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趙統來,李鴻魯,朴承甲 충남대학교 공업교육연구소 1982 論文集 Vol.5 No.1
Ternary miscibility gap of the Pb-Cu-S system is important to smelting of lead and copper, but we can not find experimental determination of this system. Ternary miscibility gap of the Pb-Cu-S sytem was experimentally determined at 1250℃. Isoactivities tie line of lead, copper and sulfer in this ternary miscibility gap of the Pb-Cu-S system was determined.
갑상선 기능항진증환자에서 치료전후의 골밀도 및 생화학적 지표변화
김유리,이명철,이승우,허갑범,이현철,임승길,이관우,김경래,김미림 대한내분비학회 1990 Endocrinology and metabolism Vol.5 No.3
Bone mineral density, serum osteocalcin and other biochemical markers were measured in 15 hyperthyroid patients before and after treatment. Bone mineral density after treatment showed slight increase in all regions, especially in femur neck, ward triangle (p$lt;0.001), and trochanter (p$lt;0.05). Serum osteocalcin level was significantly decreased after treatment (14.9±8.6 vs 3.4±2.2 ng/ml, p$lt;0.001). Also serum phosphorus (4.0±0.4 vs 3.3±0.4 mg/dl, p$lt;0.05) and alkaline phosphatase (96.8±28.7 vs 55.0±7.5 IU/L, p$lt;0.001) were significantly decreased. Twenty four hours-urine hydroxyproline revealed no change before and after treatment (86.8±65.8 vs 88.5±83.9 ug/mg). These results suggest that hyperthyroid osteopathy may be due to increased bone resorption rather than bone formation. (J Kor Soc Endocrinol 5:193~197, 1990)
Kyung Sun Lee, So Ri Kim,Young Rae Lee,Jong Suk Kim,Daphne Atlas,Yong Chul Lee,박희선,Seoung Ju Park,Kyung Hoon Min,Ka Young Lee,Yeong Hun Choe,Sang Hyun Hong,Hyo Jin Han 생화학분자생물학회 2007 Experimental and molecular medicine Vol.39 No.6
Reactive oxygen species (ROS) play an important role in the pathogenesis of airway inflammation and hyperresponsiveness. Recent studies have demonstrated that antioxidants are able to reduce airway inflammation and hyperreactivity in animal models of allergic airway disease. A newly developed antioxidant, small molecular weight thiol compound, N-acetylcysteine amide (AD4) has been shown to increase cellular levels of glutathione and to attenuate oxidative stress related disorders such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis. However, the effects of AD4 on allergic airway disease such as asthma are unknown. We used ovalbumin (OVA)-inhaled mice to evaluate the role of AD4 in allergic airway disease. In this study with OVA-inhaled mice, the increased ROS generation, the increased levels of Th2 cytokines and VEGF, the increased vascular permeability, the increased mucus production, and the increased airway resistance in the lungs were significantly reduced by the administration of AD4. We also found that the administration of AD4 decreased the increases of the NF-κB and hypoxia-inducible factor- 1α (HIF-1α ) levels in nuclear protein extracts of lung tissues after OVA inhalation. These results suggest that AD4 attenuates airway inflammation and hyperresponsiveness by regulating activation of NF-κB and HIF-1α as well as reducing ROS generation in allergic airway disease.
Kim, So Ri,Lee, Kyung Sun,Park, Seoung Ju,Min, Kyung Hoon,Lee, Ka Young,Choe, Yeong Hun,Lee, Young Rae,Kim, Jong Suk,Hong, Soo Jong,Lee, Yong Chul American Association of Immunologists 2007 Journal of Immunology Vol.179 No.10
<P>Toluene diisocyanate (TDI)-induced airway disease is a disorder characterized by chronic airway inflammation and airway remodeling. A recently discovered group of cytokines is the IL-17 family, which has been introduced as an important regulator of immune and inflammatory responses, including airway inflammation. Recently, we have reported that phosphatase and tensin homologue deleted on chromosome 10 (PTEN) plays a pivotal role in the pathogenesis of bronchial asthma. However, there are no available data for the effects of PTEN or IL-17 on TDI-induced airway disease and the relationship between PTEN and IL-17. We used a murine model to determine the role of PTEN in the pathogenesis of TDI-induced airway disease and the regulation of IL-17 production. These mice developed the typical pathophysiological features of TDI-induced airway disease and increased IL-17 expression in the lungs. Administration of phosphoinositide 3-kinase inhibitors or adenoviruses carrying PTEN cDNA (AdPTEN) reduced the pathophysiological features of TDI-induced airway disease and decreased the increased levels of IL-17 expression. Our results also showed that PI3K inhibitors or AdPTEN down-regulated a transcription factor, NF-kappaB activity, and BAY 11-7085 substantially reduced the increased levels of IL-17 after TDI inhalation. We also found that inhibition of IL-17 activity with an anti-IL-17 Ab reduced airway inflammation and airway hyperresponsiveness. These results suggest that PTEN plays a protective role in the pathogenesis of TDI-induced airway disease, at least in part through the regulation of IL-17 expression. Thus, PTEN may be a useful target for treating TDI-induced airway disease by modulating IL-17 expression.</P>
( Il Su Choi ),( Na Rae Kang ),( Young Keun Kim ),( Hyeon Jong Jun ),( Yong Choi ),( Tae Gyoung Kang ),( Chang Sik Hyun ),( Sang Hee Lee ),( Jin Gu Kim ),( Seoung Hwa Yu ),( Sun Ok Chung ) 한국농업기계학회 2018 바이오시스템공학 Vol.43 No.4
Purpose: This research was conducted to determine the design factors of a seed-metering device for the development of a seeder. The device allows the seeder to sow precisely one to three seeds of foxtail millet and sorghum. To obtain fundamental information regarding the design of the seed-metering device, examination of the physical properties of foxtail millet and sorghum was conducted. Methods: Based on the results of an adaptability test using an existing seeder with foxtail millet and sorghum, an experimental roller-type seed-metering device was made. The seeding factors considered during the experiment were the width, length, and depth, as well as the shape of the groove in the seed-metering roller. By adapting an analysis of variance, the experimental results of the seeding factors were analyzed. Results: The measured results of the respective lengths and widths of the seeds were 2.11 and 1.64 mm for foxtail millet, and 3.68 and 3.32 mm for sorghum, respectively. The weight of 1,000 seeds was 2.43 g for foxtail millet and 17.5 g for sorghum. The seeds were of an elliptical shape, considering the length and width. A sieve analysis showed that the size distribution of foxtail millet was quite regular whereas that of sorghum was irregular. Conclusions: The seeding results showed that the rates of incorrect planting were low when the groove of the roller-type metering device is an elliptical type. To sow one to three seeds, the groove of roller-type metering devices 2.0 mm x 4.0 mm x 1.5 mm (width x length x depth) for foxtail millet, and 4.0 mm x 8.0 mm x 3.0 mm and 4.5 mm x 8.0 mm x 3.0 mm (width x length x depth) for Sorghum.