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Epigenetic inactivation of RUNX3 in colorectal cancer
Eung Jin Shin,Han Jo Kim,Myoung Won Son,Tae Sung Ahn,Hyun Yong Lee,Dae Ro Lim,Sang Byung Bae,Seob Jeon,Hyungjoo Kim,Dongjun Jeong,Moon Soo Lee,Dong-Sun Kim,Jeong Se Noh,Moo-Jun Baek 대한외과학회 2018 Annals of Surgical Treatment and Research Vol.94 No.3
Epigenetic inactivation of RUNX3 in colorectal cancer
Eung Jin Shin,Han Jo Kim,Myoung Won Son,Tae Sung Ahn,Hyun Yong Lee,Dae Ro Lim,Sang Byung Bae,Seob Jeon,Hyungjoo Kim,Dongjun Jeong,Moon Soo Lee,Dong-Sun Kim,Jeong Se Noh,Moo-Jun Baek 대한외과학회 2018 Annals of Surgical Treatment and Research(ASRT) Vol.94 No.1
Purpose: The purpose of this study was to evaluate the efficacy of Betafoam in terms of wound healing and safety. Methods: Fifty-four male adult Sprague-Dawley rats (weight, 200–250 g) were used in the study. Full-thickness skin defects were created on the back of each rats. The rats were assigned to 6 groups according to the type of wound dressing used (n = 9 for each group): Betafoam, Allevyn-Ag, Mepilex-Ag, Medifoam silver, Polymem-Ag, and gauze. The wound size, histological findings, and amount of DNA on the changed dressings for each group were analyzed and compared. Results: All groups showed an effective decrease in wound size. However, the differences between Betafoam and the other dressings were statistically significant on day 14 (P < 0.05). The number of newly generated blood vessels in the Betafoam group was significantly higher than in the gauze, Allevyn-Ag, and Medifoam silver groups (P < 0.001). In the Betafoam group, the proportion of collagen deposition was highest and showed a significantly superior arrangement of collagen fibers compared with the gauze, Allevyn-Ag, Mepilex-Ag, and Medifoam silver groups. The total content of the remaining DNA counts of the exchanged dressings were significantly lower in the Betafoam group than the others. Conclusion: Betafoam is effective in wound healing and provides the best performance amongst the various types of dressing materials in terms of re-epithelialization, angiogenesis, collagen deposition, and tissue invasion.
Epigenetic inactivation of <i>RUNX3</i> in colorectal cancer
Shin, Eung Jin,Kim, Han Jo,Son, Myoung Won,Ahn, Tae Sung,Lee, Hyun Yong,Lim, Dae Ro,Bae, Sang Byung,Jeon, Seob,Kim, Hyungjoo,Jeong, Dongjun,Lee, Moon Soo,Kim, Dong-Sun,Noh, Jeong Se,Baek, Moo-Jun The Korean Surgical Society 2018 Annals of Surgical Treatment and Research(ASRT) Vol.94 No.1
<P><B>Purpose</B></P><P>Emerging evidence indicates that runt-related transcription factor 3 (<I>RUNX3</I>) is an important tumor suppressor gene in several cancer types, including colorectal cancer (CRC). However, the clinical significance of RUNX3 inactivation in CRC remains unclear. The aim of this study was to examine the correlation between clinicopathologic factors and RUNX3 hypermethylation/expression in CRC.</P><P><B>Methods</B></P><P>Sixty-two CRC patients who were treated at the Soonchunhyang University College of Medicine were recruited in this study. The hypermethylation of CpG islands in the RUNX3 promoter and the expression of RUNX3 mRNA were identified by methylation-specific polymerase chain reaction (PCR) and reverse transcriptase-PCR, respectively. The expression of RUNX3 was determined by immunohistochemical staining.</P><P><B>Results</B></P><P>Of the 62 CRC tissue samples, 20 (32.3%) presented hypermethylated RUNX3 promoters. Aberrant RUNX3 hypermethylation was found to be associated with vascular (P = 0.006) and lymphatic (P = 0.002) invasion. Hypermethylation of RUNX3 was associated with poor survival outcomes (P = 0.038). However, expression of RUNX3 was not a prognostic factor (P = 0.363).</P><P><B>Conclusion</B></P><P>Hypermethylation of RUNX3 may be a predictor of a poor prognosis in CRC.</P>
이마관자엽 치매 환자에서 나타난 하지 근력 저하와 복합부위 통증증후군에 대한 증례 보고
이광민(Kwang Min Lee),노세응(Se Eung Noh),주민철(Min Cheol Joo),황용(Yong Hwang),김지희(Ji Hee Kim) 한국산학기술학회 2017 한국산학기술학회논문지 Vol.18 No.12
이마관자엽 치매는 조기 발현형 치매 중 두 번째로 흔한 형태로 행동, 언어, 인지 장애를 보이는 신경퇴행성 질환이다. 이마관자엽 치매에서 운동 기능 이상이 동반되는 경우는 운동 신경원 질환과 파킨슨증, 진행성 핵상 마비 등으로 대표되나, 다른 동반 질환 없이 이마관자엽 치매가 중추신경계의 운동신경영역을 직접 침범하여 나타난 운동 기능 이상은 보고된 바가 없다. 또한, 임상적 치매 집단과 복합부위 통증 증후군 사이의 연관성은 보고된 바가 없다. 저자들은 이마관자엽 치매환자에서 나타난 중추신경계 원인의 하지 근력 저하를 뇌 자기공명영상과 전기진단학적 검사를 통해 진단하였고, 동반된 복합부위 통증증후군을 삼상 골주사 검사를 통해 진단하였으며, 이에 따른 임상적 치료를 시행하였다. 스테로이드를 이용한 복합부위 통증증후군 치료 후에 환자의 통증은 호전되었고, 입원 상태에서 하지 근육에 대한 기능적 전기 자극 치료, 근력강화 운동 및 보행 훈련을 포함한 포괄적 재활치료를 시행한 후에 저명한 기능적 호전을 보였다. 이마관자엽 치매에서 관찰된 중추신경계 원인의 근력 저하에 대한 재활 치료는 전반적 기능의 향상에 효과적일 것으로 추정된다. Frontotemporal dementia, the second most common cause of early onset dementia, is a neurodegenerative clinical syndrome characterized by progressive deficits in behavior, executive function and language. Although motor symptoms in frontotemporal dementia are represented by motor neuron disease, parkinsonism and progressive supranuclear palsy syndrome, there have been no reports of motor weakness caused by the direct involvement of central motor nervous systems in frontotemporal dementia. Moreover, no association between clinical dementia groups and complex regional pain syndrome has been reported. We diagnosed a rare case with motor weakness and complex regional pain syndrome of lower limbs due to central nervous system lesion in a patient with frontotemporal dementia by magnetic resonance imaging, electrodiagnostic study and three phase bone scan. Following steroid therapy for complex regional pain syndrome, pain was improved. Functional improvement was noted after rehabilitation therapy, including functional electrical stimulation, muscle strengthening exercise and gait training during hospitalization. This case report suggests that rehabilitation therapy for motor weakness in frontotemporal dementia could be effective for improving overall function.
Chan Gyu Kim,Geun Su Park,Se Eung Noh,Hyun Jeong Kim 대한예방치과학회 2024 International Journal of Clinical Preventive Denti Vol.20 No.1
Oral health care should undergo thorough easy and reliable assessment and evaluation to ensure its effectiveness and integration into daily care activities. We assessed oral hygiene and used a multi-channeled oral irrigation (MCOI) device (COMORALⓇ, SMDsolutions, Seoul, Korea) to evaluate turbidity and food residue in the oral irrigated water collected by the MCOI device as oral health indicators. A 74 years old female patient with long lasting Alzheimer’s disease and recent history of stroke and femur neck fracture was administrated at a community-based rehabilitation hospital. After oral assessment, a 3-cycle use per session use of we observed the changes of patients’ oral hygiene such as tongue coating. We visually observed turbidity of 500 ml of oral irrigated water collected by the MCOI device just after toothbrushing. The MCOI device might be integrated into regular oral care routines, given its ability to clear oral irrigated water consistently over time.
컴퓨터보조 인지재활훈련이 초기 뇌졸중 환자의 시지각 기능과 인지에 미치는 효과
정경만 ( Kyeoung-man Jung ),정유진 ( Yu-jin Jung ),노세응 ( Se-eung Noh ) 대한신경치료학회 2016 신경치료 Vol.20 No.3
Purpose This study was aimed at determining the effect of computer assisted cognitive rehabilitation on visual perception and cognition in early stroke patient. Methods Twenty early stroke patients were participated voluntarily and were assigned randomly into experimental group and control group. Participants in the experimental group received computer assisted cognitive rehabilitation (RehaCom program) training (20min) and conventional occupational therapy (20min), but participants in the control group received conventional occupational therapy(40min). Both group received training for three times per week for six weeks. Before and after 6weeks of intervention, an motor_free visual perception test(MVPT), Line Bisection Test(LBT), Mini Mental State Exam_Korean (MMSE_K) were performed and results were analyzed. Results Experimental group and control group improved more significantly after 6 weeks after treatment in MVPT, LBT, MMSE_K(p<.05). However, experimental group was more effective than control group in increasing the MVPT, MMSE_K (p<.05) and decreasing LBT(p<.05). Conclusion we suggest that the computer assisted cognitive rehabilitation(RehaCom program) training may be effective in improving the visual perception function in the early stroke patients
통합의료병원의 환자 미충족 의료서비스 및 경영개선을 위한 IPA
정문주 ( Moon-joo Cheong ),전병현 ( Byeong-hyeon Jeon ),노세응 ( Se-eung Noh ) 대한통합의학회 2021 대한통합의학회지 Vol.9 No.1
Purpose : This study explores unmet medical services within a region for patients admitted to a single medical institution in one region and was to analyze the importance and satisfaction of hospital selection attributes. Through this, we tried to solve the unmet medical needs of patients and provide useful basic data in terms of hospital management in the region. Methods : It were collected to a total of 250 questionnaires for patients admitted to the regional integrative medical hospital. However, 232 samples were used for the final analysis, excluding 18 copies not reported in good faith. For the analysis, first, demographic frequency analysis of inpatients and inpatients was performed, and second, characteristics of patients, including frequent disease receiving treatment, were analyzed. Next, descriptive statistics analysis was conducted on unmet medical service intentions. In terms of hospital selection attribute, the items of continuity maintenance (I quadrant), priority visibility (II quadrant), low priority (III quadrant), and excessive effort (IV quadrant) were derived using the IPA (importance-performance analysis) matrix technique. Results : The derived results were classified by item and area. In the priority administration area, it was the reputation and recognition of medical institutions and the service area of medical institutions. In the case of items, there were 6 items including the importance of surgery and medical expenses, and diet at hospitalization. Conclusion : Thus a result of this study, resources are efficiently allocated to priority correction areas with high importance but low satisfaction and circulatory medical treatment is performed in the departments required by patients who use medical care and, various methods, such as preparing a policy to support medical expenses, should be sought.
Chan Gyu Kim,Geun Su Park,Jong Hwa Jang,Se Eung Noh,Hyun Jeong Kim,Seong A Lee 국제차세대융합기술학회 2024 차세대융합기술학회논문지 Vol.8 No.3
본 연구의 목적은 재활병원에서 뇌졸중 환자의 구강관리를 위한 다채널구강세정기(MCOI)의 효과와 안전성 을 평가하는 것이다. 다채널구강세정기로 수집된 구강세척수의 탁도 및 음식물 잔사를 평가하였으며, 구강건강지표 인 설태와 혀마름을 함께 평가하였다. 인지장애를 동반한 11명의 환자를 포함하여 24명의 뇌졸중 환자는 부작용 없이 다채널구강세정기를 사용하였다. 연구 결과, 다채널구강세정기를 3회 연속으로 적용 후에 구강세척수의 탁도와 음식물 잔사가 유의하게 감소하였다(p<0.001). 결론적으로, 뇌졸중 환자에게 다채널구강세정기를 사용 후 구강청결 효과가 나타나 구강관리가 힘든 뇌졸중 환자의 새로운 대안이 될 수 있고, 일상적인 구강관리 뿐만 아니라 삼킴재 활치료를 하는 동안 뇌졸중 환자에게 구강청결을 시행하는 치료사의 시간을 절약할 수 있을 것으로 생각된다. The purpose of this study is to evaluate the efficacy and safety of a multi-channel oral irrigation (MCOI) device for oral care in stroke patients at a rehabilitation hospital. Turbidity and food residue in oral irrigated water collected by the MCOI were assessed, along with oral health indicators such as tongue coating and dryness. Twenty-four stroke patients, including 11 with cognitive impairment, used the MCOI without adverse effects. Following 3 consecutive cycles of the MCOI, there was a significant reduction in the turbidity and food residue of the mouth-rinsed water (p<0.001). In conclusion, the use of the MCOI in stroke patients resulted in improved oral hygiene, offering a new alternative for challenging oral care in stroke patients. Additionally, it may save therapists' time during swallowing rehabilitation sessions by incorporating oral cleaning practices.