봉독약침이 류마티스 관절염 환자의 관절 통증, 종창 및 급성 염증 반응에 미치는 영향

이상훈,이현종,백용현,김수영,박재경,홍승재,양형인,김건식,이재동,최도영,이두익,이윤호 WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2003 東西醫學硏究所 論文集 Vol.2003 No.-

Objective In order to study the effects of bee venom(BV) on the pain, edema, and acute inflammatory reactant of rheumatoid arthritis(RA) patients. Methods Patients with RA who met the ACR(American College of Rheumatology) 1987 revised criteria for the diagnosis of RA were treated with the BV therapy twice a week for 3 months. Tender Joint counts, swollen joint counts, Visual analog scale(VAS), morning stiffness, ESR. C-reactive protein(CRP) were analyzed before and after BV therapy. Results The results as follows. 1. Tender joint counts in patients after BV therapy were significantly lower than those before BV therapy(9.0±7.9 vs 15± 11.4, p=0.002). 2. Swollen joint counts of the patients after BV therapy were significantly lower than those before BV therapy(50±61 vs 15±23, p=0.001). 3. VAS in patients after BV therapy was significantly lower than those before BV therapy(608± 17.6 vs 380± 159, p=0.000). 4. Duration of morning stiffness in patients after BV therapy was significantly reduced compared with that before BV therapy(119.1± 112.6 min vs 59.0±89.7 min, p=0.009). 5. ESR and CRP were not significantly changed before and after BV therapy, suggesting BV itself could make inflammatory reaction as well as therapeutic effect. Conclusions BV therapy improved tender joint counts, swollen joint counts and duration of morning stiffness in this study, and further study is needed on long-term effect of BV therapy.

크롬(Ⅵ)의 체내 흡수와 소실속도에 관한 연구

김현영,이성배,임철홍,이권섭,정용현,이종성,한정희,전윤석,황호순,이용묵 한국산업위생학회 2003 한국산업보건학회지 Vol.13 No.1

The CrO3 mostly used in plating. metal surface disposal, leather, cosmetic manufacturing, as an experiment material by repeatedly inhaling and exposure the male S.D. rats at a 0.00, 0.2., 0.50, 1.25 mg/㎡ concentration(particle size: 0.5-0.5 aerosol)6hours a day, 5day a week in 13weeks comparing with 2weeks, 8weeks of recovery group about the noxiousness of the experiment animal and the reduce scale of the CrO3 in the internal organ especially in blook and respiratory organ with the period of convalescent and clearance. The experiment results which we received are as follows. 1. In blood the RBC, HGB and HCT experiment, rats with 0.20, 0.50 mg/㎡ concentration showed that there were some decreases but not dependent. The kidneys absolute weight compared with control group was reduced intentionally(p〈0.05) and the lungs absolute weight compared with control group showed intentional increase(p〉0.05). 2. After the exposure of the experiment material, the whole blook, l\blood plasma and red blood cell in blood by (x): the period of convalescent, per (y); the decreasing of Cr concentration, was y=66.51 e -0.057x, y=67.2 e-0.101x, y=70.01 e-0.030 in 0.50 mg/㎡ exposure concentration by calculating the clearance coefficient of correlation, and the half life (day)was estimated 12.0, 6086, 23.0 each. 3, After the exposure of the experiment material, the experiment animals lung, liver and kidneys by(x); the period of convalescent, per (y); the decreasing of Cr conentration, was y=1808 e-0.00493x, y=12.02e-0.0297x, y=67.61 e-0.0292x in 0.50mg/㎡ exposure concentration by calculating the clearance coefficient of correlation, and the half life(day)was estimated 140.6, 23.3, 23.7, each, and including lung, liver with all of the experiment internal organs, the Cr clearance decreased as the exposure concentration increased.

난소 임신 10예의 분석

김용진,이충일,이해혁,남계현,이임순,이권해 순천향의학연구소 1996 Journal of Soonchunhyang Medical Science Vol.2 No.2

Ovarian pregnancy is an uncommon form of the ectopic pregnancies. The ovarian vascularity results in maternal hemorrhage early in the first trimester, which disrupts the pregnancy and usually ruptures the ovary with sufficient hemoperitoneum to require emergency operation. This report presents 10 cases of ovarian pregnancy by retrospective review between January 1986 and December 1995 at the Department of Obstetrics and Gynecology, Soonchunhyang University Hospital. There was 19,849 deliveries and 637 ectopic pregnancies during same period. It showed that the incidence of ovarian pregnancy was 3.21 % of all ectopic pregnancies. The clinical features of ovarian pregnancy revealed that abdominal pain was the major symptom, and history of amenorrhea was obscure. Because of life-threatening course, the early diagnosis and treatment of ovarian pregnancy is important. The clinical diagnosis of ovarian pregnancy was more difficult than that of tubal pregnancy.

SD Rats를 이용 1-hexene의 흡입독성 연구

김현영,임철홍,정용현,이권섭,이성배,이준연,한정희,전윤석,이용묵 한국환경독성학회 2001 환경독성보건학회지 Vol.16 No.4

The purpose of this study was to investigate the acute (4 hours) and repeated-dose (6 hours a day, 5 days a week, 4 weeks) toxic effects of I -hexene on Sprague- Dawley (SD) rats which were treated by inhalation. The results were as follows; I. The median lethal concentration (LC_(50)) was estimated 52,694 ppm (confidence limit 95%; 49,494~55,447 ppm) in acute inhalation. Abnormal clinical signs related to the l-Hexene were not observed with the acute inhalation dose. Gross findings of necropsy revealed on evidence of specific toxicity related to the 1-hexene, II. By repeated inhalation exposure the body weight of male were more or less reduced by the dose of 2,500 ppm and 5,000 ppm compared with control group. However there were no significant variation hematology and blood biochemistry for the exposed rats compared with the control rats. Abnormal clinical signs and gross findings of necropsy related to the 1-hexene were not shown. In conclusion when we exposed I-hexene to SD rats for 4 weeks, 5 days per week, 6 hours per day, the Lowest observed effect level (LOEL) was over 2,500 ppm and Non observed effect level (NOEL) was below 500 ppm.

백서 두개관세포에서 Ipriflavone이 골조직 개조에 미치는 영향

이용승,김영준,이기헌,황현식 대한치과교정학회 2005 대한치과교정학회지 Vol.35 No.4

본 연구는 ipriflavone (isopropoxyisoflavone)의 투여가 백서 두개관세포의 증식과 골조직 개조에 미치는 영향을 알아보고자 시도되었다. 태령 20-21일째의 백서 두개관세포를 분리 배양한 후, 10^(-9) M부터 10^(-5) M까지 농도의 ipriflavone을 투여하고 1일째와 3일째에 MTT 분석을 시행하여 흡광도를 평가한 결과, 모든 농도에서 백서 두개관세포의 증식을 보이지 않았다. 한편 골조직 개조에 미치는 영향을 알아보기 위하여 14일째에 alizarin red염색을 시행하여, 형성된 석회화 결절 면적을 측정하였을 때, 10^(-8) M, 10^(-7) M, 10^(-6) M 농도를 투여한 경우 석회화 결절 형성이 유의하게 증가하였다. 골아세포의 분화에 미치는 영향을 알아보기 위하여 ipriflavone을 투여하고 7일째와 14일째에 추출한 RNA를 역전사 중합효소 연쇄반응(RT-PCR)을 시켜 bone sialoprotein (BSP), type 1 collagen (COL I), osteocalcin (OCN) 유전자 발현을 관찰한 결과 BSP와 COL I 유전자는 배양 7일째 높은 발현을 보였고, OCN 유전자는 배양 14일째 높은 발현을 보였다. 이상의 연구결과 ipriflavone이 백서 두개관세포에서 석회화를 촉진시키고 골아세포의 분화에 관여하는 BSP, COL I 및 OCN 유전자 발현을 증가시켜 골조직의 개조를 빠르게 할 수 있음을 시사하였다. lpriflavone (isoprofoxyisoflavone), a synthetic derivative from soy isoflavone diazein, has been shown to inhibit bone resorption and perhaps stimulate bone formation. This study was performed to examine the effects of ipriflavone on the proliferation and bone remodeling in rat calvarial cells in vitro. The rat calvarial cells were isolated from fetus aged 20 to 21 days and cultured in BGJb media. The graded concentration of ipriflavone (10^(-9)-10^(-5) M) was administered into cultured cells. When the cell proliferation was estimated through the measurement of MTT assay, there was no increase in cellular proliferation of the rat calvarial cell at any ipriflavone concentration. The cellular activity was evaluated through the formation of mineralized nodules stained by alizarin red. The formation of mineralized nodules significantly increased at concentrations of 10^(-8) M, 10^(-7) M and 10^(-6) M ipriflavone. Reverse transcription-polymerase chain reaction analyses (RT-PCR) were done at 7 and 14 days after culture to detect the expression of Bone Sialoprotein (BSP), Type I collagen (COL I) and Osteocalcin (OCN). As a result, the expressions of BSP and COL I increased of the 7th day of culture and the expression of OCN increased on the 14th day of culture. These results indicate that ipriflavone facilitates the bone remodeling process by promoting rat calvarial cell differentiation and stimulating mineralization through increased expression of extracellular matrix genes, such as BSP, COL I and OCN.

Study on Microstructure and Mechanical Properties of the Al–25Cr–5Si (at%) Alloy Powder Using Gas-Atomization and SPS Process

Yong‑Ho Kim,Hyo‑Sang Yoo,Jeong‑Han Lee,Ik‑Hyun Oh,Hyun‑Kuk Park,Hyeon‑Taek Son 대한금속·재료학회 2021 METALS AND MATERIALS International Vol.27 No.7

In order to investigate the microstructure and mechanical properties on Al–25Cr–5Si (at%) alloy, a mixed powder with pureelements and an alloy powder using a gas atomization process were used. Fine and high purity Al–25Cr–5Si (at%) alloypowder was successfully prepared by gas atomization and densified using a spark plasma sintering (SPS) process. The overallpowder size distribution of the mixed Al, Cr, and Si elemental powders was in the range of 10–15 μm. The atomized Al–Cr–Sialloy powder was fine and spherical in morphology and difficult to be formed by intermetallic formation. Densification wasclearly confirmed at 1000 °C, with almost isolated pores formed, by clear removal of pores between particles, deformationof particles, an increase in the number of contacts, and a change in size between particles. As a result of XRD analysis ofthe sintered compacts, single phase was observed using the mixed powder, but the compact using gas atomization remainedthe alloy phase even at the process temperature. The Vickers hardness of the compacts by mixed powder was observed at59.70 Hv and the compact using gas atomized powders on the temperature 1000 °C of the Vickers hardness increased to702.6 Hv. The compressive yield strength of the compact with mixed powder was 195.24 MPa and the compressive strengthof the compact with gas atomized powder increased to 802.07 MPa. It is considered not to be decomposed by the AlCrSi,Al13Cr4Si4and Al8Cr5phases sintering process, resulting from the improvement of mechanical properties.

중성리비의 기초적 검토 : 냉수리비·봉평비와의 비교적 시점

이용현 한국고고미술연구소 2011 고고학지 Vol.17 No.-

The Silla stone monument in Jungseong-ri, Pohang, was built in 501 with an inscription on a single face. This study analyzes the monument in connection with two other Silla monument erected in the same period, Naengsuri Monument (erected in 503) in Pohang and Bongpyeong Monument (erected in 524) in Uljin. The inscription of the monument is focused on an open discussion between eight community leaders including chiefs of the Obu (five divisions) on the recapture of a palace located at a site in today's Jungseong-ri, Pohang. It mentions that chiefs of two ministries, Takbu and Satakbu, including Galmunwang and Aganji, issued a highest-level government order called Gyo which was later reported by a group of mid-rank officials called Nama, revealing that the Silla government was largely led by the two ministries. The record shows that by 501 Silla was operating a government of six ministries consisting of Tak and Pyeong which was developed from one of two main ministries, and that the reformation of the government influenced the formation of local administrations called Oewi (outer ranks). 포항 중성리 신라비는 501년에 세워진 1면비이다. 본고에서는 동시대 신라비석자료인 503년 건립 포항 냉수리비와 524년 건립 울진 봉평비를 전거로 삼아 본 비를 분석하였다. 5부의 장 및 대표자로 구성된 쟁인(爭人)집단 8인이 포항 중성리 부근의 궁의 탈환을 두고 쟁(爭) 즉 공론한 것을 기록한 비석이다. 갈문왕(葛文王) 등 탁부와 사탁부의 장급인 아간지(阿干支)가 최고 명령인 교(敎)를 내리고, 이에 나마(奈麻)집단이 백(白) 즉 보고하고 있는데, 국가 행정체계에 주류 2부인 탁부와 사탁부가 중심이 되어 기능하고 있다. 501년 단계에 있어서, 탁과 평으로 이뤄진 6부의 모습, 관등이 탁부 등 주류 2부에서 시작하여 6부로 확장되고, 이어 지방관등인 외위(外位)의 형성에도 영향을 주고 있던 모습을 볼 수 있다.

간흡충증에서 초음파검사의 진단적 가치

이현경,김지용,성낙진,홍성태 동국대학교 경주대학 1996 東國論集 Vol.15 No.-

목적: 간흡충증에서 초음파검사의 진단적 가치를 알아보기 위하여 본 연구를 시행하였다. 대상 및 방법: 1996년 5월 한달 동안 간흡충의 농후유행지인 형산강 유역 포항지역의 436명의 자원자를 대상르로 초음파검사, 피내반응검사, 대변검사를 시행하였다. 이후 대변검사를 기준(gold standard)으로하여 초음파검사의 민감도, 특이도, 양성예측도 및 음성예측도를 알아보았다. 결과: 간내담관의 확장 및 담관주위 에코를 양성 소견으로 하였을 경우 초음파검사의 민감도 65.5%, 특이도는 64.6%, 양성예측도는 38.2%, 음성예측도는 84.3% 이었다. 결론: 초음파검사는 피내반응검사보다 민감하지는 못하나 특이적이었다. 그리고 피내반응검사 양성자에게 초음파 검사를 시행하는 것은 진단기준의 특이도를 높여 주는 효과가 있었다. Objectives: In this study we aimed to evaluate the diagnostic value of sonography on clonorchiasis. Subjectives and Methods: During a month, May 1996 sonographic examination, skin test, and stool examination were performed to 436 volunteers of Pohang which is located along the Hyong-San-Gang river and is one of well known endemic areas. Sensitivity, specificity, positive predictive value(PPV), and negative predictive value(NPV) of sonography were determined while stool examination was assumed as a gold standard. Results: The sensitivity of sonography was 65.5%; specificity, 63.2%; PPV 38.2%; NPV, 84.3% if both intrahepatic duct dilatation and periductal echogenicity were assumed as positive findings. Conclusions: Sonography was less sensitive but more specific than skin test. And sonographic examination perfomed to skin test positive subjects could increase the specificity of diagnostic criteria.

濟州道 菜蔬·花卉園藝의 生産實態, 育成方案 및 流通構造改善에 관한 硏究

李宗錫,吳現道,蘇寅燮,張田益,姜志勇 濟州大學校 亞熱帶農業硏究所 1986 亞熱帶農業硏究 Vol.3 No.-

濟州道의 施設을 理用한 菜蔬類와 球根切花類 및 洋蘭類의 재배실태를 調査한 結果는 다음과 같이 要約할 수 있다. 1. 作目이 토마토와 오이에 編重되어 있어 딸기等을 첨가하여 作目이 多樣化하여야 할 것으로 思料되었다. 2. 施設內의 土壤管理에 대한 認識이 不足하며, 均衡施肥가 施行되지 않고 있었고 土壤酸度도 矯正해야 할 농가가 많았다. 3. Mg이 缺乏된 施設이 대부분이므로 이의 是正이 時急한 課題였다. 4. 施設內 土壤에서 鹽類集積의 被害가 우려되는 곳은 거의 없었으나 裁培年限이 5年以上된 施設에서는 土壤改良이 이뤄저야 할 것으로 思料되었다. 5. 作付體係를 改善해서 年 2期作 體係가 確立되어야 겠으며 施設管利技術이 普及, 育苗技術의 改善 및 共同育苗를 施行해서 健全苗의 養成이 重要課題였다. 6. 濟州道內에서 産業的으로 栽培되고 있는 蘭類 中에서 熱帶産 Cymbidium類가 全體 洋蘭 栽培量의 67.8%로 가장 많았는데 그 中에서도 Eiko, sharnell-5, Kenny가 數的으로 많았다. 7. 溫帶産蘭(東洋蘭)類 中에서는 새우난초類가 數的으로 가장 많았고, 나도풍난, Dendrobrum moniliforme, Cymbidium 風蘭의 順位이었으며, 自生寒蘭은 대 40,396촉이 栽培되고 있었다. 8. 供試 5種의 球根類들은 virus 감염이 甚하여 全量이 virus 無病株로 대체되어야 할 것으로 판단되었다. 9. 서귀포지역의 土壤은 害蟲이 많이 分布하여 球根切花栽培에 큰 위협조건으로 나타났으며 앞으로 도양소독에 대하여 보다 집약적이고 효율적인 方法이 개발되어야 하겠다. 10. 한라산의 고냉지를 利用한 球根의 低溫處理 效果에 對하여 많은 적응시험이 요망되며 道當局은 고냉지의 개발과 利用에 적극적인 지원을 투여하여야 할 것이다. 11. 植栽되고 있는 5種의 球根類 모두 50% 以上이 外國수입에 의존하고 있으므로 國內의 組織培養技術을 利用한 virus 無病良質球根의 生産이 절실히 요망된다. Studies on various cultural practices of vegetable crops, and orchids have been conducted in Chejudo. Followings are the results of such studies. 1. Too much importance has been given to Tomato and Cucumber crops. An additional crop such as Strawberry should be included to broaden the studies. 2. In general, lack of informations on soil managements appear to be prevailing; scheduled fertilization, for instance, has not been performed and pH level must be adjusted on many farm lands. 3. Mg deficiency has been very much in common, therefore, is corection are matter of utmost importance. 4. Problems arising from salt accumulation were nearly unimportant, however, soil improvements through various cultural practices are recommended for those soils which have been continuous cropping for more than 5 years. 5. Planting system should be improved so as to establish 2-crops/year system. In addition, proper extention of various soil management techniques and improvement on nursing techiques are of inportant matters. Commonly sharing community nursing practices must be accompanied in order to provide healthy-seedlings. 6. Among commercially growing orchid species in Chejudo, the tropical Cymbidium species found to be the most widely grown, nearly 67.8% 'Kiko', 'Sharnell-5', 'Kenny' appear to be most in common. 7. Among oriental orchids, Calanthe spp are found to be most prevalent followed in the order of Aerides japonica, Dendrobium moniliforme, Cymbidiums, respectively. 8. The total number of the shoots of Cymbidium kanran being cultivated in Chejudo were found to be 40,396. 9. Virus infections appear to be universal in all 5 species of bulbs studied therefore, virus-free stocks must be essential. 10. Sogwipo-soil, in general, heavily infected by soil-born insects of various kinds are badly affecting bulb productions. More efficient methods of soilsanitations must be studied and introduced in the future. 11. The studies of low temperature treatment on bulb crops by utilizing the high altitude growing in the area of mountain Halla are in great need. An extensive assistance from the provincial government are very much in need in order for the development and utilization of the high-altitude cultivation. 12. More than 50% of the bulbs of the 5 species grown are being imported. Domestic production utilizing 'meristem culture' which enable the virus free stocks are in great demand.

올레산의 비율에 따른 아데노신의 경피 투과의 영향

남현빈,정세진,구민석,오예진,김용민,이훈희,윤수정,임정균 순천향대학교 부설 산업기술연구소 2021 순천향 산업기술연구소논문집 Vol.27 No.2

In addition to the development of functional cosmetics, technology to increase percutaneous absorption rate when applied to the skin is an important task. In this experiment, oleic acid was used as a skin absorption promoter, and its effect on transdermal permeability of adenosine was studied and analyzed using a skin-like membrane. As a result of the experiment, it was investigated that the permeability coefficient and concentration of adenosine are proportional to the content of oleic acid. This indicates that a high proportion of oleic acid is effective as a skin absorption promoter.