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- 저자 : Sehoon LEE (검색결과 228 건)
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( Sehoon Park ),( Soojin Lee ),( Yaerim Kim ),( Yeonhee Lee ),( Min Woo Kang ),( Kyungdo Han ),( Hajeong Lee ),( Jung Pyo Lee ),( Kwon Wook Joo ),( Chun Soo Lim ),( Yon Su Kim ),( Dong Ki Kim ) 대한신장학회 2020 Kidney Research and Clinical Practice Vol.39 No.2
Background: Metabolic syndrome (MetS) is linked to various chronic comorbidities, including chronic kidney disease (CKD). However, few large studies have addressed whether recovery from MetS is associated with reduction in the risks of such comorbidities. Methods: This nationwide population-based study in Korea screened 10,664,268 people who received national health screening ≥ 3 times between 2012 and 2016. Those with a history of major cardiovascular events or preexisting CKD were excluded. We classified study groups into four, according to the course of MetS state, as defined by the harmonizing criteria. The main study outcome was incidental CKD (estimated glomerular filtration rate < 60 mL/min/1.73 m<sup>2</sup> which was persistent until the last health exams). The study outcomes were investigated using multivariable logistic regression analysis, which was adjusted for clinical variables and the previous severity of MetS. Results: Four study groups included 6,315,301 subjects: 4,537,869 people without MetS, 1,034,605 with chronic MetS, 438,287 who developed MetS, and 304,540 who recovered from preexisting MetS. Those who developed MetS demonstrated higher risk of CKD (adjusted odds ratio [OR], 1.26 [1.23-1.29]) than did those who did not develop MetS. In contrast, MetSrecovery was associated with decreased risk of CKD (adjusted OR, 0.84 [0.82-0.86]) than that in people with chronic MetS. Among the MetS components, change in hypertension was associated with the largest difference in CKD risk. Conclusion: Reducing or preventing MetS may reduce the burden of CKD on a population-scale. Clinicians should consider the clinical importance of altering MetS status for risk of CKD.
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( Sehoon Park ),( Soojin Lee ),( Yaerim Kim ),( Yeonhee Lee ),( Min Woo Kang ),( Kwangsoo Kim ),( Yong Chul Kim ),( Seung Seok Han ),( Hajeong Lee ),( Jung Pyo Lee ),( Kwon Wook Joo ),( Chun Soo Lim ) 대한신장학회 2021 Kidney Research and Clinical Practice Vol.40 No.2
Background: An inverse observational association between alcohol use and the risk of chronic kidney disease (CKD) or end-stage kidney disease (ESKD) has been reported. The causal effect of alcohol use on the risk of ESKD warrants additional investigation. Methods: The study was an observational cohort study investigating the UK Biobank and performed Mendelian randomization (MR) analysis. Amounts of alcohol use were collected using a touchscreen questionnaire. In the observational analysis, 212,133 partici pants without prevalent ESKD were studied, and the association between alcohol use and the risk of prevalent CKD or incident ESKD was investigated. The genetic analysis included 337,138 participants of white British ancestry. For one-sample MR, an analysis based on a polygenic risk score (PRS) was conducted with genetically predicted alcohol intake. The MR analysis investigated ESKD outcome and related comorbidities. Results: Lower alcohol use was observationally associated with a higher risk of prevalent CKD or incident ESKD. However, the genetic risk of CKD was significantly associated with lower alcohol use, suggesting reverse causation. A higher PRS for alcohol use was signifi cantly associated with a higher risk of ESKD (per units of one phenotypical alcohol drink; adjusted odds ratio of 1.16 [95% confidence interval, 1.02-1.31]) and related comorbidities, including hypertension, diabetes mellitus, obesity, and central obesity. Conclusion: The inverse observational association between alcohol use and the risk of CKD or ESKD may have been affected by re verse causation. Our study supports a causal effect of alcohol use on a higher risk of ESKD and related predisposing comorbidities.
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( Sehoon Park ),( Soojin Lee ),( Yaerim Kim ),( Yeonhee Lee ),( Min Woo Kang ),( Kyungdo Han ),( Seoung Seok Han ),( Hajeong Lee ),( Jung Pyo Lee ),( Kwon Wook Joo ),( Chun Soo Lim ),( Yon Su Kim ),( 대한신장학회 2019 Kidney Research and Clinical Practice Vol.38 No.1
Background: Cancer risk and epidemiology in pre-dialysis chronic kidney disease (CKD) warrant further investigation in a large-scale cohort. Methods: We performed a nationwide population-based study using the national health insurance database of Korea. We screened records from 18,936,885 individuals who received a national health examination ≥ 2 times from 2009 to 2016. Pre-dialysis CKD was identified based on serum creatinine and dipstick albuminuria results. Individuals with preexisting cancer history, renal replacement therapy, or transient CKD were excluded. A control group without evidence of kidney function impairment and matched for age, sex, low-income status, and smoking history was included. Risk of cancers, as identified in the claims database, was investigated using a multivariable Cox regression model including matched variables and other unmatched clinical characteristics as covariates. Results: A total of 471,758 people with pre-dialysis CKD and the same number of matched controls were included. Urinary (adjusted hazard ratio [HR], 1.97; 95% confidence interval [95% CI], 1.82-2.13) and hematopoietic (adjusted HR, 1.53; 95% CI, 1.38-1.68) malignancy risk was increased in pre-dialysis CKD and all CKD stages. However, the risk of digestive cancer was lower in the pre-dialysis CKD group (adjusted HR, 0.89; 95% CI, 0.87-0.92). The risk of digestive, respiratory, thyroid, and prostate malignancy demonstrated a non-linear association with CKD stage, with stage 1 or stage 4/5 CKD without dialysis demonstrating relatively lower risk. Conclusion: Cancer risk varied in pre-dialysis CKD compared to controls, and the association between cancer risk and CKD stage varied depending on the cancer type.
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( Sehoon Jeong ),( Joonhang Lee ),( Kwangmin Lee ) 대한금속재료학회(구 대한금속학회) 2014 대한금속·재료학회지 Vol.52 No.6
The types of atmospheric gases used in sputtering deposition are crucial in the formation of cubic boron nitride (c-BN) films. c-BN films were deposited on an Si wafer using radio frequency (RF) magnetron sputtering with a B4C target at N2/Ar+N2 ratios of 0.2, 0.4, 0.6, 0.8, and 1.0. The characteristics of the c BN layer were significantly enhanced at a nitrogen partial pressure ratio of 0.6. The highest growth rate and the lowest surface roughness were observed at this condition. The c-BN phase structure was clearly identified by the binding energy of the B1s and N1s along with X-ray diffraction patterns of the coated layer. These results indicate that the growth rate and crystal structure of the c-BN films are significantly affected under certain atmospheric gas conditions. (Received August 8, 2013)
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Lee, Sehoon,Rao, Boddu Ananda,Son, Young-A Elsevier 2015 Sensors and actuators. B Chemical Vol.210 No.-
<P><B>Abstract</B></P> <P>Herein, we report an effective strategy based on coordination-induced signaling by introducing a rhodamine B group linkage into squaraine–diamine dyads as a reversible switch. The optimized design, synthesis and application of a new optical squaraine–bis(rhodamine-B) chemosensor (<B>SRB</B>) as an ‘off–on’ fluorescent probe for the detection of Hg<SUP>2+</SUP> ions were investigated. <B>SRB</B> exhibited high selectivity toward Hg<SUP>2+</SUP> in the presence of various metal ions, such as Al<SUP>3+</SUP>, Ag<SUP>+</SUP>, Co<SUP>2+</SUP>, Cs<SUP>+</SUP>, Cu<SUP>2+</SUP>, Fe<SUP>3+</SUP>, K<SUP>+</SUP>, Li<SUP>+</SUP>, Mg<SUP>2+</SUP>, Na<SUP>+</SUP>, Ni<SUP>2+</SUP>, Pb<SUP>2+</SUP>, and Zn<SUP>2+</SUP>, and the resulting complex [<B>SRB</B>–Hg<SUP>2+</SUP>] was investigated using UV–vis and fluorescence spectroscopy in acetonitrile (CH<SUB>3</SUB>CN). The ‘off–on’ fluorescence and color signal change of the probe are based on a Hg<SUP>2+</SUP>-triggered domino reaction that employs the open-ring form of rhodamine spirolactam to regain the conjugated system of the rhodamine skeleton. The mechanism for the opening of the rhodamine spirolactam ring induced by Hg<SUP>2+</SUP> binding and the 1:1 stoichiometric structure of <B>SRB</B> and Hg<SUP>2+</SUP> were confirmed using a Job's plot estimation, optical titration and FT-IR. Subsequently, a <B>SRB</B>–Hg<SUP>2+</SUP> complex chemosensor was employed to detect CN<SUP>−</SUP> in the presence of different anions, such as Br<SUP>−</SUP>, CH<SUB>3</SUB>COO<SUP>−</SUP> or AcO<SUP>−</SUP>, Cl<SUP>−</SUP>, ClO<SUB>4</SUB> <SUP>−</SUP>, F<SUP>−</SUP>, HPO<SUB>4</SUB> <SUP>−</SUP>, HSO<SUB>4</SUB> <SUP>−</SUP>, I<SUP>−</SUP>, N<SUB>3</SUB> <SUP>−</SUP>, NO<SUB>3</SUB> <SUP>−</SUP>, PF<SUB>6</SUB> <SUP>−</SUP> and SCN<SUP>−</SUP>, in acetonitrile. In addition, this sensor exhibited highly selective and sensitive recognition of cyanide ions upon the addition of Hg<SUP>2+</SUP> with a color change back to colorless in the same solution. Finally, <B>SRB</B> was successfully applied with the PEGDMA polymer to sense Hg<SUP>2+</SUP> ions, which was analyzed using fluorescence confocal laser scanning microscopy (CLSM) and scanning electron microscopy (SEM) images.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Design and synthesis of a new squaraine–bis(rhodamine-B) (<B>SRB</B>) chemosensor was in high yield. </LI> <LI> Chemosensor <B>SRB</B> as an ‘off–on’ fluorescent probe for the detection of Hg<SUP>2+</SUP> ion. </LI> <LI> The <B>SRB</B>–Hg<SUP>2+</SUP> complex structure was confirmed via FT-IR studies. </LI> <LI> The reversibility of the <B>SRB</B>–Hg<SUP>2+</SUP> complex was realizable by the introduction of CN<SUP>−</SUP> ion. </LI> <LI> <B>SRB</B> was mixed with PEGDMA polymer for chemosensing the Hg<SUP>2+</SUP> ion. </LI> </UL> </P>
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Lee, Soojin,Park, Sehoon,Kang, Min Woo,Yoo, Hai-Won,Han, Kyungdo,Kim, Yaerim,Lee, Jung Pyo,Joo, Kwon Wook,Lim, Chun Soo,Kim, Yon Su,Kim, Hyeongsu,Kim, Dong Ki Elsevier 2019 Journal of critical care Vol.50 No.-
<P><B>Abstract</B></P> <P><B>Purpose</B></P> <P>Dialysis-requiring acute kidney injury (AKI-D) after cardiac surgery is a major cause of in-hospital mortality. However, the long-term outcome has not been previously examined.</P> <P><B>Materials and methods</B></P> <P>We performed a nationwide, population-based cohort study using the claims data in the Korean National Health Insurance System. Patients who underwent cardiac surgery between 2006 and 2015 were considered.</P> <P><B>Results</B></P> <P>Among 52,983 patients who underwent cardiac surgery, 1261 underwent dialysis postoperatively. During the median follow-up of 3.33 years, the AKI-D group had increased risk of all-cause mortality, end-stage renal disease (ESRD) progression, and risk of developing major adverse cardiovascular events (MACEs). These results remained consistent after multivariable analysis and propensity-score matching. Even after excluding patients who continued dialysis at discharge, the AKI-D group consistently exhibited worse mortality and an increased risk of MACEs compared to the control group. Patients who underwent continuous renal replacement therapy in the AKI-D group exhibited comparable mortality and risk of MACEs but reduced progression to ESRD compared to those who received intermittent renal replacement therapy.</P> <P><B>Conclusions</B></P> <P>AKI-D following cardiac surgery was associated with worse long-term postdischarge mortality and elevated risks of dialysis dependency and MACE development. The outcomes were consistent even in the patients who recovered from the dialysis.</P> <P><B>Highlights</B></P> <P> <UL> <LI> We examined the impact of dialysis-requiring AKI following cardiac surgery. </LI> <LI> AKI-D after cardiac surgery is associated with worse long-term prognosis. </LI> <LI> Postdischarge patients who recovered from AKI-D exhibited poor long-term outcomes. </LI> </UL> </P>
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Natural Progression of Ground-glass Nodules after Curative Resection for Non-small Cell Lung Cancer
Lee Kanghoon,Kim Hyeong Ryul,Park Seung-Il,Kim Dong Kwan,Kim Yong-Hee,Choi Sehoon,Lee Geun Dong 대한의학회 2021 Journal of Korean medical science Vol.36 No.43
Background: This retrospective study investigated the natural course of synchronous groundglass nodules (GGNs) that remained after curative resection for non-small-cell lung cancer (NSCLC). Methods: Prospectively collected retrospective data were reviewed concerning 2,276 patients who underwent curative resection for NSCLC between 2008 and 2017. High-resolution computed tomography or thin-section computed tomography data of 82 patients were included in the study. Growth in size was considered the most valuable outcome, and patients were grouped according to GGN size change. Patient demographic data (e.g., age, sex, and smoking history), perioperative data (e.g., GGN characteristics, histopathology and pathological stage of the resected tumours), and other medical history were evaluated in a risk factor analysis concerning GGN size change. Results: The median duration of follow-up was 36.0 months (interquartile range, 23.0–59.3 months). GGN size decreased in 6 patients (7.3%), was stationary in 43 patients (52.4%), and increased in 33 patients (40.2%). In univariate analysis, male sex, the GGN size on initial CT, part-solid GGN and smoking history (≥ 10 pack-years) were significant risk factors. Among them, multivariate analysis revealed that lager GGN size, part-solid GGN and smoking history were independent risk factors. Conclusion: During follow-up, 40.2% of GGNs increased in size, emphasising that patients with larger GGNs, part-solid GGN or with a smoking history should be observed.
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