Possible Prognostic Role of HER2/Neu in Ductal Carcinoma In Situ and Atypical Ductal Proliferative Lesions of the Breast

Daoud, Sahar Aly,Ismail, Wesam Maghawri,Abdelhamid, Mohamed Salah,Nabil, Tamer Mohamed,Daoud, Sahar Aly Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.8

HER2/neu is a well-established prognostic and predictive factor for invasive breast cancer. However, the role of HER2/neu in ductal breast carcinoma in situ (DCIS) is debated and recent data have suggested that it is mainly linked to in situ local recurrence. Although molecular data suggest that atypical ductal hyperplasia (ADH) and duct carcinoma in situ (DCIS) are related lesions, albeit with vastly different clinical implications, the role of HER2/neu expression in atypical ductal hyperplasia is not well defined either. The aim of this study was to evaluate over expression of HER2/neu in DCIS and cases of ADH in comparison with invasive breast carcinoma. Archival primary breast carcinoma paraffin blocks (n=15), DCIS only (n=10) and ductal epithelial hyperplasia and other breast benign lesions (n=25) were analyzed for HER2/neu immunoexpression. Follow up was available for 40% of the patients. HER2/neu was positive in 80%of both DCIS and invasive carcinoma, and 67% of atypical ductal hyperplasia (ADH) cases. Thus at least a subset of patients with preinvasive breast lesions were positive, which strongly suggests a role for Her2/neu in identifying high-risk patients for malignant transformation. Although these are preliminary data, which need further studies of gene amplification within these patients as well as a larger patient cohort with longer periods of follow up, they support the implementation of routine Her2/neu testing in patients diagnosed as pure DCIS and in florid ADH.

Human Umbilical Cord Blood CD34-Positive Cells as Predictors of the Incidence and Short-Term Outcome of Neonatal Hypoxic-Ischemic Encephalopathy: A Pilot Study

Sahar M.A. Hassanein,Mohamed Hassan Nasr Eldin,Hanaa A. Amer,Adel E. Abdelhamid,Moustafa El-Houssinie,Abir Ibrahim 대한신경과학회 2017 Journal of Clinical Neurology Vol.13 No.1

Background and Purpose Neonatal hypoxic-ischemic encephalopathy (HIE) is one of the leading causes of neurological handicap in developing countries. Human umbilical cord blood (hUCB) CD34-positive (CD34+) stem cells exhibit the potential for neural repair. We tested the hypothesis that hUCB CD34+ stem cells and other cell types [leukocytes and nucleated red blood cells (NRBCs)] that are up-regulated during the acute stage of perinatal asphyxia (PA) could play a role in the early prediction of the occurrence, severity, and mortality of HIE. Methods This case-control pilot study investigated consecutive neonates exposed to PA. The hUCB CD34+ cell count in mononuclear layers was assayed using a flow cytometer. Twenty full-term neonates with PA and 25 healthy neonates were enrolled in the study. Results The absolute CD34+ cell count (p=0.02) and the relative CD34+ cell count (CD34+%) (p<0.001) in hUCB were higher in the HIE patients (n=20) than the healthy controls. The hUCB absolute CD34+ cell count (p=0.04), CD34+% (p<0.01), and Hobel risk scores (p=0.04) were higher in patients with moderate-to-severe HIE (n=9) than in those with mild HIE (n=11). The absolute CD34+ cell count was strongly correlated with CD34+% (p<0.001), Hobel risk score (p=0.04), total leukocyte count (TLC) (p<0.001), and NRBC count (p=0.01). CD34+% was correlated with TLC (p=0.02). Conclusions hUCB CD34+ cells can be used to predict the occurrence, severity, and mortality of neonatal HIE after PA.

Promoting the American Senior Tourism to Egypt

Sahar Ibrahim Elkadi,Soha Mohamed Abd el Wahab 세계문화관광학회 2008 Conference Proceedings Vol.9 No.0

Mindful of the global rapid growth in senior tourism, this research aims at studying and evaluating the industry operators' role towards increasing Egypt's market share of the American senior traffic. Within this context, three questionnaire forms were directed to the concerned public and private organizations, and to a random sample of the American seniors in Egypt to stand over the strategies of matching the Egyptian tourism product to the current seniors' wants and expectations. It was concluded that the Egyptian actors must be more senior oriented through advocating innovative approaches to satisfy the American seniors better than the competition.

Posttraumatic Acute Disseminated Encephalomyelitis in a Child Resolved by Steroid Terapy: Case Report

Sahar M.A. Hassanein,Yosra Abdelzaher Ibrahim 대한신경과학회 2016 Journal of Clinical Neurology Vol.12 No.2

A Novel and Inexpensive Method Based on Modified Ionic Gelation for pH-responsive Controlled Drug Release of Homogeneously Distributed Chitosan Nanoparticles with a High Encapsulation Efficiency

Sahar Gooneh-Farahani,Seyed Morteza Naghib,M. Reza Naimi-Jamal 한국섬유공학회 2020 Fibers and polymers Vol.21 No.9

Homogeneous chitosan nanoparticles utilizing EPR effect and pH-sensitive properties have an immense potentialfor loading and delivery of anticancer drugs. The aim of this study was preparing doxorubicin-loaded homogeneouslydistributed chitosan nanoparticles by using a simple and mild method, modified ionic gelation, with a very high encapsulationefficiency for controlled and pH-sensitive release. FESEM image revealed that the synthesized chitosan nanoparticles had auniform spherical morphology with the size range 20-35 nm. The parameters of drug stirring duration, drug amount andnanoparticles formation time were changed to achieve maximum encapsulation efficiency as well as the effect of eachparameter on the encapsulation efficiency was studied. The encapsulation efficiency toward doxorubicin under optimalconditions was 81.6±0.8 % (n=5±SD) that was higher than those previously published in literature. The investigations ofdoxorubicin release from chitosan nanoparticles in four media with different pH values showed a pH-sensitive release with ahigher release rate in an acidic environment. The drug release mechanism at all pH values was also evaluated by zero-order,first-order, Higuchi and Korsmeyer-Peppas models. The most consistent model for release curve at four pHs was Korsmeyer-Peppas model. Therefore, we presented a method for the preparation of homogeneous doxorubicin-loaded chitosannanoparticles with small size that can be industrialized because they were made based on a very simple and green methodwithout the use of a complex system and expensive materials as well as due to their high encapsulation efficiency.

ENTANGLED DEVOTIONAL COMMITMENTS: READING THE BURDAH IN EGYPT, SOUTH AFRICA, AND INDONESIA

Sahar Ishtiaque Ullah 한국외국어대학교 아프리카연구소 2020 Asian Journal of African Studies Vol.- No.48

Certain poems and stories are buried as cultural artifacts; others never die; and still others are revived from death. The thirteenth century Qaṣīdat al-Burdah, composed by Muḥammad ibn Sa’īd al-Būṣīrī (d. 693/1294), is a love poem dedicated to the Prophet Muhammad. The exemplary Arabic-Islamic work has seen renewed popularity among Muslim communities in the last two decades, from its origins in Egypt to Indonesia to locations where Muslims are a religious minority, and hundreds of youtube recordings with millions of views that demonstrate this. The poem has been dramatically staged, academically researched, and devotionally recited. In this article, I analyze the entangled devotional commitments to the Qaṣīdat al-Burdah as demonstrated by its modern iterations in Egypt, Indonesia, and South Africa and consider what we can learn about the role of audience and community in creating meaning.

Concentrically Loaded Circular RC Columns Partially Confined with FRP

Sahar Y. Ghanem,Issam E. Harik 한국콘크리트학회 2018 International Journal of Concrete Structures and M Vol.12 No.5

Wrapping reinforced concrete (RC) columns with fiber reinforced polymer (FRP) composites is effective in increasing their capacity. The current state of the art concentrates primarily on fully wrapped columns and few studies dealt with partially wrapped ones. The objective herein is to evaluate the effectiveness of partial wraps (or strips) and to develop a confined concrete compressive stress.strain (fc - εc) model that accounts for partial wrapping. Three-dimensional finite element (FE) models are generated to evaluate the influence of different parameters on the behavior of concentrically loaded RC circular columns that are partially and fully wrapped with FRP. The results indicated an increase in ductility as the number of FRP strips is increased, and revealed that longitudinal steel had little influence on the confined fc . εc relationship. The proposed fc . εc model, derived from the parametric study, accounts for the effect of partial and full confinement, the unconfined concrete strength f ′c , and yielding of transverse steel. Comparison of the results generated using the proposed model with FE and experimental results are in good agreement.

Synthesis of pure nanocrystalline ZrO2 via a simple sonochemical-assisted route

Sahar Zinatloo-Ajabshir,Masoud Salavati-Niasari 한국공업화학회 2014 Journal of Industrial and Engineering Chemistry Vol.20 No.5

Pure nanocrystalline zirconia was synthesized via a sonochemical-assisted method based on the reaction between zirconyl nitrate and propylenediamine. Here, propylenediamine for the first time was used as precipitating agent to fabricate nanocrystalline zirconia via a sonochemical-assisted method. The effect of solvent and concentration of propylenediamine on the morphology and crystallite size was investigated. It was shown that morphology and crystallite size of the as-synthesized products could be greatly affected by these parameters. The as-prepared products were characterized by SEM and TEM images, XRD patterns, FT-IR and EDS spectroscopy.

Evaluation of liquefaction potential of soil using the shear wave velocity in Tehran, Iran

Sahar Rahmanian,Fereydoun Rezaie 한국지질과학협의회 2017 Geosciences Journal Vol.21 No.1

Shear-wave velocity (VS) offers a means to determine the seismic resistance of soil to liquefaction by a fundamental soil property. Iwasaki’s (1982) method is used to measure the liquefaction potential index for both of them. It follows the general format of the Seed-Idriss (1685) simplified procedure based on standard penetration test blow count and shear wave velocity (VS) on the basis of Andrus et al. (2004) using case history data from 43 boreholes in soils ranging from fine sand, silty sand, gravely sand to profiles including silty clay layers and the average soil shear wave velocity (VS 30) in the south Tehran. Liquefaction resistance curves were established by applying a modified relationship between the shear-wave velocity and cyclic stress ratio for the constant average cyclic shear strain. The study area is the south-east of Tehran and the route of Tehran Metro Line 7. It is observed that there is not a perfect agreement between the results of the two methods based on five empirical relationships assuming cemented and non-cemented condition for soils. Moreover, the liquefaction potential index (PL) value in the Standard Penetration Test (SPT) method is more than that of the VS method. Liquefaction potential index (PL) values based on shear wave velocity (VS) using five empirical relationships in two un-cemented and cemented soil show that the used relations are overestimated and most of them have shown non-liquefaction condition for soils in the studied area.

Durability assessment of self-compacting concrete with fly ash

Sahar Deilami,Farhad Aslani,Mohamed Elchalakani 사단법인 한국계산역학회 2017 Computers and Concrete, An International Journal Vol.19 No.5

Self-Compacting Concrete (SCC) is a new technology capable to flow without segregation or any addition of energy which leads to efficient construction and cost savings. In this study, the effect of replacing the Ordinary Portland Cement (OPC) with Fly Ash (FA) on the strength, durability of the concrete was investigated experimentally, and carbon footprint and cost were also assessed. Four different replacement FA ratios (0%, 20%, 40% and 60%) were used to create four SCC mixes. Standard test methods were used to determine the workability, strength, and durability of the SCC mixes including resist chloride ion penetration, water permeability, water absorption, and initial surface absorption. The axial cube compressive strength tests were performed on the SCC mixes at 1, 7, 14, 28 and 35 days. Replacing the OPC with FA had a significant positive impact on chloride iron penetration resistance and water absorption but had a considerable negative impact on the compressive strength. The SCC mix with 60% FA had 36.7% and 15.8% enhancement in the resistance to chloride ion penetration and water absorption, respectively. Evaluation of the carbon footprint and the cost of each SCC mixes showed the CO2 emissions mixes 1, 2, 3 and 4 were significantly reduced by increasing the FA content from 0% to 60%. Compared with the control mix, the cost of all mixes increased when the FA content increased, but no significant differences were seen between the estimated costs of all four mixes.