laser activitystructure calculations. Clusters of variable sizes were embedded in simulated Coulomb elds that closely approximate the Madelungelds of the host surfaces, and ions that are the nearest neighbors to theFB defect site were allowed to relax to equilibrium in eachcase. The calculated Stokes shifted optical transition bands suggest that laser activity is relatively weak and fades quickly as thecoordination number of the surface ions decreases from 5 (at) to 4 (edge) to 3 (corner). An attempt has been made to explain thesesurfaces were deep below the lower edges of the conduction bands of the ground-state defect-free surfaces indicating that type IIFB(I):Tl+ is suitable laser defect. The probability of orientational destruction of the two centers, attributed to the assumed saddlepoint ion congurations along theh110i axis, was found to decrease as the coordination number of the surface ions decreases. Thepossibility of exciton (energy) transfer between sites of dierent coordination numbers was claried. The GlasnerTompkins empir-ical relation was generalized to include type IIFB (I):Tl+ doped surfaces. As far as photographic sensitization is concerned, a super-sensitizer increases the sensitizing capabilities of the two examined dye molecules by increasing the relative yield of quantumeciencyU.FA sensitizes the low coordination surface sites of the defect free AgBr by lowering the bottoms of the conductionbands. The dierence in the sensitizing capabilities between the two examined dyes was estimated by calculating the quasi Fermilevels.

      • F2+ defect based model for tunable laser activity and interaction of atomic halogens (F, Cl and Br) at the low coordinated surfaces of LiH: ab initio calculations

        A. S. Shalabi 한국물리학회 2002 Current Applied Physics Vol.2 No.3

        The twofold potential ofFþ2 sorption properties for atomic halogens is examined using ab initio calculations.Based on Stokes shifts of the examined clusters, theFþ2 laser activity was very weak, but increases signicantly as the coordination number decreases from 5 (at) to 4 (edge) to 3 (H.corner).The corner site is the least probable for relaxed excited state orientational destruction ofFþ2 .The exciton (energy) transfersurfaces of LiH.TheFþ2 color center change the nature of halogensurface interaction from physical adsorption to chemical ad-sorption.The halogensurface interactions were monotonically increasing functions of the electronegativity of the halogen and theamount of charge transferred between the halogen and the surface.The ‘‘covalent spin pairing’’ mechanism play the dominant rolein the course of adsorbatesubstrate interactions.. 2002 Elsevier Science B.V. All rights reserved.

      • FA(Ga+, In+, Tl+) tunable laser activity and interaction of halogen atoms (F, Cl, Br, I, At) at the (001) surface of KCl crystal:ab initio calculations

        A.S.Shalabi,T.F.El-Essawy,M.M.Assem,S.Abdel-Aal,A.M.El-Mahdy 한국물리학회 2002 Current Applied Physics Vol.2 No.2

        An attempt has been made to examineFA(Gaþ ;Inþ ;Tlþ ) tunable laser activity and adsorptivity of halogen atoms (F;Cl;Br;I;At)at the (001) surface of KCl crystal using an embedded cluster model, CIS and density functional theory calculations with eectivecore potentials. The ion clusters were embedded in a simulated Coulomb eld that closely approximates the Madelung eld at thehost surface. The nearest neighbor ions to the defect site were then allowed to relax to equilibrium. Based on the calculated strengthFA(Tlþ ) center was found to be the most laser active inagreement with the experimental observation that the optical emissions ofFA(Inþ ) and FA(Gaþ ) centers were strongly quenched.The disappearance of the anisotropy and np splitting observed in the absorption ofFA(Gaþ ;Inþ ;Tlþ ) centers were monotonicallyincreasing functions of the size of the impurity cation. TheFA(Gaþ ;Inþ ;Tlþ ) defect formation energies followed the orderFAðGaþ Þ> FAðInþ Þ> FAðTlþ Þ. The GlasnerTompkins empirical relationship between the principal optical absorption ofFcentersin solids and the fundamental absorption of the host crystal was generalized to include the positive ion species. As far as the ad-sorptivity of the halogen atoms is concerned, theF and FA(Inþ ;Tlþ physical adsorption to chemical adsorption. The adsorption energies were monotonically increasing functions of the electroneg-ativity of the halogen and the amount of charge transferred from the defect-free surface. The calculated adsorption energies wereexplainable in terms of the electron anity, the eective nuclear charge and the electrostatic potentials at the surface. The spinpairing mechanism played the dominant role in the course of adsorbatesubstrate interactions and the KCl defect-free surface can bemade semiconducting byF or FA(Inþ ;Tlþ ) surface imperfections.. 2001 Elsevier Science B.V. All rights reserved.

      • KCI등재후보
      • SCOPUSKCI등재

        Effect of β-Blocker Inhibitors on Aluminum Corrosion

        Fouda, A. S.,El-Ewady, G. Y.,Shalabi, K. Korean Chemical Society 2011 대한화학회지 Vol.55 No.2

        베타 차단제 억제제(atenolol, propranolol, timolol and nadolol)의 존재와 부존 하에서 0.1M HCl 용액에 담긴 알루미늄의 부식작용을 연구하였다. 이 연구에 무게감량, 변전위 편극, 전기화학 임피던스 분석법이 사용되었다. 억제 효과는 억제제의 농도 증가에 따라 증가하였으며, 온도가 증가함에 따라 감소하였다. 모든 억제제들은 Frumkin 등온을 따르는 알루미늄 표면에 흡착되었다. 부식반응은 전하이동과정에 의해 조절됨을 발견하였다. 억제 효과 측정을 위해 사용된 실험방법 들에 대해 조사한 결과 모두 억제효과가 우수하였다. Corrosion of aluminum in 0.1 M HCl solution in the absence and presence of ${\beta}$-blocker inhibitors (atenolol, propranolol, timolol and nadolol) was investigated using weight loss, potentiodynamic polarization and electrochemical impedance spectroscopy (EIS) techniques. The inhibition efficiency increased with inhibitor concentration and decreased with rise of temperature. Potentiodynamic polarization curves revealed that they acted as cathodic inhibitors. Some thermodynamic parameters were calculated and discussed. All inhibitors were adsorbed on Al surface obeying Frumkin isotherm. All EIS tests exhibited one capacitive loop which indicates that the corrosion reaction is controlled by charge transfer process. The inhibition efficiencies of all test methods were in good agreement.

      • SCIESCOPUSKCI등재

        The Effect of Feeding Mannan-Oligosaccharides (Bio-MOS) on the Performance of Meat Chickens under Two Different Vaccination Programs

        Shafey, T.M.,Al-Mufarej, S.,Shalaby, M.I.,Jarelnabi, A.J. Asian Australasian Association of Animal Productio 2001 Animal Bioscience Vol.14 No.4

        The effects of feeding a mannan oligosaccharide (Bio-Mos) from 0 to 3 g/kg diet and vaccination program on 1- to 35-day performance (growth and feed efficiency), metabolizable energy, nitrogen utilization and carcass composition of meat chickens were investigated. A general vaccination program was used against IB, IBD and ND with half of the birds per diet receiving a booster dose of IB and ND vaccines at 12 days of age. Dietary supplementation of Bio-Mos (BM) did not influence body weight gain, feed efficiency and nutrient utilization. The highest dietary BM (3 versus 1.5 or 0 g/kg) increased carcass abdominal fat and reduced the proportion of drumstick in the carcass of meat chickens. The booster dose reduced the performance of birds. It was concluded that the addition of BM to the diet of chickens did not significantly influence the performance and nutrient utilization of meat chickens.

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