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Jung, Seung Chai,Yoon, Bye-Ri,Oh, Jin Sun,Choi, Seung Hong,Han, Moon Hee,Lee, Jang Yeol,Cho, Hye Rim,Rhee, Kyehan,Jho, Jae Young Ovid Technologies (Wolters Kluwer) - Lippincott Wi 2012 ASAIO journal Vol.58 No.5
<P>In this study, we propose a new method for the enhancement of intraarterial thrombolysis by use of an endovascular vibrating polymer actuator probe (VPAP), which is fabricated from an ionic polymer metal composite (IPMC) actuator. The endovascular VPAP was fabricated by combining 0.8 0.8 10 mm3 IPMC samples, 0.22 mm 50 cm copper wires, and 40 cm of Teflon tube. The purpose of this study was to evaluate the thrombolysis efficiency of an endovascular VPAP in a dog model. Both renal arteries of the enrolled dogs (n = 5) were used in the current study. A distal portion of the renal artery in a mongrel dog was occluded by a blood clot from autologous venous whole blood. Intraarterial thrombolysis was performed by use of a VPAP without the actuation force (control group), by a VPAP-only (VPAP-only group), or with a combination of recombinant tissue plasminogen activator (rtPA) and a VPAP (VPAP + rtPA group). The thrombolysis efficiency was evaluated by the modified Thrombolysis in Myocardial Infarction (TIMI) grading system based on the consensus between two radiologists. The grading scales were compared according to each intraarterial thrombolysis method. The VPAP + rtPA and VPAP-only groups showed a significantly higher thrombolysis efficiency than did the control group (p < 0.05). The VPAP-only group also showed a significantly higher thrombolysis efficiency than did the control group (p < 0.05). The VPAP+ rtPA group showed a significantly higher thrombolysis efficiency than did the VPAP-only group (p < 0.05). The use of an endovascular VPAP was a feasible and useful method for intraarterial thrombolysis, and it enhanced the thrombolysis efficiency when combined with the thrombolytic agent rtPA.</P>
Evaluation on Microbial Contamination in Chinese Cabbage Cultivated Soil in Korea
Jung, Kyu-Seok,Seo, Seung-Mi,Jeon, Hye-Jin,Kim, So-Ra,Kim, Won-Il,Kim, Se-Ri,Roh, Eun-Jung,Ryu, Jae-Gee,Lee, Seung-Don 한국토양비료학회 2017 한국토양비료학회지 Vol.50 No.6
The occurrence of various pathogenic microorganisms on farms is a concern if they are able to contaminate fresh produce, which provides entry into the food supply. This study was undertaken to assess the microbiological quality and prevalence of pathogens in Chinese cabbage cultivated soil in Korea. A total of 57 Chinese cabbage cultivated soils were collected in 4 locations in Korea from February to August 2017. The soils were analyzed for the presence of total aerobic bacteria, Escherichia coli, coliforms, Salmonella spp., Escherichia coli O157:H7, Listeria monocytogenes, and Staphylococcus aureus. The total aerobic plate counts in soils were in the range of 5.7 to $8.7log\;CFU\;g^{-1}$. The coliforms and E. coli were detected in 39 and 8 out of 57 soil samples, respectively, in the range of 1.1 to $6.3log\;CFU\;g^{-1}$ and 0.7 to $4.0log\;CFU\;g^{-1}$. Salmonella spp., E. coli O157:H7, L. monocytogenes, and S. aureus were not detected from any samples. Results from these studies may help control the spread of bacterial species such as E. coli and Salmonella spp. through the farm environment.
Inhibition of Invasion and Capillary-like Tube Formation by Retrohydroxamate-based MMP Inhibitors
Choi, Seung-Su,Ji, Ae-Ri,Yu, Seung-Woo,Cho, Bong-Hwan,Park, Jung-Dae,Park, Jun-Hyoung,Lee, Hyun-Soo,Ryu, Seong-Eon,Kim, Dong-Han,Kang, Jae-Hoon,Lee, Seung-Taek Korean Chemical Society 2011 Bulletin of the Korean Chemical Society Vol.32 No.6
Matrix metalloproteinases (MMPs), a family of zinc-containing endopeptidases, participate in many normal processes such as embryonic development and wound repair, and in many pathological situations such as cancer, atherosclerosis, and arthritis. Peptidomimetic MMP inhibitors were designed and synthesized with N-formylhydroxylamine (retrohydroxamate) as a zinc-binding group and various side chains on the ${\alpha}$, P1', and P2' positions. Using in vitro MMP assays with purified MMPs (MMP-1, MMP-2, MMP-3, MMP-9, and MMP-14) and fluorogenic peptide substrates, it was found that compounds 2d and 2g selectively inhibit gelatinases (MMP-2 and MMP-9) and interstitial collagenase (MMP-1). They also inhibited the chemo-invasion of fibrosarcoma HT-1080 cells and tube formation of human umbilical vascular endothelial cells in a dose-dependent manner. Our results suggest that retrohydroxamate-based MMP inhibitors, especially compounds 2d and 2g, have the potential to be used as therapeutic drugs for cancer and other MMP-related diseases.
Genomic Alteration of Bisphenol A Treatment in the Testis of Mice
Kim, Seung-Jun,Park, Hye-Won,Youn, Jong-Pil,Ha, Jung-Mi,An, Yu-Ri,Lee, Chang-Hyeon,Oh, Moon-Ju,Oh, Jung-Hwa,Yoon, Seok-Joo,Hwang, Seung-Yong The Korean Society of Toxicogenomics and Toxicopro 2009 Molecular & cellular toxicology Vol.5 No.3
Bisphenol A (BPA) is commonly used in the production of pharmaceutical, industrial, and housing epoxy, as well as polycarbonate plastics. Owing to its extensive use, BPA can contaminate the environment either directly or through derivatives of these products. BPA has been classified as an endocrine disruptor chemicals (EDCs), and the primary toxicity of these EDCs in males involves the induction of reproductive system abnormality. First, in order to evaluate the direct effects on the Y chromosome associated with reproduction, we evaluated Y chromosome abnormalities using a Y chromosome microdeletion detection kit. However, we detected no Yq abnormality as the result of BPA exposure. Secondly, we performed high-density oligonucleotide array-based comparative genome hybridization (CGH) to assess genomic alteration as a component of our toxicity assessment. The results of our data analysis revealed some changes in copy number. Seven observed features were gains or losses in chromosomal DNA (P-value<1.0e-5, average log2 ratio>0.2). Interestingly, 21 probes of chr7:7312289-10272836 (qA1-qA2 in cytoband) were a commonly observed amplification (P-value 3.69e-10). Another region, chr14:4551029-10397399, was also commonly amplified (P-value 2.93e-12, average of log2 ratios in segment>0.3786). These regions include many genes associated with pheromone response, transcription, and signal transduction using ArrayToKegg software. These results help us to understand the molecular mechanisms underlying the reproductive effects induced by BPA.
Toxicogenomic Effect of Liver-toxic Environmental Chemicals in Human Hepatoma Cell Line
Kim, Seung-Jun,Park, Hye-Won,Yu, So-Yeon,Kim, Jun-Sub,Ha, Jung-Mi,Youn, Jong-Pil,An, Yu-Ri,Oh, Moon-Ju,Kim, Youn-Jung,Ryu, Jae-Chun,Hwang, Seung-Yong The Korean Society of Toxicogenomics and Toxicopro 2009 Molecular & cellular toxicology Vol.5 No.4
Some environmental chemicals have been shown to cause liver-toxicity as the result of bioaccumulation. Particularly, fungicides have been shown to cause varying degrees of hepatictoxicity and to disrupt steroid hormone homeostasis in in vivo models. The principal objective of this study was to evaluate the liver-toxic responses of environmental chemicals-in this case selected fungicides and parasiticides-in order to determine whether or not this agent differentially affected its toxicogenomic activities in hepatic tumor cell lines. To determine the gene expression profiles of 3 fungicides (triadimefon, myclobutanil, vinclozolin) and 1 parasiticide (dibutyl phthalate), we utilized a modified HazChem human array V2. Additionally, in order to observe the differential alterations in its time-dependent activities, we conducted two time (3 hr, 48 hr) exposures to the respective IC20 values of four chemicals. As a result, we analyzed the expression profiles of a total of 1638 genes, and we identified 70 positive significant genes and 144 negative significant genes using four fungicidic and parasiticidic chemicals, using SAM (Significant Analysis of Microarray) methods (q-value<0.5%). These genes were analyzed and identified as being related to apoptosis, stress responses, germ cell development, cofactor metabolism, and lipid metabolism in GO functions and pathways. Additionally, we found 120 genes among those time-dependently differentially expressed genes, using 1-way ANOVA (P-value<0.05). These genes were related to protein metabolism, stress responses, and positive regulation of apoptosis. These data support the conclusion that the four tested chemicals have common toxicogenomic effects and evidence respectively differential expression profiles according to exposure time.
연구논문 : 서울시의 2005~2006년 도시배경 및 상층측정망의 대기질 특성 분석
유승성 ( Seung Sung Yoo ),전재식 ( Jae Sik Jeon ),정권 ( Kweon Jung ),신은상 ( Eun Sang Shin ),정부전 ( Bu Jeon Jung ),류리나 ( Ri Na Ryu ),우정헌 ( Jung Hun Woo ),선우영 ( Woo Young Sun ) 한국환경영향평가학회 2011 환경영향평가 Vol.20 No.1
The results of comparing PM10 concentration between ``Namsan`` and ``Yongsan-gu`` air quality monitoring stations show similar values with averaged concentration in the whole Seoul. The correlation factors in both sites were 0.865, 0.828 in 2005, 2006, respectively. For ``Bukhansan`` and ``Gangbuk-gu`` air quality monitoring stations, different from the results mentioned above, they showed clear differences as altitude changes. PM10 concentration in ``Bukhansan`` monitoring stations was 10 μg/m3 lower than ``Gangbuk-gu`` monitoring station which is located near the ground. Also, averaged PM10 concentration in ``Bukhansan`` and ``Gangbuk-gu`` monitoring stations was lower than that in the whole Seoul. When comparing NO2 concentration between ``Namsan`` and ``Yongsan-gu`` monitoring stations, NO2 concentration in ``Namsan`` monitoring station was lower than ``Yongsan-gu`` monitoring station. For NO2 concentration in ``Bukhansan``, ``Gangbuk-gu`` and ``the whole Seoul``, there were the same pattern in ``Gangbuk-gu`` and the ``the whole Seoul`` and low values in ``Bukhansan`` monitoring station. The correlation factors of NO2 concentration in ``Bukhansan`` and ``Gangbukgu`` was 0.525, 0.549 in 2005, 2006, respectively, which stands for low correlationship.
Evaluation on Microbial Contamination in Chinese Cabbage Cultivated Soil in Korea
Kyu-Seok Jung,Seung-Mi Seo,Hye-Jin Jeon,So-Ra Kim,Won-Il Kim,Se-Ri Kim,Eun-Jung Roh,Jae-Gee Ryu,Seung-Don Lee 한국토양비료학회 2017 한국토양비료학회지 Vol.50 No.6
The occurrence of various pathogenic microorganisms on farms is a concern if they are able to contaminate fresh produce, which provides entry into the food supply. This study was undertaken to assess the microbiological quality and prevalence of pathogens in Chinese cabbage cultivated soil in Korea. A total of 57 Chinese cabbage cultivated soils were collected in 4 locations in Korea from February to August 2017. The soils were analyzed for the presence of total aerobic bacteria, Escherichia coli, coliforms, Salmonella spp., Escherichia coli O157:H7, Listeria monocytogenes, and Staphylococcus aureus. The total aerobic plate counts in soils were in the range of 5.7 to 8.7 log CFU g<SUP>-1</SUP>. The coliforms and E. coli were detected in 39 and 8 out of 57 soil samples, respectively, in the range of 1.1 to 6.3 log CFU g<SUP>-1</SUP> and 0.7 to 4.0 log CFU g<SUP>-1</SUP>. Salmonella spp., E. coli O157:H7, L. monocytogenes, and S. aureus were not detected from any samples. Results from these studies may help control the spread of bacterial species such as E. coli and Salmonella spp. through the farm environment.