Landsat TM과 SPOT XS데이터를 이용한 디지털 모자이킹

서두천,이효성,안기원,신석효 慶尙大學校 1998 論文集 Vol.37 No.-

In digital processing of remotely sensed image data, digital mosaicking is required for display and analysis of large regions covered by more than one image. In this paper, digital mosaic process for any given multisensor data set of Landsat Thematic Mapper(TM) and SPOT multispectral(XS) data has been described. A statistical normalization was implemented to reduce radiometric discontinuity �� 새 the multisensor and multidata reflectance. An automated digital matching technique was used to find the corresponding ground control points in the overlapped area and to generate more geometrically accurate mosaic image.

정신분열병 환자의 KCNN3 유전자에서 나타나는 삼핵산 반복서열

김도관,임신원,고효정,서민영,손성은,이소영,황혜진,진동규,김병로 大韓神經精神醫學會 2001 신경정신의학 Vol.40 No.5

연구목적 : 연구자들은 NMDA 수용체의 channel protein 합성에 관여하는 KCNN3 유전자에서 나타나는 삼핵산 반복서열(triple nucleotide repeat, TNR) 확장이 과연 정신분열병의 발병에 기여하는지를 최근 개발된 TNR copy 수를 정량화 함으로써 알아보고자 하였다. 방 법 : 연구대상은 정신과 외래 및 입원 환자 중 정신분열병 환자 245명과 건강 의학센타를 방문한 정상 성인 116명을 각각 선발하였다. 정신분열병 환자들이 정상인에 비하여 불특정 CAG 삼핵산 반복 서열 확장에 차이가 나는지 repeat expansion detection(RED) 방법을 확인한 다음, 그것이 KCNN3이나 CTG18.1 유전자의 CAG 반복서열 증가에 의한 영향인지 분석하였다. 그리고 untranslated region에서 TNR 증가를 불특정하게 일으킬 수 있는 ERDA1의 CAG 삼핵산 반복서열의 영향을 검증함으로써 KCNN3나 CTG18.1 유전자가 정신분열병의 발병에 기여하는 바를 평가하였다. 결 과 : 정신분열병 환자는 정상인에 비하여 KCNN3 유전자 부위에서 TNR 확장이 현저한 longer allele이 빈번하게 관찰되었다. 즉, KCNN3 유전자 부위에서 CAG 삼핵산 반복이 19번 이상 확장되는 염색체가 신분열병 환자군에서는 73.3% 발견되는 데 비해서 정상인군에서는 65.1% 발견되어 유의한 차이가 있었다(p=0.029, Fisher's exact test). 이러한 차이는 가족력이 있는 정신분열병 환자군(79.7%)에서 가족력이 없는 환자군(70.8%)보다 더욱 현저하게 관찰되었다(p=0.003, Fisher's exact test). 음성형과 양성형 정신분열병 환자군 간에서의 차이는 관찰되지 않았다. CTG18.1 유전자 부위의 TNR 확장이나 불특정 부위 염색체 전체에서의 TNR 확장은 환자군과 정상 대조군 간에 차이가 없었다. 환자군과 대조군 모두에서 불특정 TNR 확장은 ERDA1의 전사와 유의하게 관련성이 있었다(각각 r=0.45, p<0.001 ; r=0.44, p<0.001). 하지만 KCNN3 유전자 부위에서 TNR 확장은 ERDA1 score와 유의한 관련성을 보이지 않았다. 결 론 : 이상의 결과는 KCNN3 유전자가 한국인 정신분열병의, 특히 가족력이 있는 정신분열병의, 발병에 관여할 수 있음을 시사한다. 또한 ERDA1 전사는 불특정 TNR 확장의 원인으로 작용한다는 가설을 뒷받침한다. Objects : We investigated a possible association between the polymophic trinucleotide repeat(TNR) expansion in neuronal potassium channel gene KCNN3 and schizophrenia. Methods : CAG/CTG repeat distribution in KCNN3, CTG8.1 and ERDA1 was examined and the copy number of ligation product in repeat expansion detection(RED) was measured in Korean patients with schizophrenia(n=245) and ethnically matched healthy controls(n=116). Results : Longer alleles in the KCNN3 gene were over-represented in patients. The frequency of alleles with CAG repeats longer than 19 copy in the KCNN3 gene was higher in the patients with schizophrenia as compared to controls(73.3% vs 65.1% ; p=0.029, Fisher's exact test). And this difference was more prominent in schizophrenic patients with familial background(p=0.03, Fisher's exact test). We found no difference in the frequency of longer alleles between negative and positive subtypes of schizophrenia. Ligation product size in RED and alleles with CAG repeat number in the CTG18.1 gene was not increased in the patients. The copy number of ligation product in RED was highly correlated with CAG/CTG copies if ERDA1 in the patient group(r=0.45, p<0.001) as well as in the control group(r=0.44, p=<0.001). However, CAG repeat length in the KCNN3 gene was not correlated with ERDA1 score. Conclusions : Our results support the hypothesis that the longer allele of KCNN3 may be considered as a candidate gene for schizophrenia, especially in the case with familial background. And the RED assay results was affected by the CAG copy number of ERDA1.

급성 골수성 백혈병 환자에서 발생한 침습성 아스페르길루스중에 대한 수술적치료 1 예

배영환;어원식;어상민;김승만 김태영;박수영;서영경;정은주;안효정 인제대학교 2011 仁濟醫學 Vol.32 No.-

Invasive pulmonary aspergillosis is known to have a poor prognosis and major cause of morbidity and motality in patients with hematologic disease. Without adequate therapy, invasive pulmonary aspergillosis will almost always progress to fatal pneumonia. Early administration of antifungal agents in patient with invasive pulmonary aspergillosis is most important. And surgical resection of aspergillous-infected tissue may be useful in patients with lesions that are contiguous with great vessel and lesions causing hemoptysis. We reported a rare case of surgical resection as curative treatment for invasive pulmonary aspergillosis patient in 58-year-old man who had the history of acute myeloid leukemia.

가족성 고콜레스테롤혈증 유병자에서 HMG Co-A Reductasen Inhibitor 및 Bile Acid Resin의 투여로 인한 아킬레스건 황색종의 감소

채인호,한기훈,박영배,조주희,김효수,손대원,김철호,오병희,이명묵,최윤식,서정돈,이영우 대한순환기학회 1997 Korean Circulation Journal Vol.27 No.9

우황청심원의 고문헌기록 및 실험적 연구결과 분석을 통한 임상응용 확대의 필요성 고찰

오영택,오현묵,김서우,김원용,손창규,조정효,Oh, Young-Taeck,Oh, Hyeon-Muk,Kim, Seo-Woo,Kim, Won-Yong,Son, Chang-Gue,Cho, Jung-Hyo 대전대학교 한의학연구소 2017 혜화의학회지 Vol.26 No.1

Objectives: The aim of this study is (1) to investigate the historic changes and pharmacological efficacies of Woohwangchungsim-won and (2) to discuss the necessities for Woohwangchungsim-won's clinical applications. Methods: This study was performed through (1) investigating the ancient literature records related with Woohwangchungsim-won and analyzing Woohwangchungsim-won's composition, dosage and indications, (2) searching articles about Woohwangchungsim-won on 10 major Korean web and 3 major foreign web article search engines and analyzing Woohwangchungsim-won's pharmacological efficacies and indications. Results: Woohwangchungsim-wom has been used for cerebrovascular diseases such as stroke and palpitation. Also, there are some ancient literature records of Woohwangchungsim-won's clinical applications in neuropsychiatric disorders such as depression and bipolar disorder. In addition, there have been a number of experimental studies which demonstrate Woohwangchungsim-won's neuroprotective effect on cerebral cortex and hippocampus injury. So, it is possible to infer that Woohwangchungsim-won can be used for the treatments of neuropsychiatric disorders associated with neuronal cell death in cerebral cortex and hippocampus. But there have been no or less experimental studies which demonstrate the pharmacological efficacy of Woohwangchungsim-won on such disease. Conclusion: It is necessary that further experimental studies which demonstrate Woohwangchungsim-won's pharmacological efficacy on neuropsychiatric disorders should be done and Woohwangchungsim-won's clinical applications should be expanded on the basis of those related experimental results.

Discrimination of Potato Varieties by Random Amplified Polymorphic DNA Analysis

Hyo Won Seo(서효원),Jung Yoon Yi(이정윤),Hyun Mook Cho(조현묵),Young Eun Park(박영은),Seung Eun Oh(오승은) 한국원예학회 2001 원예과학기술지 Vol.19 No.1

Steroids and Triterpenes from the Fruit Bodies of Ganoderma lucidum and their Anti-complement Activity

Hyo Won Seo,Tran Manh Hung,나민균,정현주,Jin Cheol Kim,최재수,김정희,이형규,IkSoo Lee,배기환,Masao Hattori,민병선 대한약학회 2009 Archives of Pharmacal Research Vol.32 No.11

To determine the anti-complement activity of natural triterpenes, chromatographic separation of the EtOAc-soluble fraction from the fruiting body of Ganoderma lucidum led to the isolation of three steroids and five triterpenoids. They were identified as ergosterol peroxide (1), ergosterol (2), genoderic acid Sz (3), stella sterol (4), ganoderic aic C1 (5), ganoderic acid A (6), methyl ganoderate A (7), and lucidenic acid A (8) based on spectroscopic evidence and physicochemical properties. These compounds were examined for their anti-complement activity against the classical pathway of the complement system. Compounds 2 and 3 showed potent anti-complement activity with IC50 values of 52.0 and 44.6 μM, respectively. Compound 1 exhibited significant inhibitory activity with an IC50 value of 126.8 μM, whereas compounds 4-8 were inactive. Our findings suggested that in addition to the ketone group at C-3, the Δ7(8), Δ9(11)-lanostadiene type triterpene also plays an important role in inhibiting the hemolytic activity of human serum against erythrocytes.

Primer for the Potato Specific Internal Control DNA and Screening of Genetically Modified Potatoes by Competitive PCR

Hyo Won Seo(서효원),Jung Yoon Yi(이정윤),Hyun Mook Cho(조현묵),Sung Yeul Kim(김숭열) 한국원예학회 2002 한국원예학회 학술발표요지 Vol.2002 No.6

The effects of ethanol metabolites in liver and adipose tissue in acute alcohol-associated liver injury

Won Hyo Seo 한국실험동물학회 2021 한국실험동물학회 학술발표대회 논문집 Vol.2021 No.7

Alcoholic liver disease is liver damage that results from alcohol misuse. Years of alcohol abuse induces simple steatosis and steatohepatitis as early types of liver diseases, however, continuous liver damage are able to induce liver fibrosis/cirrhosis, and hepatocellular carcinoma as known as late stage of liver disease. Albeit ALD is a major personal/public health problem, the pathogenesis of ALD has not been understood very well. About 8 to 10 percent of Americans drink heavily and, 10 to 15 percent will go on to develop ALD. ALD not only generates personal health issues, but also creates a lot of social problems such as drunken driving. The pathogenesis of ALD involves complex and unclear biological processes. Interestingly, alcohol consumption can profoundly disturb the normal functions of adipose tissue by inducing adipocyte death and altering secretion of adipokines, pro-inflammatory mediators and free fatty acids from adipose tissue, which have important direct and indirect effects on the pathogenesis of alcoholic liver disease. The association of the oxidative metabolites of ethanol (acetaldehyde and reactive oxygen species) have been well studied as crucial factors to understand clinical and pathological spectrum of ALD. Especially, acetaldehyde is known to be toxic to the liver and alters lipid homeostasis. Acetaldehyde generated from lipid peroxidation induce collagen synthesis by their ability to form protein adducts that further activate transforming-growth-factor-β-dependent and independent profibrogenic pathways in activated hepatic stellate cells (HSCs). Besides of oxidative alcohol metabolite, we have investigated that non-oxidative metabolites generated during alcohol metabolism act as factors promoting liver damage. Fatty acid ethyl esters (FAEEs), nonoxidative metabolites of ethanol, are detectable in the blood after ethanol ingestion, and on that basis have been proposed as markers of ethanol intake. The investigation of the association of oxidative alcohol metabolites and non-oxidative alcohol metabolites would provide very informative clues to understand more about the pathogenesis of alcohol-mediated liver injury.

A 90-nm CMOS 144 GHz Injection Locked Frequency Divider with Inductive Feedback

Seo, Hyo-Gi,Seo, Seung-Woo,Yun, Jong-Won,Rieh, Jae-Sung The Institute of Electronics and Information Engin 2011 Journal of semiconductor technology and science Vol.11 No.3

This paper presents a 144 GHz divide-by-2 injection locked frequency divider (ILFD) with inductive feedback developed in a commercial 90-nm Si RFCMOS technology. It was demonstrated that division-by-2 operation is achieved with input power down to -12 dBm, with measured locking range of 0.96 GHz (144.18 - 145.14 GHz) at input power of -3 dBm. To the authors' best knowledge, this is the highest operation frequency for ILFD based on a 90-nm CMOS technology. From supply voltage of 1.8 V, the circuit draws 5.7 mA including both core and buffer. The fabricated chip occupies 0.54 mm ${\times}$ 0.69 mm including the DC and RF pads.