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현장실습과 온라인실습 유형별 간호 대학생의 실습 만족도 및 학업성취도 비교
전은영 ( Eunyoung Jeon ),김소현 ( Sohyeon Kim ),김민중 ( Minjung Kim ),김서현 ( Seohyun Kim ),김성주 ( Seongju Kim ),김소영 ( Soyeong Kim ),김소현 ( Sohyeon Kim ),김아영 ( Ayoung Kim ),김예빈 ( Yebin Kim ),김정은 ( Jeongeun Kim ) 경북대학교 간호과학연구소 2021 경북간호과학지 Vol.25 No.2
Purpose: This study aimed to compare the level of satisfaction and academic achievement of nursing students' clinical practice achievement between field and online practice. Methods: In this descriptive research, we recruited junior and senior nursing students who experienced both field and online practice from nursing college in Daegu and Gyeongbuk, Korea. Data were collected using the online survey and analyzed via a t-test, ANOVA, and paired t-test using SPSS V 25.0. Results: There was no statistically significant difference in the satisfaction of practice between field and online practice types. However, academic achievement was higher in the field group than in the online group. Out of five points, the scores of field practice and online practice were 3.66 points and 3.39 points, respectively, which indicated that academic performance was higher in field practice than online practice (t=6.21, p<.001). Conclusion: Field practice has been shown to achieve higher academic performance than online practice. Hence, research is needed in order to develop suitable field practice models for the New Normal era in preparation for situations that practice is limited, such as COVID-19 and future outbreaks.
Kim, Won Kyu,Yun, SeongJu,Park, Cheol Keun,Bauer, Sebastian,Kim, Jiyoon,Lee, Min Goo,Kim, Hoguen American Association for Cancer Research 2017 Clinical Cancer Research Vol.23 No.3
<P><B>Purpose:</B> Tumorigenesis of gastrointestinal stromal tumors (GIST) is driven by gain-of-function mutations in the <I>KIT</I> gene, which result in overexpression of activated mutant KIT proteins (MT-KIT). However, the mechanism of MT-KIT overexpression is poorly understood.</P><P><B>Experimental Design:</B> By protein expression analysis and immunofluorescent microscopic analysis, we determine the stability and localization of MT-KIT in four GIST cell lines with different mutations and HeLa cells transfected with mutant KIT model vectors. We also used 154 human GIST tissues to analyze the relationship between the expression of PKC-θ and MT-KITs, and correlations between PKC-θ overexpression and clinicopathological parameters.</P><P><B>Results:</B> We report that four different MT-KIT proteins are intrinsically less stable than wild-type KIT due to proteasome-mediated degradation and abnormally localized to the endoplasmic reticulum (ER) or the Golgi complex. By screening a MT-KIT-stabilizing factor, we find that PKC-θ is strongly and exclusively expressed in GISTs and interacts with intracellular MT-KIT to promote its stabilization by increased retention in the Golgi complex. In addition, Western blotting analysis using 50 GIST samples shows strong correlation between PKC-θ and MT-KIT expression (correlation coefficient = 0.682, <I>P</I> < 0.000001). Immunohistochemical analysis using 154 GISTs further demonstrates that PKC-θ overexpression significantly correlates with several clinicopathological parameters such as high tumor grade, frequent recurrence/metastasis, and poor patient survival.</P><P><B>Conclusions:</B> Our findings suggest that sustained MT-KIT overexpression through PKC-θ-mediated stabilization in the Golgi contributes to GIST progression and provides a rationale for anti-PKC-θ therapy in GISTs. <I>Clin Cancer Res; 23(3); 845–56. ©2016 AACR</I>.</P>
Kim, Young-Eun,Lee, Minji,Gu, Hyejung,Kim, Jeongwoo,Jeong, Seongju,Yeo, Sujin,Lee, You Jeong,Im, Sin-Hyeog,Sung, Young-Chul,Kim, Hak Jae,Weissman, Irving L.,Ahn, G-One The Company of Biologists Ltd 2018 Disease models & mechanisms Vol.11 No.7
<P><B>ABSTRACT</B></P><P>Inflammatory bowel disease (IBD) is a chronic inflammatory disease, in which the intestinal epithelium loses its barrier function. Given the existence of the oxygen gradient in the intestinal epithelium and that inflammation further contributes to the tissue hypoxia, we investigated the role of hypoxia-inducible factor (HIF), a transcription factor activated under hypoxic conditions in myeloid cells, in the progression of IBD. To do this, we utilized myeloid-specific knockout (KO) mice targeting HIF pathways, created by a Cre-loxP system with human MRP8 (hMRP8), an intracellular calcium-binding protein, as the myeloid promoter. By feeding 5% dextran sodium sulfate (DSS) to hMRP8 von Hippel Lindau (<I>Vhl</I>) KO mice, in which HIF-1α and HIF-2α are constitutively activated in myeloid cells, we found that these mice were highly susceptible to DSS-induced colitis, demonstrating greater body weight loss, increased mortality, faster onset of rectal bleeding, shortened colon length, and increased CD11b- or Gr-1-positive myeloid cells in the colon compared with wild-type (WT) mice. These parameters were restored to, if not better than, the WT levels when we examined hMRP8 <I>Hif-1a</I> KO mice upon 5% DSS feeding. hMRP8 <I>Hif-2a</I> KO mice, on the other hand, exhibited a similar degree of DSS-induced colitis to that of WT mice. Lastly, when DSS was given together with azoxymethane to induce tumorigenesis in the colon, we found that hMRP8 <I>Hif-1a</I> KO mice exhibited comparable levels of colorectal tumors to those of WT mice, indicating that HIF-1α in myeloid cells is dispensable for tumorigenesis. Collectively, our results suggest that HIF-1α activation in myeloid cells critically regulates IBD progression.</P>
Kim Seongju,Kim Dong Jun,Lee Mi-Sun,Lee Hooyeon 대한신경정신의학회 2023 PSYCHIATRY INVESTIGATION Vol.20 No.8
Objective This study examined the association between social support and postpartum depression (PPD) according to the time after childbirth within 12 months in South Korea.Methods Data were collected from 1,481 women in Chungnam Province, South Korea from September 21 to 30, 2022. Multivariate logistic regression models were used to examine the association between social support and PPD. Subgroup analysis of the associations of support from family, friends, and significant others with PPD according to the time after childbirth was undertaken using crude and adjusted models.Results Of the participants, 39.91% had PPD. The prevalence of PPD was 36.05% at <3 months, 37.50% at 3≤ to <6 months, and 44.41% at 6≤ to <12 months. A 1-point increase in the social support score was associated with an increase in the adjusted odds ratio of PPD of 0.91 (95% confidence interval=0.90–0.93). Social support from family was significantly associated with PPD regardless of the time after childbirth. Support from significant others was significantly associated with PPD after 6≤ to <12 months.Conclusion Family support should be provided consistently to women after birth; social connections with significant others can prevent PPD.