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박상효,이원훈,Sanghyo Park,Wonhoon Lee Korean Society of Applied Entomology 2023 한국응용곤충학회지 Vol.62 No.2
In this study, the genus Tagosodes Asche and Wilson, 1990 is reported for the first time in South Korea. Species distribution, measurement, host plants, description, and illustrations of diagnostic characters of Tagosodes pusanus Distant, 1912 are provided.
폐 전이 암에 대한 Lipid Coated Polymeric Nanoparticles에 관한 연구
박준영,박상효,조예림,정민지,김인우,강원준,기재홍,Park, Junyoung,Park, Sanghyo,Jo, Yerim,Jeong, Minji,Kim, Inwoo,Kang, Wonjun,Key, Jaehong 대한의용생체공학회 2018 의공학회지 Vol.39 No.4
Lung cancer and pulmonary metastasis are the leading cause of cancer mortality worldwide. Survival for patients with lung metastases is about 5%. Nanoparticles have been developed for the imaging and treatment of various cancers, including pulmonary malignancies. In this work, we report lipid coated polymeric nanoparticles (LPNs) with an average diameter of 154 nm. In vivo performance of LPNs was characterized using optical imaging system. We expect this nanoparticle can be used for finding lung cancer or lung metastasis. Eventually loading therapeutic drug with the nanoparticle will be utilized for cancer diagnosis and effective therapy at the same time.
고속 HEVC 부호화를 위한 효율적인 PU 레벨 움직임예측 병렬화 구현 기법
박수빈(Soobin Park),최기호(Kiho Choi),박상효(Sanghyo Park),장의선(Eueeseon Jang) 한국방송·미디어공학회 2012 한국방송공학회 학술발표대회 논문집 Vol.2012 No.11
본 논문에서는 차세대 비디오 표준인 High Efficiency Video Coding(HEVC)의 영상 부호화 과정의 시간복잡도 감소를 위한 효율적인 Prediction Unit(PU)레벨 움직임예측(Motion Estimation, ME) 병렬화의 구현기법을 제시하고자 한다. 움직임예측 과정은 부호화기에서 80%의 복잡도를 차지하는 과정으로 고속 부호화의 걸림돌이 되고 있다. 이를 해결하기 위한 방법으로 제안된 것이 움직임예측 알고리즘의 병렬화이다. 알고리즘 수준에서 ME 의 일부인 Merge Estimation 의 병렬화를 위해서 Merge Estimation Region (MER)기반의 ME 방법이 제안되었다. 하지만 HEVC Test Model reference software(HM)에 반영된 MER 을 이용하여 실제로 병렬화된 ME 를 구현하는 과정에서는 알고리즘 측면에서 아직 고려되지 않은 문제들이 존재한다. 이에 본 논문에서는 MER 을 사용한 안정적인 병렬 ME 를 구현하기 위한 전략으로 각 PU 의 정보를 독립적으로 사용하기 위한 부분 순차화 방법과 메모리 접근제한을 이용한 병렬화 방법을 제시한다. 실험을 통해 본 연구의 우수성이 확인되었는데, 제안된 방법에 기반을 둔 구현에서 순차적인 ME 를 이용한 부호화기 대비 평균 25.64%의 전체 부호화 과정 시간의 감소가 나타났다.
플라즈마-초음파 자극에 의한 화장품의 피부 침투 증진 연구
황윤호,조혜연,박유진,장휘진,박상효,기재홍,Yoonho Hwang,Hyeyoun Cho,Yujin Park,Hwijin Jang,Sanghyo Park,Jaehong Key 대한의용생체공학회 2023 의공학회지 Vol.44 No.4
The demand for skincare has increased due to the end of the COVID-19 pandemic, leading to a focus on skincare devices and technologies designed to improve the delivery of cosmetics. Among these technologies, skincare medical devices that utilize plasma therapy (Plasma) and sonophoresis (Sono) are commonly used in dermatology clinics. However, there is still a lack of quantitative analysis for transdermal absorption effects of Plasma and Sono skincare medical devices. In this study, we quantified enhanced transdermal absorption effects of Plasma and Sono devices through in-silico and ex-vivo studies. The Sono treatment demonstrated an increased transdermal absorption effect, showing a 10~13% difference in penetration compared to the control group in the in-silico experiment, and 159% and 184% increase in the ex-vivo experiment. The Plasma treatment revealed increased transdermal absorption effects, with a 1.0~2.5% penetration difference in the in-silico experiment, and a 124% increase in the ex-vivo experiment compared to the control group. We also observed a synergistic effect from the combined treatment of Plasma and Sono, as indicated by the highest increases of 197% and 242% in penetration. Furthermore, we have determined the optimal device settings and treatment conditions for Plasma-Sono skincare medical devices. Notably, higher on/off durations (Intensity levels) and longer Sono treatments resulted in greater transdermal absorption effects.
전하가 다른 PLGA 나노 입자의 생체 안정성 및 암세포에 미치는 영향
김인우,박승빈,지유현,박상효,기재홍,Kim, Inwoo,Park, Seungbin,Ji, Yuhyun,Park, Sanghyo,Key, Jaehong 대한의용생체공학회 2018 의공학회지 Vol.39 No.3
Cancer is a major burden of human disease worldwide. Current chemotherapy has severe side effects because the drugs affect whole body nonspecifically. In addition, the drugs to reach cancer cells are very limited. Over the last two decades, Drug Delivery System (DDS) using nanoparticles has suggested promising results to improve current limitations. In this study, we prepared PLGA nanoparticles with different charge properties and observed their stability and internalization effect to cancer cells. Results using Dynamic Light Scattering (DLS) and Fourier Transform Infrared Spectroscopy (FTIR) confirmed the size and chemical composition of the nanoparticles. The stability of the nanoparticles in pH buffers were variable depending on charge properties. The nanoparticles showed different cytotoxicity and internalization effects to MCF-7 human breast cancer cells. In conclusion, we demonstrated the importance of delicately engineered nanoparticles for better DDS in cancer.