급성 단순하부요로감염의 경험적 치료로써 레보플록사신 3일요법의 효과

이지열,이승주,이상돈,정희창,오봉렬,김세웅,최한용,조용현,윤문수 대한화학요법학회 2001 대한화학요법학회지 Vol.19 No.4

목적 : 급성 단순요로감염의 원인균에 대한 내성증가에 따른 경험적 1차치료의 선택에 대한 어려움으로 인하여 최근 미국의 Infectious Disease Society of America(IDSA)에서는 이에 대한 가이드라인을 제시하였다. IDSA의 가이드라인에 따르면 그 지역의 TMP-SMX에 대한 내성균주의 비율이 10-20% 이상일 때는 급성 단순요로감염의 경험적 1차치료제로 플루오로퀴놀론제를 선택하도록 하였다. 이에 저자들은 급성 단순하부요로감염 환자에 있어서 레보플록사신에 대한 임상적, 미생물학적 유효성 및 안전성을 알아보고자 하였다. 방법 : 시험은 전향적, 비맹검, 공개, 비비교, 다기관 임상시험으로 시행되었고 전국 5개 대학병원을 방문한 56명의 급성 단순하부요로감염 환자에게 레보플록사신 100㎎을 1일 3회, 3일간 경구 투여하여 1-3일 후에 추적 관찰하였다. 결과 : 평가가 가능하였던 53명의 환자 중 50명의 환자에서 치료 후 5-7일 후에 증상이 소실되었거나 호전되어 94%의 임상적 유효성을 보였으며, 51명의 환자에서 치료 후 1-3일 후에 원인균이 제거되어 96%의 미생물학적 유효성을 보였다. 약물 관련 이상반응은 2%의 환자에서 나타났으나 이로 인한 치료 중단 사례는 없었으며 심각한 생화학적 또는 혈액학적 이상반응은 나타나지 않았다. 결론 : 레보플록사신 100㎎ 1일 3회 3일 요법은 임상적, 미생물학적 유효성이 뒤어나며 안전한 치료요법으로 급성 단순하부요로감염의 경험적 1차 치료에 적합할 것으로 생각된다. Background : The increasing frequency of clinical failure of uncomplicated urinary tract infections (UTIs) may be due to emerging resistance to commonly prescribed antimicrobials. Infectious Diseases Society of America guidelines state that uncomplicated UTIs should be treated empirically with a fluoroquinolone, if the proportion of trimethoprim/sulfamethoxazole-resistant isolates in the community is >10%-20%. The clinical efficacy and safety of levofloxacin were assessed in patients with acute, uncomplicated lower urinary tract infection. Methods : The study was a multicenter, prospective, open label, non-comparative, non-blinded trial. Fifty-six patients with acute, uncomplicated symptomatic lower urinary tract infections from five university hospitals were treated with levofloxacin 100㎎ tid for 3 days and were followed up for 1 to 5 days. Results : Fifty-three of the 56 patients were evaluable. Ninety-four per cent of patients were symptomatically cured or improved by the fifth to seventh day after therapy started. Bacteriological eradication of initial pathogen was achieved by 1 to 3 days in 96%. Drug related adverse experiences were seen in 2% of patients. None necessitated cessation of therapy. No significant biochemical or hematological abnormalities occurred. Conclusion : These results demonstrate the clinical efficacy and safety of empirical 3-day levofloxacin for acute, uncomplicated urinary tract infections.

소아 만성 부비동염에서 단순촬영상과 OMU CT상의 비교

이병돈,박상호,김장묵,이승균,장혁순,강주원,김장욱 순천향의학연구소 1998 Journal of Soonchunhyang Medical Science Vol.4 No.1

Most commonly and widely used diagnostic tool for chronic paranasal sinusitis in children is plain X-ray check not only because of small radiation dose and easy performance, but because of low cost. However ostiomeatal unit computed tomography(OMU CT) was known to be more accurate and recommended recently by many physicians. The author have studied for both OMU CT and plain X-ray of paranasal sinuses and compaird their findings in 90 chidren(180 sides of sinus) aged from 4 to 14 years who suspected having sinusitis. OMU CT was taken after plain X-ray examination (Caldwell's view, water's view, lateral view), and the time interval betweeen these two examination was O to 14 days (average 4.7 days). The following results were obtained. Considering that OMU CT was accurate, the rate of correspondence in diagnosis of sinus pathology between plain X-ray and OMU CT was 48.3% in the ethmoid sinus, 51.1% in the maxillary sinus, 41.9% in the sphenoid sinus, 43.4% in the frontal sinus. If all OMU CT findings had been accurate, the incidence of false positives according to plain X-ray was 25.5% in the ethmoid sinus, 28.3% in the maxillary sinus, 70.8% in the spenoid sinus and 77.8% in the frontal sinus. While, the incidence of false negatives according to plain X-ray was 85.9% in the ethmoid sinus, 70.5% in the maxillary sinus, 50.0% in sphenoid sinus and 37.5% in the frontal sinus. A routine preoperative OMU CT is recommended, which allows a detailed evaluation of pathologic changes and anatomical relations of the paranasal sinuses before surgical interventiaon for the paranasal sinuses. Considering the above facts, diagnosis of pediatric sinusitis only by plain X-ray was inadequate and OMU CT was necessary.

정보통신 보호를 위한 전자서명과 접근제어

이종근,최돈승,이경석 國立 昌原大學校 精報通信硏究所 1998 精報通信論文集 Vol.2 No.-

In this paper, we introduce the authentication methods in data communication to reduce the information risks. Specially, we summarize cipher algorithms, digital signature and access control methods to protect information.

쓰레기 매립지 침출수와 하수의 병합처리

이해승,류동식,강동구,한동준 도립 강원전문대학 1999 道立 江原專門大學 論文集 Vol.2 No.-

One of the economic and efficient process to treat the leachate which venerates at the landfill is the combined treatment with the sewage, which can result in the over-loading and the side effect at the treatment of wastewater. Therefore, this study aims to compare with the generalized A/S process and BNR one in consideration of the nutrient, which apply the combination treatment, and to derive the proper mixing rate of A/S process and BNR one.

흰쥐에서 사염화탄소에 의해 유도된 간 상해에 미치는 키토산 올리고당의 영향

이영돈,박승림,강소영,김세재,박지권,고영환 제주대학교 생명과학연구소 1999 제주생명과학연구 Vol.2 No.-

Chitosan is the deacetylated product of chitin. Chitosan and its derivatives have many properties that make them attractive for a wide variety of health applications. We reported recently that water soluble chitooligosaccharides have hepatoprotective effect on ethanol induced liver injury in the mouse. The current study examined the effect of water soluble chitooligosaccharides on CC1₄-induced liver injury in rats. Male Sprague-Dawley rats were orally treated with CC1₄without or with administration of 5% chitooligosaccharides. After 5 weeks after CC1₄treatment, the histological sections and the expression of mRNA of interleukin-12(IL-12), hepatocyte growth factor(HGF), and tumor necrosis factor(TNF- ) were examined. The liver section of rats supplemented with chitooligosaccharides showed attenuated effects of the necrosis, steatosis, cirrhosis compared with those of non-supplemented rats. The level of TNF- mRNA in CC1₄-treated rats were higher than those in the rats supplemented with chitooligosaccharides, while the levels of IL-12 and HGF mRNA were higher in the rats supplemented with chitooligosaccharides than those of in CC1₄-treated rats. These findings suggested that water soluble chitooligosaccharides may have a hepatoprotective activity against CCl₄-induced liver injury in rats.

GRPC 프로토콜의 효율적인 그룹 관리시스템

이종근,최돈승 國立 昌原大學校 精報通信硏究所 1998 精報通信論文集 Vol.2 No.-

In this paper, we are proposed the Advanced Group management System for RPC. Also, in GRPC an architecture of a monitor processor(MonP) is presented for distributed network management system managing communication network for distributed system, specially for overlapping domain management. Based on these MonP and hierarchical communication management concepts, we can reduce the communication load on communication network. Our proposed protocol has been analyzed by the Petri nets.

강원대학교 쓰레기 배출 및 수집 시스템에 관한 조사연구

이찬기,이해승,류돈식,남광명 江原大學校 産業技術硏究所 1997 産業技術硏究 Vol.17 No.-

This investigation was carried out to study generation of solid waste and collection system in the College of Engineering and College of Social Science, library, dormitory and student center of Kangwon National University. It is to supply basic data for solid waste management. Each result of investigation considers effect getting generation property, unit waste generation rate and reusing.

진균성 부비동염의 임상적 고찰

이승원,김장욱,박영진,송태현,이병돈,장혁순 순천향의학연구소;Soonchunhyang Medical Research Institute 2000 Journal of Soonchunhyang Medical Science Vol.6 No.1

The fungal sinusitis is relatively rare and mainly develops in immunocompromised hosts, but is sporadically appears in the immunocompetent patients, where its incidence tends to be increasing. Because the clinical features of this disease are similar to those of chronic suppurative sinusitis, this entity may be overlooked. We analysed thirteen fungal sinusitis from January 1997 through December 1999 based on clinical features, laboratory characteristics and operative findings. The results are as follows. 1)Fungal sinusitis occurred 3.3 times as frequently in female patients as in male patients and the peak age groups are 4th and 5th decades. 2) The time intervals between the onset of symptoms and the first hospital visit were as follows: 5 cases within 3 months, 1 case between 4 and 6 months, 3 cases between 7 and 12 months, and 4 cases over 1 year. 3) The chief complaints were nasal obstruction, postnasal drip, rhinorrhea, cheek pain, headache, ocular pain, sneezing. 4) The characteristic computerized tomographic findings were hyperattenuated lesions in the maxillary sinus and in the nasal cavity near the natural ostium. 5) The most common pathogen was Aspergillus(92.3%) 6) We performed Caldwell-Luc's operation only in 4 cases, Caldwell-Luc's operation with intranasal ethmoidectomy in 3 cases, Caldwell-Luc's operation with endoscopic sinus surgery in 3 cases and endoscopic sinus sugery only in 3 cases. 7) Most of the gross specimens revealed a fungus ball containing a black-brown necrotic debris or caseous material.

참나무 목초액을 이용한 하수의 악취제거

이해승,한동준,류돈식 도립 강원전문대학 2000 道立 江原專門大學 論文集 Vol.3 No.-

This study was performed to evaluate the odor control of sewage by oak pyroligneous liquid. And, odor control experimental was compared NaOH solution(20%) to pyroligneous liquid. The results were summarized as follows ; Results of pyroligneous liquid analysis showed pH was very low, and heavy metals were most of not detected. pyroligneous liquid was showed more effective for odor control than NaOH solution(20%). NaOH solution(20%) and sewage was producted NH3 gas through chemical reaction. Suitable dilution rate of pyroligneous liquid was showed thousand times, but it was thought problems in economic. Therefore, the pyroligneous liquid would be effectively in odor control with use follow conditions ; garbage waste box, landfill waste layer and moving dressing room in tourist facilities etc.

도시근교 관광지에서의 쓰레기 배출특성에 관한 조사연구 : The Gu-Gok Falls in Summer Season 하절기 구곡폭포를 중심으로

이찬기,이해승,류돈식,강동구 江原大學校 産業技術硏究所 1997 産業技術硏究 Vol.17 No.-

This investigation was carried out ot study on the generation property, management and separate collection rate of solid waste in the Gu-Gok Falls. Generation rate of solid waste was 80.785kg/day and unit waste generation rates was 65.55g/dayㆍtourist one person. Physical component of solid waste were garbage 46%, papers 20%, empty bottles 10%, respectively. A plan is required to decrease generation rate of garbage waste, As result to investigate separated garbage can, papers and can were separated more than 60%. But empty bottles and scrap iron were separated less than 50%. P.E.T, steel can, aluminum can and empty bottles were 20% of total generation rate, and profit of reuse is ￦700,800/year.