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현장실습과 온라인실습 유형별 간호 대학생의 실습 만족도 및 학업성취도 비교
전은영 ( Eunyoung Jeon ),김소현 ( Sohyeon Kim ),김민중 ( Minjung Kim ),김서현 ( Seohyun Kim ),김성주 ( Seongju Kim ),김소영 ( Soyeong Kim ),김소현 ( Sohyeon Kim ),김아영 ( Ayoung Kim ),김예빈 ( Yebin Kim ),김정은 ( Jeongeun Kim ) 경북대학교 간호과학연구소 2021 경북간호과학지 Vol.25 No.2
Purpose: This study aimed to compare the level of satisfaction and academic achievement of nursing students' clinical practice achievement between field and online practice. Methods: In this descriptive research, we recruited junior and senior nursing students who experienced both field and online practice from nursing college in Daegu and Gyeongbuk, Korea. Data were collected using the online survey and analyzed via a t-test, ANOVA, and paired t-test using SPSS V 25.0. Results: There was no statistically significant difference in the satisfaction of practice between field and online practice types. However, academic achievement was higher in the field group than in the online group. Out of five points, the scores of field practice and online practice were 3.66 points and 3.39 points, respectively, which indicated that academic performance was higher in field practice than online practice (t=6.21, p<.001). Conclusion: Field practice has been shown to achieve higher academic performance than online practice. Hence, research is needed in order to develop suitable field practice models for the New Normal era in preparation for situations that practice is limited, such as COVID-19 and future outbreaks.
Kim, Won Kyu,Yun, SeongJu,Park, Cheol Keun,Bauer, Sebastian,Kim, Jiyoon,Lee, Min Goo,Kim, Hoguen American Association for Cancer Research 2017 Clinical Cancer Research Vol.23 No.3
<P><B>Purpose:</B> Tumorigenesis of gastrointestinal stromal tumors (GIST) is driven by gain-of-function mutations in the <I>KIT</I> gene, which result in overexpression of activated mutant KIT proteins (MT-KIT). However, the mechanism of MT-KIT overexpression is poorly understood.</P><P><B>Experimental Design:</B> By protein expression analysis and immunofluorescent microscopic analysis, we determine the stability and localization of MT-KIT in four GIST cell lines with different mutations and HeLa cells transfected with mutant KIT model vectors. We also used 154 human GIST tissues to analyze the relationship between the expression of PKC-θ and MT-KITs, and correlations between PKC-θ overexpression and clinicopathological parameters.</P><P><B>Results:</B> We report that four different MT-KIT proteins are intrinsically less stable than wild-type KIT due to proteasome-mediated degradation and abnormally localized to the endoplasmic reticulum (ER) or the Golgi complex. By screening a MT-KIT-stabilizing factor, we find that PKC-θ is strongly and exclusively expressed in GISTs and interacts with intracellular MT-KIT to promote its stabilization by increased retention in the Golgi complex. In addition, Western blotting analysis using 50 GIST samples shows strong correlation between PKC-θ and MT-KIT expression (correlation coefficient = 0.682, <I>P</I> < 0.000001). Immunohistochemical analysis using 154 GISTs further demonstrates that PKC-θ overexpression significantly correlates with several clinicopathological parameters such as high tumor grade, frequent recurrence/metastasis, and poor patient survival.</P><P><B>Conclusions:</B> Our findings suggest that sustained MT-KIT overexpression through PKC-θ-mediated stabilization in the Golgi contributes to GIST progression and provides a rationale for anti-PKC-θ therapy in GISTs. <I>Clin Cancer Res; 23(3); 845–56. ©2016 AACR</I>.</P>
Kim, Young-Eun,Lee, Minji,Gu, Hyejung,Kim, Jeongwoo,Jeong, Seongju,Yeo, Sujin,Lee, You Jeong,Im, Sin-Hyeog,Sung, Young-Chul,Kim, Hak Jae,Weissman, Irving L.,Ahn, G-One The Company of Biologists Ltd 2018 Disease models & mechanisms Vol.11 No.7
<P><B>ABSTRACT</B></P><P>Inflammatory bowel disease (IBD) is a chronic inflammatory disease, in which the intestinal epithelium loses its barrier function. Given the existence of the oxygen gradient in the intestinal epithelium and that inflammation further contributes to the tissue hypoxia, we investigated the role of hypoxia-inducible factor (HIF), a transcription factor activated under hypoxic conditions in myeloid cells, in the progression of IBD. To do this, we utilized myeloid-specific knockout (KO) mice targeting HIF pathways, created by a Cre-loxP system with human MRP8 (hMRP8), an intracellular calcium-binding protein, as the myeloid promoter. By feeding 5% dextran sodium sulfate (DSS) to hMRP8 von Hippel Lindau (<I>Vhl</I>) KO mice, in which HIF-1α and HIF-2α are constitutively activated in myeloid cells, we found that these mice were highly susceptible to DSS-induced colitis, demonstrating greater body weight loss, increased mortality, faster onset of rectal bleeding, shortened colon length, and increased CD11b- or Gr-1-positive myeloid cells in the colon compared with wild-type (WT) mice. These parameters were restored to, if not better than, the WT levels when we examined hMRP8 <I>Hif-1a</I> KO mice upon 5% DSS feeding. hMRP8 <I>Hif-2a</I> KO mice, on the other hand, exhibited a similar degree of DSS-induced colitis to that of WT mice. Lastly, when DSS was given together with azoxymethane to induce tumorigenesis in the colon, we found that hMRP8 <I>Hif-1a</I> KO mice exhibited comparable levels of colorectal tumors to those of WT mice, indicating that HIF-1α in myeloid cells is dispensable for tumorigenesis. Collectively, our results suggest that HIF-1α activation in myeloid cells critically regulates IBD progression.</P>
Kim Seongju,Kim Dong Jun,Lee Mi-Sun,Lee Hooyeon 대한신경정신의학회 2023 PSYCHIATRY INVESTIGATION Vol.20 No.8
Objective This study examined the association between social support and postpartum depression (PPD) according to the time after childbirth within 12 months in South Korea.Methods Data were collected from 1,481 women in Chungnam Province, South Korea from September 21 to 30, 2022. Multivariate logistic regression models were used to examine the association between social support and PPD. Subgroup analysis of the associations of support from family, friends, and significant others with PPD according to the time after childbirth was undertaken using crude and adjusted models.Results Of the participants, 39.91% had PPD. The prevalence of PPD was 36.05% at <3 months, 37.50% at 3≤ to <6 months, and 44.41% at 6≤ to <12 months. A 1-point increase in the social support score was associated with an increase in the adjusted odds ratio of PPD of 0.91 (95% confidence interval=0.90–0.93). Social support from family was significantly associated with PPD regardless of the time after childbirth. Support from significant others was significantly associated with PPD after 6≤ to <12 months.Conclusion Family support should be provided consistently to women after birth; social connections with significant others can prevent PPD.
대학생의 진로소명과 우연대처기술의 관계: 진로결정장벽의 조절효과를 중심으로
김성주 ( Seongju Kim ),김민정 ( Minjeong Kim ) 서강대학교 학생생활상담연구소 2018 人間理解 Vol.39 No.1
급변하는 현대 사회에서 대학생의 진로적응을 위해 높은 우연대처기술이 필요하다. 대학생의 진로소명과 우연대처기술은 관련이 있을 것으로 예상되는데, 두 변인의 관계에 진로결정장벽이 영향을 미칠 것으로 가정할 수 있다. 이에 본 연구는 대학생들의 진로소명과 우연대처기술의 관계에서 진로결정장벽의 조절효과를 살펴보았다. 대학교 재학 중인 654명을 대상으로 인구통계학적 변인 및 진로소명과 진로결정장벽, 우연대처기술을 측정하였고 SPSS 24 통계프로그램을 이용하여 위계적 회귀분석을 실시하였다. 그 결과, 대학생의 진로소명이 높을수록 우연대처기술은 높은 것으로 나타났다. 또한 진로결정장벽이 높을수록 진로소명이 우연대처기술에 미치는 영향은 감소하는 것으로 나타났다. 진로결정장벽 중 진로소명과 우연대처기술의 관계를 유의미하게 조절하는 요인은 우유부단한 성격, 자기명확성부족, 필요성인식부족이었다. 본 연구 결과를 바탕으로 대학생 진로상담에 대한 시사점과 제한점을 논의하였다. In this rapidly changing society, planned happenstance skill is necessary for undergraduate students’ career adaptation. It is hypothesized that career calling influences on planned happenstance skill and the effects differs according to career decision-making barriers in the population of undergraduates. This study investigated the moderating effect of career decision-making barriers on the relationship between career calling and planned happenstance skills. The result showed high career calling was related with planned happenstance skills. Plus, the effect of career calling on planned happenstance skills was smaller when career decision-making barriers was higher. Among the career decision-making barriers, indecisiveness, lack of self-identity, and lack of necessity recognition had significant moderating effects. The implications of these findings and limitations of the research were discussed.