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Kim, Ji-Young,Kwon, Jung,Kim, Ja Eun,Koh, Woo Suk,Chung, Moon-Koo,Yoon, Seokjoo,Song, Chang Woo,Lee, Michael Wiley Subscription Services, Inc., A Wiley Company 2005 Environmental and molecular mutagenesis Vol.45 No.1
<P>In the present study, cDNA microarray analyses were performed with mouse cDNA chips in order to evaluate similarities and differences in the gene expression profiles for compounds differing in their genotoxic and carcinogenic potential. Eight test substances were evaluated, two each from four classes of compounds: genotoxic carcinogens (1,2-dibromoethane and glycidol), genotoxic noncarcinogens (8-hydroxyquinoline and emodin), nongenotoxic carcinogens (methyl carbamate and o-nitrotoluene), and nongenotoxic noncarcinogens (D-mannitol and 1,2-dichlorobenzene). Quadruplicate hybridization experiments were performed in order to identify a set of genes with significant expression changes for these four classes of substances. Twelve genes were consistently altered more than twofold by the genotoxic noncarcinogens while four genes were consistently regulated by the nongenotoxic carcinogens. One gene (Trp63) was identified whose expression was upregulated by all four genotoxic substances regardless of the presence or absence of carcinogenicity; this finding, however, was not confirmed by quantitative real-time RT-PCR. RT-PCR did confirm the change in expression of 9 of 15 genes (60%) identified by microarray analysis. Interestingly, the downregulated genes were least likely to be validated by real-time RT-PCR. Those genes showing more than a twofold change in expression level in response to at least one substance were further analyzed with hierarchical clustering after category assignment of each gene according to its main cellular function. Clustering revealed differences in the gene expression profiles between the genotoxic and nongenotoxic substances for genes involved in cell cycle control, the stress response, and the immune response. However, no clustering specific to all four carcinogenic substances was observed in any of the functional categories. Taken together, these results suggest that gene expression profiling in mouse lymphoma cells can provide valuable information for the evaluation of potential genotoxicity but may have limitations in predicting carcinogenicity. Environ. Mol. Mutagen., 2005. © 2004 Wiley-Liss, Inc.</P>
게잡이 원숭이에서 Recombinant Human Erythropoietin의 4주간 투여 후 비장 유전자 발현 연구
윤석주(Seokjoo Yoon),황지윤(Ji-Yoon Hwang),임정선(Jung-Sun Lim),정선영(Sun-Young Jeong),김용범(Yong-Bum Kim),김달현(Dal-Hyun Kim),권명상(Myung-Sang Kwon),한상섭(Sang-Seop Han),김충용(Choong-Yong Kim) 한국독성학회 2005 Toxicological Research Vol.21 No.3
We investigated effects of recombinant human erythropoietin (rHuEPO) on profiles of mRNA transcripts in 6 male cynomolgus (M. fascicularis) monkey’s spleen for 4 weeks. Six monkeys, composed of control and treatment group (Control : M1, M2, M3; Treatment : M4, M5, M6) were intravenously administered 3 times per week without or with a dose of rHuEPO 2730 IU/0.1 ㎖/㎏. After 4 weeks rHuEPO treatment, spleen was removed for RNA isolation. Splenic gene expression was assessed using Affymetrix U133A 2.0 arrays containing 18,400 transcripts and variants, including 14,500 well-characterized human genes. Gene expression pattern was very different between individuals even in same treatment. In rHuEPO treated groups showed number of genes were up-or downregulated (M4: 79; M5: 48; M6: 73 genes). Six genes (epidermal growth factor receptor, calgranulin A, estrogen receptor binding site associated antigen, matrix metalloproteinase 19, zinc finger and BTB domain containing 16, progestin and adipoQ receptor) were commonly expressed in rHuEPO treated group. The different individual response could be major considering factor in monkey experiment. Further study is needed to clarify the different individual response to rHuEPO in molecular level. This study will be valuable in the fundamental understanding and validation of molecular toxicology for biogeneric drugs including rHuEPO in cynomolgus monkey.
위진남북조 산수화론의 신(神) 개념 - 「명불론」(明佛論)과 「화산수서」(畵山水序)를 중심으로
김김석주 ( Kim Seokjoo ) 한국미학회 2019 美學 Vol.85 No.2
종병의 「명불론」(明佛論)은 중국 위진남북조 불교 수용과 변용에 있어서 중국적 사유를 통한 불교의 이해가 드러난 논문이다. 특히 이글은 ‘신멸·신불멸’(神滅·神不滅) 논쟁에 있어서 중국의 신 개념의 변화를 보여주는 단서로, 전통적인 형신(形神)의 대비를 통한 신(神) 개념의 이해에서 법신(法身)과 열반(涅槃)으로서의 신 개념의 이해로의 전환을 보여준다. 이러한 신 개념의 변화는 종병의 「화산수서」(畵山水序)의 해석에 영향을 미치게 된다. 기존의 전통적인 도(道)와 신, 성인(聖人)의 개념은 불교 사상의 영향으로 변화되어, 새로운 「화산수서」의 해석의 토대가 된다. 이러한 「화산수서」 해석의 관점은 위진남북조 산수화론과 예술론 전반의 신 개념을 이해하는 실마리가 되며, 나아가 이러한 신 개념의 이해는 중국미학사 전반에서의 신의 맥락을 규명하는 시도가 된다. Tsung Ping’s “Treatise Clarifying Buddhism”(「明佛論」) shows the understanding of Buddhism through Chinese thought during the Six Dynasties. In particular this essay is the clue to the change of god(神) or spirit(神). the Buddhist concept of the Dharmakaya(法身) and Nirvana(涅槃) changes the traditional concept of a body(形) and a spirit(神). This change influences the understanding of Tsung Ping's “essay on painting landscapes”(「畵山水序」). This understanding leads to a wider perspective on art theories during the Six Dynasties.
COVID-19 and Risk Factors of Anxiety and Depression in South Korea
Jinhee Hyun,Seokjoo Kim,Heeguk Kim,Yun-Jung Choi,Yun-Kyeung Choi,Yu-Ri Lee,Jong-Woo Paik,Jong-Sun Lee,Kihyun Kim,Jin Yong Jun,So Hee Lee,Sunju Sohn 대한신경정신의학회 2021 PSYCHIATRY INVESTIGATION Vol.18 No.9
Objective The aims of this study were to explore the prevalence of and identify predictors of anxiety and depression related to coronavirus disease of 2019 (COVID-19) in South Korea.Methods The analysis is based on a quota survey design and a sampling frame that permitted recruitment of a national sample of 1,014 individuals between March 17–31, 2020. Several standardized measurements were used, including GAD-7, PHQ-9, COVID-19 related fear, restrictions in deaily life, as well as sociodemographic information and physical and psychosocial needs during the pandemic. Multiple logistic regression was conducted to analyze the influence of sociodemographic factors, fear, and physical/psychosocial needs on anxiety and depression.Results Significant numbers of the respondents were identifiable anxiety (19.0%) and depression group (17.5%), respectively. This indicates that the depression and anxiety prevalence rate after the COVID-19 is substantially high compared to the depression rate of 2.6% in 2020 and 2.8% in 2018 both reported in the Korea Community Health Survey and the anxiety rate of 5.7% reported in 2016 Survey of Mental Disorders in Korea. Multiple logistic regression results showed age, COVID-19 related fear, and the level of restrictions in daily as significant factors in understanding and predicting the anxiety group. Likfewise, the COVID-19 related fear, restrictions in daily life, and need for economic support were important predictors in predicting the depression group.Conclusion Findings on predictors for greater vulnerability to anxiety and depression has important implications for public mental health in the context of the COVID-19 pandemic.
김경태(Kyungtae Kim),김대원(Daewon Kim),송호승(Hoseung Song),정우진(Woojin Jeong),권동윤(Dongyoon Kwon),최신욱(Sinuk Choi),구석주(Seokjoo Koo),최지웅(Ji-Woong Choi) 한국자동차공학회 2021 한국자동차공학회 부문종합 학술대회 Vol.2021 No.6
Today, speeding accidents are constantly occurring. To prevent these accidents, speeding enforcement is implemented by measuring the speed using a camera in Korea. However, the camera-based speed enforcement can measure an instantaneous speed in one direction and has a disadvantage in that the measurement range is narrow. This paper proposes a V2X-based vehicle speed control system to overcome the shortcomings of a camera-based enforcement system. In this system, we compare accuracy using speed data extracted in GPS and IVN. Furthermore, we compare DSRC and C-V2X, leading technologies of V2X, in terms of timeliness and reliability. We conduct implementations on highways and city roads with tunnels to confirm that the V2X can be used in speed enforcement system. Based on the results, we verify both GPS/IVN of extracting vehicle speed and DSRC/CV2X of communication technology.
C-ITS 대역폭 축소에 따른 DSRC 와 C-V2X 채널 간섭에 관한 연구
김대원(Daewon Kim),김경태(Kyungtae Kim),최신욱(Sinuk Choi),구석주(Seokjoo Koo),최지웅(Ji-Woong Choi) 한국통신학회 2021 한국통신학회 학술대회논문집 Vol.2021 No.2
무선 통신 시스템을 설계할 때, 인접 채널 간 간섭은 통신 QoS 에 영향을 미치기에 반드시 고려되어야 한다. 본 논문은 V2X 통신 기술인 DSRC 와 C-V2X 의 주파수 spectrum 을 분석하고 SIR 값을 계산한다. 또한 V2X 모듈을 사용하여 BSM 메시지 송/수신 실증을 수행하고, 인접 채널 간 간섭으로 인한 PER 을 계산하고 분석한다.
Multifunctional Green Solvent for Efficient Perovskite Solar Cells
Jaemin Cho,Beomsoo Kim,Seokjoo Ryu,Alan Jiwan Yun,Bumjin Gil,Jiheon Lim,Jihyun Kim,Jinhyun Kim,Byungwoo Park 대한금속·재료학회 2023 ELECTRONIC MATERIALS LETTERS Vol.19 No.5
Organometal trihalide perovskite has recently been considered as one of the leading candidates to achieve highly effi cient perovskite solar cells (PSCs). However, current PSC procedures commonly rely on the large volume of highly toxic halogenated or highly fl ammable solvents which are not favorable for the large-scale commercialization of PSCs. Herein, we employ nontoxic and nonhalogenated salicylaldehyde from the buckwheat as a both nonpolar (antisolvent) and polar (posttreatmentdissolving) solvent for the multifunctional purpose. Salicylaldehyde has a semipolar characteristic due to the hydroxyl group (–OH) attached to the benzene ring, enabling it to utilize both polar and nonpolar solvents in the PSCs fabrications. As a result, the PSC using green solvent achieved a power conversion effi ciency (PCE) up to 20.23%. Encapsulated devices retained over 80% of their initial PCE, after ~ 750 h of constant 1-sun illumination, and after ~ 1100 h under 60 °C heat. Overall, this work demonstrates that salicylaldehyde can be an alternative solvent for green and effi cient fabrication in the PSC.
The Efficient Algorithms for Constructing Enhanced Quadtrees Using MapReduce
KIM, Hongyeon,KANG, Sungmin,LEE, Seokjoo,MIN, Jun-Ki 'Institute of Electronics, Information and Communi 2016 IEICE transactions on information and systems Vol.99e.d No.4
<P>MapReduce is considered as the de facto framework for storing and processing massive data due to its fascinating features: simplicity, flexibility, fault tolerance and scalability. However, since the MapReduce framework does not provide an efficient access method to data (i.e., an index), whole data should be retrieved even though a user wants to access a small portion of data. Thus, in this paper, we devise an efficient algorithm constructing quadtrees with MapReduce. Our proposed algorithms reduce the index construction time by utilizing a sampling technique to partition a data set. To improve the query performance, we extend the quadtree construction algorithm in which the adjacent nodes of a quadtree are integrated when the number of points located in the nodes is less than the predefined threshold. Furthermore, we present an effective algorithm for incremental update. Our experimental results show the efficiency of our proposed algorithms in diverse environments.</P>