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Nakajima, Katsuji,Yoshimoto, Shigetoshi,Kawakami, Yoichi,Hashimoto, Yukio,Takeda, Osamu,Tuchihashi, Yasue,Uno, Seiichi 통신위성우주산업연구회 2000 Joint Conference on Satellite Communications Vol.2000 No.-
An Onboard Processor (OBP) that can perform base-band circuit switching has been designed for in-orbit mobile satellite communications experiments using Japanese Engineering Test Satellite VIII (ETS-VIII). The Onboard Processor can exchange both 5.6 kbps voice and 32 kbps data using the MC-TDMA access method and can provide about 1,000 channels with digital signal processing techniques.
Nakajima, Yuki,Nishida, Hiroshi,Matsugo, Seiichi,Konishi, Tetsuya The Korean Society of Food Science and Nutrition 2009 Journal of medicinal food Vol.12 No.3
Previously, we studied the antioxidant potential of Chaga mushroom [Inonotus obliquus (persoon) Pilat] extracts and isolated several small (poly)phenolic compounds as the major antioxidant components in the 80% methanol (MeOH) extract. In the present study, these isolated phenolic ingredients together with several other types of Chaga extracts were examined for cytotoxic effects against normal (IMR90) and cancer (A549, PA-1, U937, and HL-60) cell lines. Results revealed decoctions from both the fruiting body (FB) and sclerotium (ST) parts of Chaga, especially the ST part, showed considerable cytotoxicity toward tumor cells, but the cytotoxicity appeared to be stronger against normal cells than cancer cells. The 80% MeOH ST extract also showed the same trend. On the other hand, the 80% MeOH extract of FB showed significant cytotoxicity towards tumor cell lines without affecting normal cells, for example, the 50% lethal dose was $49.4\;{\pm}\;2.9\;{\mu}g/mL$ for PA-1 cells versus $123.6\;{\pm}\;13.8\;{\mu}g/mL$ for normal cells. The phenolic components isolated from the 80% MeOH extracts had markedly greater cancer cell toxicity than the extracts themselves. In particular, two out of seven compounds showed strong cytotoxicity towards several tumor cell lines without giving rise to significant cell toxicity toward normal cells. For example, the 50% lethal dose for 3,4-dihydroxybenzalacetone was $12.2\;{\mu}mmol/L$ in PA-1 cells but was $272.8\;{\mu}mmol/L$ in IMR90 cells. Fluorescence-activated cell sorting analysis further revealed these phenolic ingredients have high potentiality for apoptosis induction in PA-1 cells.
Yuki Nakajima,Hiroshi Nishida,Seiichi Matsugo,Tetsuya Konishi 한국식품영양과학회 2009 Journal of medicinal food Vol.12 No.3
Previously, we studied the antioxidant potential of Chaga mushroom [Inonotus obliquus (persoon) Pilat] extracts and isolated several small (poly)phenolic compounds as the major antioxidant components in the 80% methanol (MeOH) extract. In the present study, these isolated phenolic ingredients together with several other types of Chaga extracts were examined for cytotoxic effects against normal (IMR90) and cancer (A549, PA-1, U937, and HL-60) cell lines. Results revealed decoctions from both the fruiting body (FB) and sclerotium (ST) parts of Chaga, especially the ST part, showed considerable cytotoxicity toward tumor cells, but the cytotoxicity appeared to be stronger against normal cells than cancer cells. The 80% MeOH ST extract also showed the same trend. On the other hand, the 80% MeOH extract of FB showed significant cytotoxicity towards tumor cell lines without affecting normal cells, for example, the 50% lethal dose was 49.4±2.9μg/mL for PA-1 cells versus 123.6±13.8μg/mL for normal cells. The phenolic components isolated from the 80% MeOH extracts had markedly greater cancer cell toxicity than the extracts themselves. In particular, two out of seven compounds showed strong cytotoxicity towards several tumor cell lines without giving rise to significant cell toxicity toward normal cells. For example, the 50% lethal dose for 3,4-dihydroxybenzalacetone was 12.2μmol/L in PA-1 cells but was 272.8μmol/L in IMR90 cells. Fluorescence-activated cell sorting analysis further revealed these phenolic ingredients have high potentiality for apoptosis induction in PA-1 cells.
Suppressed Fat Accumulation in Rats Fed a Histidine-Enriched Diet
Michiko Endo,Seiichi Kasaoka,Miki Takizawa,Kiyoko Goto,Shigeru Nakajima,Soo-Kyung Moon,In-Soo Kim,Bo-Young Jeong,Soichiro Nakamura 한국식품영양과학회 2010 Preventive Nutrition and Food Science Vol.15 No.1
The effect on body fat accumulation on male Wistar rats undergoing continuous feeding with a histidine-enriched diet was investigated. Five-week-age rats were assigned to two groups and were fed either the control diet (purified diet AIN-76™) or the histidine-enriched diet containing 3% histidine for 28 days. It was observed that both adipose tissue masses in retroperitoneal and epididymal areas of rats fed histidine-enriched diet significantly decreased (p<0.05) compared to those of control rats, while there was no significant difference in the food efficiency ratio between them. The blood levels of histidine derivatives of 3-methylhistidine and carnosine were significantly (p<0.05) increased in the rats fed a histidine-enriched diet, whereas there were no significant different between the histidine-enriched diet and control groups in the general amino acid distribution. Our results demonstrate that a histidine-enriched diet suppresses body fat accumulation in rats.
Suppressed Fat Accumulation in Rats Fed a Histidine-Enriched Diet
Endo, Michiko,Kasaoka, Seiichi,Takizawa, Miki,Goto, Kiyoko,Nakajima, Shigeru,Moon, Soo-Kyung,Kim, In-Soo,Jeong, Bo-Young,Nakamura, Soichiro The Korean Society of Food Science and Nutrition 2010 Preventive Nutrition and Food Science Vol.15 No.1
The effect on body fat accumulation on male Wistar rats undergoing continuous feeding with a histidine-enriched diet was investigated. Five-week-age rats were assigned to two groups and were fed either the control diet (purified diet AIN-$76^{TM}$) or the histidine-enriched diet containing 3% histidine for 28 days. It was observed that both adipose tissue masses in retroperitoneal and epididymal areas of rats fed histidine-enriched diet significantly decreased (p<0.05) compared to those of control rats, while there was no significant difference in the food efficiency ratio between them. The blood levels of histidine derivatives of 3-methylhistidine and carnosine were significantly (p<0.05) increased in the rats fed a histidine-enriched diet, whereas there were no significant different between the histidine-enriched diet and control groups in the general amino acid distribution. Our results demonstrate that a histidine-enriched diet suppresses body fat accumulation in rats.