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        Bisabolol-Induced Gastroprotection Against Acute Gastric Lesions: Role of Prostaglandins, Nitric Oxide, and K+ATP Channels

        S.B. Bezerra,L.K.A.M. Leal,N.A.N. Pinto,A.R. Campos 한국식품영양과학회 2009 Journal of medicinal food Vol.12 No.6

        The effects of Matricaria recutita and α-bisabolol, a bioactive component from Chamomile species, were investigated against gastric damage induced by absolute ethanol (96%, 1mL per animal) in rats. The effects of M. recutita extract and α-bisabolol on gastric mucosal damage were assessed by determination of changes in mean gastric lesion area. Mechanistic studies were carried out at with 100mg/kg α-bisabolol. We further examined the possible participation of prostaglandins, nitric oxide, and K+ATP channels in its mechanism. M. recutita reduced gastric damage in all doses tested. α-Bisabolol at oral doses of 50 and 100mg/kg markedly attenuated the gastric lesions induced by ethanol to the extent of 87% and 96%, respectively. Pretreatments with the nitric oxide antagonist N-nitro-l-arginine methyl ester (10mg/kg, i.p.) or with indomethacin, an inhibitor of cyclooxygenase, failed to block effectively the gastroprotective effect of α-bisabolol. Furthermore, the α-bisabolol effect was significantly reduced in rats pretreated with glibenclamide, an inhibitor of K+ATP channel activation. Thus we provide evidence that α-bisabolol reduces the gastric damage induced by ethanol, at least in part, by the mechanism of activation of K+ATP channels.

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        Cone beam computed tomography and intraoral radiography for diagnosis of dental abnormalities in dogs and cats

        Marcello R. Roza,Luiz Antonio F. Silva,Mauricio Barriviera,Alessandro L. Januário,Ana Cristina B. Bezerra,Maria Clorinda S. Fioravanti 대한수의학회 2011 Journal of Veterinary Science Vol.12 No.4

        The development of veterinary dentistry has substantially improved the ability to diagnose canine and feline dental abnormalities. Consequently, examinations previously performed only on humans are now available for small animals, thus improving the diagnostic quality. This has increased the need for technical qualification of veterinary professionals and increased technological investments. This study evaluated the use of cone beam computed tomography and intraoral radiography as complementary exams for diagnosing dental abnormalities in dogs and cats. Cone beam computed tomography was provided faster image acquisition with high image quality, was associated with low ionizing radiation levels, enabled image editing, and reduced the exam duration. Our results showed that radiography was an effective method for dental radiographic examination with low cost and fast execution times, and can be performed during surgical procedures.

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