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중증 전자간증 임산부의 제대동맥 이완기말 혈류 속도에 따른 제대혈 혈액소견 및 주산기 예후
오준환 ( Joon Hwan Oh ),임윤경 ( Yun Kyoung Lim ),이희종 ( Hee Jong Lee ),김행수 ( Haeng Soo Kim ),양정인 ( Jeong In Yang ),유희석 ( Hee Sug Ryu ),오기석 ( Kie Suk Oh ) 대한산부인과학회 2003 Obstetrics & Gynecology Science Vol.46 No.4
목적 : 중증 전자간증 환자를 대상으로 제대동맥 이완기말 혈류의 유무에 따른 제대혈 유핵 적혈구의 수와 주산기 예후를 비교하고자 하였다. 연구 방법 : 1999년 1월부터 2002년 9월까지 아주대학교 산부인과에 입원한 중증 전자간증 환자중 분만 72시간 전에 제대 동맥 이완기말 혈류속도를 측정한 49예를 대상으로 하여 이완기말 혈류 속도가 있었던 42예와 혈류 속도가 없는 7예 사이의 제대혈에서의 유핵 적혈구의 수와 태아의 주산기 예후를 비교하였다. Objective : To assess the umbilical nucleated red blood cell counts and perinatal outcomes according to umbilical artery Doppler end diastolic velocity in severe preeclampsia. Materials and Methods : A prospective case-control study comparing 42 severe pr
Anticomplementary Activity of Stilbenes from Medicinal Plants
Oh, Sei-Ryang,Ryu, Shi-Yong,Park, Si-Hyung,Jung, Keun-Young,Lee, Im-Seon,An, Kyung-Seop,Lee, Jung-Joon,Lee, Hyeong-Kyu The Pharmaceutical Society of Korea 1998 Archives of Pharmacal Research Vol.21 No.6
The anticomplementary activity of stilbenes from medicinal plants in Korea was investigated in vitro. 3,5-Dihydroxy-4'-methoxystilbene (3) was most potent with $IC_{50}$ value of $1.5{\times}10^{-4}M$ followed by rhapontigenin (4), oxyresverastrol (2), 2,3,4',5-tetrahydroxystilbene-2-O-beta-glucoside (9), rhaponticin (8), resverastrol (1), and piceid (7). The activity was found to be increased by a methylation on a hydroxy group of C-4' of 1, but decreased by further methylation on hydroxy groups of C-3 and C-5 and glucosylation on any hydroxy group of 1. Addition of hydroxy group on C-2' of 1 or C-3' of 3 was little affected on the anticomplementary activity but the activity was increased by O-glucosylation on C-2 of 1.
Ryu Tae Hyun,Kim Hee Yeoun,Ahn Jeongmyung,Oh Joon Seok,Kim Joong Kyung 대한이식학회 2023 Korean Journal of Transplantation Vol.37 No.1
Coronavirus disease 2019 (COVID-19) increases the risk of mortality and hospitalization in immunocompromised patients, including kidney transplant recipients (KTRs) receiving immunosuppressants. Several vaccines for COVID-19 have been developed and proven effective in decreasing the incidence of COVID-19 and the rate of progression to severe COVID-19. However, breakthrough infections have also been reported in vaccinated patients. We report cases from our center of delayed exacerbated pneumonia from COVID-19 in vaccinated KTRs receiving immunosuppressants. Of the 900 KTRs who had been vaccinated for COVID-19 and were followed up at our center from January 1, 2022, to April 30, 2022 (during the Omicron variant outbreak), 126 contracted COVID-19 (incidence rate, 14%). Thirty-four (27%) in this group were hospitalized due to COVID-19. Twenty patients did not have pneumonia but had symptoms of upper respiratory tract infection or diarrhea, which improved with conservative treatment. Nine of the 14 patients with pneumonia had delayed onset or exacerbated pneumonia 1 week after their COVID-19 diagnosis. They were treated with remdesivir, and most recovered. One patient died due to progressive pneumonia and pneumothorax. It is important that KTRs who are taking immunosuppressants be observed closely and for a prolonged period after a COVID-19 diagnosis, irrespective of their COVID-19 vaccination status.
The effects of maxillary protraction appliance (MPA) depending on vertical facial patterns
Ryu, Young-Kyu,Lee, Kee-Joon,Oh, Chang-Hun 대한치과교정학회 2002 대한치과교정학회지 Vol.32 No.6
성장기 아동에서 상악골 열성장을 보이는 제Ⅲ급 부정교합은 상악골 전방 견인 장치의 적응증이 된다. 상악골 전방 견인장치의 바람직한 효과는 상악골의 정방 이동이지만, 실제로는 상악 치아의 전방 이동, 하악골의 후하방 회전, 하악 전치의 설측 이동 등의 복합적인 결과는 Ⅲ급 관계가 개선된다고 알려져 있다. 그러나 수직적 안모 유형별로 상악골 전방 견인 장치의 효과에 대한 차이는 잘 알려진 바가 없다. 본 연구는 1998년-2000년 사이에 연세대학교 치과병원 교정과에 내원한 환자들 중 초진시 나이는 6세 6개월에서 13세 3개월 사이의 상악골 열성장을 동반한 제 Ⅲ급 부정교합으로 진단된 67명(남 36, 여 31)을 대상으로, 암모유형별로 SNMP군과 Gonial angle군에서 low, average, high로 세부군을 나누어 치료전 측모 두부방사선 규격사진을 통해 상악골 전방견인 장치의 효과를 비교하여 다음과 같은 결과를 얻었다. ① SNMP군의 low angle에서 B point의 후방이동량이 많았으며, HIgh angle에서는 A point의 전방이동양이 컸다. ② Gonial angle군의 low angle에서 A point의 전방이동양이 가장 적었으며, high angle에서는 A point의 전방이동양이 상대적으로 많았다. ③ A point에 대한 arcTan를 구한 결과 A point의 이동 각도는 장안모 군에서 더 수평적인 이동 양상을 보였고, 단안모 군에서는 수직적 이동양상이 강했다. ④ SNMP군과 Gonial angle의 세부군에서 치료기간별 유의성은 없었다. Preadolescent children with deficient maxillae are suitable candidates for the maxillary protraction appliance(MPA). The theoretical effect of the MPA is protraction or anterior displacement of the maxilla. However, it known that complex effects such as anterior displacement of the maxillary teeth, downward and backward rotation of the mandible, linguoversion of the mandibular anterior incisors, are known to play a role in improving the C1 Ⅲ malocclusion. There have been much studies with regard to maxillary protraction, but the different effects of MPAs depending on the vertical facial pattern are not known precisely. This study was based on 67 patients (31 males, 36 females) aged from 6 years 6 months to 13 years 3months, who visited the Dept. of Orthodontics at Yonsei Univ., Dental Hospital and diagnosed as skeletal Class Ⅲ with maxillary deficiency. They were divided into 3 group (low, average, high angle groups) depending on gonial angle and the SNMP (Go-Gn) angle, respectively. Pretreatment and post-treatment lateral cephalograms were used to compare the effects of MPA and the following conclusions were obtained: ① A significantly large amount of backward movement of the B point was observed in patients with a low SNMP angle. Those with a high SNMP angle had significant forward movement at A point. ②The patients with low gonial angle had the least forward movement at the A point, and those with a high angle and more forward movement. ③In comparing the arcTan of the A point, the high angle group showed more horizontal movement while the low angle group showed more vertical movement. ④ there was no significance between the treatment duration of the SNMP and the Gonial angle groups.
Oh, Hwanhee,Ryu, Je-Hwang,Jeon, Jimin,Yang, Siyoung,Chun, Churl-Hong,Park, Hongryeol,Kim, Hyung Joon,Kim, Woo-Shin,Kim, Hong-Hee,Kwon, Young-Guen,Chun, Jang-Soo Mary Ann Liebert, Inc 2012 Journal of bone and mineral research Vol.27 No.6
<P>Developing cartilage serves as a template for long-bone development during endochondral ossification. Although the coupling of cartilage and bone development with angiogenesis is an important regulatory step for endochondral ossification, the molecular mechanisms are poorly understood. One possible mechanism involves the action of Dickkopf (DKK), which is a family of soluble canonical Wnt antagonists with four members (DKK1-4). We initially observed opposite expression patterns of Dkk1 and Dkk2 during angiogenesis and chondrocyte differentiation: downregulation of Dkk1 and upregulation of Dkk2. We examined the in vivo role of Dkk1 and Dkk2 in linking cartilage/bone development and angiogenesis by generating transgenic (TG) mice that specifically express Dkk1 or Dkk2 in chondrocytes, hypertrophic chondrocytes, or endothelial cells. Despite specific expression pattern during cartilage development, chondrocyte- and hypertrophic chondrocyte-specific Dkk1 and Dkk2 TG mice showed normal developmental phenotypes. However, Dkk1 misexpression in endothelial cells resulted in defects of endochondral ossification and reduced skeletal size. The defects are caused by the inhibition of angiogenesis in developing bone and subsequent inhibition of apoptosis of hypertrophic chondrocytes and cartilage resorption.</P>