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Seo, Kyung Won,Park, Mi Jung,Park, Chang Won,Kim, Jun Gyou,Lee, Yoon Sook,Kim,Tae Wan,Song, Yeon Jung,Kim, Sang Geon,Lee, Sun Hee,Kim, Ju Il,Kil, Kwang Sup 식품의약품안전청 1998 식품의약품안전청 연보 Vol.2 No.-
Tobacco smoke condensate (TSC) has been reported to be carcinogenic to several animal species and include a nom'her of tumor initiators and tumor Promot☞rs.3-Hydroxypyridine (3-PfOH ), asignificant constituent of tobacco smoke, has been shown to induce the cytochrome P4S02El. In thisstudy we have investigated the influence of 3-PyOH on the activities of hepatic cytechromes P4SOuonooxygenases 1p450s) and UDP-glucuronyltransferase (UDP-GT), sulfotransferase (57) and gluts-thioue-5-transferase (GST) in male Sprague-Dawley rats. and compared with effect of TSC on metabo-lizing enBymes in rats hep,atocytes. We also examined if 3-PyOH and TSC would change the toxificationof acetaminophen (AA) through modulation of metaboliaing eazymes.3-PyOH (2mmo1/kg, p.o., 5 days)significantly increased the hepatic P4501Al and eST activity to 1.5 fold and 1.3 fold of control,respectivety. Treatment of TSC (250#g/m f, 2 days) dramatically enhanced the activity of PfSOIAl to7.5 fotd of control in rats hepatocytes. Smaller, but significant increase was observed with the activityof P4501A2(1.6 fold of control) in TSC-treated hepatocytes. After pretreatment of 3-PyOH (2mmo1/kg,p.o.5 days) iB ICR mice, potentiation of hepatotoricity by AA (400mg/kg, i.p., 24 hr) tras observed bymeasuring serum ALT activities. In rats hepatocytes, cytoteficity of AA was caused by pretreatmentwith TSC (250#g/mf,2 days) at non-cytotoxic concentration (ImMf. These results indicate that both of3-PyOH.and .?SC are potent inducers of PfSOIAl, but have lift)e effect on the phase rl metabolizing en-zymes. Moreover, potentiation of AA toxicity by pretreatments of 3-PyOH or TSC may be related to in-ductioa of Pfsos.
Effects of Bee Venom on Cholecystokinin Octapeptide-Induced Acute Pancreatitis in Rats :
Seo, Sang-Wan,Jung, Won-Seok,Lee, Sung-Eon,Choi, Chang-Min,Shin, Byung-Chul,Kim, Eun-Kyung,Kwon, Kang-Beom,Hong, Seung-Heon,Yun, Ki-Jung,Park, Rae-Kil,Shin, Min-Kyo,Song, Ho-Joon Ovid Technologies (Wolters Kluwer) - Lippincott Wi 2008 PANCREAS Vol.36 No.2
<P>OBJECTIVES: Bee venom (BV) has frequently been used as a remedy for inflammatory diseases. The aim of this study was to investigate the effect of BV on cholecystokinin octapeptide (CCK-8)-induced acute pancreatitis (AP) in rats. METHODS: The BV pretreatment group: 0.25 mg/kg BV was administered subcutaneously, followed by 75 mug/kg CCK-8 subcutaneously 3 times after 1, 3, and 5 hours. This whole procedure was repeated for 5 days. Control group: CCK-8 subcutaneously 3 times after 1, 3, and 5 hours for 5 days. The BV posttreatment group: CCK-8 subcutaneously 3 times at an interval of 2 hours for 3 days, and then 0.25 mg/kg of BV was administered subcutaneously. Control group: CCK-8 subcutaneously 3 times at an interval of 2 hours for 3 days. RESULTS: The BV pretreatment and posttreatment ameliorated many of the examined laboratory parameters (the pancreatic weight [PW]/body weight [BW] ratio, the serum amylase and lipase activity) and reduced histological damages in pancreas. Furthermore, BV pretreatment reduced the production of tumor necrosis factor-alpha, interleukin 1, and interleukin 6 and also decreased pancreatic nuclearfactor-kappaB binding activity compared with saline-treated group in the AP model. The BV also increased heat shock protein 60 (HSP60) and heat shock protein 72 (HSP72) compared with the saline-treated group in the AP model. CONCLUSIONS: These findings suggest that the anti-inflammatory effect of BV in CCK-8-induced AP seems to be mediated by inhibiting nuclear factor-kappaB binding activity, and that BV may have a protective effect against AP.</P>
환경시료의 방사능 분석에서 Monte Carlo 방법을 이용한 자체흡수 효과 보정
서범경,이대원,이길용,윤윤일,양태건 대한방사선 방어학회 2001 방사선방어학회지 Vol.26 No.2
환경방사능과 같은 저준위 방사능 측정에서는 원통형과 Marinelli형 측정용기가 가장 일반적으로 사용된다. 효율교정용 표준선원과 측정시료의 높이 또는 매질의 밀도가 다르면 자체흡수 효과의 차이로 인한 보정이 필요하다. 본 연구에서는 Monte Carlo 방법을 이용하여 HPGe 검출기의 전에너지 피크 효율을 계산하여 측정치와 비교하였다. 원통형 용기에 대해서는 높이에 대한 효율변화 정도를 계산하였고, 원통형 및 Marinelli 측정용기에 대해서는 밀도변화에 따른 효율을 계산하였다. 밀도에 따른 효율의 감소 정도는 1000keV이하의 에너지 영역에 대해 자체 흡수 효과의 보정치 필요하다는 것을 알았다. 또한 계산의 타당성을 검증하기 위하여 NIST SRM 4353 표준물질을 이용하여 계산값과 인증값을 상호비교한 결과 오차범위 이내로 잘 맞는다는 것을 확인하였다. In the low level radioactivity measurement, such as environmental radioactivity, there were used commonly cylindrical and Marinelli type beakers by means of measurement container. If there are differences in the matrix density or sample height between standard source and sample, it must be determined full energy peak efficiency considering self absorption effect. In this paper, we compared measured efficiency calculated full energy peak efficiencies in the HPGe detector using the Monte Carlo method. For cylindrical container, we calculated the variation of the efficiency with sample height. Also, we calculated the variation of the detection efficiency with apparent density in the cylindrical and Marinelli container. It was seen that it need to be corrected for self absorption in the energy range of below 1000keV. Also, in order to verify the validity of calculation, we compared the calculated value with reference value using NIST SRM 4353 reference soil.
Seo, Deug-Log,Yang, Je-Hoon,Won, Chung-Kil,Kim, Myeong-Ok,Lee, Jong-Hwan,Kwark, Soo-Dong,Koh, Phil-Ok The Korean Society of Veterinary Science 2005 大韓獸醫學會誌 Vol.45 No.1
In the present study, we expected the anti-tumor effect by combined treatment of arsenic trioxide and interferon (IFN)-${\alpha}$ on murine Lewis lung carcinoma (LL2) cells through in vivo study. As a experimental model, LL2 cells ($1{\times}10^{6}$/mouse) were injected subcutaneously into the back region of mice. When the tumor volume reached $100mm^3$, mice were treated with 1 mg/kg arsenic trioxide, 50000 IU IFN-${\alpha}$, or arsenic trioxide and IFN-${\alpha}$. The development of tumor cells was significantly inhibited by combined treatment with arsenic trioxide and IFN-${\alpha}$. In arsenic trioxide and IFN-${\alpha}$ treated group, apoptotic index was reached a peak valve at 48 hr after the treatment and it was restored to approximately the control level at 8 days. Also, positive signals of Bax and Bad were increased at 48 to 96 hr and decreased at 8 day. Whereas, positive cells of Bcl-2 were steadily decreased at 12 to 48 hr and restored to the background level at 8 days. Our data showed that immunoreactivity of Bcl-2 was decreased at 12 to 48 hr, while positive signals of Bax and Bad were increased in accordance with apoptotic index at these times. In conclusion, our results suggest that the combined treatment with arsenic trioxide and IFN-${\alpha}$ significantly inhibited the growth of LL2 tumor cells and induced apoptosis through the up and down-regulation of Bcl-2 gene family.