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Biodegradable micro-sized discoidal polymeric particles for lung-targeted delivery system
Park, Jun Young,Park, Sanghyo,Lee, Tae Sup,Hwang, Yong Hwa,Kim, Jung Young,Kang, Won Jun,Key, Jaehong Elsevier 2019 Biomaterials Vol.218 No.-
<P><B>Abstract</B></P> <P>Various types of particle-based drug delivery systems have been explored for the treatment of pulmonary diseases; however, bio-distribution and elimination of the particles should be monitored for better understanding of their therapeutic efficacy and safety. This study aimed to characterize the biological properties of micro-sized discoidal polymeric particles (DPPs) as lung-targeted drug delivery carriers. DPPs were prepared using a top-down fabrication approach and characterized by assessing size and zeta potential. They were labeled with zirconium-89 (<SUP>89</SUP>Zr), and bio-distribution studies and PET imaging were performed for 7 days after intravenous administration. Their hydrodynamic size was 2.8 ± 6.1 μm and average zeta potential was −39.9 ± 5.39 mV. At doses of 5, 12.5, and 25 mg/kg, they showed no acute toxicity in nude mice. Desferrioxamine (DFO)-functionalized <SUP>89</SUP>Zr-labeled DPPs gave a decay-corrected radiochemical yield of 82.1 ± 0.2%. Furthermore, <SUP>89</SUP>Zr-DPPs, from chelate-free labeling methods, showed a yield of 48.5 ± 0.9%. Bio-distribution studies and PET imaging showed <SUP>89</SUP>Zr-DFO-DPPs to be mainly accumulated in the lungs and degraded within 3 d of injection. However, <SUP>89</SUP>Zr-DFO-DPPs showed significantly low uptake in the bone. Overall, our results suggested micro-sized DPPs as promising drug delivery carriers for the targeted treatment of various pulmonary diseases.</P>
Sanghyo Park,Wonhoon Lee 한국응용곤충학회 2023 한국응용곤충학회 학술대회논문집 Vol.2023 No.10
The tribe Tropidocephalini Muir, 1915 (Delphacidae: Delphacinae) comprised 37 genera 204 species worldwide. In Korea, only three species, Epeurysa nawaii Matsumura, 1900, Tropidocephala brunnipennis (Distant, 1906), T. nigra (Matsumura, 1900), have been reported. In this study, one species, Epeurysa distincta Huang & Ding, 1979, is reported for the first time from Korea. We provide the morphological characteristics, photographs and taxonomic keys of the four species belonging to the tribe Tropidocephalini.
고속 HEVC 부호화를 위한 효율적인 PU 레벨 움직임예측 병렬화 구현 기법
박수빈(Soobin Park),최기호(Kiho Choi),박상효(Sanghyo Park),장의선(Eueeseon Jang) 한국방송·미디어공학회 2012 한국방송공학회 학술발표대회 논문집 Vol.2012 No.11
본 논문에서는 차세대 비디오 표준인 High Efficiency Video Coding(HEVC)의 영상 부호화 과정의 시간복잡도 감소를 위한 효율적인 Prediction Unit(PU)레벨 움직임예측(Motion Estimation, ME) 병렬화의 구현기법을 제시하고자 한다. 움직임예측 과정은 부호화기에서 80%의 복잡도를 차지하는 과정으로 고속 부호화의 걸림돌이 되고 있다. 이를 해결하기 위한 방법으로 제안된 것이 움직임예측 알고리즘의 병렬화이다. 알고리즘 수준에서 ME 의 일부인 Merge Estimation 의 병렬화를 위해서 Merge Estimation Region (MER)기반의 ME 방법이 제안되었다. 하지만 HEVC Test Model reference software(HM)에 반영된 MER 을 이용하여 실제로 병렬화된 ME 를 구현하는 과정에서는 알고리즘 측면에서 아직 고려되지 않은 문제들이 존재한다. 이에 본 논문에서는 MER 을 사용한 안정적인 병렬 ME 를 구현하기 위한 전략으로 각 PU 의 정보를 독립적으로 사용하기 위한 부분 순차화 방법과 메모리 접근제한을 이용한 병렬화 방법을 제시한다. 실험을 통해 본 연구의 우수성이 확인되었는데, 제안된 방법에 기반을 둔 구현에서 순차적인 ME 를 이용한 부호화기 대비 평균 25.64%의 전체 부호화 과정 시간의 감소가 나타났다.
Small Electrical Nerve Stimulator by Arm Processor
Sanghyo Woo,Changwook Kim,Mohyuddin Zia,Sangheon Lee,Euisung Chung,Jangwoo Lee,Junghyun Lee,Heejoon Park,Chulho Won,Jinho Cho 대한전자공학회 2007 ITC-CSCC :International Technical Conference on Ci Vol.2007 No.7
Recently, performance of a mobile phone has increased dramatically, and it is possible to integrate various biotechnologies into the mobile phone. Among the various biotechnologies, a transcutaneous electrical nerve stimulator has many advantages such as improve the circulation of blood and suppress a pain. To integrate the stimulator in the mobile phone, it is necessity to make small, low power, and safe module. In this paper, the transcutaneous electrical nerve stimulation module was designed and implemented by small boost converter. To reduce the power consumption, the external ADC was used to measure the value of the charged energy. Also, the module limits the maximum transmit power by tank capacitor value to inprove safety. To confirm the operation of designed module, an arm processor was used to control the module. The implemented module consumes only 6.6 ㎽ (without CPU) at normal stimulus mode.
Park, Jae-Hyoung,Lee, Sanghyo,Kim, Jung-Mu,Kim, Hong-Teuk,Kwon, Youngwoo,Kim, Yong-Kweon Institute of Electrical and Electronics Engineers 2005 Journal of microelectromechanical systems Vol.14 No.3
In this paper, fully monolithic reconfigurable millimeter-wave filters are proposed using the CPW-based periodic structures with novel multiple-contact MEMS switches. Millimeter-wave low-pass and band-pass filters were designed, fabricated, and tested. Three cascaded CPW-based periodic structures, with low-pass and band-pass intrinsic filtering characteristics, are reconfigured into a self-similar single unit cell by the operation of the novel multiple-contact MEMS switches with single actuation. By using the multiple-contact MEMS switches, the insertion loss can be reduced and the operating frequency ranges are extended to millimeter-waves with little increase of loss. Additionally, the number of the switching elements has been reduced and the bias-decoupling circuits are not required, resulting in a very small chip size. The measured results of the reconfigurable low-pass filter show the 3-dB cutoff frequency change from 67 to 28 GHz with very small change in the insertion loss from 0.32 to 0.27 dB. The center frequency of the reconfigurable band-pass filter is tuned from 55 to 20 GHz, and the measured 3-dB cutoff bandwidth changed from 32 to 12 GHz, while the average insertion loss changed from 1.27 to 1.61 dB. The chip size of the low-pass and band-pass filter including dc bias line is 1.2 mm × 1.5 mm and 1.2 mm × 4.5 mm, respectively.
Lee, Sanghyo,Ko, Wonbae,Oh, Yujin,Lee, Jongsun,Baek, Gwangho,Lee, Younhee,Sohn, Junginn,Cha, Seungnam,Kim, Jongmin,Park, Jeagun,Hong, Jinpyo Elsevier 2015 Nano energy Vol.12 No.-
<P><B>Abstract</B></P> <P>Wearable energy harvesting devices are of increasing importance for the realization of flexible smart electronics, as the basic building blocks of power sources are able to convert the mechanical energy induced from body movement to electricity. Here, we report the electrical responses of a textile substrate-based triboelectric nanogenerator (T-TENG), including nanostructured surface configurations provided by Al nanoparticles and PDMS, in which no intricate fabrication process was performed or required. Along with analysis of the working principle and finite element simulation, the textile-based output power density of 33.6mW/cm<SUP>2</SUP> was obtained from the periodic mechanical stress of an adjustable bending machine, and this was used to activate commercially available light emitting diode (LED) bulbs. Additionally, we demonstrated the generation of sufficient energy from clothes attached to a commercial arm sleeve to power the LED devices from the activity of a human arm. Our practical cloth approach may contribute to a general framework for developing functional and self-powered wearable electronic devices.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Textle substrate was used to develope functional self-powered energy harvester. </LI> <LI> Electrical features of T-TENG was manipulated by various surface configurations. </LI> <LI> A self-powered clothes was demonstrated as one example of energy harvester. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>Textile substrate-based triboelectric nanogenerator (T-TENG) including nanostructured surface configurations provided by Al nanoparticles and PDMS has been demonstrated for the generation of energy from clothes attached to a commercial arm sleeve in order to power the LED devices from the activity of a human arm.</P> <P>[DISPLAY OMISSION]</P>