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Shaji, Nitheesha,Santhoshkumar, P.,Nanthagopal, Murugan,Senthil, Chenrayan,Lee, Chang Woo Elsevier 2019 APPLIED SURFACE SCIENCE - Vol.491 No.-
<P><B>Abstract</B></P> <P>The performance of existing lithium-ion batteries (LIBs) is greatly hindered by the low specific capacity of graphite-based anodes (372 mAh g<SUP>−1</SUP>). Therefore, development of suitable anode materials that exhibit higher and stable capacity is necessary to improve performance. Transition metal oxides have attracted tremendous attention as next-generation anode materials for LIBs due to their high theoretical capacity. Herein, we report the synthesis of a porous CaFe<SUB>2</SUB>O<SUB>4</SUB> by a facile and time efficient solution combustion synthesis technique for use in an anode for LIBs. The as-prepared material exhibited improved electrochemical performance with specific discharge capacities of 441 mAh g<SUP>−1</SUP>, 518 mAh g<SUP>−1</SUP>, and 516 mAh g<SUP>−1</SUP> for the initial three cycles. It achieved stability with a deliverable specific discharge capacity of 551 mAh g<SUP>−1</SUP> after 150 cycles at a current density of 200 mA g<SUP>−1</SUP>. The porous CaFe<SUB>2</SUB>O<SUB>4</SUB> exhibits improved cyclic performance and rate capability. These improvements are attributed to the porous nature of active material and, more importantly, the presence of CaO, which effectively alleviates the volume changes by acting as a buffer matrix.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Porous CaFe<SUB>2</SUB>O<SUB>4</SUB> has been synthesized by a facile solution combustion synthesis technique. </LI> <LI> Mixed-metal oxides possessing electrochemically active-inactive constituents are reported. </LI> <LI> The porous CaFe<SUB>2</SUB>O<SUB>4</SUB> as an anode for LIBs exhibited improved electrochemical performances. </LI> <LI> The porous structure and the buffer matrices of CaO are owed for their improved activity. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Silica-coated solid lipid nanoparticles enhance antioxidant and antiradical effects of meloxicam
Jessy Shaji,Dhanila Varkey 한국약제학회 2013 Journal of Pharmaceutical Investigation Vol.43 No.5
Oxidative stress and decreased antioxidant status are the hallmarks in patients suffering from rheumatoid arthritis. A targeted nanocarrier can enhance the therapeutic efficacy of meloxicam, a preferential cyclooxygenase-2 inhibitor with potential suppressive effects on free-radical mediated damage. Silica-coated solid lipid nanoparticles of meloxicam were fabricated by melt emulsification ultrasound homogenization technique and characterized for formation, morphology, morphometrical properties, drug entrapment, drug release pattern and storage stability. The in vitro antioxidant potential of lipid nanoparticles was evaluated by various antiradical and antioxidant assays including 1,1-diphenyl-2-picryl-hydrazil free radical scavenging, nitric oxide radical inhibition, lipid peroxidation, hydroxyl radical scavenging and superoxide anion radical scavenging activity. Lipid nanoparticles were successfully characterized for morphometrical parameters by photon correlation spectroscopy measurements. Transmission electron microscopy and atomic force microscopy studies confirmed the production of lipid nanoparticles. Meloxicam was successfully encapsulated within the lipid matrix as indicated by high drug entrapment efficiency,Fourier transform infrared spectroscopy and powder X-ray diffraction studies. The drug release from lipid nanoparticles exhibited a biphasic release pattern with good storage stability. Free radical scavenging activity of silica-coated meloxicam loaded solid lipid nanoparticles in all assays was higher than the free drug and was found to increase in a dose dependent manner. A nanocarrier based delivery system of meloxicam potentiates its free radical suppression effects and can further enhance its therapeutic efficacy in the management of rheumatoid arthritis.
Sonic Impinging Jet Flows in an Industrial Air Knife
Kannan Shaji,Seok Woo Son,Abhilash Suryan,Heuy Dong Kim 대한기계학회 2021 대한기계학회 춘추학술대회 Vol.2021 No.11
Gas jet wiping is a recommended process to remove the fluid layer thickness over a solid surface. Recently air knifes are being chosen as a novel device in various processes such as hot dip galvanization, paper and photographic film production (1) etc. Impinging jet flow also plays an important role in the quenching process. After the rapid cooling process, an air knife is employed for removing the fluid particles precipitated over the solid surface (2). Since the quality and the defect rate of the product directly depend upon the particle removal performance of the air knife, the production cost can be minimalized by optimizing the wiping gas jet. The current work focuses on the Computational Fluid Dynamics stimulation of an industrial air knife jet flow, impinging on the water layer over a solid surface. Figure 1 shows the schematic diagram of the industrial air knife that makes use of a sonic jet. A two-dimensional compressible Reynolds-Averaged Navier-Stokes equations are solved for an implicit finite volume scheme to investigate the impinging jet flow characteristics. The computational results show the effects of pressure ratio and temperature ratio on the flow field. The paper proposes an optimal flow condition for the impinging gas jet wiping process.