수학자 보재 이상설(李相卨)의 근대자연과학 수용 -『백승호초(百勝胡艸)』를 중심으로-

이상구 ( Sang Gu Lee ),박종윤 ( Chong Yun Park ),김채식 ( Chae Sik Kim ),이재화 ( Jae Hwa Lee ) 한국수학교육학회 2013 수학교육논문집 Vol.27 No.4

본 논문은 한국 근대수학교육의 아버지 이상설(李相卨, 1870-1917)이 자연과학―물리학―에 기여한 내용을 다루고있다. 이상설은 ?수리(數理)?를 쓴 시기를 전후하여, 같은 시기에 붓으로 총 8면에 걸쳐 『백승호초(百勝胡艸)』라는이름의 고전물리학 원고를 써서 남겼다. 분석결과 이 책의 원전은 1879년에 동경제대 의학부 교재로 발간된 『물리학(物理學)』이다. 이상설은 『백승호초』에서 먼저 개념을 정의하고, 일상에서 나타난 대표적 현상을 선록하여 한문으로번역하였고, 『물리학』의 전체 분량에서도 특히 ‘통유성(通有性)’에 중점을 두고 설명하였다. 동양에서 서양의 수리과학이 들어와야만 말할 수 있는 ‘질량보존의 법칙’, ‘타성(惰性, 관성)’과 같은 고전물리학의 중요개념을 포함하는 내용이 19세기 말에 이미 이 책에 소개된 것으로 보아 이상설은 당대의 다른 저술에서 보기 힘들 정도로 당시 일반물리학의 최고수준의 원서를 통해 최신 정보를 수용하고 전파하기 위하여 노력하였음을 볼 수 있다. Sang-Seol Lee(1870-1917) wrote a manuscript BaekSeungHoCho(百勝胡艸) in the late 19th century. BaekSeungHo-Cho was transcribed in classical Chinese from the 1879 Japanese book Physics(物理學) by Teizo Ihimori (1851-1916). Sang-Seol Lee, a famous independence activist, is also called Father of the Modern Mathematics Education of Korea,because of his early contribution to the modern mathematics education in the 19th century. In this paper, we introduce contents of his manuscript BaekSeungHoCho for the first time and discuss the significance of this book. Also, we show his constribution on the introduction to modern physics in the late 19th century Korea.

Elevated TRAF2/6 expression in Parkinson's disease is caused by the loss of Parkin E3 ligase activity.

Chung, Ji-Yun,Park, Hee Ra,Lee, Su-Jin,Lee, Sun-Hye,Kim, Jin Sik,Jung, Youn-Sang,Hwang, Sang Hyun,Ha, Nam-Chul,Seol, Won-Gi,Lee, Jaewon,Park, Bum-Joon United States and Canadian Academy of Pathology [e 2013 Laboratory investigation Vol.93 No.6

<P>Parkinson's disease (PD) is the second leading neurodegenerative disease, and is known to be induced by environmental factors or genetic mutations. Among the verified genetic mutations of PD, Parkin, isolated from the PARK2 locus, shows an autosomal recessive inheritance pattern and is known to be an E3 ligase. However, the physiological target of Parkin and the molecular mechanism of Parkin-deficiency-induced PD have not been clearly demonstrated until now. It has recently been proposed that inflammation, suggesting as a causal factor for PD, is enhanced by Parkin deficiency. Thus, we examined the relationship between inflammation-related factors and Parkin. Here, we provide the evidence that Parkin suppresses inflammation and cytokine-induced cell death by promoting the proteasomal degradation of TRAF2/6 (TNF-α receptor-associated factor 2/6). Overexpression of Parkin can reduce the half-lives of TRAF2 and TRAF6, whereas si-Parkin can extend them. However, mutant Parkins did not alter the expression of TRAF2/6. Thus, loss of Parkin enhances sensitivity to TNF-α- or IL-1β-induced JNK activation and NF-κB activation. Indeed, si-Parkin-induced apoptosis is suppressed by the knockdown of TRAF6 or TRAF2. We also observed elevated expression levels of TRAF6 and a reduction of IκB in an 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced PD mouse model. Moreover, elevated expression levels or aggregation of TRAF6 were detected in approximately half of the human PD tissues (7/15 cases) and 2 cases, respectively. In addition, TRAF6 and Parkin expression levels show a reverse relationship in human PD tissues. Our results strongly suggest that the reduction of Parkin or overexpression of TRAF2/6 by chronic inflammation would be the reason for occurrence of PD.</P>

종 분포 모형을 이용한 구상나무림의 지속 및 쇠퇴에 관한 연구 - 전라남도 광양시 백운산을 중심으로 -

조선희 ( Seon Hee Cho ),박종영 ( Jong Young Park ),박정호 ( Jeong Ho Park ),이양근 ( Yang Geun Lee ),문이만 ( Lee Man Mun ),강상호 ( Sang Ho Kang ),김광현 ( Gwang Hyun Kim ),윤종국 ( Jong Guk Yun ) 한국산림과학회 2015 한국산림과학회지 Vol.104 No.3

The present study investigated the habitats of Korean fir trees (Abies koreana E. H. Wilson) on Mt. Baekwun (Baekwun-san), determined the current distribution, quantified the contribution of biological and nonbiological environmental factors affecting the distribution, derived actual and potential habitats, presented a plan for the establishment of protected areas, applied RCP 8.5 climate change scenario to analyze the effects of climate change on the future distribution of Korean fir trees, and predicted future potential habitats. According to the results of the study, 3,325 Korean fir trees (DBH >= 2.5 cm) inhabited Mt. Baekwun, and their distribution area was approximately 150 ha. Populations of Korean fir trees were confirmed to exist at an altitude of 900 m above sea level and were distributed up to 1,200 m. Based on potential distribution, areas appropriate for habitation by Korean fir trees were analyzed to be 450 ha, three times the current distribution area, with a focus on Sang Peak (Sang-bong), Eokbul Peak (Eokbul-bong), Ddari Peak (Ddari-bong), and Dosol Peak (Dosol-bong). The forest stands near Sang Peak, the main peak, were evaluated as those with the most appropriate potential for the habitation of Korean fir trees, and populations of the trees tended to prefer the northern slope rather than the southern slope. When climate change scenario RCP 8.5 was applied and future potential distribution was analyzed, the habitats were expected to decrease in area to 20 ha by 2050, with a focus on Sang Peak, and areas appropriate for habitation were predicted not to exist by 2080. Judging from such results, as global warming accelerates, the habitats of Korean fir trees are clearly expected to move from lowlands to highlands.

국립공원 탐방로 안전지수 및 등급분석에 관한 연구

박준효(Pak, Jun-hou),전계원(Jun, Kye-Won),박상준(Park, Sang-Jun),김명준(Kim, Myeong-Jun),윤주웅(Yun, Ju-Ung) 한국산림휴양복지학회 2020 한국산림휴양학회지 Vol.24 No.4

본 연구에서는 탐방로 안전성 평가 모델을 활용하여 21개 국립공원을 대상으로 안전지수와 등급분석을 수행하였다. 현장조사를 통해 탐방로 주변 위험요소 중 하나라도 확인되면 취약구간으로 판단하여 안전지수를 산출하였다. 취약구간은 총 180.4km로 조사되었으며 탐방로 총 연장 1,995.5km 대비 약 9.0%로 확인되었다. 안전지수는 총 200점 중 최소 42.3점에서 최대 167.0점 분포를 보이고 평균값은 101.5점으로 나타났다. 안전지수를 토대로 등급을 분석한 결과, ‘관심(Concern)’ 등급은 60.8km(34%), ‘주의(Caution)’ 등급은 57.8km(32%), ‘위험(Dangerous)’ 등급은 49.6km(27%), ‘매우위험(Very dangerous)’ 등급은 12.2km(7%)로 나타났다. 매우위험 구간은 북한산국립공원(6.0km), 지리산국립공원(3.3km), 오대산국립공원(1.6km), 설악산국립공원(0.9km), 월악산국립공원(0.4km), 속리산국립공원(0.01km) 등 6개 국립공원 탐방로에서 총 12.2km로 나타났다. 북한산국립공원은 Y계곡, 의상능선 등이 해당되며, 지리산국립공원은 칠선계곡, 구룡계곡에서 확인되었다. 오대산국립공원은 노인봉 일원, 설악산국립공원은 공룡능선, 흘림골 등에서 나타났다. 월악산국립공원은 금수산 일원, 속리산국립공원 막장봉 구간이 매우위험 구간으로 나타났다. 본 연구는 향후 재난위험 저감대책 수립과 탐방로 정비 우선순위 선정 등 국립공원 안전관리 정책을 수립하기 위한 기초자료로 활용될 수 있다. In this study, the safety indexing and grading analysis were conducted for 21 national parks, using the trail safety evaluation model. If any one of the risk factors around the trail was identified through a field survey, the safety index was calculated by judging it as a vulnerability zone. The vulnerability zone was 180.4km in total, and it was found to be about 9.0% compared to the total length of 1,995.5km. The safety index was distributed from the minimum of 42.3 to the maximum of 167.0, and the average value was 101.5 of total 200 scores. As a result of analyzing the grade based on the safety index, 60.8km (34%) was in the ‘Concern’ grade, 57.8km (32%) was in the ‘Caution’ grade, 49.6km (27%) was in the ‘Dangerous’ grade, and 12.2km (7%) was in the ‘Very dangerous’ grade. ‘Very dangerous’ sections were found to be a total of 12.2 km. including 6 national park trails: Bukhansan National Park (6.0km), Jirisan National Park (3.3km), Odaesan National Park (1.6km), Seoraksan National Park (0.9km), Woraksan National Park (0.4km), Songnisan National Park (0.01km). In terms of ‘Very dangerous’ section, Bukhansan National Park included Y Valley and Uisang Ridge, and Jirisan National Park included Chilseon Valley and Guryong Valley. The area of Noinbong in Odaesan National Park, and Gongnyong Ridge and Heulimgol in Seoraksan National Park were included. And the Geumsusan area in Wolaksan National Park and Makjangbong in Songnisan National Park were found to be ‘Very dangerous’. This study could be used as basic data to establish national park safety management policies, such as selecting priority of trail maintenance and establishing countermeasures to reduce disaster risk.

Assessing Soil Fertility Status of Edible Wild Plants Fields in Ulleung Island

Park, Sang-Jo,Park, Jun-Hong,Kim, Byung-Sung,Chung, Yun-Hak,Lee, Dong-Jun,Kwon, Oh-Heun,Park, So-Deuk,Lee, Suk-Hee 한국토양비료학회 2016 한국토양비료학회지 Vol.49 No.4

The perennial edible wild plants such as Aster glehnii, Solidago virgaurea subsp. gigantean, Allium ochotense, Athyrium acutipinnulum, Aruncus dioicus var. kamtschaticus and Codonopsis lanceolata have cultivated as the main income crops introduced into the fields about 30 years ago in Ulleung island. Soil samples were collected from 190 fields and assessed the effects of management practices on soil chemical properties at wild edible plant fields under no-till system. The strong acidic soils of pH 5.4 or less were detected in 45% of the soil samples. The level of soil organic matter was being held at mean $63{\pm}28g\;kg^{-1}$, 2.7 times higher than upland soils in Korea. Available phosphate and exchangeable potassium showed more than recommended levels of upland crops as $680{\pm}489mg\;kg^{-1}$ and $1.94{\pm}1.7cmol_c\;kg^{-1}$, respectively. The fields of Solidago and Aster showing strong soil acidity and high level of available phosphate and water soluble $NO_3{^-}$ were distinguished from other crops in analysis of variance and principal component analysis of soil chemicals. These results suggested that high frequency of acidic soil and high levels of available $P_2O_5$, exchangeable $K_2O$ and water soluble $NO_3{^-}$ were accompanied with the use of urea and NPK-fertilizer based on nitrogen in the field. However, further research is needed to understand the appropriate management of fertilization and the prevention of soil acidification for wild edible plants.

Inhibitory Effects of Water Extracts of Eucommiae Cortex and Psoraleae Semen Alone and in Combination on Osteoclast Differentiation and Bone

Park, Jin Soo,Park, Ga Young,Choi, Han Gyul,Kim, Seong Joung,Kim, June Hyun,park, Min Cheol,Kim, Yun Kyung,Han, Sang Yong,Jo, Eun Heui Korean AcupunctureMoxibustion Medicine Society 2017 대한침구의학회지 Vol.21 No.4

Objectives : The purpose of this study was to evaluate the effects of water extracts of Eucommiae cortex (EC), Psoraleae semen (PS), and their combination on receptor activator of nuclear factor-kappa-B ligand (RANKL)-induced osteoclast differentiation. Methods : We assayed the protein expression levels of nuclear factor of activated T-cells, cytoplasmic 1 (NFATc1), c-Fos, mitogen-activated protein kinases (MAPKs), and ${\beta}-actin$ in cell lysates using western blotting. Similarly, mRNA expression levels of NFATc1, c-Fos, tartrateresistant acid phosphate (TRAP), and glyceraldehyde-3-phosphate dehydrogenase, spermatogeni (GAPDHS) from bone marrow macrophages (BMMs) were analyzed using reverse transcription-polymerase chain reaction (RT-PCR). Furthermore, we determined the anti-osteoporotic effects of the water extracts of EC, PS, and their combination in a lipopolysaccharide (LPS)-induced bone-loss mouse model. Results : The in vitro data revealed showed that the combination of EC and PS extract showed a more remarkable inhibition of osteoclast differentiation than each herb did alone. The combination downregulated the induction of c-Fos, NFATc1, and TRAP by suppressing the phosphorylation of p38 and c-Jun N-terminal kinases (JNKs) and inhibiting nuclear factor kappa-light-chain-enhancer of activated B cells ($NF-{\kappa}B$). Lastly, the in vivo data showed that PS reduced the LPS-induced bone erosion. Conclusion : The result of this study suggests that EC and PS could be potential therapeutic agents for bone loss diseases such as osteoporosis.

Preparation of iron oxide nanoparticle combined with radioisotope for molecular imaging

Park, Ji Yong,Lee, Yun-Sang,Jeong, Jae Min 대한방사성의약품학회 2018 Journal of radiopharmaceuticals and molecular prob Vol.4 No.1

Molecular imaging refers to detect the biochemical process in living organisms at the cellular and molecular levels and to quantify them. Due to several advantages of nanomaterials, various molecular images using nanomaterials are being tried. Attempts have been made to combine nanoparticles, known as micro- or nanosized nanomaterials, with radioactive isotopes for molecular imaging probe. The radiolabeled nanoparticles will expend the molecular imaging due to nanoparticle's size-dependent nature. In particular, iron oxide nanoparticles can be used for magnetic resonance imaging, can be adjusted in size, easily functionalized, and biocompatible, making it a very good platform for molecular imaging. In addition, iron oxide nanoparticles may be the best example for a new approach to molecular imaging techniques. In this paper, we introduce various methods for preparation of iron oxide nanoparticle combined with radioisotope starting from various synthesis methods of iron oxide nanoparticles to utilize iron oxide nanoparticles as a platform for molecular imaging through radioactive labeling.

Factors associated with low-level physical activity in elderly patients with chronic obstructive pulmonary disease

( Sang Hee Lee ),( Ki Uk Kim ),( Haejung Lee ),( Yun Seong Kim ),( Min Ki Lee ),( Hye-kyung Park ) 대한내과학회 2018 The Korean Journal of Internal Medicine Vol.33 No.1

Background/Aims: In patients with chronic obstructive pulmonary disease (COPD), the extent of physical activity (PA) is correlated with disease severity and prognosis. However, factors associated with low-level PA in elderly COPD patients are not known. We assessed the levels of PA and clinical factors associated with low-level of PA in elderly COPD patients. Methods: This was a secondary analysis of a multicenter, prospective study of 245 patients with COPD. Among them, 160 patients with 65 years or more were included. Three PA groups were defined with respect to daily activity time (low, moderate, and high). Health related quality of life (HRQL) was measured using St. George’s respiratory questionnaire (SGRQ) and 36-item short-form health survey. Anxiety and depression status were assessed employing the hospital anxiety and depression scale (HADS). Multivariate logistic regression was performed to identify independent predictors of low-level PA in elderly COPD patients. Results: Of all the 160 patients, 103 (64.4%) engaged in low-level PA. Upon univariate analysis, a decreased exercise capacity (6-minute walk test < 250 m), an increased dyspnea (the modified medical research council [MMRC] dyspnea scale ≥ 2), a decreased HRQL (total SGRQ score), and a presence of depression (HADS-D ≥ 8) were significantly associated with low-level PA. Upon multivariate analysis, an MMRC grade ≥ 2 (hazard ratio [HR], 2.550; p = 0.034), and HADS-D ≥ 8 (HR, 2.076; p = 0.045) were independently associated with low-level PA in elderly COPD patients. Conclusions: Two-thirds of elderly patients with COPD reported low-level of PA. More severe dyspnea and a presence of depression were independently associated with low-level PA in elderly COPD patients.

Utilizing Under Voltage Load Shedding Strategy to Prevent Delayed Voltage Recovery Problem in Korean Power System

Yun-Hwan Lee,Seung-Chan Oh,Hwan-Ik Lee,Sang-Geon Park,Byong-Jun Lee 대한전기학회 2018 Journal of Electrical Engineering & Technology Vol.13 No.1

The presence of induction motor loads in a power system may cause the phenomenon of delayed voltage recovery after the occurrence of a severe fault. A high proportion of induction motor loads in the power system can be a significant influence on the voltage stability of the system. This problem referred to as FIDVR(Fault Induced Delayed Voltage Recovery) is commonly caused by stall of small HVAC unit(Heating, Ventilation, and Air Conditioner) after transmission or distribution system failure. This delayed voltage recovery arises from the dynamic characteristics associated with the kinetic energy of the induction motor load. This paper proposes the UVLS (Under Voltage Load Shedding) control strategy for dealing with FIDVR. UVLS based schemes prevent voltage instability by shedding the load and can help avoid major economic losses due to wide-ranging cascading outages. This paper review recent topic about under voltage load shedding and compare decentralized load shedding scheme with conventional load shedding scheme. The load shedding strategy is applied to an actual system in order to verify the proposed FIDVR mitigation solution. Simulations demonstrate the effectiveness of the proposed method in resolving the problem of delayed voltage recovery in the Korean Power System.

Multiple Cavitary Pulmonary Nodules Caused by Mycobacterium intracellulare

Sang Hoon Yoo,Seo Ree Kim,Joon Young Choi,Jae Woo Choi,Yu Mi Ko,Sun Hee Jang,Jun Kyu Park,Ye Gyu Sung,Yun Jung Park,Su Yun Oh,Se Young Bahk,Ju Hyun Lee,Myung Sook Kim 대한가정의학회 2016 Korean Journal of Family Medicine Vol.37 No.4

Nontuberculous mycobacteria (NTM) have been increasingly recognized as an important cause of chronic pulmonary infections. The Mycobacterium avium complex (MAC), which is composed of two species, Mycobacterium avium and Mycobacterium intracelluare, is the most commonly encountered pathogen associated with NTM lung disease. MAC pulmonary infection typically presents in a fibrocavitary form or a nodular bronchiectatic form. However, there have been atypical presentations of MAC pulmonary infections, including solitary pulmonary nodules (SPN). There have been several previous reports of SPN due to MAC infection in the United States, Japan, and Korea. In 2009, Sekine and colleagues reported a case of MAC pulmonary infection presenting with multiple nodules. To date, however, there have been no cases of NTM lung infection with multiple cavitary pulmonary nodules, and neither a fibrotic change nor nodular bronchiectasis. The present case showed a multiple cavitating nodular lung infection due to MAC, which is very rare and different from the typical presentation of MAC pulmonary infections. We also showed that percutaneous transthoracic needle aspiration can be a useful diagnostic tool to evaluate a case of multiple cavitary nodules.