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RISS 인기검색어
- 검색키워드
- 저자 : Seyed Morteza Naghib (검색결과 3 건)
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Farahnaz Behzad,Seyed Morteza Naghib,Mohammad Amin Jadidi kouhbanani,Seyede Nafise Tabatabaei,Yasser Zare,이경엽 한국공업화학회 2021 Journal of Industrial and Engineering Chemistry Vol.94 No.-
Metallic nanoparticles (MNPs) with attractive physicochemical properties are utilized in severalbiomedical domains, such as antimicrobial agents. Many researchers have tried to explore novel aspectsof the respective worth of MNPs, arising from their small size. The increasing demand for MNPs hasattracted research interest on developing simple, rapid, inexpensive, and environmentally friendlyprocesses for the synthesis of MNPs. Among the developed types of MNPs, noble metal nanoparticles(NMNPs), especially silver (Ag), gold (Au), and platinum (Pt), have received much attention, due to theirexcellent properties and diverse applications. For example, microbial contaminations are one of the mostsevere issues faced in food industries, medical device application, and water treatment. To address theseissues, nanoscale materials and nanostructures, especially NMNPs, have been developed, offering novelantimicrobial features. Herein, we review the available green approaches for producing NMNPs (AgNPs,AuNPs, and PtNPs) using different plant extracts, and discuss the antibacterial influences andbiocompatibility of these NPs. We highlight the developments of NMNPs for resolving existing toxicityconcerns, their antimicrobial effects, as well as the future challenges in thisfield.
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Sahar Gooneh-Farahani,Seyed Morteza Naghib,M. Reza Naimi-Jamal 한국섬유공학회 2020 Fibers and polymers Vol.21 No.9
Homogeneous chitosan nanoparticles utilizing EPR effect and pH-sensitive properties have an immense potentialfor loading and delivery of anticancer drugs. The aim of this study was preparing doxorubicin-loaded homogeneouslydistributed chitosan nanoparticles by using a simple and mild method, modified ionic gelation, with a very high encapsulationefficiency for controlled and pH-sensitive release. FESEM image revealed that the synthesized chitosan nanoparticles had auniform spherical morphology with the size range 20-35 nm. The parameters of drug stirring duration, drug amount andnanoparticles formation time were changed to achieve maximum encapsulation efficiency as well as the effect of eachparameter on the encapsulation efficiency was studied. The encapsulation efficiency toward doxorubicin under optimalconditions was 81.6±0.8 % (n=5±SD) that was higher than those previously published in literature. The investigations ofdoxorubicin release from chitosan nanoparticles in four media with different pH values showed a pH-sensitive release with ahigher release rate in an acidic environment. The drug release mechanism at all pH values was also evaluated by zero-order,first-order, Higuchi and Korsmeyer-Peppas models. The most consistent model for release curve at four pHs was Korsmeyer-Peppas model. Therefore, we presented a method for the preparation of homogeneous doxorubicin-loaded chitosannanoparticles with small size that can be industrialized because they were made based on a very simple and green methodwithout the use of a complex system and expensive materials as well as due to their high encapsulation efficiency.
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Javad Saberi,Mojtaba Ansari,Bahman Ebrahimi Hoseinzadeh,Soheila Salahshour Kordestani,Seyed Morteza Naghib 한국섬유공학회 2018 Fibers and polymers Vol.19 No.12
Chitosan (Cs)-poly acrylic acid (PAA) complex nanoparticles well dispersed and stable in aqueous solution was prepared by free radical polymerization of acrylic acid monomers (AA) in the presence of chitosan (Cs). Different concentrations of Cs and AA was cross-linked to form scalable hybrid nanoparticles (HNP). The physicochemical characterization of nanopolymers was investigated using FTIR, dynamic light scattering (DLS) and scanning electron microscopy (SEM). Infrared spectroscopy and electronic microscopy analysis results showed the preparation of Cs-PAA hybrid nanoparticles due to the formation of polyelectrolyte complexes and their spherical shape, respectively. The average particle size obtained under 180 nm for all samples obtained by using DLS analysis. A dhesion strength for the samples with a ratio of Cs/AA 1: 1 and 0.2: 1 was 50 to 120 kPa and 120 to 230 kPa , respectively. Cytotoxicity assay (MTT) showed that cell activity for concentrations X/5 and X/10 was over 7 5 %, demonstrating the sample extracts have suitable cytocompatibility. In addition, hemolytic assay of the samples represents below 0.5 % (according to the standard) in damage extend to red blood cells. Furthermore, prepared tissue adhesive based on Cs-PAA hybrid NPs in terms of adhesion strength was competitive with commercial samples as well as satisfactory results in terms of biocompatibility and blood compatibility were achieved in comparison with commercial available adhesives based on cyanoacrylate.
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