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Choi, Dooho,Liu, Xuan,Schelling, Patrick K.,Coffey, Kevin R.,Barmak, Katayun American Institute of Physics 2014 Journal of Applied Physics Vol.115 No.10
<P>The impact of electron scattering at surfaces and grain boundaries in nanometric polycrystalline tungsten (W) films was studied. A series of polycrystalline W films ranging in thickness from 10 to 310 nm and lateral grain size from 74 to 133 nm were prepared on thermally oxidized Si. The Fuchs-Sondheimer surface-scattering model and Mayadas-Shatzkes grain-boundary scattering model were employed for quantitative analyses. Predictions from the theoretical models were found to deviate systematically from the experimental data. Possible reasons for the failure of the theoretical models to describe the experimental data are explored. Finally, a discussion of the crucial features lacking from existing models is presented, along with possible avenues for improving the models to result in better agreement with experimental data. (C) 2014 AIP Publishing LLC.</P>
ROEDER RICHARD A.,GARBER MIKEL J.,SCHELLING GERALD T. 한국낙농육우협회 1996 낙농·육우 Vol.16 No.12
비타민 E는 결핍증을 예방하는 역할 이외에도 가축의 생산성을 향상시키는 잠재 능력을 가지고 있다는 것이 입증되고 있다. 미래의 축산 경영과 제품 마케팅 프로그램에서 비타민 E의 두가지 확실한 역할은 육질 개선과 면역 증진 효과이다.
Paola Gandolfi-Decristophoris,Gertraud Regula,Orlando Petrini,Jakob Zinsstag,Esther Schelling 대한수의학회 2013 Journal of Veterinary Science Vol.14 No.4
We investigated the distribution of commensal staphylococcal species and determined the prevalence of multi-drug resistance in healthy cats and dogs. Risk factors associated with the carriage of multi-drug resistant strains were explored. Isolates from 256 dogs and 277 cats were identified at the species level using matrix-assisted laser desorption ionisation-time of flight mass spectrometry. The diversity of coagulase-negative Staphylococci (CNS) was high, with 22 species in dogs and 24 in cats. Multi-drug resistance was frequent (17%) and not always associated with the presence of the mecA gene. A stay in a veterinary clinic in the last year was associated with an increased risk of colonisation by multi-drug resistant Staphylococci (OR = 2.4, 95% CI: 1.1∼5.2, p value LRT = 0.04). When identifying efficient control strategies against antibiotic resistance, the presence of mechanisms other than methicillin resistance and the possible role of CNS in the spread of resistance determinants should be considered. We investigated the distribution of commensal staphylococcal species and determined the prevalence of multi-drug resistance in healthy cats and dogs. Risk factors associated with the carriage of multi-drug resistant strains were explored. Isolates from 256 dogs and 277 cats were identified at the species level using matrix-assisted laser desorption ionisation-time of flight mass spectrometry. The diversity of coagulase-negative Staphylococci (CNS) was high, with 22 species in dogs and 24 in cats. Multi-drug resistance was frequent (17%) and not always associated with the presence of the mecA gene. A stay in a veterinary clinic in the last year was associated with an increased risk of colonisation by multi-drug resistant Staphylococci (OR = 2.4, 95% CI: 1.1∼5.2, p value LRT = 0.04). When identifying efficient control strategies against antibiotic resistance, the presence of mechanisms other than methicillin resistance and the possible role of CNS in the spread of resistance determinants should be considered.
Schell, Mike,Smith, Doug 대한설비공학회 2003 설비저널 Vol.32 No.6
CO2환기제어는 신축건물에서 흔히 사용되고 있지만, 기존의 건물에서는 그 적용 예가 흔하지는 않다. 아마도 개보수라는 것이 가능하다고 여겨지는 자원절감이나 이익에 대한 방대한 기록이 요구되기 때문이며 게다가 제어에 관한 개보수는 복잡하다는 인식에 기인한다. 공교롭게도, 에너지 사용 패턴에 대하 명확한 기록이 있는 기존의 건물에 가장 에너지절약적인 기회가 많다는 사실이다. 이 기고문에서는 기존 건물의 CO2개보수에 관하여 그 성능 평가에 대한 방법론을 제시하고 있으며, 현장 평가와 이 방법론을 적용한 A-등급 사무소 건물에서의 개보수를 통한 성능개선에 관하여 분석하고 있다. 대상은 첨단 DDC시스템이 있는 미국 환경청의 에너지스타 등급을 획득한 건물이다.
Type VI secretion is a major virulence determinant in <i>Burkholderia mallei</i>
Schell, Mark A.,Ulrich, Ricky L.,Ribot, Wilson J.,Brueggemann, Ernst E.,Hines, Harry B.,Chen, Dan,Lipscomb, Lyla,Kim, H. Stanley,Mrá,zek, Jan,Nierman, William C.,DeShazer, David Blackwell Publishing Ltd 2007 Molecular microbiology Vol.64 No.6
<P><B>Summary</B></P><P> <I>Burkholderia mallei</I> is a host‐adapted pathogen and a category B biothreat agent. Although the <I>B. mallei</I> VirAG two‐component regulatory system is required for virulence in hamsters, the virulence genes it regulates are unknown. Here we show with expression profiling that overexpression of <I>virAG</I> resulted in transcriptional activation of ∼60 genes, including some involved in capsule production, actin‐based intracellular motility, and type VI secretion (T6S). The 15 genes encoding the major sugar component of the homopolymeric capsule were up‐expressed > 2.5‐fold, but capsule was still produced in the absence of <I>virAG</I>. Actin tail formation required <I>virAG</I> as well as <I>bimB</I>, <I>bimC</I> and <I>bimE</I>, three previously uncharacterized genes that were activated four‐ to 15‐fold when VirAG was overproduced. Surprisingly, actin polymerization was found to be dispensable for virulence in hamsters. In contrast, genes encoding a T6S system were up‐expressed as much as 30‐fold and mutations in this T6S gene cluster resulted in strains that were avirulent in hamsters. SDS‐PAGE and mass spectrometry demonstrated that BMAA0742 was secreted by the T6S system when <I>virAG</I> was overexpressed. Purified His‐tagged BMAA0742 was recognized by glanders antiserum from a horse, a human and mice, indicating that this Hcp‐family protein is produced <I>in vivo</I> during infection.</P>
Peter D. Schellinger,Georgios Tsivgoulis,Thorsten Steiner,Martin Köhrmann 대한뇌졸중학회 2018 Journal of stroke Vol.20 No.3
The authors review the current status of percutaneous left atrial appendage (LAA) occlusion therapy in patients with atrial fibrillation with the goal to prevent ischemic stroke and systemic embolism and to reduce oral anticoagulation associated bleeding. While we cover the historical and also surgical background, and all tested devices, the main focus rests on the single currently U.S. Food and Drug Administration (FDA) approved LAA occluder, the WATCHMAN device, and its approval process. The authors also give a critical appraisal beyond the review of mere facts, trying to put the current data into perspective.
Patent Foramen Ovale: Story Closed?
Martin Köhrmann,Peter D. Schellinger,Georgios Tsivgoulis,Thorsten Steiner 대한뇌졸중학회 2019 Journal of stroke Vol.21 No.1
The optimal treatment strategy for secondary prevention in patients with cryptogenic stroke and patent foramen ovale (PFO) has been a matter of controversy for decades. After three randomized trials failed to show a benefit of closure with an excess of complications in the interventional arm, two large recent trials suggest a benefit with regard of preventing further ischemic strokes. With this discrepancy in results it is important to discuss recent trials in detail and evolve an informed clinical approach for daily practice.