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비이온 계면활성제의 화학구조에 따른 Closterium ehrenbergii 대한 생태독성
김상길,Matsui Saburo,박희경 한국환경독성학회 2000 환경독성보건학회지 Vol.15 No.1
This study was designed to evaluated the ecotoxicity to Closterium ehrenbergii using Nonionic surfactants based on its chemical structure. Nonionic surfactants ecotoxicity tended to increase with decreasing the number of ethylene oxide units. The Closterium ehrenbergii test was good in sensitivity and agreement with other published results. The use of Closterium ehrenbergii test offers promising potential for ecotoxicological applications.
Kazuhiro Ikeda,Yoshihisa Shimizu,Saburo Matsui,Takuya Oguri,Makoto Sekida,Atsusi Kawata,Taketoshi Kusakabe 대한토목학회 2008 KSCE Journal of Civil Engineering Vol.12 No.2
In this study, we investigated the partition property of pyrene onto cell membrane using synthetic membrane vesicles consisted ofseveral phospholipids and the effect of natural organic matters (NOM) on the partition. Membrane fluidity and membrane phaseaffected partition coefficient (Pmw) of pyrene onto the membrane. Pmw was larger for the liposome in liquid crystalline phase > inripple phase > in gel phase. Pyrene did not undergo the steric interfere in partition onto the membrane used in this study. Negativecharge of the membrane did not affect Pmw of pyrene. Suwannee River Natural Organic Matter (NOM) and Nordic fulvic acidaffected the partition of pyrene onto the TRANSILmembrane. The reason was confirmed that NOM associated pyrene did notpartition onto the membrane. Low molecular weigh fraction of SRNOM had strong effect on the partition as much as high molecularweigh fraction. From calorimetrical analysis, it was found that SRNOM did not affect the fluidity of the dimyristoy-lphosphatidylcholine (DMPC) membrane.
Megumi Nakai,Michiro Iizuka,Nobuaki Matsui,Kazuko Hosogi,Akiko Imai,Noriaki Abe,Hisashi Shiraishi,Ayumu Hirata,Yusuke Yagi,Kohei Jobu,Junko Yokota,Eishin Kato,Shinya Hosoda,Saburo Yoshioka,Kenichi Har 한국식품영양과학회 2016 Journal of medicinal food Vol.19 No.5
Bangle (Zingiber purpureum) is a tropical ginger that is used as a spice in Southeast Asia. Phenylbutenoid dimers isolated from Bangle have exhibited neurotrophic effects in primary cultured rat cortical neurons and PC12 cells. Furthermore, chronic treatment with phenylbutenoid dimers enhances hippocampal neurogenesis in olfactory bulbectomized mice. In this study, we investigated the effects of Bangle extract on behavior and hippocampal neurogenesis in vivo. SAMP8 mice, which are an established model for accelerated aging, with age-related learning and memory impairments, were given a Bangle-containing diet for 1 month, and subsequent behavioral tests and immunohistochemistry for Ki67, a proliferating cellmarker, were performed. We found that the Bangle-containing diet improved spatial learning and memory deficits in the Morris water maze and significantly increased the numbers of Ki67-positive cells in the dentate gyrus of the SAMP8 mice. In addition, the Bangle extract exhibited a neurotrophin-like activity as indicated by the induction of neurite sprouting in PC12 cells. Our results suggest that Bangle is beneficial for the prevention of age-related progression of cognitive impairment.