Case Reports : Allergic Bronchopulmonary Aspergillosis Coupled with Sinusitis in a Nonasthmatic Patient

( Sung Woon Park ),( Jae Chol Choi ),( Jae Yeol Kim ),( In Won Park ),( Byoung Whui Choi ),( Jong Wook Shin ) 대한결핵 및 호흡기학회 2011 Tuberculosis and Respiratory Diseases Vol.71 No.4

Allergic bronchopulmonary aspergillosis (ABPA) is a complex clinical entity resulting from an allergic immune response to Aspergillus species, and most often occurs in patients with asthma. ABPA is rarely observed in the absence of asthma, which is, in fact, the principal criterion for its diagnosis. Our patient was a 53-year-old woman with no history of bronchial asthma. She presented with a 1-month history of cough, mucopurulent nasal discharge, and localized pulmonary consolidation. Peripheral blood eosinophilia and elevated serum IgE were observed. Sinus radiography showed right maxillary sinusitis. Pathologic examination of bronchoscopic biopsy specimens revealed conglomerates of fungal hyphae. Pulmonary function and bronchial provocation tests were within normal ranges. The patient was successfully treated for 3 months with itraconazole and oral prednisolone. There has been no evidence of recurrence over a 7-month follow-up. ABPA coupled with sinusitis in a nonasthmatic patient is a very rare occurrence and warrants reporting.

Allergic Bronchopulmonary Aspergillosis in a Non-asthmatic Patient (초)

( Sung Woon Park ),( Byung Ook Lee ),( Jae Hee Lee ),( Sung Gun Cho ),( Jae Chol Choi ),( Jong Wook Shin ),( Jae Yeol Kim ),( In Won Park ),( Byoung Whui Choi ) 대한내과학회 2010 대한내과학회 추계학술대회 Vol.2010 No.-

Treadmill exercise ameliorates chemotherapy-induced memory impairment through Wnt/β-catenin signaling pathway

Sang-Seo Park,Sang-Hoon Kim,Bo-Kyun Kim,Mal-Soon Shin,Hyun-Tae Jeong,Jong-Suk Park,Tae-Woon Kim 한국운동재활학회 2023 JER Vol.19 No.6

Doxorubicin (DOX) is a widely used chemotherapy drug for various cancers and it is known to induce cognitive impairment. The aim of this study was to investigate the effect of treadmill exercise on chemother-apy-induced memory impairment. We assessed whether DOX affects inflammation, mitochondrial Ca2+ retention capacity, and Wnt/β-catenin signaling. Male Sprague-Dawley rats were divided into control group, exercise group, DOX-injection group, and DOX-injection and exercise group. To create a DOX-induced memory impairment model, animals were injected intraperitoneally with DOX (2 mg/kg) dissolved in saline solution once a week for 4 weeks. Treadmill exercise was performed once a day, 5 days a week, for 8 consecutive weeks. Short-term memo-ry was determined using the step-down avoidance test. Western blot was performed for the proinflammatory cytokines, Wnt/β-catenin sig-naling, brain-derived neurotrophic factor (BDNF), tropomyosin receptor kinase B (TrkB) in the hippocampus. Mitochondrial Ca2+ retention ca-pacity in the hippocampus was also measured. DOX-injection rats showed deterioration of short-term memory along with decreased ex-pression of BDNF and TrkB in the hippocampus. Levels of the proinflam-matory cytokines, tumor necrosis factor-α and interleukin-6, were in-creased in the DOX-injection rats. Wnt/β-catenin signaling was activat-ed and mitochondrial Ca2+ retention capacity was decreased in the DOX-injection rats. However, treadmill exercise alleviated short-term memory impairment, decreased proinflammatory cytokines, increased BDNF and TrkB expression, and enhanced mitochondrial Ca2+ retention capacity. Treadmill exercise restorated Wnt/β-catenin signaling path-way. This study demonstrated that treadmill exercise can be used for patients undergoing chemotherapy with DOX.

Original Article : Prevalence of IgG anti-HAV in patients with chronic hepatitis B and in the general healthy population in Korea

( Sang Ho Lee ),( Hyoung Su Kim ),( Kwon Oh Park ),( Jong Won Park ),( Seung Yeon Chun ),( Seung Jin Lim ),( Hyun Jung Cho ),( Sung Jun Kim ),( Hye Won Park ),( Han Kook Moon ),( Woon Geon Shin ),( Ky 대한간학회 2010 Clinical and Molecular Hepatology(대한간학회지) Vol.16 No.4

Background/Aims: Few studies have investigated hepatitis A virus (HAV) seroepidemiology in Koreans with chronic liver disease (CLD). This study compared the prevalence of IgG anti-HAV between the general healthy population and patients with hepatitis B virus-related CLD (HBV-CLD), with the aim of identifying predictors of HAV prior exposure. Methods: In total, 1,319 patients were recruited between June 2008 and April 2010. All patients were tested for IgG anti-HAV, hepatitis B surface antigen (HBsAg), and antibodies to hepatitis C virus. The patients were divided into the general healthy population group and the HBV-CLD group based on the presence of HBsAg. The seroprevalence of IgG anti-HAV was compared between these two groups. Results: The age-standardized seroprevalence rates of IgG anti-HAV in the general healthy population and patients with HBV-CLD were 52.5% and 49.1%, respectively. The age-stratified IgG anti-HAV seroprevalence rates for ages ≤19, 20-29, 30-39, 40-49, 50-59, and ≥60 years were 14.3%, 11.2%, 45.5%, 90.5%, 97.6% and 98.3%, respectively, in the general healthy population, and 0%, 9.8%, 46.3%, 91.1%, 97.7%, and 100% in the HBV-CLD group. In multivariate analysis, age (<30 vs. 30-59 years: OR=19.339, 95% CI=12.504-29.911, P<0.001; <30 vs. ≥60 years: OR=1060.5, 95% CI=142.233-7907.964, P<0.001) and advanced status of HBV-CLD (OR=19.180, 95% CI=4.550-80.856, P<0.001) were independent predictors of HAV prior exposure. Conclusions: The seroprevalence of IgG anti-HAV did not differ significantly between the general-healthy-population and HBV-CLD groups. An HAV vaccination strategy might be warranted in people younger than 35 years, especially in patients with HBV-CLD. (Korean J Hepatol 2010;16:362-368)

Development of a Practical and Cost-Effective Medium for Bioethanol Production from the Seaweed Hydrolysate in Surface-Aerated Fermentor by Repeated-Batch Operation

( Sang Eun Lee ),( Ji Eun Lee ),( Ga Young Shin ),( Woon Yong Choi ),( Do Hyung Kang ),( Hyeon Yong Lee ),( Kyung Hwan Jung ) 한국미생물 · 생명공학회 2012 Journal of microbiology and biotechnology Vol.22 No.1

To develop a practical and cost-effective medium for bioethanol production from the hydrolysate of seaweed Sargassum sagamianum, we investigated the feasibility and performance of bioethanol production in CSL (cornsteep liquor)-containing medium, where yeast Pichia stipitis was used and the repeated batch was carried out in a surface-aerated fermentor. The optimal medium replacement time during the repeated operation was determined to be 36 h, and the surface aeration rates were 30 and 100 ml/min. Under these conditions, the repeatedbatch operation was successfully carried out for 6 runs (216 h), in which the maximum bioethanol concentrations reached about 11-12 g/l at each batch operation. These results demonstrated that bioethanol production could be carried out repeatedly and steadily for 216 h. In these experiments, the total cumulative bioethanol production was 57.9 g and 58.0 g when the surface aeration rates were 30 ml/min and 100 ml/min, respectively. In addition, the bioethanol yields were 0.43 (about 84% of theoretical value) and 0.44 (about 86% of theoretical value) when the surface aeration rates were 30 ml/min and 100 ml/min, respectively. CSL was successfully used as a medium ingredient for the bioethanol production from the hydrolysate of seaweed Sargassum sagamianum, indicating that this medium may be practical and cost-effective for bioethanol production.

Effects of Methanol on Cell Growth and Lipid Production from Mixotrophic Cultivation of Chlorella sp.

Woon-Yong Choi,Sung-Ho Oh,Yong-Chang Seo,Ga-Bin Kim,강도형,Shin-Young Lee,Kyung-Hwan Jung,Jeong-Sub Cho,Ju-Hee Ahn,Geun-Pyo Choi,Hyeon-Yong Lee 한국생물공학회 2011 Biotechnology and Bioprocess Engineering Vol.16 No.5

The marine microalga Chlorella sp. was cultivated under mixotrophic conditions using methanol as an organic carbon source, which may also act to maintain the sterility of the medium for long-term outdoor cultivation. The optimal methanol concentration was determined to be 1% (v/v) for both cell growth and lipid production when supplying 5% CO_2 with 450 μE/m^2/sec of continuous illumination. Under these conditions, the maximal cell biomass and total lipid production were 4.2 g dry wt/L and 17.5% (w/w), respectively, compared to 2.2 g dry wt/L and 12.5% (w/w) from autotrophic growth. Cell growth was inhibited at methanol concentrations above 1% (v/v) due to increased toxicity, whereas 1% methanol alone sustained 1.0 g dry wt/L and 4.8% total lipid production. We found that methanol was preferentially consumed during the initial period of cultivation, and carbon dioxide was consumed when the methanol was depleted. A 12:12 h (light:dark) cyclic illumination period produced favorable cell growth (3.6 g dry wt/L). Higher lipid production was observed with cyclic illumination than with continuous illumination (18.6% (w/w) vs 17.5% (w/w)), and better lipid production was also obtained under mixotrophic rather than autotrophic conditions. Interestingly, under mixotrophic conditions with 12:12 (h) cyclic illumination,high proportions of C_(16:0), C_(18:0), and C_(18:1) were observed,which are beneficial for biodiesel production. These results strongly indicate that the carbon source is important for controlling both lipid composition and cell growth under mixotrophic conditions, and they suggest that methanol could be utilized to scale up production to an open pond type system for outdoor cultivation where light illumination changes periodically.

Interventions for Adherence Improvement in the Primary Prevention of Cardiovascular Diseases: Expert Consensus Statement

Sang-Hyun Ihm,Kwang-il Kim,Kyung Jin Lee,Jong Won Won,Jin Oh Na,Seung-Woon Rha,Hack-Lyoung Kim,Sang-Hyun Kim,Jinho Shin 대한심장학회 2022 Korean Circulation Journal Vol.52 No.1

In primary prevention for cardiovascular diseases, there are significant barriers to adherence including freedom from symptoms, long latency for therapeutic benefits, life-long duration of treatment, and need for combined lifestyle changes. However, to implement more systematic approaches, the focus on adherence improvement needs to be shifted away from patient factors to the effects of the treatment team and healthcare system. In addition to conventional educational approaches, more patient-oriented approaches such as patient-centered clinical communication skills, counseling using motivational strategies, decision-making by patient empowerment, and a multi-disciplinary team approach should be developed and implemented. Patients should be involved in a program of self-monitoring, self-management, and active counseling. Because most effective interventions on adherence improvement demand greater resources, the health care system and educational or training system of physicians and healthcare staff need to be supported for systematic improvement.

Colloidally prepared La-doped BaSnO₃ electrodes for efficient, photostable perovskite solar cells

Shin, Seong Sik,Yeom, Eun Joo,Yang, Woon Seok,Hur, Seyoon,Kim, Min Gyu,Im, Jino,Seo, Jangwon,Noh, Jun Hong,Seok, Sang Il American Association for the Advancement of Scienc 2017 Science Vol.356 No.6334

<P>Perovskite solar cells (PSCs) exceeding a power conversion efficiency (PCE) of 20% have mainly been demonstrated by using mesoporous titanium dioxide (mp-TiO2) as an electron-transporting layer. However, TiO2 can reduce the stability of PSCs under illumination (including ultraviolet light). Lanthanum (La)-doped BaSnO3 (LBSO) perovskite would be an ideal replacement given its electron mobility and electronic structure, but LBSO cannot be synthesized as well-dispersible fine particles or crystallized below 500 degrees C. We report a superoxide colloidal solution route for preparing a LBSO electrode under very mild conditions (below 300 degrees C). The PSCs fabricated with LBSO and methylammonium lead iodide (MAPbI(3)) show a steady-state power conversion efficiency of 21.2%, versus 19.7% for a mp-TiO2 device. The LBSO-based PSCs could retain 93% of their initial performance after 1000 hours of full-Sun illumination.</P>

Interleukin-8 and MCP(Monocyte Chemoattractant Protein)-1 expression by the Human Dental Pulps in cultures stimulated with Substance P

Shin, Han-Ju,Park, Sang-Hyuk,Choi, Gi-Woon 大韓齒科保存學會 2005 Restorative Dentistry & Endodontics Vol.30 No.3

본 연구에서는 발거된 건전한 치아의 치수조직으로부터 배양된 치수조직을 SP 및 TNF (tumor necrosis factor)-α, 그리고 Spantide로 15분간 배양 후 SP로 36시간 자극하여 IL-8은 및 MCP-1의 분비량을 측정하였으며, 면역염색으로 IL-8의 분비를 관찰하여 다음과 같은 결론을 얻었다. 1. 치수 조직을 SP (10^(-4)M)로 36시간 자극 시 모의 자극에 비해 IL-8이 현저히 증가하였으며 (p < 0.05), 면역 염색 결과 모의 자극 시에는 치수조직의 변연부에만, SP(10^(-4)M)로 36시간 자극시에는 flbroblast 주위로 IL-8의 발현이 관찰되었다. 2. TNF-α (40 ng/ml)로 치수조직을 36시간 자극시 모의 자극에 비해 MCP-1이 증가하였으며, SP에서는 증가 를 보이지 않았으며 (p < 0.05), 면역 염색 결과 IL-8의 발현이 관찰되지 않았으며, 치수 조직의 변연부를 따라서 약한 IL-8의 발현이 관찰되었다. 3. Spantide (10^(-5)M)는 SP (10^(-4)M)로 치수 조직을 36시간 자극 시 IL-8의 분비를 억제하였다. The induction of the IL-8 and MCP-1 by the stimulation of Substance P and TNF-α (IL-8 agonist) and the specificity for SP using Spantide (SP antagonist) in the dental pulp tissues was measured quantitatively. In addition, the secretion of the IL-8 in the human dental pulp tissue 36 hrs after the stimulation of SP was observed after the stimulation of SP qualitatively. According to this study the results were as follows: 1. There was the significant IL-8 induction at 36 h after SP (10^(-4)M) stimulation of the pulp tissue comparing with the unstimulated dental pulp tissues (p < 0.05) . IL-8 irnmunostaining was weakly detected along the periphery of the pulp tissue after Mock stimulation and IL-8 immunostaining was detected around the fibroblast in the pulp tissue 36h After SP (10^(-4)M) stimulation 2. The secretion of MCP-1 from the dental pulp tissues comparing with Mock stimulation was induced at 36 hrs after TNF-α (40 ng/ml) stimulation, but no induction with SP(10^(-4)M) TNF-α (40 ng/ml) did not induce the IL-8 secretion from the pulp tissue, weak IL-8 imrnunostaining was detected along the periphery of the pulp tissue. 3. Spantide (10^(-5)M) inhibited IL-8 induction from the pulp tissues 36 h after SP (10^(-4)M) stimulation. These results suggest that SP significantly induces IL-8 recruiting neutrophils in localized human dental pulp tissue MCP-1 appears to be less involved in the early establishment of pulpal inflammation in response to irritation such as mechanical insult of dentin. SP may have positive relation with the inflammation of the human dental pulp tissues.

All-Solution Processedn <i>n</i>-ZnO Nanorods/<i>i</i>-CdS/<i>p</i>-Cu₂O Diodes Prepared Using Diluted Solution Precursors

Shin, Jae Hui,Kim, Joo Sung,Baek, Seung Ki,Cho, Sung Woon,Kim, Yun Seok,Cho, Hyung Koun American Scientific Publishers 2017 Nanoscience and Nanotechnology Letters Vol.9 No.1